JP6030448B2 - 栄養輸送構造物を備えた角膜インレイ - Google Patents
栄養輸送構造物を備えた角膜インレイ Download PDFInfo
- Publication number
- JP6030448B2 JP6030448B2 JP2012524923A JP2012524923A JP6030448B2 JP 6030448 B2 JP6030448 B2 JP 6030448B2 JP 2012524923 A JP2012524923 A JP 2012524923A JP 2012524923 A JP2012524923 A JP 2012524923A JP 6030448 B2 JP6030448 B2 JP 6030448B2
- Authority
- JP
- Japan
- Prior art keywords
- mask
- region
- holes
- aperture
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000015097 nutrients Nutrition 0.000 title claims description 102
- 210000004087 cornea Anatomy 0.000 claims description 92
- 230000002093 peripheral effect Effects 0.000 claims description 52
- 230000005540 biological transmission Effects 0.000 claims description 32
- 230000000694 effects Effects 0.000 claims description 15
- 230000001788 irregular Effects 0.000 claims description 5
- 230000002411 adverse Effects 0.000 claims description 3
- 230000037430 deletion Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
- 238000000034 method Methods 0.000 description 191
- 210000001508 eye Anatomy 0.000 description 150
- 230000032258 transport Effects 0.000 description 92
- 239000000463 material Substances 0.000 description 90
- 239000007943 implant Substances 0.000 description 79
- 210000001747 pupil Anatomy 0.000 description 43
- 229920000642 polymer Polymers 0.000 description 41
- 230000000007 visual effect Effects 0.000 description 38
- 210000000695 crystalline len Anatomy 0.000 description 32
- 230000008569 process Effects 0.000 description 31
- 150000001875 compounds Chemical class 0.000 description 28
- 230000029663 wound healing Effects 0.000 description 26
- 210000001525 retina Anatomy 0.000 description 25
- 230000003287 optical effect Effects 0.000 description 24
- 239000002033 PVDF binder Substances 0.000 description 23
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 23
- 230000004438 eyesight Effects 0.000 description 22
- 230000015556 catabolic process Effects 0.000 description 20
- 239000003795 chemical substances by application Substances 0.000 description 20
- 238000006731 degradation reaction Methods 0.000 description 20
- 210000001519 tissue Anatomy 0.000 description 20
- 230000008901 benefit Effects 0.000 description 19
- 210000003683 corneal stroma Anatomy 0.000 description 19
- 230000001965 increasing effect Effects 0.000 description 18
- 239000000203 mixture Substances 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- 210000005252 bulbus oculi Anatomy 0.000 description 17
- 239000002904 solvent Substances 0.000 description 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 14
- 229910052799 carbon Inorganic materials 0.000 description 14
- 229920002313 fluoropolymer Polymers 0.000 description 14
- 230000002207 retinal effect Effects 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 241000219739 Lens Species 0.000 description 10
- 210000004045 bowman membrane Anatomy 0.000 description 10
- 239000000975 dye Substances 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 238000002513 implantation Methods 0.000 description 10
- 239000000178 monomer Substances 0.000 description 10
- 239000000049 pigment Substances 0.000 description 10
- 229920001296 polysiloxane Polymers 0.000 description 10
- 239000000654 additive Substances 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 230000002829 reductive effect Effects 0.000 description 9
- 239000006229 carbon black Substances 0.000 description 8
- 201000010041 presbyopia Diseases 0.000 description 8
- 229920001577 copolymer Polymers 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 239000002245 particle Substances 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 230000000144 pharmacologic effect Effects 0.000 description 6
- 239000002861 polymer material Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000004304 visual acuity Effects 0.000 description 6
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical group C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 5
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 5
- 210000003484 anatomy Anatomy 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 238000012937 correction Methods 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- -1 perfluoro Chemical group 0.000 description 5
- 229960001416 pilocarpine Drugs 0.000 description 5
- 238000002834 transmittance Methods 0.000 description 5
- 241001272720 Medialuna californiensis Species 0.000 description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229960000633 dextran sulfate Drugs 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 210000000744 eyelid Anatomy 0.000 description 4
- XUCNUKMRBVNAPB-UHFFFAOYSA-N fluoroethene Chemical compound FC=C XUCNUKMRBVNAPB-UHFFFAOYSA-N 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000009931 harmful effect Effects 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 229920001519 homopolymer Polymers 0.000 description 4
- 239000011295 pitch Substances 0.000 description 4
- 230000005855 radiation Effects 0.000 description 4
- MHABMANUFPZXEB-UHFFFAOYSA-N O-demethyl-aloesaponarin I Natural products O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C MHABMANUFPZXEB-UHFFFAOYSA-N 0.000 description 3
- 108010067787 Proteoglycans Proteins 0.000 description 3
- 102000016611 Proteoglycans Human genes 0.000 description 3
- 229920006362 Teflon® Polymers 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 238000005266 casting Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 210000005081 epithelial layer Anatomy 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 229910052737 gold Inorganic materials 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 230000001902 propagating effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000003786 sclera Anatomy 0.000 description 3
- 238000000807 solvent casting Methods 0.000 description 3
- 238000004528 spin coating Methods 0.000 description 3
- BFKJFAAPBSQJPD-UHFFFAOYSA-N tetrafluoroethene Chemical group FC(F)=C(F)F BFKJFAAPBSQJPD-UHFFFAOYSA-N 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 241000284156 Clerodendrum quadriloculare Species 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 229920000288 Keratan sulfate Polymers 0.000 description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
- 241000237509 Patinopecten sp. Species 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 208000008303 aniridia Diseases 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000002939 deleterious effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003989 dielectric material Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 230000010339 dilation Effects 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000006261 foam material Substances 0.000 description 2
- 230000006377 glucose transport Effects 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 description 2
