JP5284977B2 - ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法 - Google Patents

ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法 Download PDF

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JP5284977B2
JP5284977B2 JP2009540459A JP2009540459A JP5284977B2 JP 5284977 B2 JP5284977 B2 JP 5284977B2 JP 2009540459 A JP2009540459 A JP 2009540459A JP 2009540459 A JP2009540459 A JP 2009540459A JP 5284977 B2 JP5284977 B2 JP 5284977B2
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methyl
pyrimidin
morpholinothieno
amine
thieno
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JP2010512338A (ja
JP2010512338A5 (enExample
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トレイシー ベイリス，
イリーナ チャッコウリー，
エイドリアン フォルクス，
サリー オクセンフォード，
ナン， チー ワン，
ジョージェット カスタネード，
リチャード ゴールドスミス，
ジャネット ガンズナー，
ティム ヘフロン，
サイモン マチュー，
アラン オリベロ，
スティーヴン ステイベン，
ダニエル， ピー． サザーリン，
ビン−ヤン チュ，
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エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト
ジェネンテック， インコーポレイテッド
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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JP2009540459A 2006-12-07 2007-12-05 ホスホイノシチド３−キナーゼ阻害剤化合物及び使用方法 Active JP5284977B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87344806P 2006-12-07 2006-12-07
US60/873,448 2006-12-07
US97725707P 2007-10-03 2007-10-03
US60/977,257 2007-10-03
PCT/US2007/086543 WO2008070740A1 (en) 2006-12-07 2007-12-05 Phosphoinositide 3-kinase inhibitor compounds and methods of use

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JP2010512338A JP2010512338A (ja) 2010-04-22
JP2010512338A5 JP2010512338A5 (enExample) 2013-06-20
JP5284977B2 true JP5284977B2 (ja) 2013-09-11

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US (3) US7888352B2 (enExample)
EP (2) EP2518074B1 (enExample)
JP (1) JP5284977B2 (enExample)
KR (1) KR101460816B1 (enExample)
AR (1) AR064155A1 (enExample)
AU (1) AU2007329352B2 (enExample)
BR (1) BRPI0717923A2 (enExample)
CA (1) CA2671782C (enExample)
CL (1) CL2007003520A1 (enExample)
CO (1) CO6190615A2 (enExample)
CR (1) CR10915A (enExample)
EC (1) ECSP099496A (enExample)
ES (1) ES2544082T3 (enExample)
MA (1) MA31146B1 (enExample)
MX (1) MX2009005950A (enExample)
MY (1) MY180595A (enExample)
NO (1) NO20092566L (enExample)
NZ (1) NZ578162A (enExample)
PE (1) PE20081679A1 (enExample)
RU (1) RU2468027C2 (enExample)
TW (1) TWI499420B (enExample)
WO (1) WO2008070740A1 (enExample)

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US20080242665A1 (en) 2008-10-02
CL2007003520A1 (es) 2008-08-22
US20110097349A1 (en) 2011-04-28
EP2518074B1 (en) 2015-07-22
RU2009125897A (ru) 2011-01-20
MY180595A (en) 2020-12-03
AR064155A1 (es) 2009-03-18
US8993563B2 (en) 2015-03-31
EP2114949A1 (en) 2009-11-11
KR101460816B1 (ko) 2014-11-12
EP2518074A1 (en) 2012-10-31

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