JP5649825B2 - 安定化させたｐ５３ペプチドおよびその使用法 - Google Patents
安定化させたｐ５３ペプチドおよびその使用法 Download PDFInfo
- Publication number
- JP5649825B2 JP5649825B2 JP2009548441A JP2009548441A JP5649825B2 JP 5649825 B2 JP5649825 B2 JP 5649825B2 JP 2009548441 A JP2009548441 A JP 2009548441A JP 2009548441 A JP2009548441 A JP 2009548441A JP 5649825 B2 JP5649825 B2 JP 5649825B2
- Authority
- JP
- Japan
- Prior art keywords
- modified polypeptide
- amino acid
- acceptable salt
- pharmaceutically acceptable
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC*C(*C)C=*CNC Chemical compound CC*C(*C)C=*CNC 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88752607P | 2007-01-31 | 2007-01-31 | |
| US60/887,526 | 2007-01-31 | ||
| PCT/US2008/052580 WO2008095063A1 (en) | 2007-01-31 | 2008-01-31 | Stabilized p53 peptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137588A Division JP2014224121A (ja) | 2007-01-31 | 2014-07-03 | 安定化させたｐ５３ペプチドおよびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518017A JP2010518017A (ja) | 2010-05-27 |
| JP2010518017A5 JP2010518017A5 (OSRAM) | 2011-03-24 |
| JP5649825B2 true JP5649825B2 (ja) | 2015-01-07 |
Family
ID=39674492
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548441A Active JP5649825B2 (ja) | 2007-01-31 | 2008-01-31 | 安定化させたｐ５３ペプチドおよびその使用法 |
| JP2014137588A Pending JP2014224121A (ja) | 2007-01-31 | 2014-07-03 | 安定化させたｐ５３ペプチドおよびその使用法 |
| JP2016145368A Active JP6775344B2 (ja) | 2007-01-31 | 2016-07-25 | 安定化させたｐ５３ペプチドおよびその使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014137588A Pending JP2014224121A (ja) | 2007-01-31 | 2014-07-03 | 安定化させたｐ５３ペプチドおよびその使用法 |
| JP2016145368A Active JP6775344B2 (ja) | 2007-01-31 | 2016-07-25 | 安定化させたｐ５３ペプチドおよびその使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8889632B2 (OSRAM) |
| EP (2) | EP2952522B1 (OSRAM) |
| JP (3) | JP5649825B2 (OSRAM) |
| AU (1) | AU2008210434C8 (OSRAM) |
| CA (2) | CA2677045C (OSRAM) |
| DK (1) | DK2118123T3 (OSRAM) |
| ES (1) | ES2558928T3 (OSRAM) |
| PL (1) | PL2118123T3 (OSRAM) |
| PT (1) | PT2118123E (OSRAM) |
| WO (1) | WO2008095063A1 (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10794831B2 (en) | 2016-08-18 | 2020-10-06 | Horiba, Ltd. | Organic compound analyzer, organic compound analysis method, and program for organic compound analyzer |
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
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| US8937154B2 (en) | 2006-10-05 | 2015-01-20 | New York Blood Center, Inc. | Stabilized therapeutic small helical antiviral peptides |
| JP2010505831A (ja) | 2006-10-05 | 2010-02-25 | ニューヨーク ブラッド センター， インコーポレイテッド | 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド |
| WO2008076904A1 (en) | 2006-12-14 | 2008-06-26 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CA2677045C (en) | 2007-01-31 | 2016-10-18 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| US7981999B2 (en) | 2007-02-23 | 2011-07-19 | Aileron Therapeutics, Inc. | Triazole macrocycle systems |
| KR101623985B1 (ko) * | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
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| CA2768299C (en) * | 2009-07-13 | 2018-03-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
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| US10794831B2 (en) | 2016-08-18 | 2020-10-06 | Horiba, Ltd. | Organic compound analyzer, organic compound analysis method, and program for organic compound analyzer |
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