JP5432526B2 - モノアミン再取り込み阻害剤としてのシクロアルキルアミン - Google Patents
モノアミン再取り込み阻害剤としてのシクロアルキルアミン Download PDFInfo
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- JP5432526B2 JP5432526B2 JP2008549588A JP2008549588A JP5432526B2 JP 5432526 B2 JP5432526 B2 JP 5432526B2 JP 2008549588 A JP2008549588 A JP 2008549588A JP 2008549588 A JP2008549588 A JP 2008549588A JP 5432526 B2 JP5432526 B2 JP 5432526B2
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- 0 *C(C1(C(*)(*)CCCC1)[Al])N(*)* Chemical compound *C(C1(C(*)(*)CCCC1)[Al])N(*)* 0.000 description 15
- KWKUIKNZPCQOOK-UHFFFAOYSA-N CC(C1(CCCCC1)c(cc1Cl)ccc1Cl)=O Chemical compound CC(C1(CCCCC1)c(cc1Cl)ccc1Cl)=O KWKUIKNZPCQOOK-UHFFFAOYSA-N 0.000 description 1
- KBCAMMVKABLCAE-WBMJQRKESA-N CCNC[C@@]1([C@H](C)CCCC1)c(cc1Cl)ccc1Cl Chemical compound CCNC[C@@]1([C@H](C)CCCC1)c(cc1Cl)ccc1Cl KBCAMMVKABLCAE-WBMJQRKESA-N 0.000 description 1
- KBCAMMVKABLCAE-BLLLJJGKSA-N CCNC[C@]1([C@@H](C)CCCC1)c(cc1Cl)ccc1Cl Chemical compound CCNC[C@]1([C@@H](C)CCCC1)c(cc1Cl)ccc1Cl KBCAMMVKABLCAE-BLLLJJGKSA-N 0.000 description 1
- CYNNIAUFVFAXND-UHFFFAOYSA-N CN(C)CC(CCCC1)(C1O)[AlH2] Chemical compound CN(C)CC(CCCC1)(C1O)[AlH2] CYNNIAUFVFAXND-UHFFFAOYSA-N 0.000 description 1
- UFFRBOMGNQGCAY-UHFFFAOYSA-N CN(C)CC1(CCCCC1)c(cc1)ccc1Cl Chemical compound CN(C)CC1(CCCCC1)c(cc1)ccc1Cl UFFRBOMGNQGCAY-UHFFFAOYSA-N 0.000 description 1
- FVPYKEUHDWGTTO-UHFFFAOYSA-N CN(C)CC1(CCCCC1)c(cc1)ccc1F Chemical compound CN(C)CC1(CCCCC1)c(cc1)ccc1F FVPYKEUHDWGTTO-UHFFFAOYSA-N 0.000 description 1
- PUCWXLYHLYMUCG-UHFFFAOYSA-N CN(C)CC1(CCCCC1)c(cc1F)ccc1F Chemical compound CN(C)CC1(CCCCC1)c(cc1F)ccc1F PUCWXLYHLYMUCG-UHFFFAOYSA-N 0.000 description 1
- MRTZERJVTGGFRD-JKSUJKDBSA-N CN(C)C[C@@]1([C@H](CO)CCCC1)c1ccccc1 Chemical compound CN(C)C[C@@]1([C@H](CO)CCCC1)c1ccccc1 MRTZERJVTGGFRD-JKSUJKDBSA-N 0.000 description 1
- MRTZERJVTGGFRD-LYKKTTPLSA-N CN(C)C[C@]1(C(CO)CCCC1)c1ccccc1 Chemical compound CN(C)C[C@]1(C(CO)CCCC1)c1ccccc1 MRTZERJVTGGFRD-LYKKTTPLSA-N 0.000 description 1
- ZRJWKTLIVJYWHV-UHFFFAOYSA-N CNCC(CCCC1)(C1O)[AlH2] Chemical compound CNCC(CCCC1)(C1O)[AlH2] ZRJWKTLIVJYWHV-UHFFFAOYSA-N 0.000 description 1
- MDTFUSLGHFSRLI-UHFFFAOYSA-N CNCC1(CCCC1)c(cc1Cl)ccc1Cl Chemical compound CNCC1(CCCC1)c(cc1Cl)ccc1Cl MDTFUSLGHFSRLI-UHFFFAOYSA-N 0.000 description 1
- JCPLIJBMSKJFQE-UHFFFAOYSA-N CNCC1(CCCCC1)c1cc(F)ccc1 Chemical compound CNCC1(CCCCC1)c1cc(F)ccc1 JCPLIJBMSKJFQE-UHFFFAOYSA-N 0.000 description 1