- 238000003698 laser cutting Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 210000001328 optic nerve Anatomy 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229920013653 perfluoroalkoxyethylene Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920002959 polymer blend Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 235000020637 scallop Nutrition 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- MIZLGWKEZAPEFJ-UHFFFAOYSA-N 1,1,2-trifluoroethene Chemical group FC=C(F)F MIZLGWKEZAPEFJ-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 241000669003 Aspidiotus destructor Species 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 101001065614 Bos taurus Lumican Proteins 0.000 description 1
- 229940113549 Cholesterol inhibitor Drugs 0.000 description 1
- 108010059480 Chondroitin Sulfate Proteoglycans Proteins 0.000 description 1
- 102000005598 Chondroitin Sulfate Proteoglycans Human genes 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 208000030275 Chondronectin Diseases 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 229920004934 Dacron® Polymers 0.000 description 1
- 229920000045 Dermatan sulfate Polymers 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102100037362 Fibronectin Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010020675 Hypermetropia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920006370 Kynar Polymers 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 102000007547 Laminin Human genes 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- YCUVUDODLRLVIC-UHFFFAOYSA-N Sudan black B Chemical compound C1=CC(=C23)NC(C)(C)NC2=CC=CC3=C1N=NC(C1=CC=CC=C11)=CC=C1N=NC1=CC=CC=C1 YCUVUDODLRLVIC-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 102100035140 Vitronectin Human genes 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 229960003216 aceclidine Drugs 0.000 description 1
- WRJPSSPFHGNBMG-UHFFFAOYSA-N acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester Chemical compound C1CC2C(OC(=O)C)CN1CC2 WRJPSSPFHGNBMG-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 150000001449 anionic compounds Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 239000003080 antimitotic agent Substances 0.000 description 1
- 229940034982 antineoplastic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 201000009310 astigmatism Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000013590 bulk material Substances 0.000 description 1
- 229960004484 carbachol Drugs 0.000 description 1
- AIXAANGOTKPUOY-UHFFFAOYSA-N carbachol Chemical compound [Cl-].C[N+](C)(C)CCOC(N)=O AIXAANGOTKPUOY-UHFFFAOYSA-N 0.000 description 1
- 229960003184 carprofen Drugs 0.000 description 1
- IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 201000001891 corneal deposit Diseases 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 108010040063 dermatan sulfate proteoglycan Proteins 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- MUCZHBLJLSDCSD-UHFFFAOYSA-N diisopropyl fluorophosphate Chemical compound CC(C)OP(F)(=O)OC(C)C MUCZHBLJLSDCSD-UHFFFAOYSA-N 0.000 description 1
- 208000029436 dilated pupil Diseases 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000003560 epithelium corneal Anatomy 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 125000002573 ethenylidene group Chemical group [*]=C=C([H])[H] 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N ferrosoferric oxide Chemical compound O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 150000002367 halogens Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 108700020610 human chondronectin Proteins 0.000 description 1
- 102000043667 human chondronectin Human genes 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- YDZQQRWRVYGNER-UHFFFAOYSA-N iron;titanium;trihydrate Chemical compound O.O.O.[Ti].[Fe] YDZQQRWRVYGNER-UHFFFAOYSA-N 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000005499 meniscus Effects 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 229960004857 mitomycin Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-M naproxen(1-) Chemical compound C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-M 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 210000004738 parenchymal cell Anatomy 0.000 description 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
- 229960001697 physostigmine Drugs 0.000 description 1
- 230000000485 pigmenting effect Effects 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920005594 polymer fiber Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000004478 pupil constriction Effects 0.000 description 1
- 210000003370 receptor cell Anatomy 0.000 description 1
- 208000014733 refractive error Diseases 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 208000035736 spondylodysplastic type Ehlers-Danlos syndrome Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 239000003356 suture material Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/15—Implant having one or more holes, e.g. for nutrient transport, for facilitating handling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/145—Corneal inlays, onlays, or lenses for refractive correction
- A61F2/1451—Inlays or onlays
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/046—Contact lenses having an iris pattern
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/16—Shades; shields; Obturators, e.g. with pinhole, with slot
- G02C7/165—Shades; shields; Obturators, e.g. with pinhole, with slot with stenopaeic apertures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0023—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
- A61F2250/0024—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity made from both porous and non-porous parts, e.g. adjacent parts
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23380209P | 2009-08-13 | 2009-08-13 | |
| US61/233,802 | 2009-08-13 | ||
| PCT/US2010/045541 WO2011020074A1 (en) | 2009-08-13 | 2010-08-13 | Corneal inlay with nutrient transport structures |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013501597A JP2013501597A (ja) | 2013-01-17 |
| JP6030448B2 true JP6030448B2 (ja) | 2016-11-24 |
Family
ID=43586540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524923A Expired - Fee Related JP6030448B2 (ja) | 2009-08-13 | 2010-08-13 | 栄養輸送構造物を備えた角膜インレイ |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9427311B2 (https=) |
| EP (1) | EP2464310B1 (https=) |
| JP (1) | JP6030448B2 (https=) |
| KR (1) | KR101304014B1 (https=) |
| CN (1) | CN102470033B (https=) |
| AU (1) | AU2010282307A1 (https=) |
| BR (1) | BR112012008079A2 (https=) |
| CA (1) | CA2770732C (https=) |
| IL (1) | IL218022A0 (https=) |
| IN (1) | IN2012DN02153A (https=) |
| WO (1) | WO2011020074A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000052516A2 (en) | 1999-03-01 | 2000-09-08 | Boston Innovative Optics, Inc. | System and method for increasing the depth of focus of the human eye |
| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
| US20050046794A1 (en) | 2003-06-17 | 2005-03-03 | Silvestrini Thomas A. | Method and apparatus for aligning a mask with the visual axis of an eye |
| CA2770732C (en) | 2009-08-13 | 2017-04-25 | Acufocus, Inc. | Corneal inlay with nutrient transport structures |
| US9492272B2 (en) | 2009-08-13 | 2016-11-15 | Acufocus, Inc. | Masked intraocular implants and lenses |
| US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
