JP5330274B2 - Ｐｉｍキナーゼ阻害剤およびその使用方法 - Google Patents

Ｐｉｍキナーゼ阻害剤およびその使用方法 Download PDF

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JP5330274B2
JP5330274B2 JP2009551895A JP2009551895A JP5330274B2 JP 5330274 B2 JP5330274 B2 JP 5330274B2 JP 2009551895 A JP2009551895 A JP 2009551895A JP 2009551895 A JP2009551895 A JP 2009551895A JP 5330274 B2 JP5330274 B2 JP 5330274B2
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tert
butyl
amino
piperidin
ylcarbamate
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JP2010520228A (ja
JP2010520228A5 (enExample
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マシュー・バーガー
ミカ・リンドヴァル
ハン・ウソク
ラン・ジオン
ジゼル・ニシグチ
シンシア・シェイファー
コーネリア・ベラマシナ
ケイ・フー
ゴーダナ・アタラー
クリストファー・マクブライド
ウィリアム・アントニオス−マクレア・ジュニア
タチアナ・ザボロティンスカヤ
アンネッテ・ヴァルター
パブロ・ガルシア
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009551895A 2007-03-01 2008-03-03 Ｐｉｍキナーゼ阻害剤およびその使用方法 Active JP5330274B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89244407P 2007-03-01 2007-03-01
US60/892,444 2007-03-01
US2377708P 2008-01-25 2008-01-25
US61/023,777 2008-01-25
PCT/US2008/055724 WO2008106692A1 (en) 2007-03-01 2008-03-03 Pim kinase inhibitors and methods of their use

Publications (3)

Publication Number Publication Date
JP2010520228A JP2010520228A (ja) 2010-06-10
JP2010520228A5 JP2010520228A5 (enExample) 2011-03-17
JP5330274B2 true JP5330274B2 (ja) 2013-10-30

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JP2009551895A Active JP5330274B2 (ja) 2007-03-01 2008-03-03 Ｐｉｍキナーゼ阻害剤およびその使用方法

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US (1) US8822497B2 (enExample)
EP (1) EP2132177B1 (enExample)
JP (1) JP5330274B2 (enExample)
KR (1) KR101514853B1 (enExample)
CN (1) CN101679266B (enExample)
AU (1) AU2008221263B2 (enExample)
BR (1) BRPI0808523A2 (enExample)
CA (1) CA2679659C (enExample)
EA (1) EA019951B1 (enExample)
ES (1) ES2431163T3 (enExample)
MX (1) MX2009009304A (enExample)
WO (1) WO2008106692A1 (enExample)

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CA2679659A1 (en) 2008-09-04
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