- OMEZNRIAKKKRHT-UHFFFAOYSA-N CNCC1(CCCCC1)c1ccc(C(F)(F)F)cc1 Chemical compound CNCC1(CCCCC1)c1ccc(C(F)(F)F)cc1 OMEZNRIAKKKRHT-UHFFFAOYSA-N 0.000 description 1
- KTOBNAHVVQAFAO-ZIAGYGMSSA-N CNC[C@@](CCCC1)([C@@H]1O)c(cc1)ccc1Cl Chemical compound CNC[C@@](CCCC1)([C@@H]1O)c(cc1)ccc1Cl KTOBNAHVVQAFAO-ZIAGYGMSSA-N 0.000 description 1
- YDFJSUAVFRHHMT-UONOGXRCSA-N CNC[C@@](CCCC1)([C@H]1O)c(cc1)ccc1OC(F)(F)F Chemical compound CNC[C@@](CCCC1)([C@H]1O)c(cc1)ccc1OC(F)(F)F YDFJSUAVFRHHMT-UONOGXRCSA-N 0.000 description 1
- YDFJSUAVFRHHMT-KGLIPLIRSA-N CNC[C@](CCCC1)([C@@H]1O)c(cc1)ccc1OC(F)(F)F Chemical compound CNC[C@](CCCC1)([C@@H]1O)c(cc1)ccc1OC(F)(F)F YDFJSUAVFRHHMT-KGLIPLIRSA-N 0.000 description 1
- KTOBNAHVVQAFAO-KBPBESRZSA-N CNC[C@](CCCC1)([C@H]1O)c(cc1)ccc1Cl Chemical compound CNC[C@](CCCC1)([C@H]1O)c(cc1)ccc1Cl KTOBNAHVVQAFAO-KBPBESRZSA-N 0.000 description 1
- YKCRXOONSJLXJF-UHFFFAOYSA-N COC(C(CC(CC1)(c2cc3ccccc3cc2)C#N)=C1O)=O Chemical compound COC(C(CC(CC1)(c2cc3ccccc3cc2)C#N)=C1O)=O YKCRXOONSJLXJF-UHFFFAOYSA-N 0.000 description 1
- GLQFOZOMSZTEEP-UHFFFAOYSA-N COC(CCC(CCC(OC)=O)(c1cc(cccc2)c2cc1)C#N)=O Chemical compound COC(CCC(CCC(OC)=O)(c1cc(cccc2)c2cc1)C#N)=O GLQFOZOMSZTEEP-UHFFFAOYSA-N 0.000 description 1
- LDOCXVURCAZCEO-UHFFFAOYSA-N CO[C@H](CC1)CC[C@]1(CN)[AlH2] Chemical compound CO[C@H](CC1)CC[C@]1(CN)[AlH2] LDOCXVURCAZCEO-UHFFFAOYSA-N 0.000 description 1
- GPIQOFWTZXXOOV-UHFFFAOYSA-N COc1nc(Cl)nc(OC)n1 Chemical compound COc1nc(Cl)nc(OC)n1 GPIQOFWTZXXOOV-UHFFFAOYSA-N 0.000 description 1
- SDJCWDPUYSQZSS-UHFFFAOYSA-N C[C@](CC1)(CC[C@H]1O)[AlH2] Chemical compound C[C@](CC1)(CC[C@H]1O)[AlH2] SDJCWDPUYSQZSS-UHFFFAOYSA-N 0.000 description 1
- OSGKBDJZNCVTPD-CALCHBBNSA-N C[C@](CC1)(CC[C@]1(CN(C)C)c1ccc2OCOc2c1)O Chemical compound C[C@](CC1)(CC[C@]1(CN(C)C)c1ccc2OCOc2c1)O OSGKBDJZNCVTPD-CALCHBBNSA-N 0.000 description 1
- FVDURJLJWSLTMP-GASCZTMLSA-N C[C@](CC1)(CC[C@]1(CN)c(cc1)cc2c1OCO2)O Chemical compound C[C@](CC1)(CC[C@]1(CN)c(cc1)cc2c1OCO2)O FVDURJLJWSLTMP-GASCZTMLSA-N 0.000 description 1
- DNAVEBIILOFSOW-CALCHBBNSA-N C[C@](CC1)(CC[C@]11c2ccc3OCOc3c2CN(C)C1)O Chemical compound C[C@](CC1)(CC[C@]11c2ccc3OCOc3c2CN(C)C1)O DNAVEBIILOFSOW-CALCHBBNSA-N 0.000 description 1
- NPQMBXIEBWOOSQ-UHFFFAOYSA-N N#CC(CCC1)(CC1=O)c(cc1Cl)ccc1Cl Chemical compound N#CC(CCC1)(CC1=O)c(cc1Cl)ccc1Cl NPQMBXIEBWOOSQ-UHFFFAOYSA-N 0.000 description 1
