CN1802388B - Cd20特异抗体及使用它们的方法 - Google Patents
Cd20特异抗体及使用它们的方法 Download PDFInfo
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- CN1802388B CN1802388B CN2004800160927A CN200480016092A CN1802388B CN 1802388 B CN1802388 B CN 1802388B CN 2004800160927 A CN2004800160927 A CN 2004800160927A CN 200480016092 A CN200480016092 A CN 200480016092A CN 1802388 B CN1802388 B CN 1802388B
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- mab
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
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- Hematology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- General Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
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- Urology & Nephrology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46945103P | 2003-05-09 | 2003-05-09 | |
| US60/469,451 | 2003-05-09 | ||
| PCT/US2004/014326 WO2005000901A2 (en) | 2003-05-09 | 2004-05-07 | Cd20-specific antibodies and methods of employing same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1802388A CN1802388A (zh) | 2006-07-12 |
| CN1802388B true CN1802388B (zh) | 2011-01-05 |
Family
ID=33551414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800160927A Expired - Fee Related CN1802388B (zh) | 2003-05-09 | 2004-05-07 | Cd20特异抗体及使用它们的方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9416187B2 (https=) |
| EP (2) | EP2960251A1 (https=) |
| JP (6) | JP5416338B2 (https=) |
| KR (2) | KR101351122B1 (https=) |
| CN (1) | CN1802388B (https=) |
| AU (1) | AU2004252067B2 (https=) |
| CA (2) | CA2525251C (https=) |
| HK (1) | HK1219487A1 (https=) |
| NZ (2) | NZ543960A (https=) |
| WO (1) | WO2005000901A2 (https=) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005110249A1 (en) | 2004-05-17 | 2005-11-24 | Imp Limited | Apparatus for use in orthopaedic surgery |
| AU2005249566B2 (en) | 2004-06-04 | 2010-11-11 | Genentech, Inc. | Method for treating multiple sclerosis |
| AU2005274905B2 (en) | 2004-08-04 | 2010-12-23 | Mentrik Biotech, Llc | Variant Fc regions |
| TW200637574A (en) * | 2005-01-13 | 2006-11-01 | Genentech Inc | Treatment method |
| JP5156392B2 (ja) | 2005-02-03 | 2013-03-06 | トポターゲット ユーケー リミテッド | Hdac阻害剤を用いる併用療法 |
| HUE025945T2 (en) * | 2005-02-15 | 2016-07-28 | Univ Duke | Anti-CD19 antibodies and their applications in oncology |
| US8444973B2 (en) | 2005-02-15 | 2013-05-21 | Duke University | Anti-CD19 antibodies and uses in B cell disorders |
| CA2603414C (en) | 2005-03-31 | 2012-09-18 | Biomedics Inc. | Anti-cd20 monoclonal antibody |
| EP2096166A1 (en) * | 2005-03-31 | 2009-09-02 | Osaka University | Method for production of antibody directed against cell membrane surface antigen epitope and assaying method |
| ATE542527T1 (de) | 2005-05-13 | 2012-02-15 | Topotarget Uk Ltd | Pharmazeutische formulierungen von hdac-hemmern |
| ZA200709956B (en) | 2005-05-20 | 2009-02-25 | Genentech Inc | Pretreatment of a biological sample from an autoimmune disease subject |
| JP2008541758A (ja) * | 2005-06-02 | 2008-11-27 | アストラゼネカ エービー | Cd20に対する抗体およびその使用 |
| WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| RU2474585C2 (ru) | 2007-01-22 | 2013-02-10 | Дженентек, Инк. | Осаждение и очистка белков полиэлектролитами |
| AU2016228280B2 (en) * | 2007-07-12 | 2019-02-21 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| MX2010000970A (es) | 2007-07-31 | 2010-03-09 | Regeneron Pharma | Anticuerpos humanos contra cd20 humano y metodo para utilizarlos. |
