JP5437063B2 - 多数血管の腎神経変性方法および腎神経変性装置 - Google Patents
多数血管の腎神経変性方法および腎神経変性装置 Download PDFInfo
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- JP5437063B2 JP5437063B2 JP2009515580A JP2009515580A JP5437063B2 JP 5437063 B2 JP5437063 B2 JP 5437063B2 JP 2009515580 A JP2009515580 A JP 2009515580A JP 2009515580 A JP2009515580 A JP 2009515580A JP 5437063 B2 JP5437063 B2 JP 5437063B2
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Description
本願は2005年5月13日出願の同時係属中の米国特許出願第11/129,765号の部分継続出願であり、かかる特許出願は2004年10月5日出願の米国仮出願第60/616,254号(a)および2004年11月2日出願の米国仮出願第60/624,793号(b)の優先権を主張するものである。
本明細書で言及されている公開文献と特許出願文献は全て、引例に挙げて言及することでそれらが特定的かつ個別的に本件に組入れられていると認識される限り、ここに援用することで本件の一部とされるものとする。
本発明は神経変性法および神経変性装置に関するものである。或る実施例においては、本発明は腎神経変性を達成する方法および装置に関連している。
本発明の方法および装置は、腎機能に寄与する神経線維を変性するために利用することができるとともに、所望の神経変性を達成する好適な神経変性技術を活用することができる。本発明の幾つかの実施例は、パルス電界(PEF)、刺激電界、局所薬物搬送、高周波超音波、熱技術、非熱技術、それ以外の各種技術、または、上記技術の各種組合せにより神経変性を施すための方法および装置である。神経変性が果たす効能としては、例えば、標的神経線維における不可逆電気穿孔または不可逆電気融解、細胞壊死、細胞死誘発、細胞壊死と細胞死誘発の両方、遺伝子発現形質の変動、活動電位妨害または活動電位減衰、サイトカイン上方調整の変動、および、上記以外の各種変化がある。幾つかの実施例において、多数血管法および多数血管装置により、多数本の血管の内部、1本の血管の多分岐部の内部、または、その両方に設置された神経変性素子を使って神経変性が達成される。
ここで図1を参照すると、人体の腎臓の解剖学的構造では、腎臓Kは酸素添加された血液が腎動脈RAによって供給されており、腎動脈RAは腹部大動脈AAによって心臓に導通している。脱酸素後の血液が腎臓から腎静脈RVおよび下大静脈IVCを経由して心臓に流入している。図2は、腎臓の解剖学的構造の一部をより詳細に例示している。より特定すると、腎臓の解剖学的構造では、更に、腎神経RNが概ね腎動脈RAの長尺領域Lに沿って長手方向に延在しているが、大抵は動脈の血管外膜の内側に位置している。腎動脈RAは平滑筋細胞SMCを含んでおり、一般的にこの細胞は動脈周辺部を包囲しながら動脈の角度軸線θの周囲で螺旋状に延在する。従って、腎動脈の平滑筋細胞は、腎動脈の長手領域を相関的に横断する方向(すなわち、平行ではない方向)に延在している長尺部すなわち長手方向領域を含んでいる。腎神経の長手領域と平滑筋細胞の長手領域の不整合は「細胞不整合」と定義される。
図4から図7を参照すると、多数血管パルス電界システムおよび多数血管パルス電界法の各種実施例が記載されている。図4は、多数血管パルス電界装置100の一実施例に、パルス電界を腎臓神経線維に伝播して腎神経変性を施す構成の多数電極110が設けられているのを例示している。電極110は、主腎動脈RAから分岐した多数血管内に設置されている。装置100はカテーテル102を更に備えており、このカテーテルを通して電極110が血管の各分岐部に搬送される。カテーテルはまた、以下で説明されているように、位置決め素子104を備えているようにしてもよい。例えば、2005年5月13日出願の同時係属中の米国特許出願連続番号11/129,765号などにおいて、本件出願人は血管内パルス電界システムを既に開示しており、この出願の内容全体は、ここに援用することにより本件の一部を成すものとする。
Claims (10)
- 患者の腎臓に神経変性を施す装置であって、
患者の外部に設置されるように構成された電界発生器と、
縮小搬送形態で血管内を搬送され、拡張治療形態に展開配備されるように構成されたカテーテルと、
前記カテーテルに連結され患者の腎動脈内に血管を通して設置されるよう構成され、前記電界発生器に作動的に連結された第1電極を備えている第1要素と、
患者の腎静脈内に血管を通して設置されるよう構成され、前記電界発生器に作動的に接続された第2電極を備えている第2要素と、を備え、
前記装置は、前記第1要素が前記腎動脈内に配置され前記第2要素が前記腎静脈内に配置されている間、前記電界発生器から前記第1電極および前記第2電極に電界を伝播させて、前記患者の腎臓を神経支配する神経線維に沿った神経交通を遮るように構成されている、
ことを特徴とする装置。 - 前記装置は、前記第1電極と前記第2電極の間で電界を伝播させるように構成されている、
請求項1に記載の装置。 - 前記第1電極および前記第2電極に伝播される電界は、神経線維を少なくとも部分的に切断するように構成されている、
請求項2に記載の装置。 - 前記カテーテルは長手方向軸線を有し、
該カテーテルの長手方向軸線は、腎動脈の長さ方向に沿って位置決めされるように構成されている、
請求項1に記載の装置。 - 前記第1電極は、前記カテーテルの長手方向軸線から横方向に間隔をおいて配置されるように構成されている、
請求項4に記載の装置。 - 前記第1電極および前記第2電極は、前記第1電極と患者の外部に配置された接地バッドとの間および前記第2電極と前記接地パッドとの間で、電界をモノポーラ伝播するように構成されている、
請求項1に記載の装置。 - 前記第1電極および前記第2電極は、前記第1電極と前記第2電極との間で電界をバイポーラ伝播するように構成されている、
請求項1に記載の装置。 - 前記カテーテルは第1カテーテルであり、
前記第2要素は、腎静脈内で血管内搬送されるように構成された第2カテーテルに結合されている、
請求項1に記載の装置。 - 前記第1および第2電極は、互いに横方向に整列するように構成されている、
請求項1に記載の装置。 - 前記第1および第2電極は、互いに横方向に間隔をおくように構成されている、
請求項1に記載の装置。
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US11/451,728 US7853333B2 (en) | 2002-04-08 | 2006-06-12 | Methods and apparatus for multi-vessel renal neuromodulation |
PCT/US2007/070799 WO2007146834A2 (en) | 2006-06-12 | 2007-06-08 | Methods and apparatus for multi-vessel renal neuromodulation |
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CA2655099A1 (en) | 2007-12-21 |
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US7853333B2 (en) | 2010-12-14 |
EP2029223B1 (en) | 2019-07-31 |
EP2029223A2 (en) | 2009-03-04 |
WO2007146834A3 (en) | 2008-08-28 |
CN101489624A (zh) | 2009-07-22 |
US10537734B2 (en) | 2020-01-21 |
US8433423B2 (en) | 2013-04-30 |
US20180021574A1 (en) | 2018-01-25 |
WO2007146834A2 (en) | 2007-12-21 |
US20180264260A1 (en) | 2018-09-20 |
JP2009539565A (ja) | 2009-11-19 |
US9108040B2 (en) | 2015-08-18 |
US9950161B2 (en) | 2018-04-24 |
ES2751912T3 (es) | 2020-04-02 |
US20060235474A1 (en) | 2006-10-19 |
US20170021170A1 (en) | 2017-01-26 |
US20150374974A1 (en) | 2015-12-31 |
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