FR20C1066I2 - Pièges à gdf pour l'utilisation dans le traitment de l'anémie - Google Patents

Pièges à gdf pour l'utilisation dans le traitment de l'anémie

Info

Publication number
FR20C1066I2
FR20C1066I2 FR20C1066C FR20C1066C FR20C1066I2 FR 20C1066 I2 FR20C1066 I2 FR 20C1066I2 FR 20C1066 C FR20C1066 C FR 20C1066C FR 20C1066 C FR20C1066 C FR 20C1066C FR 20C1066 I2 FR20C1066 I2 FR 20C1066I2
Authority
FR
France
Prior art keywords
anemia
treatment
gdf traps
gdf
traps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR20C1066C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acceleron Pharma Inc
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of FR20C1066I1 publication Critical patent/FR20C1066I1/fr
Application granted granted Critical
Publication of FR20C1066I2 publication Critical patent/FR20C1066I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
FR20C1066C 2008-08-14 2020-12-19 Pièges à gdf pour l'utilisation dans le traitment de l'anémie Active FR20C1066I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18909408P 2008-08-14 2008-08-14
PCT/US2009/004659 WO2010019261A1 (fr) 2008-08-14 2009-08-13 Utilisation de pièges à gdf pour augmenter les taux d’érythrocytes

Publications (2)

Publication Number Publication Date
FR20C1066I1 FR20C1066I1 (fr) 2021-03-05
FR20C1066I2 true FR20C1066I2 (fr) 2023-03-24

Family

ID=41669153

Family Applications (1)

Application Number Title Priority Date Filing Date
FR20C1066C Active FR20C1066I2 (fr) 2008-08-14 2020-12-19 Pièges à gdf pour l'utilisation dans le traitment de l'anémie

Country Status (21)