| US9233025B2 (en) * | 2010-09-25 | 2016-01-12 | Gregory John Roy Spooner | Laser apparatus and method for refractive surgery |
| TWI586612B (zh) | 2011-11-18 | 2017-06-11 | 康寧公司 | 用於修整移動玻璃帶之設備及方法 |
| EP2785296B1 (en) * | 2011-12-02 | 2018-06-20 | AcuFocus, Inc. | Ocular mask having selective spectral transmission |
| DE112013001018T5 (de) | 2012-02-16 | 2014-10-30 | Acufocus, Inc. | Eine Maske aufweisende Okularvorrichtung zur Implantation neben einer Intraokularlinse |
| TWI588560B (zh) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | 用於屈光不正之鏡片、裝置、方法及系統 |
| US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| HK1212194A1 (en) | 2012-10-17 | 2016-06-10 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| US20140131905A1 (en) | 2012-11-09 | 2014-05-15 | Acufocus, Inc. | Process for manufacturing an intraocular lens |
| US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
| US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
| CN105392455B (zh) * | 2013-05-30 | 2018-04-06 | 株式会社实瞳 | 环状器件 |
| DE202013104393U1 (de) | 2013-09-26 | 2013-10-09 | Vr Vision Research Gmbh | Lochblende zum Implantieren in eine Augenvorderkammer |
| US9594259B2 (en) * | 2014-08-29 | 2017-03-14 | Johnson & Johnson Vision Care, Inc. | Mask lens design and method for preventing and/or slowing myopia progression |
| JP2017533807A (ja) | 2014-11-06 | 2017-11-16 | オフタ イノベーションズ インコーポレイテッド | 美容のための角膜インレー及びその移植方法 |
| EP3220859B8 (en) * | 2014-11-19 | 2020-06-10 | AcuFocus, Inc. | Fracturable mask for treating presbyopia |
| USD844145S1 (en) * | 2014-12-22 | 2019-03-26 | Henry Ford Health System | Vision assessment chart |
| US11696823B2 (en) | 2015-04-14 | 2023-07-11 | Z Optics, Inc. | High definition and extended depth of field intraocular lens |
| US11547554B2 (en) | 2015-04-14 | 2023-01-10 | Z Optics, Inc. | High definition and extended depth of field intraocular lens |
| US10687935B2 (en) | 2015-10-05 | 2020-06-23 | Acufocus, Inc. | Methods of molding intraocular lenses |
| JP7055747B2 (ja) | 2015-11-24 | 2022-04-18 | アキュフォーカス・インコーポレーテッド | 焦点深度の拡張を伴うトーリック小開口眼内レンズ |
| SE539167C2 (en) * | 2015-12-22 | 2017-05-02 | Rafat Mehrdad | A composite collagen hydrogel material, an implantable ophthalmic device comprising such material and methods of producing the composite collagen hydrogel material and the implantable ophthalmic device |
| TWI606850B (zh) * | 2015-12-22 | 2017-12-01 | 美樺興業股份有限公司 | 人工水晶體以及其製作方法 |
| CN112433419B (zh) * | 2017-02-24 | 2022-03-25 | 大立光电股份有限公司 | 遮光片、光学镜片组、成像镜头与电子装置 |
| SG11201910016VA (en) | 2017-04-28 | 2019-11-28 | Univ Illinois | Flexible keratoprosthesis devices and uses thereof |
| US20190212583A1 (en) * | 2018-01-08 | 2019-07-11 | Brighten Optix Corp. | Filter area structure of lens |
| EP3790508B1 (en) | 2018-05-09 | 2026-04-29 | AcuFocus, Inc. | Intraocular implant with optic |
| KR102117329B1 (ko) * | 2018-07-11 | 2020-06-01 | 현동원 | 안구내 조절성 렌즈 제조방법 |
| WO2020048917A1 (de) * | 2018-09-07 | 2020-03-12 | Carl Zeiss Meditec Ag | Intraokulares implantat und verfahren zur herstellung eines intraokularen implantats |
| US11154052B2 (en) | 2018-09-14 | 2021-10-26 | University Of Miami | Dual-chamber vial for corneal graft preservation |
| US12268449B2 (en) * | 2019-04-10 | 2025-04-08 | Smartlens, Inc. | Intraocular pressure monitoring devices and methods of using the same |
| USD948724S1 (en) | 2019-04-16 | 2022-04-12 | Henry Ford Health System | Vision assessment chart |
| US11950997B2 (en) * | 2019-05-20 | 2024-04-09 | The Trustees Of The Stevens Institute Of Technology | Artificial cornea with double-side microtextured pHEMA hydrogel |
| BR112021024889A2 (pt) | 2019-06-13 | 2022-05-03 | Z Optics Inc | Alta definição e profundidade estendida de lente intraocular de campo |
| FR3097980B1 (fr) * | 2019-06-28 | 2022-08-19 | Laurent Galinier | Lentille multifocale à aberration de coma |
| US20220273422A1 (en) * | 2019-07-31 | 2022-09-01 | Rvo 2.0, Inc. D/B/A Optics Medical | Corneal inlay design and methods of correcting vision |
| CN114423379A (zh) * | 2019-09-12 | 2022-04-29 | 科尔尼特视觉有限公司 | 用于治疗近视和眼科病症的移植补片 |
Family Cites Families (301)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2350421A (en) | 1941-01-22 | 1944-06-06 | William P Schoder | Method of producing inlaid jewels |
| US2470927A (en) | 1947-01-10 | 1949-05-24 | South Chester Corp | Fastening means |
| US3034403A (en) | 1959-04-03 | 1962-05-15 | Neefe Hamilton Res Company | Contact lens of apparent variable light absorption |
| US3458870A (en) | 1964-05-25 | 1969-08-05 | William Stone Jr | Artificial corneal implants having a removable lens member |
| US3270099A (en) | 1964-12-07 | 1966-08-30 | Richard N Camp | A method for making multi-focal length contact lenses |
| GB1276003A (en) | 1969-03-10 | 1972-06-01 | Frank Auld | Corneal contact device |
| US3578850A (en) | 1970-02-11 | 1971-05-18 | Alan H Grant | Anti-flare contact lens |
| US3794414A (en) | 1972-05-12 | 1974-02-26 | Jessen Inc Wesley | Multiple focal contact lens |
| US3776230A (en) | 1973-04-18 | 1973-12-04 | C Neefe | Method of rapidly reshaping the cornea to eliminate refractive errors |
| US3877502A (en) | 1973-08-29 | 1975-04-15 | Hunckler Products Inc | Nut locking means and method for muffler clamps |
| US3996627A (en) | 1975-09-22 | 1976-12-14 | American Optical Corporation | Artificial intraocular lens |
| US4010496A (en) | 1975-10-01 | 1977-03-08 | Neefe Charles W | Bifocal lens which positions within the anterior chamber |
| US4116439A (en) | 1976-09-30 | 1978-09-26 | C.F.F. Inc. | Pool ball |
| US4210391A (en) | 1977-09-14 | 1980-07-01 | Cohen Allen L | Multifocal zone plate |
| US4340283A (en) | 1978-12-18 | 1982-07-20 | Cohen Allen L | Phase shift multifocal zone plate |
| US4767647A (en) | 1979-12-17 | 1988-08-30 | The D. L. Auld Company | Decorative emblem |
| DE3169818D1 (en) | 1980-08-05 | 1985-05-15 | Choyce David P | Intraocular lens |
| US4450593A (en) | 1981-11-09 | 1984-05-29 | Lynell Medical Technology Inc. | Intraocular and contact lens construction |
| US4402579A (en) | 1981-07-29 | 1983-09-06 | Lynell Medical Technology Inc. | Contact-lens construction |
| SU1380743A1 (ru) | 1982-02-15 | 1988-03-15 | Московский научно-исследовательский институт микрохирургии глаза | Искусственный хрусталик глаза |
| US4423728A (en) | 1982-02-26 | 1984-01-03 | Lieberman David M | Cam-guided trephine |
| US4639105A (en) | 1982-09-13 | 1987-01-27 | Neefe Charles W | Spin cast ocular cosmetic device with color separation |
| US4505855A (en) | 1982-09-30 | 1985-03-19 | Massachusetts General Hospital | Transparent non-fibrilized collagen material by ultracentrifugation |
| US4701038A (en) | 1983-01-31 | 1987-10-20 | Bausch & Lomb Incorporated | Cosmetic contact lens |
| US4563565A (en) | 1983-03-02 | 1986-01-07 | Minnesota Mining And Manufacturing Company | Method for forming a peripheral edge on contact lenses |
| DE3332313A1 (de) | 1983-09-07 | 1985-04-04 | Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg | Multifokale, insbesondere bifokale intraokulare kuenstliche augenlinse |
| US4665913A (en) | 1983-11-17 | 1987-05-19 | Lri L.P. | Method for ophthalmological surgery |