| US8642809B2 (en) | 2007-09-25 | 2014-02-04 | Topotarget Uk Ltd. | Methods of synthesis of certain hydroxamic acid compounds |
| ES2533266T5 (es) | 2007-10-30 | 2018-04-18 | Genentech, Inc. | Purificación de anticuerpos mediante cromatografía de intercambio catiónico |
| US9669057B2 (en) | 2008-04-25 | 2017-06-06 | Duke University | Regulatory B cells and their uses |
| US10611835B2 (en) * | 2008-07-10 | 2020-04-07 | Toray Industries, Inc. | Pharmaceutical composition for treatment and prevention of cancer |
| US8652843B2 (en) | 2008-08-12 | 2014-02-18 | Oncomed Pharmaceuticals, Inc. | DDR1-binding agents and methods of use thereof |
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| DE102008044845B4 (de) * | 2008-08-28 | 2015-04-09 | Epcos Ag | Bias-Netzwerk |
| CN103599541A (zh) | 2008-09-10 | 2014-02-26 | 弗·哈夫曼-拉罗切有限公司 | 用于防止蛋白质氧化降解的组合物和方法 |
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| KR20110128876A (ko) * | 2009-02-16 | 2011-11-30 | 바이오렉스 쎄라퓨틱스, 인코포레이티드 | 인간화된 항-cd20 항체 및 이용 방법 |
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| TWI622402B (zh) | 2010-02-24 | 2018-05-01 | 免疫遺傳股份有限公司 | 葉酸受體1抗體類和免疫共軛物類及彼等之用途 |
| SG10201501803YA (en) | 2010-03-12 | 2015-05-28 | Immunogen Inc | Cd37-binding molecules and immunoconjugates thereof |
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| BR112012027828A2 (pt) | 2010-05-03 | 2016-08-09 | Genentech Inc | composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína |
| SG186783A1 (en) | 2010-06-24 | 2013-02-28 | Genentech Inc | Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations |
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| EP2600878A4 (en) * | 2010-08-04 | 2014-06-11 | Univ Duke | REGULATORY B-CELLS AND ITS USES |
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| WO2012088272A1 (en) | 2010-12-21 | 2012-06-28 | Duke University | Methods and compositions combining immunotherapy with monocyte activation |
| BR112013025415B1 (pt) | 2011-04-01 | 2021-03-16 | Immunogen, Inc | uso de um imunoconjugado antirreceptor de folato 1 (folr1) |
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| JP5969577B2 (ja) | 2016-08-17 |
| AU2004252067B2 (en) | 2012-04-12 |
| NZ568403A (en) | 2009-10-30 |
| JP2015044852A (ja) | 2015-03-12 |
| CA2525251C (en) | 2015-10-27 |
| KR101351122B1 (ko) | 2014-01-14 |
| JP2016146840A (ja) | 2016-08-18 |
| CA2897608C (en) | 2018-07-31 |
| WO2005000901A2 (en) | 2005-01-06 |
| US20170088625A1 (en) | 2017-03-30 |
| JP2011015683A (ja) | 2011-01-27 |
| CN1802388A (zh) | 2006-07-12 |
| NZ543960A (en) | 2008-11-28 |
| US9416187B2 (en) | 2016-08-16 |
| JP2013198490A (ja) | 2013-10-03 |
| WO2005000901A3 (en) | 2005-06-23 |
| JP2018082723A (ja) | 2018-05-31 |
| KR101412271B1 (ko) | 2014-06-25 |
| JP2007535301A (ja) | 2007-12-06 |
| KR20120065420A (ko) | 2012-06-20 |
| CA2897608A1 (en) | 2005-01-06 |
| EP1626993B1 (en) | 2015-03-11 |
| KR20060022238A (ko) | 2006-03-09 |
| AU2004252067A1 (en) | 2005-01-06 |
| JP5756147B2 (ja) | 2015-07-29 |
| EP2960251A1 (en) | 2015-12-30 |
| HK1219487A1 (en) | 2017-04-07 |
| US20090136516A1 (en) | 2009-05-28 |
| CA2525251A1 (en) | 2005-01-06 |
| JP5416338B2 (ja) | 2014-02-12 |
| EP1626993A2 (en) | 2006-02-22 |
| AU2004252067A2 (en) | 2005-01-06 |
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