JP5950825B2 - 活性化合物の持続放出のための分解性の取り外し可能なインプラント - Google Patents

活性化合物の持続放出のための分解性の取り外し可能なインプラント Download PDF

Info

Publication number
JP5950825B2
JP5950825B2 JP2012543843A JP2012543843A JP5950825B2 JP 5950825 B2 JP5950825 B2 JP 5950825B2 JP 2012543843 A JP2012543843 A JP 2012543843A JP 2012543843 A JP2012543843 A JP 2012543843A JP 5950825 B2 JP5950825 B2 JP 5950825B2
Authority
JP
Japan
Prior art keywords
microparticles
implant
tube
poly
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012543843A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013514971A5 (show.php
JP2013514971A (ja
Inventor
シヤクター，デボラ・エム
ベール，リーベン・エルビール・コレツト
クラウス，ギユンター
ツアン，チヤン
チユン，イクス
Original Assignee
ヤンセン・サイエンシズ・アイルランド・ユーシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ヤンセン・サイエンシズ・アイルランド・ユーシー filed Critical ヤンセン・サイエンシズ・アイルランド・ユーシー
Publication of JP2013514971A publication Critical patent/JP2013514971A/ja
Publication of JP2013514971A5 publication Critical patent/JP2013514971A5/ja
Application granted granted Critical
Publication of JP5950825B2 publication Critical patent/JP5950825B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012543843A 2009-12-21 2010-12-20 活性化合物の持続放出のための分解性の取り外し可能なインプラント Active JP5950825B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28837309P 2009-12-21 2009-12-21
US61/288,373 2009-12-21
PCT/EP2010/070246 WO2011080141A2 (en) 2009-12-21 2010-12-20 Degradable removable implant for the sustained release of an active compound

Publications (3)

Publication Number Publication Date
JP2013514971A JP2013514971A (ja) 2013-05-02
JP2013514971A5 JP2013514971A5 (show.php) 2014-02-13
JP5950825B2 true JP5950825B2 (ja) 2016-07-13

Family

ID=43743502

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012543843A Active JP5950825B2 (ja) 2009-12-21 2010-12-20 活性化合物の持続放出のための分解性の取り外し可能なインプラント

Country Status (18)

Country Link
US (3) US8784858B2 (show.php)
EP (1) EP2515877B1 (show.php)
JP (1) JP5950825B2 (show.php)
KR (1) KR101798430B1 (show.php)
CN (1) CN102740837B (show.php)
AU (1) AU2010338425B2 (show.php)
BR (1) BR112012015114B1 (show.php)
CA (1) CA2784530C (show.php)
ES (1) ES2600878T3 (show.php)
IL (1) IL219685B (show.php)
MX (1) MX2012007210A (show.php)
MY (1) MY163383A (show.php)
NZ (1) NZ600156A (show.php)
RU (1) RU2593790C2 (show.php)
SG (1) SG181759A1 (show.php)
UA (1) UA112155C2 (show.php)
WO (1) WO2011080141A2 (show.php)
ZA (1) ZA201204583B (show.php)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2916425A1 (en) * 2013-06-20 2014-12-24 Mercy Medical Research Institute Extended release drug-delivery contact lenses and methods of making
AU2015301432B2 (en) 2014-08-15 2019-11-21 The Johns Hopkins University Composite material for tissue restoration
WO2016149561A1 (en) * 2015-03-17 2016-09-22 Oak Crest Institute Of Science Subdermal implants for the sustained delivery of water-soluble drugs
US11779435B2 (en) 2015-08-26 2023-10-10 Flexscrewdriver I.K.E. Dental screwdriver
CN106702597B (zh) * 2016-12-20 2019-06-18 华南理工大学 一种核-壳结构纳米纤维膜及其制备方法和应用
MX2020000376A (es) 2017-07-11 2020-07-14 Sustained Nano Systems Llc Formulaciones farmaceuticas hipercomprimidas.
IL278525B2 (en) 2018-05-09 2024-04-01 Univ Johns Hopkins Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
WO2019217765A1 (en) 2018-05-09 2019-11-14 The Johns Hopkins University Nanofiber-hydrogel composites for cell and tissue delivery
EP3793537A1 (en) * 2018-05-16 2021-03-24 Spirox, Inc. Allergic rhinitis drug delivery implant
CN113260350A (zh) 2018-10-16 2021-08-13 三角研究所 皮下可生物降解储器装置
IL297145A (en) * 2020-04-07 2022-12-01 Res Triangle Inst Multidrug compositions for a biodegradable subcutaneous reservoir device
EP4151673A4 (en) * 2020-05-12 2024-03-20 Laboratorios Farmacéuticos Rovi, S.A. METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182111A (en) * 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
WO1993009176A2 (en) * 1991-10-29 1993-05-13 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5645684A (en) 1994-03-07 1997-07-08 The Regents Of The University Of California Multilayer high vertical aspect ratio thin film structures
US5660680A (en) 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
JPH09512250A (ja) * 1994-03-07 1997-12-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞移植体の隔離に用いる微小加工カプセル
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
US5651900A (en) 1994-03-07 1997-07-29 The Regents Of The University Of California Microfabricated particle filter
CN1378445B (zh) 1999-08-06 2013-02-06 得克萨斯系统大学评议会 药物释放生物可降解纤维植入物
US7033603B2 (en) 1999-08-06 2006-04-25 Board Of Regents The University Of Texas Drug releasing biodegradable fiber for delivery of therapeutics
KR100792391B1 (ko) 1999-10-06 2008-01-08 티보텍 파마슈티칼즈 리미티드 레트로바이러스 프로테아제 저해제로서의헥사하이드로푸로[2,3-ｂ]푸란-3-일-Ｎ-[3-[(1,3-벤조디옥솔-5-일설포닐)(이소부틸)아미노]-1-벤질-2-하이드록시프로필]카바메이트
TWI284048B (en) 2000-01-27 2007-07-21 Zentaris Ag Compressed microparticles for dry injection
US20040115268A1 (en) 2000-04-26 2004-06-17 Control Delivery Systems, Inc. Systemic delivery of antiviral agents
DE10050199A1 (de) * 2000-10-11 2002-04-25 Ethicon Gmbh Flächiges Implantat mit im Ultraschall detektierbaren Elementen
WO2002092054A2 (en) * 2001-05-11 2002-11-21 Ortho-Mcneil Pharmaceutical, Inc. Immune modulation device for use in animals
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
US7497855B2 (en) 2002-09-04 2009-03-03 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US20040156878A1 (en) * 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
TWI457136B (zh) * 2005-04-04 2014-10-21 Tibotec Pharm Ltd Ｈｉｖ-感染之預防
CA2603851A1 (en) 2005-04-11 2006-10-19 The Board Of Trustees Of The Leland Stanford Junior Unversity Multi-layer structure having a predetermined layer pattern including an agent
US20060252049A1 (en) 2005-05-04 2006-11-09 Shuler Richard O Growth-promoting and immunizing subcutaneous implant
US7261529B2 (en) 2005-09-07 2007-08-28 Southwest Research Institute Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents
AR059097A1 (es) * 2006-01-20 2008-03-12 Tibotec Pharm Ltd Tratamiento a largo plazo de la infeccion por vih
WO2008060360A2 (en) * 2006-09-28 2008-05-22 Surmodics, Inc. Implantable medical device with apertures for delivery of bioactive agents
ES2394952T3 (es) * 2007-06-12 2013-02-07 Concert Pharmaceuticals Inc. Derivados de axapéptido como inhibidores de la proteasa VIH
WO2009046299A2 (en) * 2007-10-04 2009-04-09 Boston Scientific Scimed, Inc Implantable drug depot for intrathecal drug delivery system for pain management
WO2010047819A1 (en) * 2008-10-24 2010-04-29 Concert Pharmaceuticals, Inc. Hydroxyethylamino sulfonamide derivatives
KR101726615B1 (ko) 2008-12-24 2017-04-13 얀센 사이언시즈 아일랜드 유씨 Ｈｉｖ 치료용 체내 임플란트 장치