| US5041133A (en) | 1984-04-11 | 1991-08-20 | Pharmacia Ab | Intraocular implant |
| JPS642644Y2 (https=) | 1984-09-10 | 1989-01-23 | ||
| US4605409A (en) | 1984-05-21 | 1986-08-12 | Kelman Charles D | Intraocular lens with miniature optic having expandable and contractible glare-reducing means |
| US4976732A (en) * | 1984-09-12 | 1990-12-11 | International Financial Associates Holdings, Inc. | Optical lens for the human eye |
| JPH027954Y2 (https=) | 1984-09-18 | 1990-02-26 | ||
| US4624669A (en) | 1984-09-26 | 1986-11-25 | Surgidev Corporation | Corneal inlay with holes |
| US4575373A (en) | 1984-11-02 | 1986-03-11 | Johnson Don R | Laser adjustable intraocular lens and method of altering lens power |
| US4669466A (en) | 1985-01-16 | 1987-06-02 | Lri L.P. | Method and apparatus for analysis and correction of abnormal refractive errors of the eye |
| US4646720A (en) | 1985-03-12 | 1987-03-03 | Peyman Gholam A | Optical assembly permanently attached to the cornea |
| US4669834A (en) | 1985-04-30 | 1987-06-02 | Richter Judy C | Light reflective contact lens |
| US6264648B1 (en) | 1985-07-29 | 2001-07-24 | Bausch & Lomb Incorporated | Corneal curvature modification via internal ablation |
| US4676791A (en) | 1985-08-01 | 1987-06-30 | Surgidev Corporation | Intraocular lens and method for making same |
| US4676790A (en) | 1985-09-25 | 1987-06-30 | Kern Seymour P | Method of manufacture and implantation of corneal inlays |
| US4678422A (en) | 1985-11-12 | 1987-07-07 | York Kenneth K | Systems and methods for precise, accurate formation of products by photoablation |
| GB2185124B (en) | 1986-01-03 | 1989-10-25 | Choyce David P | Intra-corneal implant |
| DE3610833A1 (de) | 1986-04-01 | 1987-10-08 | Inprohold Ets | Intraokulare implantationslinse |
| JPS62167343U (https=) | 1986-04-14 | 1987-10-23 | ||
| US4799931A (en) | 1986-05-14 | 1989-01-24 | Lindstrom Richard L | Intracorneal lens |
| US5030230A (en) | 1986-05-16 | 1991-07-09 | Great Plains Eye Clinic, Ltd. | Corneal implant |
| US5269812A (en) | 1986-05-16 | 1993-12-14 | White Thomas C | Methods and devices employed in replacement of the corneal endothelium |
| US4807623A (en) | 1986-05-30 | 1989-02-28 | David M. Lieberman | Device for simultaneously forming two incisions along a path on an eye |
| US4799784A (en) | 1986-06-23 | 1989-01-24 | Aran Safir | Visual vertex finder |
| US4715858A (en) | 1986-07-25 | 1987-12-29 | Lindstrom Richard L | Epicorneal lens |
| US4842599A (en) | 1986-10-28 | 1989-06-27 | Ann M. Bronstein | Prosthetic cornea and method of implantation therefor |
| JPS63199908A (ja) | 1987-02-10 | 1988-08-18 | 金沢 秀樹 | 固定構造 |
| US6387379B1 (en) | 1987-04-10 | 2002-05-14 | University Of Florida | Biofunctional surface modified ocular implants, surgical instruments, medical devices, prostheses, contact lenses and the like |
| US4798608A (en) | 1987-08-24 | 1989-01-17 | Grendahl Dennis T | Laminated zone of focus artificial lens |
| US4795462A (en) | 1987-08-24 | 1989-01-03 | Grendahl Dennis T | Cylindrically segmented zone of focus artificial lens |
| US4817789A (en) | 1987-09-23 | 1989-04-04 | Allergan, Inc. | Lens container assembly |
| US5171318A (en) | 1987-11-09 | 1992-12-15 | Chiron Ophthalmics, Inc. | Treated corneal prosthetic device |
| US4851003A (en) | 1988-01-05 | 1989-07-25 | Lindstrom Richard L | Corneal implant lens with fixation holes |
| US5112328A (en) | 1988-01-25 | 1992-05-12 | Refractive Laser Research & Development Program, Ltd. | Method and apparatus for laser surgery |
| US5192316A (en) | 1988-02-16 | 1993-03-09 | Allergan, Inc. | Ocular device |
| US5067961A (en) | 1988-02-18 | 1991-11-26 | Autogenesis Technologies, Inc. | Non-biodegradable two phase corneal implant and method for preparing same |
| US4969912A (en) | 1988-02-18 | 1990-11-13 | Kelman Charles D | Human collagen processing and autoimplant use |
| US4907586A (en) | 1988-03-31 | 1990-03-13 | Intelligent Surgical Lasers | Method for reshaping the eye |
| US4994080A (en) | 1988-07-15 | 1991-02-19 | Shepard Dennis D | Optical lens having at least one stenopaeic opening located in the central area thereof |
| US5120121A (en) | 1988-07-21 | 1992-06-09 | Allergan, Inc. | Colored lens |
| US5185107A (en) | 1988-10-26 | 1993-02-09 | Iovision, Inc. | Fabrication of an intraocular lens |
| US4903695C1 (en) | 1988-11-30 | 2001-09-11 | Lri L P | Method and apparatus for performing a keratomileusis or the like operation |
| GB8900616D0 (en) | 1989-01-12 | 1989-03-08 | Galley Geoffrey H | Methods of manufacturing contact lenses |
| US5098443A (en) | 1989-03-23 | 1992-03-24 | University Of Miami | Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents |
| US5358520A (en) | 1989-04-28 | 1994-10-25 | Nestle S.A. | Supplementary intraocular lens system |
| US5055602A (en) | 1989-05-02 | 1991-10-08 | Bausch & Lomb Incorporated | Polymerizable dye |
| US5013319A (en) | 1989-06-05 | 1991-05-07 | Mount Sinai School Of Medicine Of The City University Of New York | Apparatus and method for cornea marking |
| FR2649605B1 (fr) | 1989-07-13 | 1995-07-21 | France Chirurgie Instr | Implant corneen |
| US4955904A (en) | 1989-08-21 | 1990-09-11 | The Beth Israel Hospital Association | Masked intraocular lens and method for treating a patient with cataracts |
| FR2660859B1 (fr) | 1990-04-12 | 1992-07-10 | Hanna Khalil | Keratotome destine a la realisation d'incisions arciformes. |
| US5372580A (en) | 1990-07-12 | 1994-12-13 | University Of Miami | Gel injection adjustable keratoplasty |
| US5547468A (en) | 1990-07-12 | 1996-08-20 | University Of Miami | Instruments for use in performing gel injection adjustable keratoplasty |
| US5090955A (en) | 1990-07-12 | 1992-02-25 | University Of Miami | Gel injection adjustable keratoplasty |
| US5607437A (en) | 1990-07-12 | 1997-03-04 | University Of Miami | Instruments for use in performing gel injection adjustable keratoplasty |
| US5120120A (en) | 1990-07-27 | 1992-06-09 | Cohen Allen L | Multifocal optical device with spurious order suppression and method for manufacture of same |
| IL95381A0 (en) | 1990-08-06 | 1991-06-30 | Wolman Michael | Rimless molded eyeglasses |
| EP0551383A4 (en) | 1990-10-05 | 1993-11-03 | University Of Florida | Improved ocular implants and methods for their manufacture |
| US5314961A (en) | 1990-10-11 | 1994-05-24 | Permeable Technologies, Inc. | Silicone-containing polymers, compositions and improved oxygen permeable hydrophilic contact lenses |
| US5260727A (en) | 1990-10-22 | 1993-11-09 | Oksman Henry C | Wide depth of focus intraocular and contact lenses |
| DE4134320C2 (de) | 1990-10-22 | 1993-10-28 | Gerhard M Krahmer | Künstliches Haar |
| JPH04158859A (ja) | 1990-10-23 | 1992-06-01 | Seiko Epson Corp | 人工角膜 |
| US5137441A (en) | 1990-10-30 | 1992-08-11 | Minnesota Mining And Manufacturing Company | Mold assembly for making an ocular lens blank |
| US5288436A (en) | 1990-11-06 | 1994-02-22 | Colloptics, Inc. | Methods of fabricating a collagen lenticule precursor for modifying the cornea |
| US5094521A (en) | 1990-11-07 | 1992-03-10 | Vision Research Laboratories | Apparatus for evaluating eye alignment |