Country Link
US (10) US8058229B2 (fr)
EP (3) EP3494986B1 (fr)
JP (6) JP5922928B2 (fr)
AU (1) AU2009282441B2 (fr)
CA (1) CA2733911C (fr)
CY (3) CY1121971T1 (fr)
DK (3) DK3750552T5 (fr)
ES (3) ES2808139T3 (fr)
FI (1) FI3750552T3 (fr)
FR (1) FR20C1066I2 (fr)
HR (3) HRP20230761T1 (fr)
HU (4) HUE045456T2 (fr)
LT (4) LT3750552T (fr)
NL (1) NL301082I2 (fr)
NO (1) NO2020045I1 (fr)
PL (3) PL3750552T3 (fr)
PT (3) PT3494986T (fr)
SI (3) SI3494986T1 (fr)
TR (1) TR201910890T4 (fr)
TW (7) TW201919685A (fr)
WO (1) WO2010019261A1 (fr)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2332977T3 (en) * 2004-07-23 2016-02-29 Acceleron Pharma Inc ActRII receptor polypeptides
EP1855694B1 (fr) 2005-02-09 2020-12-02 Sarepta Therapeutics, Inc. Composition antisens permettant de traiter une atrophie musculaire
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
CA2631013C (fr) 2005-11-23 2019-06-11 Acceleron Pharma Inc. Antagonistes de l'activine-actriia et utilisations pour activer la croissance osseuse
US20100028332A1 (en) * 2006-12-18 2010-02-04 Acceleron Pharma Inc. Antagonists of actriib and uses for increasing red blood cell levels
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
ES2415666T3 (es) * 2007-02-01 2013-07-26 Acceleron Pharma, Inc. Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama
TW201627320A (zh) 2007-02-02 2016-08-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
CN101687016B (zh) 2007-02-09 2014-12-31 阿塞勒隆制药公司 活化素-actriia拮抗剂和促进癌症患者骨骼生长的用途
WO2013106175A1 (fr) * 2011-12-19 2013-07-18 Amgen Inc. Variants polypeptidiques du récepteur de l'activine, seuls ou en combinaison avec une chimiothérapie, et leurs utilisations
TWI573802B (zh) 2007-03-06 2017-03-11 安美基公司 變異之活動素受體多肽及其用途
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US7960343B2 (en) 2007-09-18 2011-06-14 Acceleron Pharma Inc. Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
NZ590327A (en) * 2008-06-26 2013-12-20 Acceleron Pharma Inc Methods for dosing an activin-actriia antagonist and monitoring of treated patients
DK3750552T5 (da) 2008-08-14 2024-08-26 Acceleron Pharma Inc Gdf-fælder
US8216997B2 (en) * 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
SG171813A1 (en) 2008-11-26 2011-07-28 Amgen Inc Variants of activin iib receptor polypeptides and uses thereof
US8138142B2 (en) 2009-01-13 2012-03-20 Acceleron Pharma Inc. Methods for increasing adiponectin in a patient in need thereof
WO2010144452A1 (fr) 2009-06-08 2010-12-16 Acceleron Pharma Inc. Procédé visant à augmenter le nombre d'adipocytes thermogènes
KR20180026795A (ko) 2009-06-12 2018-03-13 악셀레론 파마 인코포레이티드 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
EP3117829B1 (fr) * 2009-08-13 2020-10-07 Acceleron Pharma Inc. Utilisation combinée de pièges gdf et activateurs du récepteur de l'érythropoïétine pour augmenter les taux d'érythrocytes
AU2015203400A1 (en) * 2009-08-13 2015-07-16 Acceleron Pharma Inc. Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels
CA2773494A1 (fr) * 2009-09-09 2011-03-17 Acceleron Pharma Inc. Antagonistes d'actriib, et dosage et administration associes
CA2779472C (fr) * 2009-11-03 2021-03-16 Acceleron Pharma Inc. L'utilisation d'une composition renfermant un polypeptide recepteur d'activine de type iib pour le traitement de steatose hepatique
AU2010322011B2 (en) 2009-11-17 2016-03-31 Acceleron Pharma Inc. ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
IN2012DN05169A (fr) * 2009-12-02 2015-10-23 Acceleron Pharma Inc
JO3340B1 (ar) 2010-05-26 2019-03-13 Regeneron Pharma مضادات حيوية لـعامل تمايز النمو 8 البشري
WO2011162210A1 (fr) * 2010-06-21 2011-12-29 協和発酵キリン株式会社 Procédé de purification d'une protéine utilisant un acide aminé
CA2817008A1 (fr) 2010-11-08 2012-05-18 Acceleron Pharma Inc. Agents de liaison a actriia et leurs utilisations
EP2718328A4 (fr) * 2011-06-08 2014-12-24 Acceleron Pharma Inc Compositions et procédés pour augmenter la demi-vie sérique
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
KR20220075438A (ko) * 2011-10-17 2022-06-08 악셀레론 파마 인코포레이티드 비효율적 적혈구생성 치료를 위한 방법 및 조성물
US8871209B2 (en) 2011-11-14 2014-10-28 Regeneron Pharmaceuticals, Inc. Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing GDF8 and or Activin A
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
WO2014030683A1 (fr) * 2012-08-21 2014-02-27 国立大学法人九州大学 Biomarqueur pour la détection d'un facteur pour l'anémie chez un patient anémique
CN112933223A (zh) * 2012-10-24 2021-06-11 细胞基因公司 用于治疗贫血的方法
WO2014066486A2 (fr) * 2012-10-24 2014-05-01 Celgene Corporation Biomarqueur utilisable dans le traitement de l'anémie
RU2678117C2 (ru) 2012-11-02 2019-01-23 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
EP2951205B1 (fr) 2013-02-01 2021-08-11 Santa Maria Biotherapeutics, Inc. Composés anti-activine pour le traitement du cancer des ovaires
