JP5665946B2 - セサミン類とビタミンb1類とを配合した組成物 - Google Patents
セサミン類とビタミンb1類とを配合した組成物 Download PDFInfo
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- JP5665946B2 JP5665946B2 JP2013225880A JP2013225880A JP5665946B2 JP 5665946 B2 JP5665946 B2 JP 5665946B2 JP 2013225880 A JP2013225880 A JP 2013225880A JP 2013225880 A JP2013225880 A JP 2013225880A JP 5665946 B2 JP5665946 B2 JP 5665946B2
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- Prior art keywords
- sesamin
- vitamin
- fatigue
- thiamine
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Description
1.少なくとも1種のセサミン類と少なくとも1種のビタミンB1類とを配合した組成物であって、前記セサミン類の総配合量が、組成物全重量に対して1重量%以上である、組成物。
2.セサミン類が、セサミン、エピセサミン、又はこれらの混合物である、上記1に記載の組成物。
3.ビタミンB1類が、チアミン、チアミンジスルフィド、ベンフォチアミン、フルスルチアミン、ビスベンチアミン、ジセチアミン、チアミンエチルジスルフィド、チアミンプロピルジスルフィドおよびそれらの塩から選択された1種または2種以上である、上記1又は2に記載の組成物。
4.ビタミンB1類の総配合量が、組成物全重量に対して、0.001〜20重量%である、請求項1〜3のいずれかに記載の組成物。
5.経口用である、上記1〜4のいずれかに記載の組成物。
6.飲食品である、上記1〜5のいずれかに記載の組成物。
7.少なくとも1種のセサミン類と少なくとも1種のビタミンB1類を含有する飲料であって、飲料100mL中のセサミン類の総含量が1〜100mgであり、ビタミンB1類の総含量が1〜100mgである、飲料。
8.少なくとも1種のセサミン類と少なくとも1種のビタミンB1類とを有効成分として含有する抗疲労剤。
9.慢性疲労症候群を治療または予防するための、上記8記載の抗疲労剤。
10.抗疲労剤を製造するための、少なくとも1種のセサミン類および少なくとも1種のビタミンB1類を含む組成物の使用。
11.疲労状態の予防または治療方法であって、少なくとも1種のセサミン類および少なくとも1種のビタミンB1類を含む組成物を、それを必要とする対象に投与することを含む、方法。
本発明のセサミン類とは、セサミンおよびその類縁体を含む一連の化合物の総称である。前記のセサミン類縁体としては、エピセサミンの他、例えば特開平4−9331号公報に記載されたジオキサビシクロ〔3.3.0〕オクタン誘導体がある。セサミン類の具体例としては、セサミン、セサミノール、エピセサミノール、セサモリン等を例示でき、これらの立体異性体又はラセミ体を単独で、あるいは混合して使用することができる。本発明においては、セサミン、エピセサミン又はこれらの混合物が好ましく用いられる。また、セサミン類の代謝体(例えば、特開2001−139579号公報に記載)も、本発明の効果を示す限り、本発明のセサミン類に含まれるセサミン類縁体として、本発明に使用することができる。
ビタミンB1類は、チアミンとも称される水溶性のビタミンであり、生体内ではチアミン二リン酸(TPP)に変換されピルビン酸デヒドロゲナーゼの補酵素として糖代謝に関わることや、TCA回路のα−ケトグルタール酸デヒドロゲナーゼの補酵素として働くことが知られている。
本発明の組成物は、セサミン類とビタミンB1類との配合により、セサミン類の生理活性作用である抗疲労作用の相乗的な増強が得られる。また、本発明の組成物は高い抗疲労作用を有する飲食品として利用することができる。
少なくとも1種のセサミン類と少なくとも1種のビタミンB1類とを飲料中に含有させることにより、セサミン類の生理活性作用である抗疲労作用を相乗的に増強させた飲料を提供することができる。本発明の飲料中のセサミン類の総含量は、飲料100mL当たり1〜100mg、好ましくは1〜60mg、より好ましくは1〜20mgである。飲料中のビタミンB1類の総含量は、セサミン類の抗疲労作用の相乗的増強効果が発揮される範囲であれば特に制限されないが、飲料100mL当たり1〜100mg程度、好ましくは1〜60mg程度、より好ましくは1〜20mg程度がよい。
本発明の組成物は、ヒトおよび非ヒト動物の抗疲労剤としても有用である。ここで、非ヒト動物とは、産業動物、ペットおよび実験動物を表し、より詳細には、産業動物とは、ウシ、ウマ、ブタ、ヤギ、ヒツジ等の家畜や競争馬、猟犬等を表し、ペットとはイヌ、ネコ、マーモセット、ハムスター等を表し、実験動物とはマウス、ラット、モルモット、ビーグル犬、ミニブタ、アカゲザル、カニクイザル等の医学、生物学、農学、薬学等の分野で研究に供用される動物を表す。本発明の抗疲労剤は、疲労を知覚するヒト、産業動物、ペットおよび実験動物に用いられ、特にヒトに対して好適に用いられる。
