JP5794761B2 - セサミン類及びビタミンeを含有する抗疲労剤 - Google Patents
セサミン類及びビタミンeを含有する抗疲労剤 Download PDFInfo
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- JP5794761B2 JP5794761B2 JP2009533157A JP2009533157A JP5794761B2 JP 5794761 B2 JP5794761 B2 JP 5794761B2 JP 2009533157 A JP2009533157 A JP 2009533157A JP 2009533157 A JP2009533157 A JP 2009533157A JP 5794761 B2 JP5794761 B2 JP 5794761B2
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- 235000019144 δ-tocotrienol Nutrition 0.000 description 1
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Description
1.少なくとも一つのセサミン類及び少なくとも一つのビタミンEを有効成分として含有する抗疲労剤、
2.疲労に関連する疾患または状態を予防または処置するための医薬組成物または飲食物である、前記1に記載の抗疲労剤、
3.セサミン類が、セサミン及び/又はエピセサミンである、前記1又は2に記載の抗疲労剤、
4.ビタミンEが(±)−α−トコフェロールである、前記1乃至3のいずれか一つに記載の抗疲労剤、
5.抗疲労剤を製造するための、少なくとも一つのセサミン類及び少なくとも一つのビタミンEの使用、及び
6.疲労状態の予防または治療方法であって、該予防または治療を必要とする対象に、少なくとも一つのセサミン類及び少なくとも一つのビタミンEを含有する組成物を投与することを含む方法。
<セサミン類>
本発明において、セサミン類とは、セサミン及びその類縁体を含む化合物の総称である。前記のセサミン類縁体としては、エピセサミンの他、例えば特開平4−9331号公報に記載されたジオキサビシクロ[3.3.0]オクタン誘導体がある。セサミン類の具体例としては、セサミン、セサミノール、エピセサミノール、セサモリン等を例示でき、これらの立体異性体又はラセミ体を単独で、または混合して使用することができる。本発明においては、セサミン及び/又はエピセサミンを好適に用いることができる。また、セサミン類の代謝体(例えば、特開2001−139579号公報に記載)も、本発明の効果を示す限り、本発明のセサミン類に含まれるセサミン類縁体であり、本発明に使用することができる。
<ビタミンE>
本発明において、ビタミンEとは、α−トコフェロール、β−トコフェロール、γ−トコフェロール及びδ−トコフェロール等のトコフェロール化合物、並びに、酢酸トコフェロール等のトコフェロールのエステル誘導体を意味するものである。そして、本発明の抗疲労剤において、ビタミンEとしては、トコフェロール化合物の一種のみを用いることができ、または、二種以上を組み合わせて用いることもできる。また、トコフェロール化合物は不斉炭素を有しているため立体異性体が存在するが、本発明において、各トコフェロール化合物は、単一の立体異性体のみを用いることができ、また、それら異性体の任意の割合の混合物(ラセミ体を含む)として用いることもできる。
<抗疲労作用>
本発明の抗疲労剤は、ヒトやヒト以外の動物に抗疲労作用を示すものである。ここで、ヒト以外の動物とは、産業動物、ペットおよび実験動物を表す。具体的には、産業動物とは、ウシ、ウマ、ブタ、ヤギ及びヒツジ等の家畜、ニワトリ、アヒル、ウズラ、七面鳥及びダチョウ等の家禽、並びに、ブリ、ハマチ、マダイ、マアジ、コイ、ニジマス及びウナギ等の魚類等、産業上飼養することが必要とされている動物をいう。ペットとはイヌ、ネコ、マーモセット、小鳥及びハムスター等のいわゆる愛玩動物、コンパニオン・アニマルをいい、実験動物とはマウス、ラット、モルモット、ビーグル犬、ミニブタ、アカゲザル及びカニクイザル等、医学、生物学、農学及び薬学等の分野で研究に供用される動物を表す。中でも本発明の抗疲労剤は、疲労を知覚するヒト、産業動物、ペット及び実験動物に用いられ、特にヒトに対して好適に用いられる。