TW201920262A (zh) 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素ａ之抗體及其用途
EP3119418B1 (fr) * 2014-03-21 2022-02-23 Acceleron Pharma Inc. Composition pour son utilisation dans une methode de traitement ou de prevention de l'anemie par l'inhibition de l'activine b et du gdf11
AU2015247459A1 (en) * 2014-04-18 2016-10-27 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating sickle-cell disease
MX2016016531A (es) 2014-06-13 2017-04-25 Acceleron Pharma Inc Metodos y composiciones para el tratamiento de las ulceras.
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
JP6663428B2 (ja) 2014-10-30 2020-03-11 アクセルロン ファーマ， インコーポレイテッド Ｇｄｆ１５ポリペプチドを使用する、赤血球を増加させるための方法および組成物
MA41119A (fr) 2014-12-03 2017-10-10 Acceleron Pharma Inc Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique
HUE062189T2 (hu) 2014-12-03 2023-09-28 Celgene Corp Aktivin-ACTRII-antagonisták és alkalmazások mielodiszpláziás szindróma kezelésére
WO2016128523A1 (fr) 2015-02-12 2016-08-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés pour prédire la réactivité d'un patient atteint d'une maladie hématologique maligne à un traitement par chimiothérapie et procédés de traitement de ces maladies
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
PT3280727T (pt) 2015-04-06 2021-04-23 Acceleron Pharma Inc Proteínas de fusão do recetor de braço único do tipo i e tipo ii e respetivas utilizações
AU2016246708B2 (en) 2015-04-06 2020-12-24 Acceleron Pharma Inc. ALK7:actRIIB heteromultimers and uses thereof
MA41919A (fr) * 2015-04-06 2018-02-13 Acceleron Pharma Inc Hétéromultimères alk4:actriib et leurs utilisations
CN107771081A (zh) 2015-04-15 2018-03-06 瑞泽恩制药公司 用gdf8抑制剂增加力量和功能的方法
BR112017022658A2 (pt) 2015-04-22 2018-07-17 Alivegen Usa Inc proteína isolada, molécula de ácido nucleico isolada, vetor recombinante, célula hospedeira, método de produção de uma proteína actriib híbrida, composição farmacêutica, métodos de tratamentos de distúrbios relacionados à miostatina ou relacionados à ativina a, de doença de desgaste dos músculos, de doença cardiovascular, de distúrbios metabólicos, de células cancerígenas, de doença renal, de doença inflamatória/autoimune, de uma doença de fibrose, de anemia, da dor, da condição de envelhecimento, de distúrbios ósseos, de um desgaste dos músculos ou distúrbio metabólico ou fibrótico ou inflamatório ou relacionado à ativina em indivíduos, e, método de indução do crescimento das células-tronco para o reparo de tecido ou regeneração do órgão em um indivíduo
WO2016183280A1 (fr) * 2015-05-13 2016-11-17 Celgene Corporation Traitement de la beta-thalassemia à l'aide de pièges à ligand actrii
EP3298034A4 (fr) * 2015-05-20 2019-02-13 Celgene Corporation Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii
EP3359668A4 (fr) 2015-10-09 2019-06-05 Sarepta Therapeutics, Inc. Compositions et méthodes pour traiter la dystrophie musculaire de duchenne et troubles associés
US11123430B2 (en) 2015-11-04 2021-09-21 Acceleron Pharma Inc. Methods for increasing red blood cell levels and treating ineffective erythropoiesis
AU2016359695A1 (en) 2015-11-23 2018-06-14 Acceleron Pharma Inc. Methods for treating eye disorders
EP3439741A4 (fr) 2016-04-06 2020-05-06 Acceleron Pharma Inc. Antagonistes d'alk7 et leurs utilisations
PT3496739T (pt) 2016-07-15 2021-06-21 Acceleron Pharma Inc Composições compreendendo polipéptidos actriia para uso no tratamento de hipertensão pulmonar
KR102359192B1 (ko) 2016-07-25 2022-02-04 세파론, 인코포레이티드 친화성 크로마토그래피 세정 완충액
BR112019001615A2 (pt) * 2016-07-27 2019-04-30 Acceleron Pharma Inc. métodos e composições para tratar mielofibrose
BR112019006993A2 (pt) 2016-10-05 2019-09-03 Acceleron Pharma Inc heteromultímeros de alk4:actriib e usos dos mesmos
CA3039525A1 (fr) * 2016-10-05 2018-04-12 Acceleron Pharma Inc. Proteines actriib a variant et leurs utilisations
JP7139326B2 (ja) 2016-11-10 2022-09-20 ケロス セラピューティクス インコーポレイテッド アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物
JOP20180036A1 (ar) 2017-04-18 2019-01-30 Vifor Int Ag أملاح لمثبطات فروبورتين جديدة
US11484573B2 (en) 2017-11-09 2022-11-01 Keros Therapeutics, Inc. Activin receptor type IIa variants and methods of use thereof
JP7510875B2 (ja) 2018-01-12 2024-07-04 ケロス セラピューティクス インコーポレイテッド アクチビンｉｉｂ型受容体変異体および同変異体を含む医薬組成物
EA202092064A1 (ru) 2018-03-01 2020-12-21 Ридженерон Фармасьютикалз, Инк. Способы изменения состава тела
WO2019217715A1 (fr) * 2018-05-09 2019-11-14 Keros Therapeutics, Inc. Variants du récepteur de l'activine de type iia et leurs procédés d'utilisation
CN116134049A (zh) * 2020-02-03 2023-05-16 阿塞勒隆制药公司 变体actriib蛋白及其用途
AU2023210700A1 (en) 2022-01-28 2024-08-15 35Pharma Inc. Activin receptor type iib variants and uses thereof

