JP5261575B2 - 化学化合物 - Google Patents
化学化合物 Download PDFInfo
- Publication number
- JP5261575B2 JP5261575B2 JP2011515631A JP2011515631A JP5261575B2 JP 5261575 B2 JP5261575 B2 JP 5261575B2 JP 2011515631 A JP2011515631 A JP 2011515631A JP 2011515631 A JP2011515631 A JP 2011515631A JP 5261575 B2 JP5261575 B2 JP 5261575B2
- Authority
- JP
- Japan
- Prior art keywords
- thiazolidine
- dione
- phenyl
- methylidene
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *c(c(*)c1*)cc(C=O)c1F Chemical compound *c(c(*)c1*)cc(C=O)c1F 0.000 description 1
- PCPARURGLGSLFB-CJAAZZPWSA-N CN(C)[C@@H](CC1)CN1c(c(/C=C(/C(N1)=O)\SC1=O)ccc1)c1[Br]=C Chemical compound CN(C)[C@@H](CC1)CN1c(c(/C=C(/C(N1)=O)\SC1=O)ccc1)c1[Br]=C PCPARURGLGSLFB-CJAAZZPWSA-N 0.000 description 1
- SYFAMQSVMVHCIS-NSHDSACASA-N CN(C)[C@@H](CC1)CN1c1c(C=O)cccc1Br Chemical compound CN(C)[C@@H](CC1)CN1c1c(C=O)cccc1Br SYFAMQSVMVHCIS-NSHDSACASA-N 0.000 description 1
- DCEQRIXNZLRPRR-PXNMLYILSA-N COc(c(OC)c1)cc(/C=C(/C(N2)=O)\SC2=O)c1N(CC1)CC1NCCO Chemical compound COc(c(OC)c1)cc(/C=C(/C(N2)=O)\SC2=O)c1N(CC1)CC1NCCO DCEQRIXNZLRPRR-PXNMLYILSA-N 0.000 description 1
- VWJNQFFHSJTVGQ-CJAAZZPWSA-N C[n]1c(C(N[C@@H](CC2)CN2c(c(/C=C(/C(N2)=O)\SC2=O)ccc2)c2Cl)=O)ncc1 Chemical compound C[n]1c(C(N[C@@H](CC2)CN2c(c(/C=C(/C(N2)=O)\SC2=O)ccc2)c2Cl)=O)ncc1 VWJNQFFHSJTVGQ-CJAAZZPWSA-N 0.000 description 1
- WLDPWZQYAVZTTP-UHFFFAOYSA-N C[n]1c(C(O)=O)ncc1 Chemical compound C[n]1c(C(O)=O)ncc1 WLDPWZQYAVZTTP-UHFFFAOYSA-N 0.000 description 1
- NJYIOPRYGAGQCB-ISAHRAOESA-N N[C@@H](CC1)CN1c(c(/C=C(/C(N1)=O)\SC1=O)ccc1)c1Cl Chemical compound N[C@@H](CC1)CN1c(c(/C=C(/C(N1)=O)\SC1=O)ccc1)c1Cl NJYIOPRYGAGQCB-ISAHRAOESA-N 0.000 description 1
- MCUJKPPARUPFJM-UWCCDQBKSA-N N[C@H](CCC1)CN1c1c(/C=C(/C(N2)=O)\SC2=O)cccc1-c1ccccc1 Chemical compound N[C@H](CCC1)CN1c1c(/C=C(/C(N2)=O)\SC2=O)cccc1-c1ccccc1 MCUJKPPARUPFJM-UWCCDQBKSA-N 0.000 description 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N O=C(CS1)NC1=O Chemical compound O=C(CS1)NC1=O ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7763908P | 2008-07-02 | 2008-07-02 | |
| US61/077,639 | 2008-07-02 | ||
| US18327809P | 2009-06-02 | 2009-06-02 | |
| US61/183,278 | 2009-06-02 | ||
| PCT/GB2009/050773 WO2010001169A2 (en) | 2008-07-02 | 2009-07-02 | Chemical compounds 251 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013031176A Division JP2013139459A (ja) | 2008-07-02 | 2013-02-20 | 化学化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011526616A JP2011526616A (ja) | 2011-10-13 |
| JP2011526616A5 JP2011526616A5 (enExample) | 2013-04-11 |
| JP5261575B2 true JP5261575B2 (ja) | 2013-08-14 |
Family
ID=41050276
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011515631A Expired - Fee Related JP5261575B2 (ja) | 2008-07-02 | 2009-07-02 | 化学化合物 |
| JP2013031176A Ceased JP2013139459A (ja) | 2008-07-02 | 2013-02-20 | 化学化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013031176A Ceased JP2013139459A (ja) | 2008-07-02 | 2013-02-20 | 化学化合物 |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8901307B2 (enExample) |
