JP5535641B2 - 婦人科および直腸科分野における生物活性成分投与のための組成物とその使用方法 - Google Patents
婦人科および直腸科分野における生物活性成分投与のための組成物とその使用方法 Download PDFInfo
- Publication number
- JP5535641B2 JP5535641B2 JP2009538800A JP2009538800A JP5535641B2 JP 5535641 B2 JP5535641 B2 JP 5535641B2 JP 2009538800 A JP2009538800 A JP 2009538800A JP 2009538800 A JP2009538800 A JP 2009538800A JP 5535641 B2 JP5535641 B2 JP 5535641B2
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- JP
- Japan
- Prior art keywords
- composition
- rectal
- gum
- vaginal
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Description
生物活性物質 200mg
グアーガム 1.2g
賦形剤 1.6g
生物活性剤 250mg
タラガム 1.1g
賦形剤 1.85g
生物活性物質 150mg
カルシウムアルギネート 0.8g
賦形剤 1.25g
Lactobacillus rhamnosus 25 109CFU
イヌリン 0.80g
グアーガム 0.15g
カルシウムアルギネート 0.10g
塩化ナトリウム 0.10g
クエン酸マグネシウム 0.08g
Bifidobacterium animalis ssp.lactis
20.109CFU
フルクトオリゴ糖(FOS) 0.40g
イヌリン 0.40g
タラガム 0.18g
塩化ナトリウム 0.15g
炭酸カルシウム 0.02g
ヒドロキシプロピルメチルセルロース(HPMC) 0.11g
Lactobacillus fermentus 25.109CFU
アラビノガラクタン 0.40g
ガラクトオリゴ糖(GOS) 0.40g
タラガム 0.05g
塩化ナトリウム 0.025g
クエン酸 0.005g
結晶セルロース 0.03g
Lactobacillus paracasei 25.109CFU
グルコマンナン 0.90g
塩化ナトリウム 0.45g
クエン酸 0.04g
ヒドロキシプロピルセルロース(HPC) 0.48g
Bifidobacterium breve 20.109CFU
フルクトオリゴ糖(FOS) 0.40g
イヌリン 0.40g
タラガム 1.0g
塩化ナトリウム 0.45g
ヒドロキシプロピルセルロース(HPMC) 0.40g
Claims (9)
- 固形の組成物であって、
ビフィドバクテリウム・ブレーベ(Bifidobacterium breve)と、
増粘剤としてのタラガムと、を含む組成物であって、前記組成物は、水に懸濁/溶解されてから直腸もしくは膣内への投与により直腸および膣での感染病理を治療するための組成物。 - 請求項1に記載の組成物であって、前記組成物は、さらにプレバイオティック繊維を含む組成物。
- 請求項2に記載の組成物であって、前記プレバイオティック繊維は、フルクトオリゴ糖(FOS)、ガラクトオリゴ糖(GOS)、トランス−ガラクトオリゴ糖(TOS)、キシロオリゴ糖(XOS)、キトサンオリゴ糖(COS)、ラフィノーズおよびスタキオースから選択されるα−ガラクトシド、ペクチン、ガム、部分的に加水されたガム、イヌリン、オオバコ、アラビノガラクタン、アカシア、イナゴマメ、オーツ、竹の繊維、柑橘類の繊維を含む一群から選択される組成物。
- 請求項1から3のいずれかに記載の組成物と親水性液体培地を含む配合物。
- 請求項4に記載の配合物であって、前記増粘剤は、最終的な配合物の体積に対して、0.05%(w/v)以上存在し、好ましくは0.2%から20%(w/v)の間で存在する配合物。
- 請求項1から3のいずれかに記載の組成物であって、医薬品として使われる組成物。
- 請求項1から3のいずれかに記載の組成物を含む医薬品配合物であって、前記組成物は、医薬品として使用するために生理的に適合した親水性液体に予め懸濁されている医薬品配合物。
- 直腸および膣および/または治癒的治療のための医薬品配合物を生成するための請求項1から3のいずれかに記載の組成物の使用。
- 請求項8に記載の使用であって、前記組成物は、水に懸濁/溶解されてから直腸もしくは膣内への投与により直腸および膣での感染病理を治療するための使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2006A002286 | 2006-11-28 | ||
IT002286A ITMI20062286A1 (it) | 2006-11-28 | 2006-11-28 | Una composizione per la somministrazione di principi biologicamente attivi in ambito ginecologico e rettale nonche' i suoi usi |
PCT/IB2007/003491 WO2008065492A2 (en) | 2006-11-28 | 2007-11-12 | A composition for the administration of biologically active principles in gynaecologic and rectal field and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010511033A JP2010511033A (ja) | 2010-04-08 |
JP5535641B2 true JP5535641B2 (ja) | 2014-07-02 |
Family
ID=39468316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009538800A Expired - Fee Related JP5535641B2 (ja) | 2006-11-28 | 2007-11-12 | 婦人科および直腸科分野における生物活性成分投与のための組成物とその使用方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100092440A1 (ja) |
EP (1) | EP2120864B1 (ja) |
JP (1) | JP5535641B2 (ja) |