| US5269795A (en) | 1991-07-03 | 1993-12-14 | Arnott Eric J | Trephine device for removing anterior epithelial cells from corneal surfaces |
| UA35578C2 (uk) | 1991-08-16 | 2001-04-16 | Майлс Е. Гелін | Передньокамерний очний імплантат, спосіб його одержання та спосіб лікування короткозорості |
| JP3092233B2 (ja) | 1991-09-04 | 2000-09-25 | 三菱化学株式会社 | 液晶性ポリエステルアミド |
| US5196026A (en) | 1991-09-16 | 1993-03-23 | Chiron Ophthalmics, Inc. | Method of implanting corneal inlay lenses smaller than the optic zone |
| US5864128A (en) | 1991-10-15 | 1999-01-26 | Geo Labs, Inc. | Lens with variable focal length |
| US5647865A (en) | 1991-11-01 | 1997-07-15 | Swinger; Casimir A. | Corneal surgery using laser, donor corneal tissue and synthetic material |
| JPH0539527U (ja) | 1991-11-05 | 1993-05-28 | 株式会社メニコン | 角膜ホストマーカー |
| ATE218904T1 (de) | 1991-11-06 | 2002-06-15 | Shui T Lai | Vorrichtung für hornhautchirurgie |
| US5786883A (en) | 1991-11-12 | 1998-07-28 | Pilkington Barnes Hind, Inc. | Annular mask contact lenses |
| US5188494A (en) | 1992-04-21 | 1993-02-23 | Itt Corporation | Torque indicator device and method for use with a threaded fastener |
| US5312330A (en) | 1992-05-20 | 1994-05-17 | Summit Technology, Inc. | Medical treatment of the eye involving removal of the epithelium |
| US5292514A (en) | 1992-06-24 | 1994-03-08 | Minnesota Mining And Manufacturing Company | Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof |
| US5354331A (en) | 1992-07-15 | 1994-10-11 | Schachar Ronald A | Treatment of presbyopia and other eye disorders |
| AU650156B2 (en) | 1992-08-05 | 1994-06-09 | Lions Eye Institute Limited | Keratoprosthesis and method of producing the same |
| US5288293A (en) | 1992-09-24 | 1994-02-22 | Donnell Jr Francis E O | In vivo modification of refractive power of an intraocular lens implant |
| ATE189591T1 (de) | 1992-10-02 | 2000-02-15 | Bausch & Lomb Surgical Inc | Ringeinlage für die hornhaut |
| US6090141A (en) | 1993-03-05 | 2000-07-18 | Lindstrom; Richard L. | Small intracorneal lens |
| US5507740A (en) | 1993-05-03 | 1996-04-16 | O'donnell, Jr.; Francis E. | Corneal topography enhancement device |
| US5870167A (en) | 1993-07-14 | 1999-02-09 | Knopp; Carl F. | Apparatus and method for imaging anterior structures of the eye |
| US5474548A (en) | 1993-07-14 | 1995-12-12 | Knopp; Carl F. | Method of establishing a unique machine independent reference frame for the eye |
| BR9407215A (pt) | 1993-08-02 | 1996-09-17 | Keravision Inc | Implante corneal intra-estromal pré-formado segmentado |
| ATE261705T1 (de) | 1993-08-02 | 2004-04-15 | Addition Technology Inc | Zusammenlegbarer, intrastromaler, kornealer einsatz aus mehreren segmenten |
| JP3246604B2 (ja) | 1993-08-18 | 2002-01-15 | コロリト ハンガリー オプティカイ クタト，フェイレストー エーシュ ジャールトー レースベニュタルササーグ | 色覚の改善又は変更のための光学手段及びその光学手段の製造方法 |
| TW257671B (https=) | 1993-11-19 | 1995-09-21 | Ciba Geigy | |
| JP3439809B2 (ja) | 1993-12-24 | 2003-08-25 | 京セラ株式会社 | 人工角膜 |
| SG52647A1 (en) | 1994-01-07 | 1998-09-28 | Keravision Inc | Improved device and method for inserting a biocompatible material into the corneal stoma |
| JP3406677B2 (ja) | 1994-03-31 | 2003-05-12 | 京セラ株式会社 | 人工角膜 |
| US6197019B1 (en) | 1994-04-25 | 2001-03-06 | Gholam A. Peyman | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US6302877B1 (en) | 1994-06-29 | 2001-10-16 | Luis Antonio Ruiz | Apparatus and method for performing presbyopia corrective surgery |
| US5910537A (en) | 1994-07-22 | 1999-06-08 | Staar Surgical Company Inc. | Biocompatible, optically transparent, ultraviolet light absorbing, polymeric material based upon collagen and method of making |
| JP3640690B2 (ja) | 1994-10-03 | 2005-04-20 | 株式会社ニデック | 眼内レンズ |
| JP3816099B2 (ja) | 1994-10-06 | 2006-08-30 | スター サージカル カンパニー | 眼内コンタクトレンズ |
| JPH08164155A (ja) | 1994-12-14 | 1996-06-25 | Nikon Corp | 眼科用照明装置 |
| JP3625097B2 (ja) | 1995-02-07 | 2005-03-02 | セイコーエプソン株式会社 | 着色コンタクトレンズおよびその製造法 |
| US5653752A (en) | 1995-02-28 | 1997-08-05 | Keravision, Inc. | Adjustable devices for corneal curvature adjustment |
| US5628795A (en) | 1995-03-15 | 1997-05-13 | Langerman David W | Spare parts for use in ophthalmic surgical procedures |
| US6110166A (en) | 1995-03-20 | 2000-08-29 | Escalon Medical Corporation | Method for corneal laser surgery |
| US5697923A (en) | 1995-03-29 | 1997-12-16 | Poler; Stanley | Corneal drape for use in performing a photorefractory keratectomy procedure |
| US5693094A (en) | 1995-05-09 | 1997-12-02 | Allergan | IOL for reducing secondary opacification |
| US5752967A (en) | 1995-07-27 | 1998-05-19 | Kritzinger; Michiel S. | Corneal surface marker and marking method for improving laser centration |
| USD375245S (en) | 1995-08-18 | 1996-11-05 | Irving Thomas W E | Pistol lock |
| US20050143717A1 (en) | 2001-04-27 | 2005-06-30 | Peyman Gholam A. | Method of treatment of refractive errors using subepithelial or intrastromal corneal inlay with bonding coating |
| US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
| US20010027314A1 (en) | 1995-10-20 | 2001-10-04 | Peyman Gholam A. | Intrastromal corneal modification via laser |
| US5722971A (en) | 1995-10-20 | 1998-03-03 | Peyman; Gholam A. | Intrastromal corneal modification |
| US5919185A (en) | 1997-04-25 | 1999-07-06 | Peyman; Gholam A. | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US6221067B1 (en) | 1995-10-20 | 2001-04-24 | Gholam A. Peyman | Corneal modification via implantation |
| US6989008B2 (en) | 2001-03-23 | 2006-01-24 | Minu Llc | Adjustable ablatable inlay |
| US5964748A (en) | 1995-10-20 | 1999-10-12 | Peyman; Gholam A. | Intrastromal corneal modification |
| US6551307B2 (en) | 2001-03-23 | 2003-04-22 | Gholam A. Peyman | Vision correction using intrastromal pocket and flap |
| US20090069817A1 (en) | 1995-10-20 | 2009-03-12 | Acufocus, Inc. | Intrastromal corneal modification |
| US6203538B1 (en) | 1995-11-03 | 2001-03-20 | Gholam A. Peyman | Intrastromal corneal modification |
| US5702440A (en) | 1996-01-26 | 1997-12-30 | Allergan | Multifocal ophthalmic lens for dim-lighting conditions |
| US5624456A (en) | 1996-02-07 | 1997-04-29 | Hellenkamp; Johann F. | Automatic surgical device for cutting a cornea |
| MX9707772A (es) | 1996-02-09 | 1998-02-28 | Keravision Inc | Inserto corneo intrastromal segmentado para alterar las propiedades de refraccion de la cornea y metodos para el mismo. |
| US5628794A (en) | 1996-03-08 | 1997-05-13 | Lindstrom; Richard L. | Multifocal corneal implant lens having a hydrogelo coating |
| US6171336B1 (en) | 1996-03-26 | 2001-01-09 | Mark R. Sawusch | Method, implant, and apparatus for refractive keratoplasty |
| US5693268A (en) | 1996-04-01 | 1997-12-02 | Johnson & Johnson Vision Products, Inc. | Wedge demolding of cast lens mold assemblies |
| US5662706A (en) | 1996-06-14 | 1997-09-02 | Pbh, Inc. | Variable transmissivity annular mask lens for the treatment of optical aberrations |
| US5905561A (en) | 1996-06-14 | 1999-05-18 | Pbh, Inc. | Annular mask lens having diffraction reducing edges |
| US5746558A (en) | 1996-07-24 | 1998-05-05 | Lockheed Martin Corporation | Locking apparatus for fastening system |
