JP6283320B2 - ウイルス感染の治療のためのピペリジノ−ピリミジン誘導体 - Google Patents
ウイルス感染の治療のためのピペリジノ−ピリミジン誘導体 Download PDFInfo
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- JP6283320B2 JP6283320B2 JP2014556041A JP2014556041A JP6283320B2 JP 6283320 B2 JP6283320 B2 JP 6283320B2 JP 2014556041 A JP2014556041 A JP 2014556041A JP 2014556041 A JP2014556041 A JP 2014556041A JP 6283320 B2 JP6283320 B2 JP 6283320B2
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- PBNWEDWXMJZREX-UHFFFAOYSA-N CC1=NC(C)=CS2C1C2 Chemical compound CC1=NC(C)=CS2C1C2 PBNWEDWXMJZREX-UHFFFAOYSA-N 0.000 description 1
- 0 CCCC(CCO)(C1)[C@]1Nc1c(CN(CC2)C(c3c[s]c(C)n3)=*)c2nc(N)n1 Chemical compound CCCC(CCO)(C1)[C@]1Nc1c(CN(CC2)C(c3c[s]c(C)n3)=*)c2nc(N)n1 0.000 description 1
- OXYLSEGFCZHCPR-UHFFFAOYSA-N CCCCNc1c(CN(CC2)C(C3CCC3)=O)c2nc(N)n1 Chemical compound CCCCNc1c(CN(CC2)C(C3CCC3)=O)c2nc(N)n1 OXYLSEGFCZHCPR-UHFFFAOYSA-N 0.000 description 1
- UEUDJVVHQQCTQJ-UHFFFAOYSA-N CCCCNc1nc(N)nc(C2)c1CCN2C(C1=CC=CC1CCC)=O Chemical compound CCCCNc1nc(N)nc(C2)c1CCN2C(C1=CC=CC1CCC)=O UEUDJVVHQQCTQJ-UHFFFAOYSA-N 0.000 description 1
- RYJBSWANUOUDDD-AWEZNQCLSA-N CCCC[C@@H](CCO)Nc1nc(N)nc(C2)c1CCN2C(c1ccc[n]1C)=O Chemical compound CCCC[C@@H](CCO)Nc1nc(N)nc(C2)c1CCN2C(c1ccc[n]1C)=O RYJBSWANUOUDDD-AWEZNQCLSA-N 0.000 description 1
- RKUYNGIBWIWGFR-NSHDSACASA-N CCC[C@@H](CCO)Nc1c(CN(CC2)C(c3c[s]cn3)=O)c2nc(N)n1 Chemical compound CCC[C@@H](CCO)Nc1c(CN(CC2)C(c3c[s]cn3)=O)c2nc(N)n1 RKUYNGIBWIWGFR-NSHDSACASA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12154474 | 2012-02-08 | ||
| EP12154474.6 | 2012-02-08 | ||
| PCT/EP2013/052372 WO2013117615A1 (en) | 2012-02-08 | 2013-02-07 | Piperidino-pyrimidine derivatives for the treatment of viral infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015506380A JP2015506380A (ja) | 2015-03-02 |
| JP6283320B2 true JP6283320B2 (ja) | 2018-02-21 |
Family
ID=47678822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556041A Expired - Fee Related JP6283320B2 (ja) | 2012-02-08 | 2013-02-07 | ウイルス感染の治療のためのピペリジノ−ピリミジン誘導体 |
Country Status (22)
Families Citing this family (165)
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|---|---|---|---|---|
| JP6046694B2 (ja) | 2011-04-08 | 2016-12-21 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染治療用のピリミジン誘導体 |
| ES2690082T3 (es) | 2011-11-09 | 2018-11-19 | Janssen Sciences Ireland Uc | Derivados de purina para el tratamiento de infecciones virales |
| MX357296B (es) | 2012-02-08 | 2018-07-03 | Janssen Sciences Ireland Uc | Derivados piperidinopirimidinicos para el tratamiento de infecciones viricas. |
| SI2872515T1 (sl) | 2012-07-13 | 2016-10-28 | Janssen Sciences Ireland Uc | Makrociklični purini za zdravljanje virusnih infekcij |
| TR201807076T4 (tr) | 2012-10-10 | 2018-06-21 | Janssen Sciences Ireland Uc | Viral enfeksiyonların ve diğer hastalıkların tedavisine yönelik pirolo[3,2-d]pirimidin derivatları. |
| CA2886635C (en) | 2012-11-16 | 2021-01-05 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
| EP2958900B1 (en) | 2013-02-21 | 2019-04-10 | Janssen Sciences Ireland Unlimited Company | 2-aminopyrimidine derivatives for the treatment of viral infections |
| MX366481B (es) | 2013-03-29 | 2019-07-09 | Janssen Sciences Ireland Uc | Deaza-purinonas macrociclicas para el tratamiento de infecciones virales. |
| EA034674B1 (ru) | 2013-05-24 | 2020-03-05 | Янссен Сайенсиз Айрлэнд Юси | Производные пиридона для лечения нарушений, в которое вовлечены модуляции tlr7 и/или tlr8 |
| CN109369643B (zh) | 2013-06-27 | 2021-05-18 | 爱尔兰詹森科学公司 | 用于治疗病毒感染和其他疾病的吡咯并[3,2-d]嘧啶衍生物 |
| CN105492446B (zh) | 2013-07-30 | 2018-08-03 | 爱尔兰詹森科学公司 | 用于治疗病毒性感染的噻吩并[3,2-d]嘧啶衍生物 |
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