Also Published As

Publication number Publication date
MX2012007210A (es) 2012-07-23
NZ600156A (en) 2015-01-30
SG181759A1 (en) 2012-07-30
EP2515877A2 (en) 2012-10-31
WO2011080141A2 (en) 2011-07-07
IL219685A0 (en) 2012-07-31
US20200330654A1 (en) 2020-10-22
WO2011080141A3 (en) 2012-03-08
KR20120101084A (ko) 2012-09-12
BR112012015114A2 (pt) 2020-09-01
RU2593790C2 (ru) 2016-08-10
US11395867B2 (en) 2022-07-26
US20120277690A1 (en) 2012-11-01
US20140296799A1 (en) 2014-10-02
US10744235B2 (en) 2020-08-18
IL219685B (en) 2019-03-31
KR101798430B1 (ko) 2017-11-16
UA112155C2 (uk) 2016-08-10
RU2012131282A (ru) 2014-01-27
ZA201204583B (en) 2022-03-30
BR112012015114B1 (pt) 2023-01-10
CA2784530A1 (en) 2011-07-07
ES2600878T3 (es) 2017-02-13
CN102740837A (zh) 2012-10-17
EP2515877B1 (en) 2016-08-10
CN102740837B (zh) 2017-06-06
US8784858B2 (en) 2014-07-22
MY163383A (en) 2017-09-15
JP2013514971A (ja) 2013-05-02
AU2010338425A1 (en) 2012-06-07
AU2010338425B2 (en) 2015-07-23
CA2784530C (en) 2018-05-22

Similar Documents

Publication Publication Date Title
JP5950825B2 (ja) 活性化合物の持続放出のための分解性の取り外し可能なインプラント
JP4769119B2 (ja) 微粒子
JP2012211199A (ja) 生物学的活性剤を含有する生分解性微粒子の製造
MXPA05001499A (es) Composiciones farmaceuticas de electrohilado amorfo.
JPH05178740A (ja) 徐放性組成物およびその製造方法
JP2004535431A (ja) ゼロ次長期放出同軸インプラント
AU2723899A (en) Pharmaceutical compositions in form of nanoparticles comprising lipidic substances and amphiphilic substances and related preparation process
AU2002324447A1 (en) Zero-order prolonged release coaxial implants
US5569467A (en) Process for the preparation of microballs and microballs thus obtained
JP2002502809A (ja) 押出および球状化処理により得られた高分子微小粒子形態の医薬組成物
JP2911732B2 (ja) 徐放性多核マイクロスフェア製剤およびその製法
AU685094B2 (en) Process for the preparation of microballs and microballs thus obtained
HK1177679B (en) Degradable removable implant for the sustained release of an active compound
HK1177679A (en) Degradable removable implant for the sustained release of an active compound
JP2003522097A (ja) 可溶化デリバリーシステムおよび製造方法
ESLAMI et al. Preparation and characterization of estradiol valerate microspheres using biodegradable polymers
JP2004526759A (ja) 医薬品、その製造および使用
WO2009051845A2 (en) Biodegradable implants with controlled bulk density

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131219

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131219

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140829

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140903

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141203

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141210

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141229

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150302

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20150617

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150813

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151211

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160114

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160511

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160607

R150 Certificate of patent or registration of utility model

Ref document number: 5950825

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250