BR (1) | BRPI0719549B8 (ja) |
CA (1) | CA2670578C (ja) |
DK (1) | DK2120864T3 (ja) |
ES (1) | ES2626841T3 (ja) |
IT (1) | ITMI20062286A1 (ja) |
PL (1) | PL2120864T3 (ja) |
RU (1) | RU2445073C2 (ja) |
WO (1) | WO2008065492A2 (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1403661B1 (it) * | 2011-01-28 | 2013-10-31 | Probiotical Spa | Composizione effervescente in forma solida per uso in applicazioni vaginali per il trattamento di infezioni vaginali. |
ITMI20110791A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri in grado di metabolizzare gli ossalati. |
ITMI20110792A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri appartenenti al genere bifidobacterium per uso nel trattamento della ipercolesterolemia. |
ITMI20110793A1 (it) | 2011-05-09 | 2012-11-10 | Probiotical Spa | Ceppi di batteri probiotici e composizione sinbiotica contenente gli stessi destinata alla alimentazione dei neonati. |
ITRM20110477A1 (it) | 2011-09-09 | 2013-03-10 | Giovanni Mogna | Composizione comprendente n-acetilcisteina e/o lisozima microincapsulato gastroprotetto in associazione con batteri probiotici in grado di ripristinare l'effetto barriera proprio dello stomaco che viene perso durante il trattamento farmacologico dell |
ITMI20111718A1 (it) | 2011-09-23 | 2013-03-24 | Probiotical Spa | Un materiale impermeabile alla umidita e allo ossigeno per confezionare prodotti dietetici, cosmetici e specialita medicinali. |
EP2809301A1 (en) | 2012-01-31 | 2014-12-10 | Biosoma B.V. | Method for administration of a probiotic |
ITMI20130793A1 (it) * | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle cistiti ricorrenti. |
ITMI20130794A1 (it) * | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici per uso nel trattamento preventivo e/o curativo delle vaginosi batteriche. |
ITMI20130795A1 (it) * | 2013-05-14 | 2014-11-15 | Probiotical Spa | Composizione comprendente batteri lattici e/o bifidobatteri per uso nel trattamento preventivo e/o curativo delle infezioni batteriche e/o delle infiammazioni del tratto urinario e/o della prostata che sono la causa di prostatiti e ipertrofia prostat |
ITMI20131280A1 (it) * | 2013-07-30 | 2015-01-31 | Probiotical Spa | Produzione di materie prime e prodotti finiti atossici testati mediante un metodo innovativo a base di batteri probiotici per la determinazione della tossicità verso i batteri probiotici. |
WO2016020861A2 (pt) * | 2014-08-05 | 2016-02-11 | Palmeira De Oliveira Ana Cristina | Composição vaginal para tratamento e prevenção de infeções urogenitais, processos de obtenção e suas aplicações |
AU2017376780A1 (en) | 2016-12-15 | 2019-07-04 | Novome Biotechnologies, Inc. | Compositions and methods for modulating growth of a genetically modified gut bacterial cell |
MX2021008072A (es) | 2019-01-18 | 2021-08-16 | Cp Kelco Us Inc | Composicion prebiotica y su uso. |
CN112813011A (zh) * | 2021-03-23 | 2021-05-18 | 北京宝源广通科技发展有限公司 | 一种干酪乳杆菌及其在制备水苏糖合生元酸奶中的应用 |