<抗疲労剤>
本発明の抗疲労剤はセサミン類とビタミンEとを有効成分として含有する。そして、抗疲労剤の使用態様に応じて、その効果を損なわない限り、その他の任意の成分を含有することができる。任意の成分としては、例えば、ビタミンB及びビタミンC等のビタミン類、ミネラル類、ホルモン、栄養成分及び香料等の生理活性成分のほか、製剤化において配合される乳化剤、緊張化剤(等張化剤)、緩衝剤、溶解補助剤、防腐剤、安定化剤、増量剤及び抗酸化剤等を適宜配合することができる。
被験物質となるセサミン類及びビタミンEとして、それぞれ、セサミン/エピセサミン混合物(セサミン:エピセサミン(質量比)=5:5)及び(±)−α−トコフェロール(和光純薬工業)を用いた。
本発明の抗疲労剤の製造例を以下に示す。
(製剤例1)顆粒剤
セサミン 10g
酢酸トコフェロール 10g
無水ケイ酸 20g
トウモロコシデンプン 110g
以上の粉体を均一に混合した後に10%のハイドロキシプロピルセルロース・エタノール溶液100mlを加え、常法通り練和し、押し出し、乾燥して顆粒剤を得た。
(製剤例2)カプセル剤
ゼラチン 60.0%
グリセリン 30.0%
パラオキシ安息香酸メチル 0.15%
パラオキシ安息香酸プロピル 0.51%
水 適量
上記成分からなるソフトカプセル剤皮の中に、以下に示す組成物を常法により充填し、1粒360mgのソフトカプセルを得た。
ビタミンE 35mg
グリセリン脂肪酸エステル 15.0mg
ミツロウ 15.0mg
小麦胚芽油 223mg
(製剤例3)錠剤
セサミン 10g
ビタミンE 60g
デンプン 223g
ショ糖脂肪酸エステル 9.0g
酸化ケイ素 9.0g
これらを混合し、単発式打錠機にて打錠して径9mm、質量300mgの錠剤を製造した。
(製剤例4)ドリンク剤
呈味: DL−酒石酸ナトリウム 0.1g
コハク酸 0.009g
甘味:液糖 800g
酸味:クエン酸 12g
ビタミンC 10g
セサミン 1g
ビタミンE 20g
シクロデキストリン 5g
乳化剤 5g
香料 15ml
塩化カリウム 1g
硫酸マグネシウム 0.5g
上記成分を配合し、水を加えて10リットルとした。このドリンク剤は、1回あたり約100mlを飲用する。
Claims (5)
- 少なくとも一つのセサミン類および少なくとも一つのビタミンEを有効成分として含有する抗疲労剤であって、セサミン類を1〜10重量%含み、セサミン類の総量1に対してビタミンEの総量を8〜12の割合で含む、前記抗疲労剤。
- 疲労に関連する疾患または状態を予防または処置するための医薬組成物または飲食物である、請求項1に記載の抗疲労剤。
- セサミン類が、セサミン及び/又はエピセサミンである、請求項1又は2に記載の抗疲労剤。
- ビタミンEが(±)−α−トコフェロールである、請求項1乃至3のいずれか一項に記載の抗疲労剤。
- 抗疲労剤を製造するための、少なくとも一つのセサミン類及び少なくとも一つのビタミンEの使用であって、前記抗疲労剤はセサミン類を1〜10重量%含み、セサミン類の総量1に対してビタミンEの総量を8〜12の割合で含むものである、前記使用。
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Non-Patent Citations (5)
Title |
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JPN6008054528; 原田雅己: 'セサミンの生理活性-抗酸化作用と生体防御-' Bio Industry Vol.17,No.3, 2000, p.23-31 * |
JPN6008054532; 平本恵一ら: '酸化ストレスと疲労' 医学のあゆみ Vol.204,No.5, 2003, p.309-313 * |
JPN6008054535; 片岡洋祐: '酸化ストレスと脳の疲労' 医学のあゆみ Vol.204,No.5, 2003, p.314-318 * |
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JPN6013042070; Experimental Gerontology Vol.38, 2003, p.285-290 * |
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