- KQNPVCKYTVMKRK-UHFFFAOYSA-N N#CCC(C1)Cc2ccccc2C1c(cc1)cc(Cl)c1Cl Chemical compound N#CCC(C1)Cc2ccccc2C1c(cc1)cc(Cl)c1Cl KQNPVCKYTVMKRK-UHFFFAOYSA-N 0.000 description 1
- SVGMBLIFYWKNDC-UHFFFAOYSA-N NCC(CCC1)(CC1(F)F)c(cc1Cl)ccc1Cl Chemical compound NCC(CCC1)(CC1(F)F)c(cc1Cl)ccc1Cl SVGMBLIFYWKNDC-UHFFFAOYSA-N 0.000 description 1
- XZUTVZVXEKNHHN-UHFFFAOYSA-N NCC1(CCCCC1)c(cc1)cc(cc2)c1cc2F Chemical compound NCC1(CCCCC1)c(cc1)cc(cc2)c1cc2F XZUTVZVXEKNHHN-UHFFFAOYSA-N 0.000 description 1
- PXJDTWINCCFEMX-GXFFZTMASA-N NC[C@@](CCC1)(C[C@H]1O)c(cc1Cl)ccc1Cl Chemical compound NC[C@@](CCC1)(C[C@H]1O)c(cc1Cl)ccc1Cl PXJDTWINCCFEMX-GXFFZTMASA-N 0.000 description 1
- PXJDTWINCCFEMX-MFKMUULPSA-N NC[C@](CCC1)(C[C@@H]1O)c(cc1Cl)ccc1Cl Chemical compound NC[C@](CCC1)(C[C@@H]1O)c(cc1Cl)ccc1Cl PXJDTWINCCFEMX-MFKMUULPSA-N 0.000 description 1
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
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- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
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- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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| ES2566479T3 (es) * | 2006-01-06 | 2016-04-13 | Sunovion Pharmaceuticals Inc. | Inhibidores de reabsorción de monoamina con base en tetralona |
| EP2816024B8 (en) | 2006-03-31 | 2018-04-04 | Sunovion Pharmaceuticals Inc. | Chiral amines |
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| EP2124913A1 (en) * | 2006-12-22 | 2009-12-02 | Novartis AG | 1-aminomethyl- l- phenyl- cyclohexane derivatives as ddp-iv inhibitors |
| ZA200904686B (en) * | 2007-01-18 | 2010-09-29 | Sepracor Inc | Inhibitiors of D-amino acid oxidase |
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| US20110021928A1 (en) * | 2009-07-23 | 2011-01-27 | The Boards Of Trustees Of The Leland Stanford Junior University | Methods and system of determining cardio-respiratory parameters |
| US20110034434A1 (en) * | 2009-08-07 | 2011-02-10 | Sepracor Inc. | Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase |
| SG186885A1 (en) | 2010-06-04 | 2013-02-28 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
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| CN104039753B (zh) | 2011-12-30 | 2016-09-14 | 雷维瓦药品公司 | 苯基环烷基甲胺衍生物的组合物、合成以及使用方法 |
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| WO2014141110A2 (en) * | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
