JP5997708B2 - 揺動装置を含むバイオリアクター - Google Patents
揺動装置を含むバイオリアクター Download PDFInfo
- Publication number
- JP5997708B2 JP5997708B2 JP2013555390A JP2013555390A JP5997708B2 JP 5997708 B2 JP5997708 B2 JP 5997708B2 JP 2013555390 A JP2013555390 A JP 2013555390A JP 2013555390 A JP2013555390 A JP 2013555390A JP 5997708 B2 JP5997708 B2 JP 5997708B2
- Authority
- JP
- Japan
- Prior art keywords
- tray
- over
- intermediate plate
- bioreactor over
- bioreactor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/16—Vibrating; Shaking; Tilting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/50—Means for positioning or orientating the apparatus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Description
2 揺動軸
3 ハウジング
4 トレー
5 クランプ装置
6 ガススプリングダンパー
7 第2の軸
8 中間プレート
9 開口
10 ヨーク
11 フランジ
12 開口
13 第3の軸
Claims (7)
- プラスチックバッグの形態の1以上のリアクター容器と、前記1以上のバッグを保持するためのトレー(4)と、前記トレー(4)を揺動軸(2)の周りで限定揺動運動させるための揺動装置とを含むバイオリアクターであって、前記揺動軸(2)に平行で揺動軸(2)から離隔した第2の軸(7)の周りで水平に対して60〜90°の角度をなす直立位置まで前記トレー(4)を旋回させることができる装置(6、7、8、9)によって特徴付けられるバイオリアクター。
- 前記トレー(4)を第2の軸の周りで旋回させることができる装置(6、7、8、9)が1以上のガススプリングダンパー(6)を備える、請求項1記載のバイオリアクター。
- 前記バイオリアクターが、前記トレーを設定位置に解除可能にロックする手段(10〜12)を備える、請求項2記載のバイオリアクター。
- 前記トレー(4)が中間プレート(8)に取外し可能に取り付けられ、中間プレートが前記揺動軸(2)から離隔した位置にあるヒンジ式連結部(7)によって前記揺動装置に取り付けられ、前記1以上のガススプリングダンパー(6)の一端が中間プレート(8)に枢動可能に取り付けられる、請求項2又は請求項3記載のバイオリアクター。
- 前記揺動装置が揺動プラットホーム(1)を備えており、揺動プラットホーム(1)にヒンジ式連結部(7)によって前記中間プレート(8)が取り付けられ、ヒンジ式連結部(7)に1以上のガススプリングダンパー(6)が枢動可能に取り付けられる、請求項4記載のバイオリアクター。
- ヨーク(10)がその一端で前記中間プレート(8)に枢動可能に取り付けられ、ヨークの反対側の端部が、前記中間プレートを1以上の設定位置にロックするために揺動プラットホーム(1)上に設けられたロック手段(11、12)内に挿入できる、請求項3又は請求項5記載のバイオリアクター。
- 前記トレー(4)が、トレー(4)の平面に垂直な軸(13)の周りで枢動させることができる、請求項1乃至請求項6のいずれか1項記載のバイオリアクター。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1150154 | 2011-02-23 | ||
SE1150154-1 | 2011-02-23 | ||
PCT/SE2012/050187 WO2012115581A1 (en) | 2011-02-23 | 2012-02-21 | Bioreactor including a rocking device |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014506479A JP2014506479A (ja) | 2014-03-17 |
JP2014506479A5 JP2014506479A5 (ja) | 2016-05-12 |
JP5997708B2 true JP5997708B2 (ja) | 2016-09-28 |
Family
ID=46721122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013555390A Active JP5997708B2 (ja) | 2011-02-23 | 2012-02-21 | 揺動装置を含むバイオリアクター |
Country Status (5)
Country | Link |
---|---|
US (3) | US9738863B2 (ja) |
EP (1) | EP2678416B1 (ja) |
JP (1) | JP5997708B2 (ja) |
CN (2) | CN103391996A (ja) |
WO (1) | WO2012115581A1 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5997708B2 (ja) | 2011-02-23 | 2016-09-28 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 揺動装置を含むバイオリアクター |