| US5769889A (en) | 1996-09-05 | 1998-06-23 | Kelman; Charles D. | High myopia anterior chamber lens with anti-glare mask |
| CA2688799C (en) | 1996-11-15 | 2014-09-30 | Marsupial Holdings, Inc. | In-line holographic mask for micromachining |
| US20010041884A1 (en) | 1996-11-25 | 2001-11-15 | Frey Rudolph W. | Method for determining and correcting vision |
| US5965330A (en) | 1996-12-06 | 1999-10-12 | Pbh, Inc. | Methods for fabricating annular mask lens having diffraction-reducing edges |
| CA2229093A1 (en) | 1997-02-13 | 1998-08-13 | Joseph J. Berto | Handlebar device |
| US6228114B1 (en) | 1997-04-01 | 2001-05-08 | Joseph Y. Lee | Adjustable corneal ring |
| US6063073A (en) | 1997-04-25 | 2000-05-16 | Peyman; Gholam A. | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US20010034516A1 (en) | 1997-04-25 | 2001-10-25 | Peyman Gholam A. | Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US5980040A (en) | 1997-06-30 | 1999-11-09 | Wesley Jessen Corporation | Pinhole lens and contact lens |
| US5964776A (en) | 1997-09-24 | 1999-10-12 | Peyman; Gholam A. | Internal keratome apparatus and method for using the same to form a pocket/flap between layers of a live cornea |
| MC2461A1 (fr) | 1997-09-26 | 1998-12-18 | Exsymol Sa | Dispositifs ophtalmiques et implantables recouverts d'un revêtement et procédés pour la production de ces derniers |
| RU2138837C1 (ru) | 1997-10-31 | 1999-09-27 | Институт автоматики и электрометрии СО РАН | Растровая дифракционно-апертурная маска для коррекции недостатков зрения |
| WO1999054784A1 (en) | 1998-04-21 | 1999-10-28 | University Of Connecticut | Free-form nanofabrication using multi-photon excitation |
| PL198716B1 (pl) | 1998-10-02 | 2008-07-31 | Scient Optics | Sposób wytwarzania modelu powierzchni rogówki, wykorzystywany do wytwarzania soczewek kontaktowych |
| US6178593B1 (en) | 1998-10-23 | 2001-01-30 | Robert J. Carlson | Vertical pin automobile door hinge wear compensator |
| US20020010510A1 (en) | 1998-11-04 | 2002-01-24 | Thomas A. Silvestrini | Variable modulus corneal implant and fabrication methods |
| US6228115B1 (en) | 1998-11-05 | 2001-05-08 | Bausch & Lomb Surgical, Inc. | Intraocular lenses with improved axial stability |
| US6102946A (en) | 1998-12-23 | 2000-08-15 | Anamed, Inc. | Corneal implant and method of manufacture |
| US6361560B1 (en) | 1998-12-23 | 2002-03-26 | Anamed, Inc. | Corneal implant and method of manufacture |
| WO2000052516A2 (en) | 1999-03-01 | 2000-09-08 | Boston Innovative Optics, Inc. | System and method for increasing the depth of focus of the human eye |
| US6138307A (en) | 1999-05-06 | 2000-10-31 | Surgical Concepts, Inc. | Corneal intra-stromel prostheses |
| US6152959A (en) | 1999-05-14 | 2000-11-28 | Portney; Valdemar | Iris fixated intraocular lens |
| US6461384B1 (en) | 1999-06-17 | 2002-10-08 | Bausch & Lomb Incorporated | Intraocular lenses |
| US6423093B1 (en) | 1999-09-14 | 2002-07-23 | The Lions Eye Institute Of Western Australia Incorporated | Method of insertion of keratoprostheses |
| US6352764B1 (en) | 1999-08-09 | 2002-03-05 | 3M Innovative Properties Company | Multi-layer articles including UV-absorbing polymeric compositions |
| US6217596B1 (en) | 1999-09-01 | 2001-04-17 | Samir G. Farah | Corneal surface and pupillary cardinal axes marker |
| US7008396B1 (en) | 1999-09-03 | 2006-03-07 | Restorvision, Inc. | Ophthalmic device and method of manufacture and use |
| US20020082288A1 (en) | 1999-09-16 | 2002-06-27 | Gerald Horn | Ophthalmic formulations comprising an imidazoline |
| US6280471B1 (en) | 1999-09-16 | 2001-08-28 | Gholam A. Peyman | Glare-free intraocular lens and method for using the same |
| US6277146B1 (en) | 1999-09-16 | 2001-08-21 | Gholam A. Peyman | Glare-free intraocular lens and method for using the same |
| EP1214065A4 (en) | 1999-09-16 | 2009-01-07 | Ocularis Pharma Inc | METHOD USING THE ALPHA AGONIST TO OPTIMIZE THE SIZE OF THE PUPIL |
| US6649722B2 (en) | 1999-12-10 | 2003-11-18 | Novartis Ag | Contact lens |
| CA2295431A1 (en) | 2000-01-06 | 2001-07-06 | Scott Howard Phillips | Ophthalmic apparatus |
| US6228113B1 (en) | 2000-01-10 | 2001-05-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Intracorneal astigmatic onlay |
| DE10010683A1 (de) | 2000-03-04 | 2001-09-06 | Morcher Gmbh | Intraoculare Linse |
| US6458141B1 (en) | 2000-03-10 | 2002-10-01 | Gholam A. Peyman | Method and apparatus for creating a flap in the cornea and incisions or shrinkage under the flap to correct vision disorders |
| US6949093B1 (en) | 2000-03-21 | 2005-09-27 | Minu, L.L.C. | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US6436092B1 (en) | 2000-03-21 | 2002-08-20 | Gholam A. Peyman | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
| US6755858B1 (en) | 2000-04-07 | 2004-06-29 | Thomas C. White | Prosthetic corneal graft and method |
| US7635388B1 (en) | 2000-05-04 | 2009-12-22 | Tyler Thomas D | Device and method for incremental correction of sight disorders and occular diseases |
| US6554860B2 (en) | 2000-05-15 | 2003-04-29 | Bausch & Lomb Incorporated | Foldable iris fixated intraocular lenses |
| US20010050750A1 (en) | 2000-06-08 | 2001-12-13 | Breger Joseph L. | Pinhole presbyopic contact lenses |
| US6419697B1 (en) | 2000-07-07 | 2002-07-16 | Charles David Kelman | Clip-on optic assembly |
| US6544286B1 (en) | 2000-07-18 | 2003-04-08 | Tissue Engineering Refraction, Inc. | Pre-fabricated corneal tissue lens method of corneal overlay to correct vision |
| AR030341A1 (es) | 2000-08-14 | 2003-08-20 | Novartis Ag | Articulos biomedicos moldeados |
| US6543610B1 (en) | 2000-09-12 | 2003-04-08 | Alok Nigam | System for packaging and handling an implant and method of use |
| JP3709335B2 (ja) | 2000-09-28 | 2005-10-26 | 株式会社ニデック | 眼科装置 |
| US6726322B2 (en) | 2000-09-28 | 2004-04-27 | Novartis Ag | Fenestrated lens for increased tear flow and method of making the same |
| US6607527B1 (en) | 2000-10-17 | 2003-08-19 | Luis Antonio Ruiz | Method and apparatus for precision laser surgery |
| US6515006B2 (en) | 2000-11-08 | 2003-02-04 | Hmt Pharma, Inc. | Ophthalmic formulation which modulates dilation |
| US6811256B1 (en) | 2000-12-08 | 2004-11-02 | Paul Douglas Becherer | Post-ophthalmologic procedure lenses and methods |
| US20020167640A1 (en) | 2000-12-22 | 2002-11-14 | Francis Charles Auxilium | Contact lens with opaque iris pattern |
| US20020120329A1 (en) | 2001-02-28 | 2002-08-29 | Allergan Sales, Inc. | Moveable intraocular lenses and combinations of intraocular lenses |
| US20050182488A1 (en) | 2001-04-27 | 2005-08-18 | Peyman Gholam A. | Implant and method for altering the refractive properties of the eye |
| US20050222679A1 (en) | 2001-04-27 | 2005-10-06 | Peyman Gholam A | Bifocal implant and method for altering the refractive properties of the eye |
| US6589280B1 (en) | 2001-05-11 | 2003-07-08 | Jeffrey E. Koziol | Method for producing a multifocal corneal surface using intracorneal microscopic lenses |
| US7645299B2 (en) | 2001-05-11 | 2010-01-12 | Koziol Jeffrey E | Intracorneal lens system having connected lenses |