Family Cites Families (210)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1265208A (en) 1915-09-07 1918-05-07 Edward C Kahn Liquid-fuel burner.
JPH0637520B2 (ja) * 1985-07-03 1994-05-18 味の素株式会社 ポリペプチド
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4973577A (en) * 1986-04-04 1990-11-27 The Salk Institute For Biological Studies FSH-releasing peptides
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
EP0548276A4 (en) * 1990-09-13 1993-12-29 Children's Hospital Medical Center Of Northern California Method for increasing red blood cell production by treatment with activin or activin-related peptides
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5885794A (en) * 1991-05-10 1999-03-23 The Salk Institute For Biological Studies Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily
JPH06500574A (ja) 1991-05-10 1994-01-20 ザ　ソーク　インスティテュート　フォア　バイオロジカル　スタディーズ アクチビン／ＴＧＦ―βスーパーファミリーのレセプターのクローニングおよび組換えによる産生
US20050186593A1 (en) 1991-05-10 2005-08-25 The Salk Institute For Biological Studies Cloning and recombinant production of CRF receptor(s)
US6162896A (en) * 1991-05-10 2000-12-19 The Salk Institute For Biological Studies Recombinant vertebrate activin receptors
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
KR100255415B1 (ko) 1991-06-25 2000-05-01 브루스 엠. 에이센 비엠피-9 조성물
US6692925B1 (en) * 1992-11-17 2004-02-17 Ludwig Institute For Cancer Research Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use
WO1994015965A1 (fr) 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Facteur-3 de croissance et de differenciation
US5354934A (en) 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
BR9406716A (pt) 1993-05-12 1996-02-06 Genetics Inst Molécula de DNA isolada célula hospedeira vetor método para produzir uma proteina (BMP-10) polipeptideo de proteina-10 morfogenética de osso purificada (BMP-10) e molécula de DNA quimérica
US5637480A (en) 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5831050A (en) * 1993-06-07 1998-11-03 Creative Biomolecules, Inc. Morphogen cell surface receptor
AU701623B2 (en) 1993-10-14 1999-02-04 President And Fellows Of Harvard College Method of inducing and maintaining neuronal cells
US5525490A (en) 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5658876A (en) * 1994-04-28 1997-08-19 The General Hospital Corporation Activin antagonists as novel contraceptives
US5760010A (en) 1995-01-01 1998-06-02 Klein; Ira Method of treating liver disorders with a macrolide antibiotic
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
NZ306767A (en) 1995-04-11 2000-03-27 Univ Johns Hopkins Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems
US6132988A (en) * 1995-10-27 2000-10-17 Takeda Chemical Industries, Ltd. DNA encoding a neuronal cell-specific receptor protein
GB9526131D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
US20050244867A1 (en) 1996-03-26 2005-11-03 Human Genome Sciences, Inc. Growth factor HTTER36
US6004780A (en) 1996-03-26 1999-12-21 Human Genome Sciences, Inc. Growth factor HTTER36
US6372480B1 (en) * 1996-04-19 2002-04-16 Mycogen Corporation Pesticidal proteins
KR20000052807A (ko) 1996-10-25 2000-08-25 윌리암스 로저 에이 순환 교환된 에리트로포이에틴 수용체 아고니스트
US6017534A (en) * 1996-11-20 2000-01-25 Ecogen, Inc. Hybrid Bacillus thuringiensis δ-endotoxins with novel broad-spectrum insecticidal activity
US6605699B1 (en) * 1997-01-21 2003-08-12 Human Genome Sciences, Inc. Galectin-11 polypeptides
US6034062A (en) 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6231880B1 (en) * 1997-05-30 2001-05-15 Susan P. Perrine Compositions and administration of compositions for the treatment of blood disorders
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
WO1999006559A1 (fr) 1997-08-01 1999-02-11 The Johns Hopkins University School Of Medicine Procedes d'identification des recepteurs des facteurs de differenciation de la croissance
US6696260B1 (en) * 1997-08-01 2004-02-24 The Johns Hopkins University School Of Medicine Methods to identify growth differentiation factor (GDF) binding proteins
US6656475B1 (en) * 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
WO1999010364A1 (fr) 1997-08-29 1999-03-04 Human Genome Sciences, Inc. Follistatine-3
US6953662B2 (en) * 1997-08-29 2005-10-11 Human Genome Sciences, Inc. Follistatin-3
ES2293691T3 (es) 1997-10-03 2008-03-16 Chugai Seiyaku Kabushiki Kaisha Anticuerpo humano natural.
US6696411B1 (en) 1998-04-22 2004-02-24 Cornell Research Foundation, Inc. Canine erythropoietin gene and recombinant protein
CA2343268A1 (fr) 1998-09-17 2000-03-23 Eli Lilly And Company Preparation a base de proteines
JP2002526073A (ja) 1998-09-22 2002-08-20 龍 余 新規のヒト生長分化因子のコード配列、そのｄｎａ配列によりコードされるポリペプチド、およびこれらの製造方法。
US6472179B2 (en) 1998-09-25 2002-10-29 Regeneron Pharmaceuticals, Inc. Receptor based antagonists and methods of making and using
US6548634B1 (en) 1998-09-30 2003-04-15 Chiron Corporation Synthetic peptides having FGF receptor affinity
IL142717A0 (en) 1998-10-30 2002-03-10 Genetics Inst Inhibition of differentiation of cytotoxic t-cells by p-selectin ligand (psgl) antagonists
US6238860B1 (en) 1998-11-05 2001-05-29 Dyax Corp. Binding moieties for human parvovirus B19
US6777205B1 (en) 1998-11-06 2004-08-17 Sterrenbeld Biotechnologie North America, Inc. Host cells expressing recombinant human erythropoietin
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
JP2003517580A (ja) 1999-01-21 2003-05-27 メタモーフイクス・インコーポレーテツド 増殖分化因子インヒビター及びそれらの用途
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
EP1174149A1 (fr) 1999-04-19 2002-01-23 Kyowa Hakko Kogyo Co., Ltd. Inhibiteur de proliferation cellulaire pour tumeurs androgeno-independantes
US6468543B1 (en) * 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
JP2003513681A (ja) 1999-11-12 2003-04-15 マキシゲン・ホールディングス・リミテッド インターフェロンガンマ・コンジュゲート
WO2001043763A1 (fr) 1999-12-15 2001-06-21 Research Development Foundation Betaglycane utilise comme recepteur de l'inhibine et ses utilisations
US20030224501A1 (en) 2000-03-17 2003-12-04 Young Paul E. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
JP4487376B2 (ja) * 2000-03-31 2010-06-23 味の素株式会社 腎疾患治療剤