CN113558246B (zh) * | 2021-07-21 | 2023-10-20 | 石河子大学 | 一种共生双歧杆菌复合微胶囊及制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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DK242083D0 (da) * | 1983-05-27 | 1983-05-27 | Hansens Chr Bio Syst | Vaginalkapsler |
JPH06101994B2 (ja) * | 1989-08-16 | 1994-12-14 | ユニコロイド株式会社 | 耐消化性腸内有用細菌及びその製法 |
DE4123330A1 (de) * | 1991-07-15 | 1993-01-21 | Gerhard Netz | Verfahren zur peranalen keimapplikation |
JPH05262657A (ja) * | 1992-01-22 | 1993-10-12 | Miyarisan Seibutsu Igaku Kenkyusho:Kk | 酪酸菌含有液剤の製造法 |
US5292534A (en) * | 1992-03-25 | 1994-03-08 | Valentine Enterprises, Inc. | Sustained release composition and method utilizing xanthan gum and an active ingredient |
US5531989A (en) * | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Immunoglobulin and fiber-containing composition for human gastrointestinal health |
US6093394A (en) * | 1997-04-11 | 2000-07-25 | Gynelogix, Inc. | Vaginal lactobacillus medicant |
JPH1121231A (ja) * | 1997-07-03 | 1999-01-26 | Okamoto Ind Inc | 水溶性潤滑剤 |
DE69802260T2 (de) * | 1998-04-30 | 2002-07-04 | Vesely Renata Maria Cavaliere | Pharmazeutische Zusammensetzungen enthaltend Lactobacillus brevis und Lactobacillus salivarius zur Behandlung von Vaginainfektionen |
JP2003128588A (ja) * | 2001-08-10 | 2003-05-08 | Toray Ind Inc | 多糖類含有組成物およびその用途 |
WO2003026687A1 (en) * | 2001-09-28 | 2003-04-03 | Nutraceutix, Inc. | Delivery system for biological component |
WO2005060937A1 (en) * | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
-
2006
- 2006-11-28 IT IT002286A patent/ITMI20062286A1/it unknown
-
2007
- 2007-11-12 US US12/516,512 patent/US20100092440A1/en not_active Abandoned
- 2007-11-12 CA CA2670578A patent/CA2670578C/en not_active Expired - Fee Related
- 2007-11-12 PL PL07825668T patent/PL2120864T3/pl unknown
- 2007-11-12 DK DK07825668.2T patent/DK2120864T3/en active
- 2007-11-12 EP EP07825668.2A patent/EP2120864B1/en not_active Not-in-force
- 2007-11-12 WO PCT/IB2007/003491 patent/WO2008065492A2/en active Application Filing
- 2007-11-12 ES ES07825668.2T patent/ES2626841T3/es active Active
- 2007-11-12 RU RU2009121623/15A patent/RU2445073C2/ru active
- 2007-11-12 BR BRPI0719549A patent/BRPI0719549B8/pt not_active IP Right Cessation
- 2007-11-12 JP JP2009538800A patent/JP5535641B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2008065492A3 (en) | 2009-03-19 |
EP2120864B1 (en) | 2017-03-22 |
BRPI0719549A2 (pt) | 2014-01-21 |
PL2120864T3 (pl) | 2017-08-31 |
JP2010511033A (ja) | 2010-04-08 |
WO2008065492A2 (en) | 2008-06-05 |
BRPI0719549B1 (pt) | 2020-05-19 |
DK2120864T3 (en) | 2017-05-01 |
ITMI20062286A1 (it) | 2008-05-29 |
US20100092440A1 (en) | 2010-04-15 |
RU2445073C2 (ru) | 2012-03-20 |
EP2120864A2 (en) | 2009-11-25 |
CA2670578C (en) | 2016-01-26 |
BRPI0719549B8 (pt) | 2021-05-25 |
RU2009121623A (ru) | 2011-01-10 |
ES2626841T3 (es) | 2017-07-26 |
CA2670578A1 (en) | 2008-06-05 |
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