EA201691619A1 - Конденсированные гетероциклические соединения - Google Patents

Конденсированные гетероциклические соединения

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Publication number
EA201691619A1
EA201691619A1 EA201691619A EA201691619A EA201691619A1 EA 201691619 A1 EA201691619 A1 EA 201691619A1 EA 201691619 A EA201691619 A EA 201691619A EA 201691619 A EA201691619 A EA 201691619A EA 201691619 A1 EA201691619 A1 EA 201691619A1
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EA
Eurasian Patent Office
Prior art keywords
compounds
condensed heterocyclic
heterocyclic compounds
diabetes
proposed
Prior art date
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EA201691619A
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English (en)
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EA032201B1 (ru
Inventor
Минору Сасаки
Кейко Какегава
Фумиаки Кикути
Зенити Икеда
Еити Нисикава
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Такеда Фармасьютикал Компани Лимитед
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Publication of EA201691619A1 publication Critical patent/EA201691619A1/ru
Publication of EA032201B1 publication Critical patent/EA032201B1/ru

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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

Предложены конденсированные гетероциклические соединения, обладающие ингибирующим энтеропептидазу действием, и применение указанных соединений в качестве лекарственных средств для лечения или профилактики ожирения, сахарного диабета и т.д. Более конкретно, предложены соединения, представленные формулой (I), где каждый символ имеет указанные в описании значения, или их соли, и использование указанных соединений в качестве лекарственных средств для лечения или профилактики ожирения, сахарного диабета и т.д.
EA201691619A 2014-02-13 2015-02-12 Конденсированные гетероциклические соединения EA032201B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014025832 2014-02-13
PCT/JP2015/000639 WO2015122187A1 (en) 2014-02-13 2015-02-12 Fused heterocyclic compound

Publications (2)

Publication Number Publication Date
EA201691619A1 true EA201691619A1 (ru) 2017-01-30
EA032201B1 EA032201B1 (ru) 2019-04-30

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EA201691619A EA032201B1 (ru) 2014-02-13 2015-02-12 Конденсированные гетероциклические соединения

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US (2) US9346776B2 (ru)
EP (1) EP3105213B1 (ru)
JP (2) JP6383427B2 (ru)
KR (1) KR102378454B1 (ru)
CN (1) CN105980370B (ru)
AR (1) AR099400A1 (ru)
AU (1) AU2015216438B2 (ru)
BR (1) BR112016018455B1 (ru)
CA (1) CA2938191C (ru)
CL (1) CL2016001911A1 (ru)
CR (1) CR20160367A (ru)
CY (1) CY1121534T1 (ru)
DK (1) DK3105213T3 (ru)
DO (1) DOP2016000206A (ru)
EA (1) EA032201B1 (ru)
EC (1) ECSP16067137A (ru)
ES (1) ES2717113T3 (ru)
HR (1) HRP20190369T1 (ru)
HU (1) HUE042709T2 (ru)
IL (1) IL246838B (ru)
JO (1) JO3472B1 (ru)
LT (1) LT3105213T (ru)
MA (1) MA39246A1 (ru)
ME (1) ME03422B (ru)
MX (1) MX368392B (ru)
MY (1) MY173607A (ru)
NZ (1) NZ722035A (ru)
PE (1) PE20161243A1 (ru)
PH (1) PH12016501582A1 (ru)
PL (1) PL3105213T3 (ru)
PT (1) PT3105213T (ru)
RS (1) RS58498B1 (ru)
SG (1) SG11201605654QA (ru)
SI (1) SI3105213T1 (ru)
TR (1) TR201903892T4 (ru)
TW (1) TWI669297B (ru)
UA (1) UA118280C2 (ru)
UY (1) UY35994A (ru)
WO (1) WO2015122187A1 (ru)

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