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| CN105085436B (zh) * | 2014-04-19 | 2019-08-16 | 广东东阳光药业有限公司 | 磺酰胺类衍生物及其在药物上的应用 |
| MA40082B1 (fr) | 2014-08-20 | 2019-09-30 | Bristol Myers Squibb Co | Nouveau compose de substitution sphingosine phosphate utile traitement maladie rhumatisme |
| CN104387279B (zh) * | 2014-10-29 | 2016-04-06 | 河南师范大学 | 一种简便合成3,3-二氟环己基甲胺的方法 |
| RU2637928C2 (ru) * | 2016-02-08 | 2017-12-08 | Закрытое Акционерное Общество "Вертекс" | Производные арилциклоалкиламинов, нейропротектор (варианты), вещество, обладающее сочетанным нейропротекторным, анальгетическим и антидепрессивным действием, фармацевтические композиции на его основе |
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| WO2021085468A1 (ja) | 2019-10-29 | 2021-05-06 | 株式会社エーピーアイ コーポレーション | 高純度2-ナフチルアセトニトリル及びその製造方法 |
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- 2007-01-05 RU RU2008132320A patent/RU2430913C2/ru active
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013209390A (ja) * | 2006-01-06 | 2013-10-10 | Sunovion Pharmaceuticals Inc | モノアミン再取り込み阻害剤としてのシクロアルキルアミン |
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| Publication number | Publication date |
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| RU2430913C2 (ru) | 2011-10-10 |
| US20150126511A1 (en) | 2015-05-07 |
| AU2007205114A1 (en) | 2007-07-19 |
| CA2636324A1 (en) | 2007-07-19 |
| RU2008132320A (ru) | 2010-02-20 |
| EP1976513B1 (en) | 2016-08-24 |
| JP2009531277A (ja) | 2009-09-03 |
| ZA200806145B (en) | 2010-02-24 |
| NZ569630A (en) | 2011-09-30 |
| US9868718B2 (en) | 2018-01-16 |
| RU2011119990A (ru) | 2012-11-27 |
| KR20080083201A (ko) | 2008-09-16 |
| KR101294014B1 (ko) | 2013-08-09 |
| US20180230120A1 (en) | 2018-08-16 |
| WO2007081857A2 (en) | 2007-07-19 |
| CN101394847B (zh) | 2017-05-24 |
| EP1976513A4 (en) | 2012-04-18 |
| ES2594156T3 (es) | 2016-12-16 |
| AU2007205114B2 (en) | 2012-11-08 |
| IL192613A (en) | 2015-11-30 |
| US10562878B2 (en) | 2020-02-18 |
| CN101394847A (zh) | 2009-03-25 |
| EP1976513A2 (en) | 2008-10-08 |
| BRPI0706365A2 (pt) | 2011-03-22 |
| WO2007081857A3 (en) | 2007-11-08 |
| US8877975B2 (en) | 2014-11-04 |
| US20070203111A1 (en) | 2007-08-30 |
| US20100190861A1 (en) | 2010-07-29 |
| JP2013209390A (ja) | 2013-10-10 |
| IL192613A0 (en) | 2009-09-22 |
| CA2636324C (en) | 2012-03-20 |
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