EP2639294A1 (fr) * | 2012-03-15 | 2013-09-18 | CellProthera | Automate et procédé automatisé de culture cellulaire |
FR2992865B1 (fr) * | 2012-07-04 | 2014-08-29 | Maco Pharma Sa | Appareil pour extraire un composant sanguin contenu dans un systeme a poches |
FR2997703B1 (fr) * | 2012-11-07 | 2016-12-30 | Biomerieux Sa | Procede de traitement d'au moins un echantillon biologique |
EP2975111B1 (de) | 2014-07-14 | 2018-05-16 | Sartorius Stedim Biotech GmbH | Mischvorrichtung zum Mischen eines Inhalts eines Behälters |
ES2738391T3 (es) * | 2015-02-05 | 2020-01-22 | Gen Electric | Sistema de biorreactor para el cultivo celular |
WO2016205546A1 (en) * | 2015-06-19 | 2016-12-22 | Protein Technologies, Inc. | Chemical reaction vessel and synthesis systems and methods |
CN108138116A (zh) * | 2015-08-25 | 2018-06-08 | 通用电气公司 | 在生物制造设备中和涉及其的改进 |
EP3341467A1 (en) * | 2015-08-25 | 2018-07-04 | General Electric Company | Improvements in and relating to biomanufacturing apparatus |
WO2018052991A1 (en) | 2016-09-14 | 2018-03-22 | Vbc Holdings Llc | Systems, apparatus and methods for controlling a movement of a cell culture to optimize cell growth |
WO2018077994A1 (en) * | 2016-10-28 | 2018-05-03 | General Electric Company | Bioreactor tray |
CN109863240A (zh) * | 2016-10-31 | 2019-06-07 | 通用电气公司 | 生物反应器组件 |
US20200148987A1 (en) * | 2018-11-13 | 2020-05-14 | Ge Healthcare Bio-Sciences Corp. | Apparatus, system and method for bioprocessing |
CN115209980A (zh) * | 2019-10-30 | 2022-10-18 | 布拉默生物Ma有限责任公司 | 用于保持溶液均质性的摇动平台 |
GB2592566B (en) * | 2020-01-13 | 2022-05-18 | Oribiotech Ltd | An apparatus for, and a method of, processing cells |
KR102418908B1 (ko) | 2021-11-18 | 2022-07-11 | (주)마이크로디지탈 | 세포 배양 시스템 |
CN114874879B (zh) * | 2022-07-11 | 2022-09-16 | 浙江金仪盛世生物工程有限公司 | 具有夹紧功能的支撑架及生物反应装置 |
US20240117290A1 (en) * | 2022-10-04 | 2024-04-11 | Global Life Sciences Solutions Usa Llc | Apparatus, system, and method for bioprocessing utilizing a rocker bioreactor |
WO2024085604A1 (ko) * | 2022-10-17 | 2024-04-25 | 주식회사 엔셀 | 경사각을 포함하는 회전 롤러식 미생물 배양시스템 |
Family Cites Families (21)
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US3501131A (en) * | 1968-07-23 | 1970-03-17 | Coulter Electronics | Blood sample handling apparatus |
US3735964A (en) * | 1972-02-07 | 1973-05-29 | R K Lorenzen | Powered mechanical shaker device |
JPS62289175A (ja) * | 1986-06-09 | 1987-12-16 | Oji Paper Co Ltd | 回転培養器を有する培養装置 |
JPH0353679Y2 (ja) * | 1987-03-31 | 1991-11-25 | ||
DE3788026T2 (de) * | 1986-08-27 | 1994-04-21 | Kawasumi Lab Inc | Verfahren und Vorrichtung zur Kultivierung von Zellen. |
US6190913B1 (en) * | 1997-08-12 | 2001-02-20 | Vijay Singh | Method for culturing cells using wave-induced agitation |
CH697035A5 (de) | 1999-05-04 | 2008-03-31 | Marcel Roell | Bioreaktor. |
JP4247859B2 (ja) | 1999-08-17 | 2009-04-02 | 河淳株式会社 | 商品陳列用ワゴン |
CN2468896Y (zh) * | 2000-12-14 | 2002-01-02 | 郑士元 | 自卸船 |
US20050186669A1 (en) | 2004-02-20 | 2005-08-25 | Cesco Bioengineering Co., Ltd. | Apparatus and method for preparing and culturing cells |
US7195394B2 (en) * | 2004-07-19 | 2007-03-27 | Vijay Singh | Method for resonant wave mixing in closed containers |
EP1739165A1 (en) * | 2005-06-29 | 2007-01-03 | Cellution Biotech B.V. | Method and apparatus for cultivating cells utilizing wave motion |
CN200977885Y (zh) * | 2006-11-10 | 2007-11-21 | 山东时风(集团)有限责任公司 | 一种机动车自卸式货厢 |
DE102007026230A1 (de) * | 2007-06-05 | 2008-12-11 | Stabilus Gmbh | Antrieb zum Verschwenken einer an einer Karosserie eines Fahrzeugs angeordneten Klappe |
DK2155852T3 (da) * | 2007-06-15 | 2014-01-20 | Cellution Biotech B V | Forbedret fleksibel bioreaktor |
EP2356207A1 (en) * | 2008-11-11 | 2011-08-17 | Ds Genomics | Continuous flow bioreactor |
DE102009008736A1 (de) * | 2009-02-12 | 2010-09-09 | Lear Corp., Southfield | Fahrzeugsitzanordnung mit bequemem Rückenlehnenabschnitt |
CN201406422Y (zh) * | 2009-05-18 | 2010-02-17 | 郑州威瑞生物技术有限公司 | 恒温箱或培养箱摇摆机构 |
JP2011078386A (ja) * | 2009-10-09 | 2011-04-21 | Nihon Bio Energy Kk | 植物培養装置及びこれに用いる培養容器 |
CN101812405B (zh) * | 2010-04-30 | 2013-05-22 | 惠倪 | 多边形塑料袋摇摆细胞反应器及培养动物细胞的方法 |
JP5997708B2 (ja) | 2011-02-23 | 2016-09-28 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | 揺動装置を含むバイオリアクター |
-
2012
- 2012-02-21 JP JP2013555390A patent/JP5997708B2/ja active Active
- 2012-02-21 CN CN2012800099497A patent/CN103391996A/zh active Pending
- 2012-02-21 WO PCT/SE2012/050187 patent/WO2012115581A1/en active Application Filing
- 2012-02-21 US US13/984,887 patent/US9738863B2/en active Active
- 2012-02-21 CN CN201910891788.2A patent/CN110777045A/zh active Pending
- 2012-02-21 EP EP12749410.2A patent/EP2678416B1/en active Active
-
2017
- 2017-07-18 US US15/653,501 patent/US11613726B2/en active Active
-
2023
- 2023-02-24 US US18/174,322 patent/US11981887B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2012115581A1 (en) | 2012-08-30 |
US9738863B2 (en) | 2017-08-22 |
CN110777045A (zh) | 2020-02-11 |
EP2678416B1 (en) | 2019-10-02 |
JP2014506479A (ja) | 2014-03-17 |
CN103391996A (zh) | 2013-11-13 |
EP2678416A4 (en) | 2016-06-08 |
US20230212497A1 (en) | 2023-07-06 |
US11981887B2 (en) | 2024-05-14 |
US20170313967A1 (en) | 2017-11-02 |
US11613726B2 (en) | 2023-03-28 |
EP2678416A1 (en) | 2014-01-01 |
US20130316446A1 (en) | 2013-11-28 |
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