JP6021117B2 - エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 - Google Patents

エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 Download PDF

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JP6021117B2
JP6021117B2 JP2013551434A JP2013551434A JP6021117B2 JP 6021117 B2 JP6021117 B2 JP 6021117B2 JP 2013551434 A JP2013551434 A JP 2013551434A JP 2013551434 A JP2013551434 A JP 2013551434A JP 6021117 B2 JP6021117 B2 JP 6021117B2
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Prior art keywords
pirfenidone
pyridone analog
mcg
aqueous solution
lung
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JP2014503598A (ja
JP2014503598A5 (enExample
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サーバー，マーク，ウィリアム
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ジェノア ファーマシューティカルズ，インク．
ジェノア ファーマシューティカルズ，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013551434A 2011-01-31 2012-01-31 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 Active JP6021117B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161438203P 2011-01-31 2011-01-31
US61/438,203 2011-01-31
US201161508542P 2011-07-15 2011-07-15
US61/508,542 2011-07-15
US201161559670P 2011-11-14 2011-11-14
US61/559,670 2011-11-14
US201261584119P 2012-01-06 2012-01-06
US61/584,119 2012-01-06
PCT/US2012/023406 WO2012106382A1 (en) 2011-01-31 2012-01-31 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016187607A Division JP6738576B2 (ja) 2011-01-31 2016-09-26 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用

Publications (3)

Publication Number Publication Date
JP2014503598A JP2014503598A (ja) 2014-02-13
JP2014503598A5 JP2014503598A5 (enExample) 2015-03-26
JP6021117B2 true JP6021117B2 (ja) 2016-11-02

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Family Applications (6)

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JP2013551434A Active JP6021117B2 (ja) 2011-01-31 2012-01-31 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2016187607A Active JP6738576B2 (ja) 2011-01-31 2016-09-26 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2018149771A Active JP6904929B2 (ja) 2011-01-31 2018-08-08 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2022208515A Pending JP2023076821A (ja) 2011-01-31 2022-12-26 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2024216979A Pending JP2025060674A (ja) 2011-01-31 2024-12-11 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2025037836A Pending JP2025108419A (ja) 2011-01-31 2025-03-10 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用

Family Applications After (5)

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JP2016187607A Active JP6738576B2 (ja) 2011-01-31 2016-09-26 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2018149771A Active JP6904929B2 (ja) 2011-01-31 2018-08-08 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2022208515A Pending JP2023076821A (ja) 2011-01-31 2022-12-26 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2024216979A Pending JP2025060674A (ja) 2011-01-31 2024-12-11 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
JP2025037836A Pending JP2025108419A (ja) 2011-01-31 2025-03-10 エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用

Country Status (10)

Country Link
US (3) US10092552B2 (enExample)
EP (2) EP4059499A1 (enExample)
JP (6) JP6021117B2 (enExample)
AU (2) AU2012212269B2 (enExample)
CA (1) CA2824432C (enExample)
DK (1) DK2670242T3 (enExample)
ES (1) ES2913095T3 (enExample)
HU (1) HUE058753T2 (enExample)
LT (1) LT2670242T (enExample)
WO (1) WO2012106382A1 (enExample)

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JP2015523395A (ja) * 2012-07-24 2015-08-13 ジェノア ファーマシューティカルズ，インク． エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
JP2020073494A (ja) * 2012-07-24 2020-05-14 アヴァリン ファーマ インク． エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
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JP7120984B2 (ja) 2012-07-24 2022-08-17 アヴァリン ファーマ インク． エアロゾルのピルフェニドン及びピリドンのアナログの化合物、及び、その使用
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