BRPI0110914B8 (pt) 2000-05-15 2021-05-25 Hoffmann La Roche 'composição farmacêutica líquida, processo para preparação da mesma e uso de uma composicão farmacêutica'
US6627424B1 (en) 2000-05-26 2003-09-30 Mj Bioworks, Inc. Nucleic acid modifying enzymes
WO2002008277A2 (fr) 2000-07-19 2002-01-31 Eli Lilly And Company Acides nucleiques, vecteurs, cellules hotes, polypeptides et leurs utilisations
US6632180B1 (en) 2000-09-07 2003-10-14 John H. Laragh Method for evaluating and treating hypertension
DE10045591A1 (de) 2000-09-15 2002-04-04 Klaus Pfizenmaier Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine)
US7087224B2 (en) 2000-10-31 2006-08-08 Amgen Inc. Method of treating anemia by administering IL-1ra
CN1474831A (zh) 2000-11-20 2004-02-11 ����ŵ˹������ѧ�йܻ� 膜支架蛋白
AU2002236558A1 (en) 2000-12-01 2002-06-11 Regents Of The University Of California Method and composition for modulating bone growth
US20030082233A1 (en) 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
TWI329129B (en) * 2001-02-08 2010-08-21 Wyeth Corp Modified and stabilized gdf propeptides and uses thereof
US20040132675A1 (en) 2002-02-08 2004-07-08 Calvin Kuo Method for treating cancer and increasing hematocrit levels
US7294472B2 (en) 2001-03-14 2007-11-13 Caden Biosciences Method for identifying modulators of G protein coupled receptor signaling
WO2002074340A1 (fr) 2001-03-16 2002-09-26 Takeda Chemical Industries, Ltd. Procede de fabrication d'une preparation a liberation continue
ATE542545T1 (de) 2001-05-24 2012-02-15 Zymogenetics Inc Taci-immunoglobulin-fusionsproteine
AU2001286171B2 (en) 2001-05-25 2008-01-10 Serono Genetics Institute S.A. Human CDNAs and proteins and uses thereof
AUPR638101A0 (en) * 2001-07-13 2001-08-09 Bioa Pty Limited Composition and method for treatment of disease
ATE448481T1 (de) 2001-07-17 2009-11-15 Teijin Ltd Selektionsverfahren für eine durch das austesten einer ppard aktivierenden wirkung charakterisierten substanz und arzneistoff
US6855344B2 (en) * 2001-07-17 2005-02-15 Integrated Chinese Medicine Holdings, Ltd. Compositions and methods for prostate and kidney health and disorders, an herbal preparation
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
US7320789B2 (en) * 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
US6784154B2 (en) * 2001-11-01 2004-08-31 University Of Utah Research Foundation Method of use of erythropoietin to treat ischemic acute renal failure
CN1602360A (zh) 2001-12-06 2005-03-30 法布罗根股份有限公司 提高内源性红细胞生成素(epo)的方法
US20030144203A1 (en) 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
US20060234918A1 (en) 2001-12-19 2006-10-19 Voyager Pharmaceutical Corporation Methods for treating and preventing cancers that express the hypothalamic-pituitary-gonadal axis of hormones and receptors
US6998118B2 (en) 2001-12-21 2006-02-14 The Salk Institute For Biological Studies Targeted retrograde gene delivery for neuronal protection
US20030224397A1 (en) 2002-02-11 2003-12-04 Genentech, Inc. Antibody variants with faster antigen association rates
MXPA04008150A (es) * 2002-02-21 2005-06-17 Wyeth Corp Gasp1: una proteina que contiene dominio de folistatina.
US20030219846A1 (en) 2002-02-28 2003-11-27 Pfizer Inc. Assay for activity of the ActRIIB kinase
AU2003232485A1 (en) 2002-04-18 2003-10-27 Mtm Laboratories Ag Neopeptides and methods useful for detection and treatment of cancer
DE10234192B4 (de) 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
KR20050083635A (ko) 2002-08-16 2005-08-26 와이어쓰 Ｂｍｐ-2 에스트로겐 반응 요소 및 이의 사용 방법
US7842691B2 (en) 2002-10-15 2010-11-30 Celgene Corporation Method for the treatment of myelodysplastic syndromes using cyclopropanecarboxylic acid {2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-3-OXO-2,3-dihydro-1 H-isoindol-4-yl}-amide
AR047392A1 (es) * 2002-10-22 2006-01-18 Wyeth Corp Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
AU2002953327A0 (en) 2002-12-12 2003-01-09 Monash University Methods of diagnosing prognosing and treating activin associated diseases and conditions
DK1592416T3 (da) 2003-02-07 2009-04-20 Prometic Biosciences Inc Fedtsyrer med middel kædelængde, glycerider og analoger som stimulatorer af erythropoiesis
WO2004073633A2 (fr) 2003-02-14 2004-09-02 The Board Of Trustees Of The Leland Stanford Junior University Methodes et compositions permettant de moduler le developpement de cellules souches
GB0304424D0 (en) 2003-02-26 2003-04-02 Glaxosmithkline Biolog Sa Novel compounds
US20040197828A1 (en) * 2003-03-26 2004-10-07 Gaddy Dana P. Method for diagnosis and treatment of bone turnover
US20070184052A1 (en) * 2003-05-09 2007-08-09 Lin Herbert Y Soluble tgf-b type III receptor fusion proteins
MXPA05012965A (es) 2003-06-02 2006-03-09 Wyeth Corp Uso de inhibidores de miostatina (gdf8) en conjuncion con corticoesteroides para el tratamiento de desordenes neuromusculares y composiciones farmaceuticas para ello.
RS20050934A (en) 2003-06-16 2008-04-04 Celltech R. & D. Inc., Antibodies specific for sclerostin and methods fo r increasing bone mineralization
WO2005009460A2 (fr) 2003-07-25 2005-02-03 Medexis, S.A. Composition pharmaceutique comportant l'activine a, l'alk-4 ou leurs derives pour le traitement des troubles ophtalmiques ou du cancer
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
AU2005206277B2 (en) 2004-01-22 2011-06-23 Merck Patent Gmbh Anti-cancer antibodies with reduced complement fixation
US20050197292A1 (en) 2004-01-30 2005-09-08 Glennda Smithson Compositions and methods for treating T-cell mediated pathological conditions
US7625867B2 (en) 2004-03-26 2009-12-01 Acceleron Pharma Inc. BMP-3 propeptides and related methods
US7459527B2 (en) 2004-03-31 2008-12-02 Xencor, Inc. BMP-7 variants with improved properties
WO2005113590A2 (fr) 2004-05-12 2005-12-01 Acceleron Pharma Inc. Propeptides de bmp10 et procédés correspondants
AU2005258286A1 (en) 2004-06-24 2006-01-05 Acceleron Pharma Inc. GDF3 propeptides and related methods
EP1789391B1 (fr) 2004-07-23 2017-06-28 Endocyte, Inc. Groupes de liaison bivalents et conjugués de ceux-ci
