JP5922928B2 - 赤血球レベルを高めるためのgdfトラップの使用 - Google Patents

赤血球レベルを高めるためのgdfトラップの使用 Download PDF

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JP5922928B2
JP5922928B2 JP2011523000A JP2011523000A JP5922928B2 JP 5922928 B2 JP5922928 B2 JP 5922928B2 JP 2011523000 A JP2011523000 A JP 2011523000A JP 2011523000 A JP2011523000 A JP 2011523000A JP 5922928 B2 JP5922928 B2 JP 5922928B2
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seq
amino acid
polypeptide
actriib
acid sequence
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JP2011530599A5 (enExample
JP2011530599A (ja
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ジャスバー シーラ,
ジャスバー シーラ,
ロバート スコット ピアソール,
ロバート スコット ピアソール,
ラビンドラ クマール,
ラビンドラ クマール,
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アクセルロン ファーマ, インコーポレイテッド
アクセルロン ファーマ, インコーポレイテッド
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796Receptors; Cell surface antigens; Cell surface determinants for hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
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    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103Receptor protein serine/threonine kinase (2.7.11.30)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
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  • Diabetes (AREA)
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  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
JP2011523000A 2008-08-14 2009-08-13 赤血球レベルを高めるためのgdfトラップの使用 Active JP5922928B2 (ja)

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US18909408P 2008-08-14 2008-08-14
US61/189,094 2008-08-14
PCT/US2009/004659 WO2010019261A1 (en) 2008-08-14 2009-08-13 Use of gdf traps to increase red blood cell levels

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JP2011530599A JP2011530599A (ja) 2011-12-22
JP2011530599A5 JP2011530599A5 (enExample) 2012-08-30
JP5922928B2 true JP5922928B2 (ja) 2016-05-24

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JP2011523000A Active JP5922928B2 (ja) 2008-08-14 2009-08-13 赤血球レベルを高めるためのgdfトラップの使用
JP2014172279A Withdrawn JP2014224154A (ja) 2008-08-14 2014-08-27 赤血球レベルを高めるためのgdfトラップの使用
JP2016204858A Withdrawn JP2017019860A (ja) 2008-08-14 2016-10-19 赤血球レベルを高めるためのgdfトラップの使用
JP2018104584A Active JP6649432B2 (ja) 2008-08-14 2018-05-31 赤血球レベルを高めるためのgdfトラップの使用
JP2020005252A Active JP6968917B2 (ja) 2008-08-14 2020-01-16 赤血球レベルを高めるためのgdfトラップの使用
JP2021175400A Active JP7329573B2 (ja) 2008-08-14 2021-10-27 赤血球レベルを高めるためのgdfトラップの使用

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JP2016204858A Withdrawn JP2017019860A (ja) 2008-08-14 2016-10-19 赤血球レベルを高めるためのgdfトラップの使用
JP2018104584A Active JP6649432B2 (ja) 2008-08-14 2018-05-31 赤血球レベルを高めるためのgdfトラップの使用
JP2020005252A Active JP6968917B2 (ja) 2008-08-14 2020-01-16 赤血球レベルを高めるためのgdfトラップの使用
JP2021175400A Active JP7329573B2 (ja) 2008-08-14 2021-10-27 赤血球レベルを高めるためのgdfトラップの使用

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US (10) US8058229B2 (enExample)
EP (3) EP3750552B1 (enExample)
JP (6) JP5922928B2 (enExample)
AU (1) AU2009282441B2 (enExample)
CA (1) CA2733911C (enExample)
CY (3) CY1121971T1 (enExample)
DK (3) DK2340031T3 (enExample)
ES (3) ES2738543T3 (enExample)
FI (1) FI3750552T3 (enExample)
FR (1) FR20C1066I2 (enExample)
HR (3) HRP20191109T1 (enExample)
HU (4) HUE051137T2 (enExample)
LT (4) LT2340031T (enExample)
NL (1) NL301082I2 (enExample)
NO (1) NO2020045I1 (enExample)
PL (3) PL3750552T3 (enExample)
PT (3) PT2340031T (enExample)
SI (3) SI3494986T1 (enExample)
SM (3) SMT202300222T1 (enExample)
TR (1) TR201910890T4 (enExample)
TW (7) TW201803586A (enExample)
WO (1) WO2010019261A1 (enExample)

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