| CA2455357C (en) | 2001-06-15 | 2009-09-01 | The University Of Houston System | Thin film optical detectors for retinal implantation and methods for making and using same |
| WO2003000500A1 (en) | 2001-06-22 | 2003-01-03 | Bausch & Lomb Incorporated | Lens with colored portion |
| US6497700B1 (en) | 2001-06-28 | 2002-12-24 | Lahaye Leon C. | Multi-function surgical instrument for facilitating ophthalmic laser surgery |
| US6655804B2 (en) | 2001-06-29 | 2003-12-02 | Daniel G. Streibig | Colored contact lens and method of making same |
| US20030014042A1 (en) | 2001-07-13 | 2003-01-16 | Tibor Juhasz | Method of creating stromal pockets for corneal implants |
| US6638304B2 (en) | 2001-07-20 | 2003-10-28 | Massachusetts Eye & Ear Infirmary | Vision prosthesis |
| US20030045930A1 (en) | 2001-08-30 | 2003-03-06 | Allergan Sales, Inc. | Apparatus and methods for packaging intrcorneal implants and facilitating placement thereof |
| US6702807B2 (en) | 2001-09-10 | 2004-03-09 | Minu, L.L.C. | Ablatable intracorneal inlay with predetermined refractive properties |
| US6575573B2 (en) | 2001-10-17 | 2003-06-10 | Carl Zeiss Ophthalmic Systems, Inc. | Method and apparatus for measuring a corneal profile of an eye |
| US6786926B2 (en) | 2001-11-09 | 2004-09-07 | Minu, L.L.C. | Method and apparatus for alignment of intracorneal inlay |
| CA2473703A1 (en) | 2002-01-17 | 2003-07-31 | Edward Perez | Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses |
| US8048155B2 (en) | 2002-02-02 | 2011-11-01 | Powervision, Inc. | Intraocular implant devices |
| US20030216763A1 (en) | 2002-05-14 | 2003-11-20 | Patel Anilbhai S. | Method of determining the visual axis of an eye |
| WO2003102498A1 (en) | 2002-05-30 | 2003-12-11 | Visx, Inc. | “tracking torsional eye orientation and position” |
| US6951556B2 (en) | 2002-07-01 | 2005-10-04 | Epstein Robert L | Method and apparatus for correcting off-center laser ablations in refractive surgery |
| US6855163B2 (en) * | 2002-07-19 | 2005-02-15 | Minu, Llc | Gradual correction of corneal refractive error using multiple inlays |
| US7364674B1 (en) * | 2002-07-23 | 2008-04-29 | Advanced Optical Technologies, Inc. | Corneal implants produced by irradiation of polymer films |
| US20040019379A1 (en) | 2002-07-25 | 2004-01-29 | Advanced Medical Optics, Inc. | Intracorneal lens with flow enhancement area for increased nutrient transport |
| MXPA05001570A (es) | 2002-08-09 | 2005-08-19 | Ottawa Health Research Inst | Matriz biosintetica y sus usos. |
| US20040106929A1 (en) | 2002-08-20 | 2004-06-03 | Samuel Masket | Method and apparatus for performing an accurately sized and placed anterior capsulorhexis |
| MXPA05002669A (es) | 2002-09-13 | 2005-08-19 | Ocular Sciences Inc | Dispositivos y metodos para mejorar la vision. |
| US20040056371A1 (en) | 2002-09-25 | 2004-03-25 | Medennium, Inc. | Method of manufacturing ophthalmic lenses made from hydrophobic acrylic polymers |
| US20040068317A1 (en) | 2002-10-07 | 2004-04-08 | Knight Patricia M. | Anterior chamber intraocular lens with size and position indicators |
| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
| US20050046794A1 (en) | 2003-06-17 | 2005-03-03 | Silvestrini Thomas A. | Method and apparatus for aligning a mask with the visual axis of an eye |
| WO2005001553A1 (en) | 2003-06-30 | 2005-01-06 | Fiala Werner J | Intra-ocular lens or contact lens exhibiting large depth of focus |
| JP4038454B2 (ja) | 2003-07-31 | 2008-01-23 | 株式会社ニデック | 眼内レンズ |
| US20050033422A1 (en) | 2003-08-08 | 2005-02-10 | Advanced Medical Optics, Inc. | Glare reducing rough surfaces |
| US7025455B2 (en) | 2003-12-19 | 2006-04-11 | J&J Vision Care, Inc. | Multifocal contact lenses having a pinhole |
| JP4896737B2 (ja) | 2003-12-29 | 2012-03-14 | アボット・メディカル・オプティクス・インコーポレイテッド | 可視光選択的透過領域を有する眼内レンズ |
| US20050187621A1 (en) | 2004-02-24 | 2005-08-25 | Brady Daniel G. | Foldable unitary intraocular lens |
| US20060064077A1 (en) | 2004-08-13 | 2006-03-23 | Peyman Gholam A | Method for correcting hyperopia and presbyopia using a laser and an inlay outside the visual axis of eye |
| EP1827330A1 (en) | 2004-10-22 | 2007-09-05 | Acufocus | System and method for aligning an optic with an axis of an eye |
| WO2006047698A1 (en) | 2004-10-25 | 2006-05-04 | Advanced Medical Optics, Inc. | Ophthalmic lens with multiple phase plates |
| US7455691B2 (en) | 2004-11-03 | 2008-11-25 | Biovision, Ag | Intraocular and intracorneal refractive lenses |
| US7491350B2 (en) | 2004-12-01 | 2009-02-17 | Acufocus, Inc. | Method of making an ocular implant |
| US20060113054A1 (en) | 2004-12-01 | 2006-06-01 | Silvestrini Thomas A | Method of making an ocular implant |
| US7446157B2 (en) | 2004-12-07 | 2008-11-04 | Key Medical Technologies, Inc. | Nanohybrid polymers for ophthalmic applications |
| DE102004061943A1 (de) | 2004-12-22 | 2006-07-06 | *Acri.Tec Gesellschaft für ophthalmologische Produkte mbH | Künstlicher in ein Auge implantierbarer Irisersatz |
| US20060235428A1 (en) | 2005-04-14 | 2006-10-19 | Silvestrini Thomas A | Ocular inlay with locator |
| US7976577B2 (en) | 2005-04-14 | 2011-07-12 | Acufocus, Inc. | Corneal optic formed of degradation resistant polymer |
| US7842367B2 (en) | 2005-05-05 | 2010-11-30 | Key Medical Technologies, Inc. | Ultra violet, violet, and blue light filtering polymers for ophthalmic applications |
| EP1924222A1 (en) | 2005-08-05 | 2008-05-28 | Visiogen, Inc. | Accommodating diffractive intraocular lens |
| WO2007047425A1 (en) | 2005-10-12 | 2007-04-26 | Cellular Bioengineering, Inc. | Resorbable cornea button |
| ITBO20050647A1 (it) | 2005-10-26 | 2007-04-27 | Marinella Bergamaschi | Lenti a contatto fotocromatiche a foro |
| US20070129797A1 (en) | 2005-12-01 | 2007-06-07 | Revision Optics, Inc. | Intracorneal inlays |
| GB0603734D0 (en) | 2006-02-24 | 2006-04-05 | Applied Multilayers Ltd | Method and apparatus for forming a coated optical lens |
| US8113651B2 (en) | 2006-03-20 | 2012-02-14 | High Performance Optics, Inc. | High performance corneal inlay |
| CN100484498C (zh) | 2006-04-19 | 2009-05-06 | 华中科技大学 | 一种柔性视网膜芯片及其制备方法 |
| US20070258143A1 (en) | 2006-05-08 | 2007-11-08 | Valdemar Portney | Aspheric multifocal diffractive ophthalmic lens |
| US20080033546A1 (en) * | 2006-05-31 | 2008-02-07 | Junzhong Liang | Methods and apparatus for improving vision |
| US20080077238A1 (en) | 2006-09-21 | 2008-03-27 | Advanced Medical Optics, Inc. | Intraocular lenses for managing glare, adhesion, and cell migration |
| US8568478B2 (en) | 2006-09-21 | 2013-10-29 | Abbott Medical Optics Inc. | Intraocular lenses for managing glare, adhesion, and cell migration |
| US20080151190A1 (en) | 2006-12-21 | 2008-06-26 | Bentley Joseph R | Corneal measurment apparatus and a method of using the same |
| US7641337B2 (en) | 2006-12-22 | 2010-01-05 | Bausch & Lomb Incorporated | Ophthalmic lens including photochromic material |
| US20080306587A1 (en) | 2007-02-21 | 2008-12-11 | Jingjong Your | Lens Material and Methods of Curing with UV Light |
| US20080255663A1 (en) * | 2007-04-13 | 2008-10-16 | Akpek Esen K | Artificial Cornea and Method of Making Same |
| CN101322663A (zh) | 2007-06-14 | 2008-12-17 | 苏州六六视觉科技股份有限公司 | 带虹膜隔人工晶状体 |