DK2332977T3 (en) 2004-07-23 2016-02-29 Acceleron Pharma Inc ActRII receptor polypeptides
EP1794191B1 (fr) 2004-08-05 2016-05-18 The Regents of The University of California Molecules ayant un effet sur le developpement et la fonction cellulaire
EP1778275A2 (fr) 2004-08-12 2007-05-02 Wyeth Traitement combine du diabete, de l'obesite et de maladies cardiovasculaires, faisant appel a des inhibiteurs de gdf-8
US7095608B2 (en) 2004-08-12 2006-08-22 Audiovox Corporation Video display mounting system and method
CA2581896C (fr) 2004-09-29 2015-11-10 Mount Sinai School Of Medicine Of New York University Compositions et methodes modulant la fsh et le recepteur de la fsh, inhibant la resorption osseuse osteoclastique et les pertes osseuses de l'osteoporose
BRPI0518728A2 (pt) 2004-12-09 2008-12-02 Univ Pittsburgh vacinas para a resposta rÁpida À pandemia de gripe aviÁria
NZ538097A (en) 2005-02-07 2006-07-28 Ovita Ltd Method and compositions for improving wound healing
ES2547866T3 (es) 2005-02-16 2015-10-09 The General Hospital Corporation Uso de proteínas de fusión de hemojuvelina para regular el metabolismo del hierro mediado por hepcidina
CN101198321A (zh) 2005-04-26 2008-06-11 味之素株式会社 骨髓祖红细胞分化诱导剂
JP2007099764A (ja) 2005-09-09 2007-04-19 Ajinomoto Co Inc 血糖低下剤
CA2621623A1 (fr) 2005-09-28 2007-04-05 Zymogenetics, Inc. Antagonistes anti il-17a et anti il-17f et leurs methodes d'utilisation
EP1934246B8 (fr) 2005-10-07 2012-02-08 Istituto di Ricerche di Biologia Molecolare P. Angeletti S.R.L. Vaccin de metalloproteinase 11 matricielle
US8067562B2 (en) 2005-11-01 2011-11-29 Amgen Inc. Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
CA2631013C (fr) * 2005-11-23 2019-06-11 Acceleron Pharma Inc. Antagonistes de l'activine-actriia et utilisations pour activer la croissance osseuse
AU2006321906C1 (en) 2005-12-06 2014-01-16 Amgen Inc. Uses of myostatin antagonists
CA2632936A1 (fr) 2005-12-20 2007-06-28 Merck Frosst Canada Ltd. Composes heteroaromatiques en tant qu'inhibiteurs de stearoyl-coenzyme a delta-9 desaturase
JP2009521452A (ja) 2005-12-21 2009-06-04 シェーリング コーポレイション コレステロール降下剤およびｈ３受容体アンタゴニスト／逆アゴニストを使用する非アルコール性脂肪性肝疾患の処置
EP1973909A2 (fr) 2005-12-22 2008-10-01 Biogen Idec MA Inc. Modulateurs du facteur de croissance transformant
JP4925364B2 (ja) * 2006-01-20 2012-04-25 ベックマン コールター， インコーポレイテッド 鉄欠乏を検出する方法
WO2007087505A2 (fr) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Composés destinés au traitement des troubles du métabolisme
MX2008011022A (es) 2006-02-28 2008-09-10 Wellstat Therapeutics Corp Compuestos para el tratamiento de trastornos metabolicos.
CA2650131A1 (fr) 2006-04-14 2007-10-25 Amgen Inc. Anticorps diriges contre un agoniste du recepteur de l'erythropoietine
WO2007123391A1 (fr) 2006-04-20 2007-11-01 Academisch Ziekenhuis Leiden Intervention thérapeutique dans une maladie génétique chez un individu en modifiant l'expression d'un gène exprimé de manière aberrante.
CA2652235A1 (fr) * 2006-05-09 2007-11-22 Hemaquest Pharmaceuticals, Inc. Procedes de traitement de troubles sanguins
CN101522021B (zh) * 2006-07-21 2014-07-30 莱因实验室 醋酸钙的液体组合物
GB0615129D0 (en) 2006-07-29 2006-09-06 Univ Cardiff Anti-cancer activity of BMP-9 and BMP-10 and their use in cancer therapies
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
US7547781B2 (en) * 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
WO2008060139A1 (fr) 2006-11-17 2008-05-22 Erasmus University Medical Center Rotterdam Procédés destinés à contrôler la minéralisation d'une matrice extracellulaire, procédés thérapeutiques se fondant sur ces procédés et médicaments destinés à être utilisés dans le cadre de ces procédés
US20100003190A1 (en) 2006-12-08 2010-01-07 Caritas St. Elizabeth's Medical Center Of Boston, Inc. Method for protecting renal tubular epithelial cells from radiocontrast nephropathy (RCN)
EP2103628A4 (fr) 2006-12-14 2012-02-22 Forerunner Pharma Res Co Ltd Anticorps monoclonal anti-claudine 3, et traitement et diagnostic du cancer au moyen d'un tel anticorps
WO2008076437A2 (fr) 2006-12-18 2008-06-26 Acceleron Pharma Inc. Antagonistes de l'activine-actrii et ses utilisations pour accroître les niveaux de globules rouges
US20100028332A1 (en) 2006-12-18 2010-02-04 Acceleron Pharma Inc. Antagonists of actriib and uses for increasing red blood cell levels
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
ES2415666T3 (es) 2007-02-01 2013-07-26 Acceleron Pharma, Inc. Composiciones farmacéuticas que comprenden antagonistas de Activina-ActRIIa para uso en la prevención o el tratamiento de metástasis de cáncer de mama o pérdida ósea relacionada con el cáncer de mama
TW201627320A (zh) * 2007-02-02 2016-08-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
CN101687016B (zh) 2007-02-09 2014-12-31 阿塞勒隆制药公司 活化素-actriia拮抗剂和促进癌症患者骨骼生长的用途
TWI573802B (zh) 2007-03-06 2017-03-11 安美基公司 變異之活動素受體多肽及其用途
WO2013106175A1 (fr) 2011-12-19 2013-07-18 Amgen Inc. Variants polypeptidiques du récepteur de l'activine, seuls ou en combinaison avec une chimiothérapie, et leurs utilisations
US8501678B2 (en) 2007-03-06 2013-08-06 Atara Biotherapeutics, Inc. Variant activin receptor polypeptides and uses thereof
US20090017019A1 (en) * 2007-06-01 2009-01-15 Wyeth Methods and compositions for modulating bmp-10 activity
WO2009009059A1 (fr) 2007-07-09 2009-01-15 Biogen Idec Ma Inc. Composés spiro en tant qu'antagonistes du tgf-bêta
CN101678107A (zh) 2007-08-03 2010-03-24 萨米特公开有限公司 用于治疗杜兴型肌营养不良的药物组合物
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
GB0715938D0 (en) 2007-08-15 2007-09-26 Vastox Plc Method of treatment of duchenne muscular dystrophy
WO2009025651A1 (fr) 2007-08-17 2009-02-26 University Of Maine System Board Of Trustees Peptide biologiquement actif et procédé d'utilisation correspondant
US20100279409A1 (en) 2007-09-13 2010-11-04 Neil Robson Method for modifying celluar immune resonse by modulating activin activity
US7960343B2 (en) 2007-09-18 2011-06-14 Acceleron Pharma Inc. Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
PE20091163A1 (es) 2007-11-01 2009-08-09 Wyeth Corp Anticuerpos para gdf8
