JP6256882B2 - 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途 - Google Patents

第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途 Download PDF

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JP6256882B2
JP6256882B2 JP2014557620A JP2014557620A JP6256882B2 JP 6256882 B2 JP6256882 B2 JP 6256882B2 JP 2014557620 A JP2014557620 A JP 2014557620A JP 2014557620 A JP2014557620 A JP 2014557620A JP 6256882 B2 JP6256882 B2 JP 6256882B2
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factor viii
xten
amino acid
sequence
seq
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JP2015512876A5 (enExample
JP2015512876A (ja
Inventor
フォルカー シェレンバーガー，
フォルカー シェレンバーガー，
ペイ−ユン チャン，
ペイ−ユン チャン，
ファトバルダ ヴァルファイ，
ファトバルダ ヴァルファイ，
シェン ディン，
シェン ディン，
ジョシュア シルバーマン，
ジョシュア シルバーマン，
チア−ウェイ ワン，
チア−ウェイ ワン，
ベンジャミン スピンク，
ベンジャミン スピンク，
ウィレム ピー． ステマー，
ウィレム ピー． ステマー，
ネイサン ギーティング，
ネイサン ギーティング，
ジョン クルマン，
ジョン クルマン，
トンヤオ リウ，
トンヤオ リウ，
ギャラベット ジー． トビー，
ギャラベット ジー． トビー，
ハイヤン ジアン，
ハイヤン ジアン，
ロバート ピーターズ，
ロバート ピーターズ，
デピン ワン，
デピン ワン，
バイソン メイ，
バイソン メイ，
Original Assignee
アムニクス オペレーティング インコーポレイテッド
アムニクス オペレーティング インコーポレイテッド
バイオベラティブ セラピューティクス インコーポレイテッド
バイオベラティブ セラピューティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2014557620A 2012-02-15 2012-07-11 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途 Active JP6256882B2 (ja)

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US201261599400P 2012-02-15 2012-02-15
US61/599,400 2012-02-15
PCT/US2012/046326 WO2013122617A1 (en) 2012-02-15 2012-07-11 Factor viii compositions and methods of making and using same

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JP2015138941A Division JP2015180697A (ja) 2012-02-15 2015-07-10 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2017134582A Division JP6527918B2 (ja) 2012-02-15 2017-07-10 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途

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JP2014557620A Active JP6256882B2 (ja) 2012-02-15 2012-07-11 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2015138941A Pending JP2015180697A (ja) 2012-02-15 2015-07-10 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2017134582A Active JP6527918B2 (ja) 2012-02-15 2017-07-10 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2018204089A Active JP6574040B2 (ja) 2012-02-15 2018-10-30 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2019148815A Active JP7015810B2 (ja) 2012-02-15 2019-08-14 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2022008583A Active JP7320090B2 (ja) 2012-02-15 2022-01-24 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途

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JP2017134582A Active JP6527918B2 (ja) 2012-02-15 2017-07-10 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2018204089A Active JP6574040B2 (ja) 2012-02-15 2018-10-30 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2019148815A Active JP7015810B2 (ja) 2012-02-15 2019-08-14 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
JP2022008583A Active JP7320090B2 (ja) 2012-02-15 2022-01-24 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途

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US (3) US10421798B2 (enExample)
EP (3) EP3564260B1 (enExample)
JP (6) JP6256882B2 (enExample)
KR (1) KR102097263B1 (enExample)
CN (5) CN119192402A (enExample)
AU (3) AU2012327217B2 (enExample)
BR (1) BR112014020694A2 (enExample)
CA (1) CA2864904C (enExample)
CL (2) CL2014002166A1 (enExample)
CO (1) CO7051009A2 (enExample)
CY (1) CY1122800T1 (enExample)
DK (2) DK3564260T5 (enExample)
EA (1) EA201491470A1 (enExample)
ES (2) ES2935489T3 (enExample)
FI (1) FI3564260T3 (enExample)
HR (2) HRP20221531T1 (enExample)
HU (2) HUE060629T2 (enExample)
IL (1) IL234108B (enExample)
LT (2) LT3564260T (enExample)
MX (2) MX369862B (enExample)
MY (1) MY188897A (enExample)
PH (2) PH12014501849B1 (enExample)
PL (2) PL2814840T3 (enExample)
PT (2) PT2814840T (enExample)
RS (2) RS59833B1 (enExample)
SG (2) SG10201606783RA (enExample)
SI (2) SI2814840T1 (enExample)
WO (1) WO2013122617A1 (enExample)

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