被験物質となるセサミン類としてはセサミン/エピセサミン混合物(セサミン:エピセサミン(重量比)=5:5)を用い、ビタミンB1類としては塩酸チアミン(ナカライテスク社)を用いた。
表2のようにマウスを群分けし、鼻先が水面から最終的に水没するまで(再浮上しなくなるまで)の水没時までの時間を限界水泳時間としたこと以外は、実施例1と同様にして、ビタミンB1類とセサミン類による抗疲労作用を評価した。表2におけるビタミンB1類の量は、用いた塩酸チアミンをチアミンに換算した量で示している。
表3、表4のようにマウスを群分けしたこと以外は、実施例1と同様にして、ビタミンB1類の単独投与による抗疲労作用を評価した。表3、表4におけるビタミンB1類の量は、用いた塩酸チアミンをチアミンに換算した際の量として示している。
セサミン 10g
塩酸チアミン 10g
酢酸トコフェロール 50g
無水ケイ酸 20g
トウモロコシデンプン 110g
以上の紛体を均一に混合した後、10%ハイドロキシプロピルセルロース・エタノール溶液100mlを加え、常法通り練和し、押出し、乾燥して顆粒剤を得た。
ゼラチン 60.0%
グリセリン 30.0%
パラオキシ安息香酸メチル 0.15%
パラオキシ安息香酸プロピル 0.51%
水 適量
上記成分からなるソフトカプセル剤皮の中に、以下に示す組成物を常法により充填し、1粒360mgのソフトカプセルを得た:
セサミン 3.5mg
塩酸チアミン 0.4mg
グリセリン脂肪酸エステル 15.0mg
ミツロウ 15.0mg
小麦胚芽油 245mg
セサミン 10g
硝酸チアミン 30g
デンプン 172g
ショ糖脂肪酸エステル 9.0g
酸化ケイ素 9.0g
これらを混合し、単発式打錠機にて打錠し、径9mm、重量300mgの錠剤を製造した。
呈味: DL−酒石酸ナトリウム 0.1g
コハク酸 0.009g
甘味:液糖 800g
酸味:クエン酸 12g
ビタミンC 10g
セサミン 1g
ビタミンB1 1g
ビタミンE 20g
シクロデキストリン 5g
乳化剤 5g
香料 15ml
塩化カリウム 1g
硫酸マグネシウム 0.5g
上記成分を配合し、水を加えて10リットルとした。この飲料は、1回あたり約100mlを飲用する。
Claims (8)
- 少なくとも1種のセサミン類と少なくとも1種のビタミンB1類を含有する飲料であって、
飲料100mL中のセサミン類の総含量が1〜100mgであり、ビタミンB1類の総含量が1〜100mgであり、
セサミン類が、セサミン、エピセサミン、又はこれらの混合物であり、
ビタミンB1類が、チアミン、チアミンジスルフィド、ベンフォチアミン、フルスルチアミン、ビスベンチアミン、ジセチアミン、チアミンエチルジスルフィド、チアミンプロピルジスルフィドおよびそれらの塩から選択された1種または2種以上であり、
セサミン類とビタミンB1類の配合量比が1:1〜2:1である、
前記飲料。 - 少なくとも1種のセサミン類と少なくとも1種のビタミンB1類とを有効成分として含有する抗疲労剤であって、
セサミン類が、セサミン、エピセサミン、又はこれらの混合物であり、
ビタミンB1類が、チアミン、チアミンジスルフィド、ベンフォチアミン、フルスルチアミン、ビスベンチアミン、ジセチアミン、チアミンエチルジスルフィド、チアミンプロピルジスルフィドおよびそれらの塩から選択された1種または2種以上であり、
セサミン類とビタミンB1類の配合量比が1:1〜2:1である、
前記抗疲労剤。 - 慢性疲労症候群を治療または予防するための、請求項2記載の抗疲労剤。
- ビタミンB1類の総配合量が、抗疲労剤全重量に対して0.01〜10重量%である、請求項2又は3記載の抗疲労剤。
- ビタミンB1類の総配合量が、抗疲労剤全重量に対して0.1〜5重量%である、請求項2〜4のいずれか一項記載の抗疲労剤。
- 抗疲労剤を製造するための、少なくとも1種のセサミン類および少なくとも1種のビタミンB1類を含む組成物の使用であって、
セサミン類が、セサミン、エピセサミン、又はこれらの混合物であり、
ビタミンB1類が、チアミン、チアミンジスルフィド、ベンフォチアミン、フルスルチアミン、ビスベンチアミン、ジセチアミン、チアミンエチルジスルフィド、チアミンプロピルジスルフィドおよびそれらの塩から選択された1種または2種以上であり、
前記組成物におけるセサミン類とビタミンB1類の配合量比が1:1〜2:1である、
前記使用。 - ビタミンB1類の総配合量が、組成物全重量に対して0.01〜10重量%である、請求項6記載の使用。
- ビタミンB1類の総配合量が、組成物全重量に対して0.1〜5重量%である、請求項6又は7記載の使用。
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US (1) | US8703789B2 (ja) |
EP (1) | EP2189160A4 (ja) |
JP (2) | JP5450075B2 (ja) |
KR (1) | KR101528381B1 (ja) |
CN (1) | CN101868238B (ja) |
AU (1) | AU2008301699B2 (ja) |
SG (2) | SG10201510301UA (ja) |
TW (1) | TWI549680B (ja) |
WO (1) | WO2009038095A1 (ja) |
Families Citing this family (9)