CN101925611A (zh) 2007-11-21 2010-12-22 安姆根有限公司 Wise结合剂和表位
US8507501B2 (en) 2008-03-13 2013-08-13 The Brigham And Women's Hospital, Inc. Inhibitors of the BMP signaling pathway
EP2283119B1 (fr) 2008-05-06 2015-01-07 Joslin Diabetes Center, Inc. Procédés et compositions pour induire une adipogenèse brune
WO2009137075A1 (fr) 2008-05-06 2009-11-12 Acceleron Pharma Inc. Anticorps anti-activine et leurs utilisations pour promouvoir la croissance osseuse
EP2303917B1 (fr) * 2008-06-26 2020-11-11 Acceleron Pharma Inc. ANTAGONISTES D'ACTRIIB ET UTILISATIONS POUR AUGMENTER LES TAUX 
D'ÉRYTHROCYTES
NZ590327A (en) 2008-06-26 2013-12-20 Acceleron Pharma Inc Methods for dosing an activin-actriia antagonist and monitoring of treated patients
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
DK3750552T5 (da) 2008-08-14 2024-08-26 Acceleron Pharma Inc Gdf-fælder
US20110293526A1 (en) 2008-11-20 2011-12-01 University Of Southern California Compositions and methods to modulate hair growth
SG171813A1 (en) 2008-11-26 2011-07-28 Amgen Inc Variants of activin iib receptor polypeptides and uses thereof
US8138142B2 (en) 2009-01-13 2012-03-20 Acceleron Pharma Inc. Methods for increasing adiponectin in a patient in need thereof
US8110355B2 (en) 2009-02-20 2012-02-07 GenRemedy, LLC Methods for identifying agents that inhibit cell migration, promote cell adhesion and prevent metastasis
MY153078A (en) 2009-04-27 2014-12-31 Novartis Ag Compositions and methods for increasing muscle growth
WO2010144452A1 (fr) 2009-06-08 2010-12-16 Acceleron Pharma Inc. Procédé visant à augmenter le nombre d'adipocytes thermogènes
KR20180026795A (ko) 2009-06-12 2018-03-13 악셀레론 파마 인코포레이티드 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
EP3117829B1 (fr) 2009-08-13 2020-10-07 Acceleron Pharma Inc. Utilisation combinée de pièges gdf et activateurs du récepteur de l'érythropoïétine pour augmenter les taux d'érythrocytes
CA2773494A1 (fr) 2009-09-09 2011-03-17 Acceleron Pharma Inc. Antagonistes d'actriib, et dosage et administration associes
CA2779472C (fr) 2009-11-03 2021-03-16 Acceleron Pharma Inc. L'utilisation d'une composition renfermant un polypeptide recepteur d'activine de type iib pour le traitement de steatose hepatique
AU2010322011B2 (en) 2009-11-17 2016-03-31 Acceleron Pharma Inc. ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
WO2012027065A2 (fr) 2010-08-27 2012-03-01 Celgene Corporation Polythérapie pour traiter des maladies
US9595813B2 (en) 2011-01-24 2017-03-14 Soraa Laser Diode, Inc. Laser package having multiple emitters configured on a substrate member
US8580922B2 (en) 2011-03-04 2013-11-12 Shire Human Genetic Therapies, Inc. Peptide linkers for polypeptide compositions and methods for using same
PL2726099T3 (pl) 2011-07-01 2018-12-31 Novartis Ag Sposób leczenia zaburzeń metabolicznych
KR20220075438A (ko) 2011-10-17 2022-06-08 악셀레론 파마 인코포레이티드 비효율적 적혈구생성 치료를 위한 방법 및 조성물
WO2013063536A1 (fr) 2011-10-27 2013-05-02 Acceleron Pharma, Inc. AGENTS DE LIAISON À ActRIIB ET UTILISATIONS DE CEUX-CI
US8765385B2 (en) 2011-10-27 2014-07-01 Ravindra Kumar Method of detection of neutralizing anti-actriib antibodies
CN104023731A (zh) 2011-10-28 2014-09-03 帕仁塔生物科技有限公司 治疗粘液分泌亢进的方法
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
EP3521310A1 (fr) 2012-06-14 2019-08-07 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Utilisation d'agents de blocage de signalisation de protéine morphogénique osseuse (bmp) pour le traitement de maladies neuro-inflammatoires et neurodégénératives
CN104411720B (zh) 2012-07-02 2018-05-11 协和发酵麒麟株式会社 以抗bmp9抗体作为有效成分的、对肾性贫血、癌性贫血等贫血的治疗剂
CN112933223A (zh) 2012-10-24 2021-06-11 细胞基因公司 用于治疗贫血的方法
WO2014066486A2 (fr) 2012-10-24 2014-05-01 Celgene Corporation Biomarqueur utilisable dans le traitement de l'anémie
WO2014064292A1 (fr) 2012-10-26 2014-05-01 Universite Pierre Et Marie Curie (Paris 6) Méthode pour la prévention ou le traitement de la fibrillation auriculaire
RU2678117C2 (ru) 2012-11-02 2019-01-23 Селджин Корпорейшн Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
SG11201503637SA (en) 2012-11-08 2015-06-29 Clearside Biomedical Inc Methods and devices for the treatment of ocular diseases in human subjects
US20150328249A1 (en) 2012-12-11 2015-11-19 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Modulation of myofiber repair by anti-myostatin strategies and/or ppar gamma ligands, alone or in combination with stem cells, for the therapy of critical limb ischemia and other ischemic processes affecting the skeletal muscle
US20140220033A1 (en) 2013-02-01 2014-08-07 Santa Maria Biotherapeutics, Inc. Administration of an Anti-Activin-A Compound to a Subject
WO2014152940A1 (fr) 2013-03-14 2014-09-25 Shire Human Genetic Therapies, Inc. Compositions thérapeutiques à base d'arnm et leur utilisation pour traiter des maladies et des troubles
TW201920262A (zh) 2013-07-30 2019-06-01 美商再生元醫藥公司 抗活化素ａ之抗體及其用途
EP3033358A2 (fr) 2013-08-14 2016-06-22 Novartis AG Traitement de la myosite corps d'inclusion sporadique
JP2017505428A (ja) 2013-12-16 2017-02-16 パランタ バイオサイエンス リミテッド 診断及び治療の方法
EP3094751A4 (fr) 2014-01-14 2017-06-07 Santa Maria Biotherapeutics, Inc. Prédiction de réponse à l'inhibiteur de l'activine et utilisations à des fins de traitement
WO2015111008A2 (fr) 2014-01-27 2015-07-30 Novartis Ag Biomarqueurs prédictifs de l'atrophie musculaire, procédé et utilisation associés
WO2015152183A1 (fr) 2014-03-31 2015-10-08 大日本住友製薬株式会社 Agent prophylactique et agent thérapeutique pour la fibrodysplasie ossifiante progressive
AU2015247459A1 (en) 2014-04-18 2016-10-27 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating sickle-cell disease
TW201622746A (zh) 2014-04-24 2016-07-01 諾華公司 改善或加速髖部骨折術後身體復原之方法
AP2016009647A0 (en) 2014-06-13 2016-12-31 Santa Maria Biotherapeutics Inc Formulated receptor polypeptides and related methods
MX2016016531A (es) 2014-06-13 2017-04-25 Acceleron Pharma Inc Metodos y composiciones para el tratamiento de las ulceras.
WO2016183280A1 (fr) 2015-05-13 2016-11-17 Celgene Corporation Traitement de la beta-thalassemia à l'aide de pièges à ligand actrii