| US8740978B2 (en) | 2007-08-27 | 2014-06-03 | Amo Regional Holdings | Intraocular lens having extended depth of focus |
| EP2224881B1 (en) | 2007-10-16 | 2014-04-23 | Donald Tan | Ophthalmic surgical device for endothelial keratoplasty for descemet's stripping automated endothelial keratoplasty (dsaek) surgery |
| ATE523810T1 (de) | 2008-02-15 | 2011-09-15 | Amo Regional Holdings | System, brillenglas und verfahren zur erweiterung der fokustiefe |
| KR20100114133A (ko) | 2008-03-18 | 2010-10-22 | 픽셀옵틱스, 인크. | 진보한 전기-활성 광학 장치 |
| IL190577A0 (en) | 2008-04-02 | 2008-12-29 | Nulens Ltd | Cartridge for storing an iol and forceps for use therewith |
| US20090306773A1 (en) | 2008-06-04 | 2009-12-10 | Acufocus, Inc. | Opaque corneal insert for refractive correction |
| US8292953B2 (en) | 2008-10-20 | 2012-10-23 | Amo Groningen B.V. | Multifocal intraocular lens |
| NZ592645A (en) | 2008-11-20 | 2013-01-25 | Insight Innovations Llc | Biocompatible biodegradable intraocular implant system |
| US20120232649A1 (en) | 2008-11-20 | 2012-09-13 | Insight Innovations, Llc | Intraocular Lens Cell Migration Inhibition System |
| US20100312336A1 (en) | 2009-06-09 | 2010-12-09 | Xin Hong | Zonal diffractive multifocal intraocular lens with central monofocal diffractive region |
| US9492272B2 (en) | 2009-08-13 | 2016-11-15 | Acufocus, Inc. | Masked intraocular implants and lenses |
| CA2770732C (en) | 2009-08-13 | 2017-04-25 | Acufocus, Inc. | Corneal inlay with nutrient transport structures |
| US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
| US20120203239A1 (en) | 2009-10-13 | 2012-08-09 | Acufocus,Inc. | Method and apparatus for centration of an ocular implant |
| BR112012009422A2 (pt) | 2009-10-20 | 2016-06-14 | Univelsal View Co Ltda | lente de contato macia |
| EP2319457A1 (en) | 2009-11-10 | 2011-05-11 | Lenspecial S.r.L. | Vision aiding system comprising at least one intraocular dioptric lens |
| USD656526S1 (en) | 2009-11-10 | 2012-03-27 | Acufocus, Inc. | Ocular mask |
| US8287593B2 (en) | 2009-11-24 | 2012-10-16 | Valdemar Portney | Adjustable multifocal intraocular lens system |
| EP2506803A1 (en) | 2009-12-04 | 2012-10-10 | AcuFocus, Inc. | Corneal implant for refractive correction |
| WO2011088107A2 (en) | 2010-01-12 | 2011-07-21 | Acufocus, Inc. | Ocular inlay delivery system and method of use |
| US8308800B2 (en) | 2010-04-09 | 2012-11-13 | Chu Milton W | Intraocular lenses with high contrast haptics, materials, and methods |
| EP3211026B1 (en) | 2010-07-07 | 2018-06-27 | California Institute of Technology | On-demand photoinitiated polymerization |
| AU2011317283B2 (en) | 2010-10-18 | 2015-11-05 | University Of Utah Research Foundation | Vision correction system |
| USD645337S1 (en) | 2011-01-15 | 2011-09-20 | Group-A Autosports, Inc. | Small washer |
| EP2785296B1 (en) | 2011-12-02 | 2018-06-20 | AcuFocus, Inc. | Ocular mask having selective spectral transmission |
| US8950859B2 (en) | 2011-12-25 | 2015-02-10 | Global-Ok Vision, Inc. | Multi-focal optical lenses |
| CA2861865C (en) | 2012-01-24 | 2020-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Modular intraocular lens designs and methods |
| DE112013001018T5 (de) | 2012-02-16 | 2014-10-30 | Acufocus, Inc. | Eine Maske aufweisende Okularvorrichtung zur Implantation neben einer Intraokularlinse |
| WO2014054946A1 (en) | 2012-10-01 | 2014-04-10 | Akkolens International B.V. | Artificial asymmetrical pupil for extended depth of field |
| US20140131905A1 (en) | 2012-11-09 | 2014-05-15 | Acufocus, Inc. | Process for manufacturing an intraocular lens |
| US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
| US9427922B2 (en) | 2013-03-14 | 2016-08-30 | Acufocus, Inc. | Process for manufacturing an intraocular lens with an embedded mask |
| BR102013015451A2 (pt) | 2013-06-19 | 2014-06-10 | Claudio Lovaglio Cancado Trindade | Implante intra-ocular de pequena abertura (pinhole) para ampliação da profundidade de foco |
| WO2015021323A1 (en) | 2013-08-08 | 2015-02-12 | Acufocus, Inc. | Intraocular lens with elastic mask |
| WO2015069927A1 (en) | 2013-11-06 | 2015-05-14 | Nexisvision, Inc. | Bimodular contact lenses |
| US9341864B2 (en) | 2013-11-15 | 2016-05-17 | Nexisvision, Inc. | Contact lenses having a reinforcing scaffold |
-
2010
- 2010-08-13 CA CA2770732A patent/CA2770732C/en not_active Expired - Fee Related
- 2010-08-13 IN IN2153DEN2012 patent/IN2012DN02153A/en unknown
- 2010-08-13 EP EP10808854.3A patent/EP2464310B1/en not_active Not-in-force
- 2010-08-13 KR KR1020127006604A patent/KR101304014B1/ko not_active Expired - Fee Related
- 2010-08-13 US US13/390,080 patent/US9427311B2/en not_active Expired - Fee Related
- 2010-08-13 AU AU2010282307A patent/AU2010282307A1/en not_active Abandoned
- 2010-08-13 BR BR112012008079A patent/BR112012008079A2/pt not_active Application Discontinuation
- 2010-08-13 WO PCT/US2010/045541 patent/WO2011020074A1/en not_active Ceased
- 2010-08-13 CN CN201080026877.8A patent/CN102470033B/zh not_active Expired - Fee Related
- 2010-08-13 JP JP2012524923A patent/JP6030448B2/ja not_active Expired - Fee Related
-
2012
- 2012-02-09 IL IL218022A patent/IL218022A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011020074A9 (en) | 2011-11-03 |
| EP2464310B1 (en) | 2019-02-27 |
| BR112012008079A2 (pt) | 2016-03-01 |
| WO2011020074A1 (en) | 2011-02-17 |
| CA2770732A1 (en) | 2011-02-17 |
| IN2012DN02153A (https=) | 2015-08-07 |
| JP2013501597A (ja) | 2013-01-17 |
| KR101304014B1 (ko) | 2013-09-04 |
| CN102470033A (zh) | 2012-05-23 |
| IL218022A0 (en) | 2012-04-30 |
| AU2010282307A1 (en) | 2012-04-05 |
| EP2464310A4 (en) | 2015-01-21 |
| US9427311B2 (en) | 2016-08-30 |
| CA2770732C (en) | 2017-04-25 |
| CN102470033B (zh) | 2016-02-24 |
| KR20120090041A (ko) | 2012-08-16 |
| EP2464310A1 (en) | 2012-06-20 |
| US20120143325A1 (en) | 2012-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6030448B2 (ja) | 栄養輸送構造物を備えた角膜インレイ | |
| CA2614536C (en) | Corneal mask formed of degradation resistant polymer | |
| EP2785296B1 (en) | Ocular mask having selective spectral transmission | |
| US20120245683A1 (en) | Corneal implant for refractive correction | |
| WO2006113411A1 (en) | Ocular inlay with locator | |
| HK1169935A (en) | Corneal inlay with nutrient transport structures |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130717 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140314 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140324 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140624 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140722 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141125 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150113 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20150206 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160607 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160707 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160805 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20161020 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6030448 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |