JP5996429B2 - 関節リウマチの治療、診断及びモニターするための方法 - Google Patents

関節リウマチの治療、診断及びモニターするための方法 Download PDF

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JP5996429B2
JP5996429B2 JP2012528063A JP2012528063A JP5996429B2 JP 5996429 B2 JP5996429 B2 JP 5996429B2 JP 2012528063 A JP2012528063 A JP 2012528063A JP 2012528063 A JP2012528063 A JP 2012528063A JP 5996429 B2 JP5996429 B2 JP 5996429B2
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JP2013503643A5 (enExample
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ジュニア, グリン デニス,
ジュニア, グリン デニス,
フラビウス マーティン,
フラビウス マーティン,
マイケル ジェー. タウンゼンド,
マイケル ジェー. タウンゼンド,
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Genentech Inc
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JP2012528063A 2009-09-03 2010-09-02 関節リウマチの治療、診断及びモニターするための方法 Active JP5996429B2 (ja)

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US27594809P 2009-09-03 2009-09-03
US61/275,948 2009-09-03
US25242409P 2009-10-16 2009-10-16
US61/252,424 2009-10-16
PCT/US2010/047734 WO2011028945A1 (en) 2009-09-03 2010-09-02 Methods for treating, diagnosing, and monitoring rheumatoid arthritis

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JP2016124696A Active JP6895718B2 (ja) 2009-09-03 2016-06-23 関節リウマチの治療、診断及びモニターするための方法
JP2020158134A Pending JP2021019594A (ja) 2009-09-03 2020-09-23 関節リウマチの治療、診断及びモニターするための方法

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CN (2) CN102597268B (enExample)
BR (1) BR112012004777A2 (enExample)
CA (1) CA2772929A1 (enExample)
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Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2672640T3 (es) 2003-11-05 2018-06-15 Roche Glycart Ag Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas
TW201438738A (zh) * 2008-09-16 2014-10-16 建南德克公司 治療進展型多發性硬化症之方法
CN102597268B (zh) 2009-09-03 2017-09-22 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控类风湿性关节炎的方法
US9023997B2 (en) 2010-01-20 2015-05-05 Merck Sharp & Dohme Corp. Anti-ILT5 antibodies and ILT5-binding antibody fragments
WO2011091181A1 (en) 2010-01-20 2011-07-28 Tolerx, Inc. Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
CN107496917B (zh) 2010-02-26 2021-06-11 诺沃—诺迪斯克有限公司 包含稳定抗体的组合物
PH12012502193A1 (en) 2010-05-06 2021-08-09 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
EA201291180A1 (ru) 2010-05-06 2013-05-30 Новартис Аг Композиции и способы применения терапевтических антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)
MX2012013586A (es) 2010-05-28 2013-01-24 Novo Nordisk As Composiciones multi-dosis estables que comprenden un anticuerpo y un conservante.
MX379481B (es) 2010-12-06 2025-03-11 Seagen Inc Anticuerpos humanizados a liv-1 y uso de los mismos para tratar cancer
JP5885926B2 (ja) * 2011-01-28 2016-03-16 シスメックス株式会社 関節リウマチの存在の評価方法およびその方法に用いられるバイオマーカーセット
RU2013140975A (ru) 2011-02-28 2015-04-10 Дженентек, Инк. Биологические маркеры и способы прогнозирования восприимчивости к антагонистам в-клеток
WO2012167186A1 (en) * 2011-06-02 2012-12-06 Health Datastream Inc. System and method for scoring illness complexity to predict healthcare cost
SG11201401717VA (en) 2011-11-04 2014-05-29 Novartis Ag Low density lipoprotein-related protein 6 (lrp6) - half life extender constructs
EP2812445A2 (en) 2012-02-10 2014-12-17 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2013135789A1 (en) * 2012-03-15 2013-09-19 Universiteit Hasselt Means and methods for the determination of the joint destruction progression rate in rheumatoid arthritis patients
WO2013164440A1 (en) 2012-05-03 2013-11-07 Novo Nordisk A/S Methods related to treatment of inflammatory diseases and disorders
WO2014028374A1 (en) * 2012-08-17 2014-02-20 Eli Lilly And Company Biomarkers predictive of rheumatoid arthritis or systemic lupus erythematosus response to anti-baff antibody therapy
WO2014118550A1 (en) * 2013-01-31 2014-08-07 The University Of Birmingham Biomarkers of autoimmune and/or chronic diseases associated with joint inflammation
EP2813850A1 (en) * 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting rheumatoid arthritis treatment response
WO2014204274A1 (ko) * 2013-06-21 2014-12-24 가톨릭대학교 산학협력단 류마티스 관절염 진단 또는 활성도 평가용 바이오마커
TWI725931B (zh) 2013-06-24 2021-05-01 美商建南德克公司 抗fcrh5抗體
CN103399147B (zh) * 2013-08-07 2015-06-17 苏州大学 多聚半乳糖醛酸的新应用
KR101628035B1 (ko) * 2013-09-13 2016-06-09 인제대학교 산학협력단 Vsig4를 이용한 난소암 치료제 스크리닝 방법
CN103513040B (zh) * 2013-10-16 2015-03-11 常晓天 蛋白cd38在制备类风湿性关节炎诊断标记物中的应用
EP2863231A1 (en) * 2013-10-17 2015-04-22 Institut D'Investigaciones Biomédiques August Pi i Sunyer Diagnostic method for detecting a GABA(A) related autoimmune disease and related subject-matter
WO2015138803A1 (en) 2014-03-12 2015-09-17 Icahn School Of Medicine At Mount Sinai Method for identifying kidney allograft recipients at risk for chronic injury
RU2554755C1 (ru) * 2014-05-26 2015-06-27 Федеральное бюджетное учреждение науки "Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии им. Пастера" (ФБУН НИИ эпидемиологии и микробиологии имени Пастера) Способ диагностики ревматоидного артрита
AU2015279542B2 (en) 2014-06-26 2021-07-29 Icahn School Of Medicine At Mount Sinai Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets
KR20160048442A (ko) * 2014-10-24 2016-05-04 가톨릭대학교 산학협력단 류마티스 관절염 관련 바이오마커
WO2016120387A1 (en) * 2015-01-29 2016-08-04 Ares Trading S.A. Immunoassays for high positively charged proteins
CN105988009B (zh) * 2015-02-28 2018-03-13 复旦大学附属华山医院 Netrin‑4在制备检测胃癌及预后标志物的制剂中的用途
WO2016154553A1 (en) * 2015-03-25 2016-09-29 La Jolla Institute For Allergy And Immunology Cxcl13 as an indicator of germinal center activity and immune response
WO2016183310A1 (en) 2015-05-12 2016-11-17 Steere Allen C Autoantigens for diagnosis of rheumatoid arthritis
ES2957567T3 (es) 2015-06-16 2024-01-22 Hoffmann La Roche Anticuerpos humanizados y de afinidad madurada contra FcRH5 y procedimientos de uso
CN105200159B (zh) * 2015-11-06 2018-06-15 北京致成生物医学科技有限公司 骨性关节炎诊疗试剂及其应用
GB201521357D0 (en) * 2015-12-03 2016-01-20 Univ Liverpool Methods for predicting response to anti-TNF therapy
KR20220157515A (ko) 2016-03-15 2022-11-29 씨젠 인크. Liv1-adc와 화학요법제를 사용한 병용 요법
US11644473B2 (en) * 2016-04-15 2023-05-09 Rowan University Serum biomarkers for predicting and evaluating response to TNF inhibitor therapy in rheumatoid arthritis patients
US20170321286A1 (en) * 2016-05-05 2017-11-09 Exact Sciences Corporation Detection of lung neoplasia by amplification of rna sequences
EP3463441B1 (en) 2016-06-07 2023-10-25 The General Hospital Corporation Identification of a t cell epitope of prevotella copri that induces t cell responses in patients with rheumatoid arthritis
RU2622597C1 (ru) * 2016-07-05 2017-06-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО КубГМУ Минздрава России) Способ прогнозирования суставного болевого синдрома у пациентов с признаками дисплазии соединительной ткани
GB201616557D0 (en) * 2016-09-29 2016-11-16 Secretary Of State For Health The Assay for distinguishing between sepsis and systemic inflammatory response syndrome
CN106526196B (zh) * 2016-10-08 2018-08-10 北京大学人民医院 Sr-a作为类风湿关节炎诊断标志物及干预靶点的应用
KR102049987B1 (ko) * 2016-11-09 2019-11-28 아이씨엠 주식회사 Nkx3.2 단편 및 이를 함유하는 약학 조성물
US11466094B2 (en) 2016-11-15 2022-10-11 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
KR102588627B1 (ko) * 2017-03-08 2023-10-16 김성진 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
WO2018164507A2 (ko) * 2017-03-08 2018-09-13 주식회사 길로 Mast4 유전자를 이용한 세포외 기질 생산용 조성물 및 그 제조방법
WO2019041024A1 (en) * 2017-08-29 2019-03-07 Gary Levy FGL2 ANTIBODIES AND BINDING FRAGMENTS THEREOF AND USES THEREOF
CA3036161C (en) * 2017-11-13 2023-03-28 The Multiple Myeloma Research Foundation, Inc. Integrated, molecular, omics, immunotherapy, metabolic, epigenetic, and clinical database
JP7652566B2 (ja) * 2018-01-24 2025-03-27 ジェネンテック, インコーポレイテッド 関節リウマチ(ra)の処置のための診断方法及び治療方法
CN108359726B (zh) * 2018-02-28 2020-09-04 固安博健生物技术有限公司 Coro2b作为分子诊治标志物的用途
EP3765634A4 (en) 2018-03-16 2021-12-01 Scipher Medicine Corporation METHODS AND SYSTEMS FOR PREDICTING THE RESPONSE TO ANTI-TNF THERAPIES
SG11202008400SA (en) 2018-04-11 2020-09-29 Rocket Pharmaceuticals Ltd Compositions and methods for stem cell transplant
JP7464279B2 (ja) 2018-04-16 2024-04-09 アイカーン スクール オブ メディスン アット マウント シナイ レシピエント血液における移植前トランスクリプトームシグネチャーを使用した急性拒絶反応および腎臓同種異系移植喪失の予測のための方法およびキット
US20190336585A1 (en) * 2018-05-03 2019-11-07 John Lawrence Mee Method for sustainable human cognitive enhancement
US20190359985A1 (en) * 2018-05-22 2019-11-28 John Lawrence Mee Adjustable method for sustainable human cognitive enhancement
CN109142729B (zh) * 2018-06-14 2021-04-23 郑州大学第一附属医院 一种肺癌标志物抗-hmgb3自身抗体及其应用
CA3104440A1 (en) * 2018-06-21 2019-12-26 Astraveus Microfluidic device and method for processing particles
US20190390193A1 (en) * 2018-06-23 2019-12-26 John Lawrence Mee Reversible method for sustainable human cognitive enhancement
US10723191B1 (en) 2018-07-01 2020-07-28 Softwheel Ltd. In-wheel three-arm suspension for vehicles
CN110917351A (zh) * 2018-09-20 2020-03-27 华中科技大学同济医学院附属同济医院 Mbd2抑制剂在预防和治疗纤维化疾病中的用途
EP3866835B1 (en) * 2018-10-19 2024-01-03 The Regents Of The University Of Michigan Method for monitoring autoimmune disease
CN109207584A (zh) * 2018-11-01 2019-01-15 固安博健生物技术有限公司 Marco作为早期诊断骨关节炎的分子标志物的应用
WO2020163876A1 (en) * 2019-02-08 2020-08-13 The Regents Of The University Of California Compositions and methods involving layilin
US12247015B2 (en) 2019-04-29 2025-03-11 Solent Therapeutics, Llc 3-amino-4H-benzo[e][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2
PE20220763A1 (es) * 2019-05-08 2022-05-16 Janssen Biotech Inc Materiales y metodos para modular la inmunidad mediada por celulas t
JP2022541125A (ja) 2019-06-27 2022-09-22 サイファー メディシン コーポレーション 患者を層別化するための分類子の開発
CN114573663B (zh) * 2019-08-27 2023-08-11 广东菲鹏生物有限公司 瓜氨酸肽及其应用、类风湿关节炎的检测试剂与试剂盒
CN110408590B (zh) * 2019-09-06 2022-10-25 遵义医学院附属医院 一种诱导人间充质干细胞向成骨细胞分化的方法与应用
GB201914079D0 (en) * 2019-09-30 2019-11-13 Univ London Queen Mary Method of predicting requirement for biologic therapy
KR102596937B1 (ko) * 2019-11-07 2023-11-03 가톨릭대학교 산학협력단 류마티스 관절염의 판누스 진단용 바이오마커 및 이의 이용
CN111091909B (zh) * 2019-11-26 2022-05-31 中国信息通信研究院 一种医学影像识别方法和装置
CN113122628B (zh) * 2019-12-30 2023-08-11 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用
CN115023615A (zh) * 2020-01-10 2022-09-06 私募蛋白质体操作有限公司 确定葡萄糖耐量减低的方法
AU2021270453A1 (en) 2020-05-14 2023-01-05 Ampel Biosolutions, Llc Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
CN112114126B (zh) * 2020-08-13 2023-03-24 川北医学院 一种系统性红斑狼疮的诊断标志物及其应用
WO2022064163A1 (en) * 2020-09-22 2022-03-31 The Secretary Of State For Defence Apparatus, kits and methods for predicting the development of sepsis
EP4237003A4 (en) 2020-10-28 2025-07-09 Janssen Biotech Inc COMPOSITIONS AND METHODS FOR MODULATING GAMMA DELTA CHAIN-MEDIATED IMMUNITY
IL302400A (en) 2020-11-04 2023-06-01 Genentech Inc Subcutaneous dosing of bispecific anti-CD20/anti-CD3 antibodies
CA3196191A1 (en) 2020-11-04 2022-05-12 Chi-Chung Li Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
CA3196539A1 (en) 2020-11-04 2022-05-12 Chi-Chung Li Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
CN112646887B (zh) * 2020-12-23 2023-02-28 广州医科大学附属第五医院 Znf239作为肝癌诊治的靶标
CN112946269B (zh) * 2020-12-29 2022-12-27 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) Abca1与cd68作为预后标记物在制备肝癌预后预测试剂盒中的应用
GB202103241D0 (en) * 2021-03-09 2021-04-21 Univ Oxford Innovation Ltd Biomaker
CN113186281B (zh) * 2021-04-02 2023-02-28 广州医科大学附属第五医院 作为肝细胞癌标志物的inava
CN113512582A (zh) * 2021-04-15 2021-10-19 上海鸿准生物医药科技有限公司 Slc22a18在过敏变态反应性疾病与炎症性疾病中的应用
CN113307835B (zh) * 2021-04-21 2022-12-13 南通大学 一种siRNA及其在制备慢性疼痛治疗药物中的应用
EP4327101A1 (en) * 2021-04-21 2024-02-28 Sorbonne Universite Markers of autoimmune diseases
AU2021443318A1 (en) 2021-04-30 2023-09-07 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
WO2022241235A1 (en) 2021-05-14 2022-11-17 Genentech, Inc. Methods for treatment of cd20-positive proliferative disorder with mosunetuzumab and polatuzumab vedotin
WO2022264134A1 (en) * 2021-06-13 2022-12-22 Technion Research & Development Foundation Limited Method for determining suitability to anti-tnf alpha therapy
IL312692A (en) 2021-11-16 2024-07-01 Genentech Inc Methods and compositions for the treatment of systemic lupus erythematosus (SLE) with musontuzumab
WO2023158713A1 (en) * 2022-02-16 2023-08-24 Ampel Biosolutions, Llc Unsupervised machine learning methods
CN114994327B (zh) * 2022-04-12 2025-04-15 浙江大学医学院附属第二医院 一种生物标志物gsdme的应用
WO2024108154A2 (en) * 2022-11-18 2024-05-23 The United States Government As Represented By The Department Of Veterans Affairs Methods for treating rheumatoid arthritis using a syndecan-1 inhibitor or syntenin-1 inhibitor
CN116144761A (zh) * 2023-02-24 2023-05-23 山西医科大学 一种类风湿性关节炎诊断分类器的构建方法及其应用
CN116064784A (zh) * 2023-03-23 2023-05-05 上海市光华中西医结合医院 Fgf10在制备检测类风湿性关节炎试剂盒中的应用
JP2024179174A (ja) * 2023-06-14 2024-12-26 シスメックス株式会社 膜性腎症患者に対する化学療法の奏効性に関する情報を取得する方法、膜性腎症患者に対する化学療法の奏効性の判定を補助する方法及び試薬キット
TWI901424B (zh) * 2023-11-10 2025-10-11 長庚醫療財團法人林口長庚紀念醫院 抗-pdgfrl中和抗體在治療關節炎上的用途
CN117567626B (zh) * 2024-01-15 2024-04-26 北京大学人民医院 一种抗瓜氨酸化清道夫受体a多肽抗体及其在制备诊断类风湿关节炎的产品中的应用
WO2025184328A1 (en) * 2024-02-28 2025-09-04 Acurex Biosciences Corporation Polypeptides binding to miro1
WO2025218746A1 (en) * 2024-04-17 2025-10-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis
TW202544254A (zh) * 2024-04-29 2025-11-16 中國醫藥大學 一種利用基因變異作為生物標誌以評估類風濕性關節炎患者對Janus激酶抑制劑治療反應之方法
CN119424633B (zh) * 2024-11-07 2025-07-25 浙江赛尔共银生物科技有限公司 一种包含间充质干细胞治疗退行性关节炎的组合物及其制备方法

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434227A (en) 1982-02-08 1984-02-28 Abbott Laboratories Immunoassay for class specific immunoglobulin antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
CA1261257A (en) 1984-09-19 1989-09-26 Helgi Valdimarsson Prognostic value of rheumatoid factor isotypes and their association with disease activity
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5484892A (en) 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US6139832A (en) 1995-02-08 2000-10-31 Human Genome Sciences, Inc. Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
WO1996024668A1 (en) 1995-02-08 1996-08-15 Human Genome Sciences, Inc. Human chemokine beta-11 and human chemokine alpha-1
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
CA2219486A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
KR19990022283A (ko) 1995-06-05 1999-03-25 벤슨 로버트 에이치. 인체 케모킨 베타-11 및 인체 케모킨 알파-1
EP0888125B1 (en) 1996-03-20 2004-05-26 Immunomedics, Inc. GLYCOSYLATED IgG ANTIBODIES
EP0939804B2 (en) 1996-10-25 2011-06-15 Human Genome Sciences, Inc. NEUTROKINE alpha
EP2305027B1 (en) 1996-12-03 2014-07-02 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
AU5705898A (en) 1996-12-17 1998-07-15 Schering Corporation Mammalian cell surface antigens; related reagents
US6183744B1 (en) 1997-03-24 2001-02-06 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
CA2232743A1 (en) 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
AU9315298A (en) 1997-09-12 1999-03-29 Apotech S.A. Kay - a novel immune system protein
PT1033134E (pt) * 1997-10-29 2007-07-11 Otsuka Pharma Co Ltd Composições que inibem a proliferação de músculo liso e processo de diagonóstico da arteriosclerose
US6110695A (en) 1997-12-02 2000-08-29 The Regents Of The University Of California Modulating the interaction of the chemokine, B Lymphocyte Hemoattractant, and its Receptor, BLR1
AU2093499A (en) 1997-12-30 1999-07-19 Chiron Corporation Members of tnf and tnfr families
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
DE69937291T2 (de) 1998-04-02 2008-07-10 Genentech, Inc., South San Francisco Antikörpervarianten und fragmente davon
SK288176B6 (sk) 1999-01-07 2014-04-02 Zymogenetics, Inc. Farmaceutický prostriedok obsahujúci fúzny proteín, izolovaná molekula polynukleotidu, expresný vektor, kultivovaná bunka, spôsob prípravy polypeptidu a izolovaný polypeptid
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
KR101077001B1 (ko) 1999-01-15 2011-10-26 제넨테크, 인크. 효과기 기능이 변화된 폴리펩티드 변이체
EP1194167B1 (en) 1999-06-09 2009-08-19 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target b-cells
KR20090016772A (ko) 1999-08-17 2009-02-17 바이오겐 아이덱 엠에이 인코포레이티드 Baff 수용체(bcma), 면역조절제
DE10041402A1 (de) 2000-08-23 2002-03-14 Morphochem Ag Neue Verbindungen, die Faktor Xa-Aktivität inhibieren
AU7338500A (en) * 1999-09-01 2001-03-26 Boehringer Ingelheim Pharmaceuticals, Inc. Methods and compositions for treating autoimmune disease
US7105149B1 (en) 1999-11-29 2006-09-12 The Trustees Of Columbia University In The City Of New York Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma
EP1280826B1 (en) 2000-05-12 2007-05-02 Amgen Inc. Polypeptides for inhibiting april-mediated b- and t-cell proliferation.
DE60143798D1 (de) 2000-06-16 2011-02-17 Cambridge Antibody Tech Immunspezifisch bindende antikörper gegen blys
EP2267015A3 (en) 2000-08-18 2011-04-20 Human Genome Sciences, Inc. Binding polypeptides for B lymphocyte stimulator protein (BLyS)
UA83458C2 (uk) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
CA2428242A1 (en) 2000-11-07 2002-05-16 Zymogenetics, Inc. Human tumor necrosis factor receptor
WO2002066516A2 (en) 2001-02-20 2002-08-29 Zymogenetics, Inc. Antibodies that bind both bcma and taci
US6818406B2 (en) 2001-03-23 2004-11-16 Mayo Foundation For Medical Education And Research Rheumatoid arthritis markers
JP4516719B2 (ja) 2001-05-11 2010-08-04 アムジエン・インコーポレーテツド Tall−1と結合するペプチド及び関連分子
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
CN1636067A (zh) 2001-08-03 2005-07-06 杰南技术公司 TACls和BR3多肽及其用途
WO2003024991A2 (en) 2001-09-21 2003-03-27 Amgen Inc. Tall-1 receptor molecules and uses thereof
US7825089B2 (en) 2001-10-24 2010-11-02 National Jewish Health Three-dimensional structures of TALL-1 and its cognate receptors and modified proteins and methods related thereto
US20050202421A1 (en) 2001-10-31 2005-09-15 Raphael Hirsch Method for diagnosis and treatment of rheumatoid arthritis
US20030224386A1 (en) * 2001-12-19 2003-12-04 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of rheumatoid arthritis
CA2476166C (en) 2002-02-14 2011-11-15 Immunomedics, Inc. Anti-cd20 antibodies and fusion proteins thereof and methods of use
WO2003072736A2 (en) 2002-02-21 2003-09-04 Duke University Reagents and treatment methods for autoimmune diseases
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
US7258221B2 (en) 2002-07-18 2007-08-21 Fabio Perini S.P.A. Storage unit for elongated products
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
PL216630B1 (pl) 2002-10-17 2014-04-30 Genmab As Izolowane ludzkie przeciwciało monoklonalne wiążące ludzki CD20, związane z tym przeciwciałem transfektoma, komórka gospodarza, transgeniczne zwierzę lub roślina, kompozycja, immunokoniugat, cząsteczka bispecyficzna, wektor ekspresyjny, kompozycja farmaceutyczna, zastosowanie medyczne, zestaw oraz przeciwciało antyidiotypowe i jego zastosowanie
ES2347241T3 (es) 2002-12-16 2010-10-27 Genentech, Inc. Variantes de inmunoglobulina y sus utilizaciones.
SE0300959D0 (sv) * 2002-12-19 2003-04-02 Pharmacia Ab Methods for predicting therapeutic response to agents acting on the growth hormone receptor
US6962006B2 (en) 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20050163775A1 (en) 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
AU2004256042A1 (en) 2003-06-05 2005-01-20 Genentech, Inc. BlyS antagonists and uses thereof
IL156495A0 (en) 2003-06-17 2004-01-04 Prochon Biotech Ltd Use of fgfr3 antagonists for treating t cell mediated diseases
EP1664796B1 (en) 2003-09-15 2010-12-15 Oklahoma Medical Research Foundation Method of using cytokine assays to diagnose, treat, and evaluate ankylosing spondylitis
DE102004016437A1 (de) * 2004-04-04 2005-10-20 Oligene Gmbh Verfahren zur Erkennung von Signaturen in komplexen Genexpressionsprofilen
CA2501422C (en) 2004-04-29 2014-08-12 University Of Rochester Lymphoid chemokines in the diagnosis, monitoring and treatment of autoimmune disease
PA8635501A1 (es) 2004-06-04 2006-06-02 Genentech Inc Uso de un anticuerpo para el tratamiento del lupus
WO2006039238A2 (en) 2004-09-30 2006-04-13 The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Irta2 antibodies and methods of use
ZA200702335B (en) 2004-10-05 2009-05-27 Genentech Inc Method for treating vasculitis
WO2006138275A2 (en) 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2616386A1 (en) * 2005-07-25 2007-02-01 Trubion Pharmaceuticals Inc. Single dose use of cd20-specific binding molecules
AU2006278229B2 (en) 2005-08-09 2011-10-27 Ares Trading S.A. Methods for treating B-cell malignancies using TACI-Ig fusion molecule
WO2007038501A2 (en) 2005-09-27 2007-04-05 The Feinstein Institute For Medical Research Rheumatoid arthritis markers
US7935482B2 (en) * 2005-09-27 2011-05-03 Source Precision Medicine, Inc. Gene expression profiling for identification monitoring and treatment of rheumatoid arthritis
US20090128815A1 (en) 2006-03-15 2009-05-21 Koninklijke Philips Electronics N.V. Remote control pointing technology with roll detection
GB0607774D0 (en) 2006-04-20 2006-05-31 Renovo Group Plc Medicaments
WO2007124414A2 (en) 2006-04-21 2007-11-01 Centocor, Inc. Cxcl13 antagonists and their use for the treatment of inflammatory diseases
AU2007254206A1 (en) * 2006-05-16 2007-11-29 Source Mdx Assessment of effect of an agent on a human biological condition using rodent gene expression panels
EP1857559A1 (en) 2006-05-16 2007-11-21 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for predicting responsiveness to TNF alpha blocking agents
US20070269827A1 (en) * 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
WO2008156494A1 (en) * 2006-11-03 2008-12-24 The Johns Hopkins University Use of high-dose oxazaphosphorine drugs in combination with monoclonal antibodies for treating immune disorders
JP2010508838A (ja) 2006-11-09 2010-03-25 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル(イーエヌエスエーエールエム) TNF−α遮断薬に対する治療応答性の予測方法
US20080227704A1 (en) 2006-12-21 2008-09-18 Kamens Joanne S CXCL13 binding proteins
US20080199481A1 (en) 2007-02-21 2008-08-21 Astrazeneca Ab Compounds
EP2132343B1 (en) 2007-03-01 2012-08-29 Université Catholique de Louvain Method for the determination and the classification of rheumatic conditions
CA2682666A1 (en) 2007-03-30 2008-10-09 Centocor Ortho Biotech Inc. Cxcl13 antagonists and their use for the treatment of inflammatory diseases
CL2008000948A1 (es) * 2007-04-02 2008-10-10 Genentech Inc Uso de un antagonista de celulas b para tratar la artritis reumatoide a condicion que se observe la presencia de polimorfismo de nucleotido simple, epitope compartido o ambos en una muestra genetica del paciente.
WO2008132176A2 (en) 2007-04-27 2008-11-06 Universite Catholique De Louvain Method for evaluating the response of an individual to tnf blocking therapy
BRPI0812461A2 (pt) 2007-06-08 2017-06-13 Biogen Idec Inc método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
CN101842705A (zh) 2007-09-03 2010-09-22 普罗塔根股份公司 用于类风湿性关节炎的标记序列及其应用
US20090202474A1 (en) 2007-11-19 2009-08-13 Wyeth Expression of orphan gpr64 in inflammatory diseases
US8121883B2 (en) * 2008-02-07 2012-02-21 International Business Machines Corporation Method and system for automatically prioritizing opportunity based customer requirements
KR20120057565A (ko) 2009-04-01 2012-06-05 제넨테크, 인크. 항-FcRH5 항체 및 면역접합체 및 사용 방법
CN102597268B (zh) 2009-09-03 2017-09-22 弗·哈夫曼-拉罗切有限公司 用于治疗、诊断和监控类风湿性关节炎的方法

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US9822400B2 (en) 2017-11-21
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US20110052488A1 (en) 2011-03-03
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