Also Published As

Publication number Publication date
US20200199548A1 (en) 2020-06-25
PL2340031T3 (pl) 2019-10-31
NL301082I2 (nl) 2021-02-03
US8361957B2 (en) 2013-01-29
JP2022009561A (ja) 2022-01-14
EP3494986A1 (fr) 2019-06-12
WO2010019261A1 (fr) 2010-02-18
ES2808139T3 (es) 2021-02-25
US10377996B2 (en) 2019-08-13
NL301082I1 (fr) 2020-12-23
CA2733911C (fr) 2019-09-03
JP5922928B2 (ja) 2016-05-24
JP2011530599A (ja) 2011-12-22
PT2340031T (pt) 2019-07-25
US11155791B2 (en) 2021-10-26
JP7329573B2 (ja) 2023-08-18
DK3494986T3 (da) 2020-08-03
TWI784538B (zh) 2022-11-21
PL3494986T3 (pl) 2020-11-16
TW201618807A (zh) 2016-06-01
US20200199547A1 (en) 2020-06-25
HUS2000054I1 (hu) 2021-01-28
HUE045456T2 (hu) 2019-12-30
SI3750552T1 (sl) 2023-10-30
US8058229B2 (en) 2011-11-15
HRP20230761T1 (hr) 2023-10-13
US20100068215A1 (en) 2010-03-18
US20200165583A1 (en) 2020-05-28
LT2340031T (lt) 2019-08-12
US20200208124A1 (en) 2020-07-02
EP3750552B1 (fr) 2023-05-10
SI2340031T1 (sl) 2019-09-30
US20200199546A1 (en) 2020-06-25
PT3750552T (pt) 2023-06-28
DK2340031T3 (da) 2019-07-15
AU2009282441A1 (en) 2010-02-18
TW202135851A (zh) 2021-10-01
NO2020045I1 (no) 2020-12-17
SI3494986T1 (sl) 2020-10-30
US20170204382A1 (en) 2017-07-20
PL2340031T4 (pl) 2020-12-28
JP2014224154A (ja) 2014-12-04
CY2020043I2 (el) 2021-03-12
CY2020043I1 (el) 2021-03-12
EP2340031B1 (fr) 2019-04-24
JP6968917B2 (ja) 2021-11-17
TW201803586A (zh) 2018-02-01
TW201513879A (zh) 2015-04-16
TR201910890T4 (tr) 2019-08-21
JP6649432B2 (ja) 2020-02-19
US20220098559A1 (en) 2022-03-31
CY1121971T1 (el) 2020-10-14
TWI617316B (zh) 2018-03-11
TWI626945B (zh) 2018-06-21
TWI472336B (zh) 2015-02-11
CY1123217T1 (el) 2020-11-25
TWI748373B (zh) 2021-12-01
US9505813B2 (en) 2016-11-29
TW202023602A (zh) 2020-07-01
FR20C1066I1 (fr) 2021-03-05
AU2009282441B2 (en) 2015-01-22
DK3750552T3 (da) 2023-07-24
US11162085B2 (en) 2021-11-02
HUE063136T2 (hu) 2023-12-28
ES2949049T3 (es) 2023-09-25
EP3494986B1 (fr) 2020-06-03
PT3494986T (pt) 2020-07-14
LTC2340031I2 (lt) 2022-06-27
EP2340031A4 (fr) 2013-01-09
JP2020055883A (ja) 2020-04-09
JP2018130126A (ja) 2018-08-23
TW201919685A (zh) 2019-06-01
JP2017019860A (ja) 2017-01-26
ES2738543T3 (es) 2020-01-23
US20120015877A1 (en) 2012-01-19
LTPA2020006I1 (lt) 2021-01-11
CA2733911A1 (fr) 2010-02-18
US11168311B2 (en) 2021-11-09
LT3750552T (lt) 2023-06-26
EP3750552A1 (fr) 2020-12-16
HRP20191109T1 (hr) 2019-09-20
TW201006487A (en) 2010-02-16
FI3750552T3 (fi) 2023-07-25
EP2340031A1 (fr) 2011-07-06
HUE051137T2 (hu) 2021-03-01
PL3750552T3 (pl) 2023-11-06
LT3494986T (lt) 2020-07-10
US20130244324A1 (en) 2013-09-19
DK3750552T5 (da) 2024-08-26
HRP20201185T1 (hr) 2020-12-11

Similar Documents

Publication Publication Date Title
FR20C1066I2 (fr) Pièges à gdf pour l'utilisation dans le traitment de l'anémie
DK1905443T3 (da) Væske omfattende trehalose til anvendelse ved forhindring af vævsadhæsion
FR2907011B1 (fr) Utilisation de la citrulline pour le traitement des etats de denutrition
FR2935611B1 (fr) Utilisation d'agents anti-connexines pour moduler l'effet therapeutique de molecules psychotropes
FR2907461B1 (fr) Composition de graisse pour utilisation dans des joints homocinetiques
BRPI0916125A2 (pt) "dispositivo de tratamento"
DK3385384T3 (da) Aptamer-lægemidler nyttige ved behandlingen af komplement-relaterede lidelser
BRPI0815527A2 (pt) "filtro"
FR2902324B1 (fr) Utilisation d'acide ellagique pour le traitement de la canitie
BRPI0816038A2 (pt) "composição de tratamento dos cabelos"
ATE519836T1 (de) Flüssige weissgraderhaltungszusammensetzung
BRPI0914010A2 (pt) "suporte hidráulico selado por liquído"
DK1709082T3 (da) Sammensætning til behandling af patologi knyttet til MSRV/HERV-W
FR2917622B1 (fr) Utilisation d'un antagoniste par1 dans le traitement de la fibrillation atriale.
FR2897533B1 (fr) Agent oxydant pour le traitement des cheveux
DK2323644T3 (da) N-substituerede benzenpropanamid- eller benzenpropenamidderivater til anvendelse ved behandlingen af smerte
FR2919305B1 (fr) Vecteurs viraux adeno-associes pour l'expression de la dysferline.
FR2903999B1 (fr) Modulateurs de sc4mol dans le traitement de l'acne ou de l'hyperseborrhee
BRPI0916080A2 (pt) "composição de limpeza pessoal líquida ou sólido-macia"
FR2941864B1 (fr) Substance active pour la protection de fgf-2
FR2938436B1 (fr) Composition cosmetique pour le nettoyage de la peau
FR2923694B1 (fr) Accessoire pour l'utilisation de sachets de preparation de boissons
FR2900954B1 (fr) Anti vol pour casque integral pour cycles moto cycles et assimiles
FR2903998B1 (fr) Modulateurs de elovl5 dans le traitement de l'acne ou de l'hyperseborrhee
FR2937550B1 (fr) Utilisation de la citrulline pour le traitement et la prevention du syndrome d'ischemie-reperfusion