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SG10201510301UA (en) * | 2007-09-19 | 2016-01-28 | Suntory Holdings Ltd | Compositions incorporating sesamin-class compounds and vitamin b1 class compounds |
ITRM20110216A1 (it) * | 2011-04-27 | 2012-10-28 | Antonio Costantini | Vitamina b1 per uso nel trattamento di malattie infiammatorie - autoimmunitarie. |
ITRM20110283A1 (it) * | 2011-06-08 | 2012-12-09 | Antonio Costantini | Vitamina b1 per uso nel trattamento della malattia celiaca e di malattie del sistema nervoso. |
ITRM20120077A1 (it) * | 2012-03-01 | 2013-09-02 | Antonio Costantini | Nuovo uso vitamina b1. |
WO2012147003A1 (en) * | 2011-04-27 | 2012-11-01 | Costantini Antonio | Vitamin b1 for treatment of chronic fatigue |
KR101488612B1 (ko) * | 2013-08-12 | 2015-01-30 | 주식회사 엘지생활건강 | 흑색 식품소재를 함유하는 건강식품 및 약학적 조성물 |
JP6779861B2 (ja) * | 2015-03-23 | 2020-11-04 | サントリーホールディングス株式会社 | 概日リズム改善用組成物 |
JP6420797B2 (ja) * | 2015-08-07 | 2018-11-07 | 国立大学法人 筑波大学 | 活動意欲向上剤 |
WO2021065664A1 (ja) * | 2019-10-04 | 2021-04-08 | サントリーホールディングス株式会社 | 生活活動量の維持、低下予防、低下抑制又は改善用組成物 |
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SG10201510301UA (en) * | 2007-09-19 | 2016-01-28 | Suntory Holdings Ltd | Compositions incorporating sesamin-class compounds and vitamin b1 class compounds |
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- 2008-09-17 US US12/678,583 patent/US8703789B2/en active Active
- 2008-09-17 CN CN2008801072298A patent/CN101868238B/zh active Active
- 2008-09-17 WO PCT/JP2008/066772 patent/WO2009038095A1/ja active Application Filing
- 2008-09-17 JP JP2009533161A patent/JP5450075B2/ja active Active
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Also Published As
Publication number | Publication date |
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JPWO2009038095A1 (ja) | 2011-01-06 |
KR101528381B1 (ko) | 2015-06-11 |
KR20100074190A (ko) | 2010-07-01 |
TW200927126A (en) | 2009-07-01 |
US8703789B2 (en) | 2014-04-22 |
EP2189160A1 (en) | 2010-05-26 |
EP2189160A4 (en) | 2010-10-13 |
SG184771A1 (en) | 2012-10-30 |
SG10201510301UA (en) | 2016-01-28 |
JP2014055148A (ja) | 2014-03-27 |
WO2009038095A1 (ja) | 2009-03-26 |
TWI549680B (zh) | 2016-09-21 |
US20100184793A1 (en) | 2010-07-22 |
AU2008301699A1 (en) | 2009-03-26 |
JP5450075B2 (ja) | 2014-03-26 |
CN101868238B (zh) | 2012-05-23 |
AU2008301699B2 (en) | 2014-10-02 |
CN101868238A (zh) | 2010-10-20 |
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