JP5416338B2 - Ｃｄ２０特異的抗体およびその使用方法 - Google Patents

Ｃｄ２０特異的抗体およびその使用方法 Download PDF

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JP5416338B2
JP5416338B2 JP2006532859A JP2006532859A JP5416338B2 JP 5416338 B2 JP5416338 B2 JP 5416338B2 JP 2006532859 A JP2006532859 A JP 2006532859A JP 2006532859 A JP2006532859 A JP 2006532859A JP 5416338 B2 JP5416338 B2 JP 5416338B2
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seq
cells
amino acid
antibody
cell
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JP2007535301A5 (https=
JP2007535301A (ja
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トーマス エフ． テッダー，
純二 内田
儒人 濱口
ジョナサン シー． ポー，
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Duke University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
JP2006532859A 2003-05-09 2004-05-07 Ｃｄ２０特異的抗体およびその使用方法 Expired - Fee Related JP5416338B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46945103P 2003-05-09 2003-05-09
US60/469,451 2003-05-09
PCT/US2004/014326 WO2005000901A2 (en) 2003-05-09 2004-05-07 Cd20-specific antibodies and methods of employing same

Related Child Applications (1)

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JP2010163432A Division JP2011015683A (ja) 2003-05-09 2010-07-20 Ｃｄ２０特異的抗体およびその使用方法

Publications (3)

Publication Number Publication Date
JP2007535301A JP2007535301A (ja) 2007-12-06
JP2007535301A5 JP2007535301A5 (https=) 2010-09-09
JP5416338B2 true JP5416338B2 (ja) 2014-02-12

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Application Number Title Priority Date Filing Date
JP2006532859A Expired - Fee Related JP5416338B2 (ja) 2003-05-09 2004-05-07 Ｃｄ２０特異的抗体およびその使用方法
JP2010163432A Pending JP2011015683A (ja) 2003-05-09 2010-07-20 Ｃｄ２０特異的抗体およびその使用方法
JP2013114057A Expired - Fee Related JP5756147B2 (ja) 2003-05-09 2013-05-30 Ｃｄ２０特異的抗体およびその使用方法
JP2014236224A Expired - Fee Related JP5969577B2 (ja) 2003-05-09 2014-11-21 Ｃｄ２０特異的抗体およびその使用方法
JP2016049258A Withdrawn JP2016146840A (ja) 2003-05-09 2016-03-14 Ｃｄ２０特異的抗体およびその使用方法
JP2018023333A Pending JP2018082723A (ja) 2003-05-09 2018-02-13 Ｃｄ２０特異的抗体およびその使用方法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2010163432A Pending JP2011015683A (ja) 2003-05-09 2010-07-20 Ｃｄ２０特異的抗体およびその使用方法
JP2013114057A Expired - Fee Related JP5756147B2 (ja) 2003-05-09 2013-05-30 Ｃｄ２０特異的抗体およびその使用方法
JP2014236224A Expired - Fee Related JP5969577B2 (ja) 2003-05-09 2014-11-21 Ｃｄ２０特異的抗体およびその使用方法
JP2016049258A Withdrawn JP2016146840A (ja) 2003-05-09 2016-03-14 Ｃｄ２０特異的抗体およびその使用方法
JP2018023333A Pending JP2018082723A (ja) 2003-05-09 2018-02-13 Ｃｄ２０特異的抗体およびその使用方法

Country Status (10)

Country Link
US (2) US9416187B2 (https=)
EP (2) EP2960251A1 (https=)
JP (6) JP5416338B2 (https=)
KR (2) KR101351122B1 (https=)
CN (1) CN1802388B (https=)
AU (1) AU2004252067B2 (https=)
CA (2) CA2525251C (https=)
HK (1) HK1219487A1 (https=)
NZ (2) NZ543960A (https=)
WO (1) WO2005000901A2 (https=)

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JP5156392B2 (ja) 2005-02-03 2013-03-06 トポターゲット ユーケー リミテッド Ｈｄａｃ阻害剤を用いる併用療法
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US8444973B2 (en) 2005-02-15 2013-05-21 Duke University Anti-CD19 antibodies and uses in B cell disorders
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AU2016228280B2 (en) * 2007-07-12 2019-02-21 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
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AU2004252067B2 (en) 2012-04-12
CN1802388B (zh) 2011-01-05
NZ568403A (en) 2009-10-30
JP2015044852A (ja) 2015-03-12
CA2525251C (en) 2015-10-27
KR101351122B1 (ko) 2014-01-14
JP2016146840A (ja) 2016-08-18
CA2897608C (en) 2018-07-31
WO2005000901A2 (en) 2005-01-06
US20170088625A1 (en) 2017-03-30
JP2011015683A (ja) 2011-01-27
CN1802388A (zh) 2006-07-12
NZ543960A (en) 2008-11-28
US9416187B2 (en) 2016-08-16
JP2013198490A (ja) 2013-10-03
WO2005000901A3 (en) 2005-06-23
JP2018082723A (ja) 2018-05-31
KR101412271B1 (ko) 2014-06-25
JP2007535301A (ja) 2007-12-06
KR20120065420A (ko) 2012-06-20
CA2897608A1 (en) 2005-01-06
EP1626993B1 (en) 2015-03-11
KR20060022238A (ko) 2006-03-09
AU2004252067A1 (en) 2005-01-06
JP5756147B2 (ja) 2015-07-29
EP2960251A1 (en) 2015-12-30
HK1219487A1 (en) 2017-04-07
US20090136516A1 (en) 2009-05-28
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AU2004252067A2 (en) 2005-01-06

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