JP6204350B2 - 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 - Google Patents

抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 Download PDF

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JP6204350B2
JP6204350B2 JP2014514947A JP2014514947A JP6204350B2 JP 6204350 B2 JP6204350 B2 JP 6204350B2 JP 2014514947 A JP2014514947 A JP 2014514947A JP 2014514947 A JP2014514947 A JP 2014514947A JP 6204350 B2 JP6204350 B2 JP 6204350B2
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antigen
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amino acid
antibody
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JP2014528906A (ja
JP2014528906A5 (https=
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智之 井川
智之 井川
敦彦 前田
敦彦 前田
風太 味元
風太 味元
太一 倉持
太一 倉持
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Chugai Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2014514947A 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子 Active JP6204350B2 (ja)

Priority Applications (1)

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JP2014514947A JP6204350B2 (ja) 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
JP2011218736 2011-09-30
JP2011218736 2011-09-30
JPPCT/JP2012/058603 2012-03-30
PCT/JP2012/058603 WO2012133782A1 (ja) 2011-03-30 2012-03-30 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
JP2012123781 2012-05-30
JP2012123773 2012-05-30
JP2012123773 2012-05-30
JP2012123781 2012-05-30
JP2012123782 2012-05-30
JP2012123782 2012-05-30
JP2012139211 2012-06-20
JP2012139211 2012-06-20
JP2012177311 2012-08-09
JP2012177311 2012-08-09
PCT/JP2012/006218 WO2013046704A2 (en) 2011-09-30 2012-09-28 THERAPEUTIC ANTIGEN-BINDING MOLECULE WITH A FcRn-BINDING DOMAIN THAT PROMOTES ANTIGEN CLEARANCE
JP2014514947A JP6204350B2 (ja) 2011-09-30 2012-09-28 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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JP2017166638A Division JP6541730B2 (ja) 2011-09-30 2017-08-31 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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JP2014528906A JP2014528906A (ja) 2014-10-30
JP2014528906A5 JP2014528906A5 (https=) 2015-11-12
JP6204350B2 true JP6204350B2 (ja) 2017-09-27

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JP2017166638A Active JP6541730B2 (ja) 2011-09-30 2017-08-31 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2019108321A Active JP7001637B2 (ja) 2011-09-30 2019-06-11 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2021211155A Pending JP2022034037A (ja) 2011-09-30 2021-12-24 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2024072301A Pending JP2024097064A (ja) 2011-09-30 2024-04-26 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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JP2019108321A Active JP7001637B2 (ja) 2011-09-30 2019-06-11 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2021211155A Pending JP2022034037A (ja) 2011-09-30 2021-12-24 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
JP2024072301A Pending JP2024097064A (ja) 2011-09-30 2024-04-26 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子

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Country Link
US (3) US10253100B2 (https=)
EP (3) EP2760890B1 (https=)
JP (5) JP6204350B2 (https=)
KR (1) KR20140069332A (https=)
CN (2) CN103958547B (https=)
AU (2) AU2012313670B2 (https=)
BR (1) BR112014007290A2 (https=)
CA (1) CA2850035A1 (https=)
HK (1) HK1257946A1 (https=)
MX (1) MX2014003891A (https=)
RU (2) RU2014117500A (https=)
SG (2) SG11201401098TA (https=)
TW (3) TW201817744A (https=)
WO (1) WO2013046704A2 (https=)

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JP2018048120A (ja) * 2011-09-30 2018-03-29 中外製薬株式会社 抗原クリアランスを促進するＦｃＲｎ結合ドメインを有する治療用抗原結合分子
US11780912B2 (en) 2016-08-05 2023-10-10 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of IL-8 related diseases
US12415857B2 (en) 2021-06-25 2025-09-16 Chugai Seiyaku Kabushiki Kaisha Anti-CTLA-4 antibody and use thereof
US12595299B2 (en) 2015-02-05 2026-04-07 Chugai Seiyaku Kabushiki Kaisha FC variants

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ES2892925T3 (es) 2006-03-31 2022-02-07 Chugai Pharmaceutical Co Ltd Métodos para controlar la farmacocinética en sangre de anticuerpos
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