| EP (1) | EP2310010A2 (enExample) |
| JP (2) | JP5261575B2 (enExample) |
| KR (1) | KR20110031367A (enExample) |
| CN (2) | CN103804371A (enExample) |
| AR (1) | AR072791A1 (enExample) |
| AU (1) | AU2009265362B2 (enExample) |
| BR (1) | BRPI0914599A2 (enExample) |
| CA (1) | CA2729557A1 (enExample) |
| CL (1) | CL2010001636A1 (enExample) |
| CO (1) | CO6341555A2 (enExample) |
| CR (1) | CR20110016A (enExample) |
| DO (1) | DOP2010000408A (enExample) |
| EA (1) | EA018989B1 (enExample) |
| EC (1) | ECSP10010735A (enExample) |
| HN (1) | HN2010002786A (enExample) |
| IL (1) | IL210127A0 (enExample) |
| MX (1) | MX2010014233A (enExample) |
| MY (1) | MY155961A (enExample) |
| NI (1) | NI201100007A (enExample) |
| NZ (1) | NZ590859A (enExample) |
| PE (1) | PE20120304A1 (enExample) |
| SV (1) | SV2011003786A (enExample) |
| TW (1) | TWI461423B (enExample) |
| UY (1) | UY31952A (enExample) |
| WO (1) | WO2010001169A2 (enExample) |
| ZA (1) | ZA201100844B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013139459A (ja) * | 2008-07-02 | 2013-07-18 | Astrazeneca Ab | 化学化合物 |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3184526T3 (en) | 2005-12-13 | 2019-01-14 | Incyte Holdings Corp | PYRROLO [2,3-D] PYRIMIDINE DERIVATIVES AS A JANUS-KINASE INHIBITOR |
| EP2740731B1 (en) | 2007-06-13 | 2016-03-23 | Incyte Holdings Corporation | Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| WO2010135621A1 (en) | 2009-05-22 | 2010-11-25 | Incyte Corporation | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
| ES2487542T3 (es) | 2009-05-22 | 2014-08-21 | Incyte Corporation | Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus |
| WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| SMT201800137T1 (it) | 2010-03-10 | 2018-07-17 | Incyte Holdings Corp | Derivati di piperidin-4-il azetidina come inibitori di jak1 |
| PH12012502296B1 (en) | 2010-05-21 | 2017-10-06 | Incyte Holdings Corp | Topical formulation for a jak inhibitor |
| ES2536415T3 (es) | 2010-11-19 | 2015-05-25 | Incyte Corporation | Pirrolopiridinas y pirrolopirimidinas sustituidas heterocíclicas como inhibidores de JAK |
| SG190839A1 (en) | 2010-11-19 | 2013-07-31 | Incyte Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| WO2012177606A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| WO2013051672A1 (ja) * | 2011-10-04 | 2013-04-11 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とする医薬品 |
| US9422246B2 (en) | 2012-03-30 | 2016-08-23 | Rohto Pharmaceutical Co., Ltd. | Benzylidene azolidine derivative or salt thereof |
| WO2013173720A1 (en) | 2012-05-18 | 2013-11-21 | Incyte Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| WO2014007228A1 (ja) | 2012-07-03 | 2014-01-09 | 小野薬品工業株式会社 | ソマトスタチン受容体作動活性を有する化合物およびその医薬用途 |
| PE20151157A1 (es) | 2012-11-15 | 2015-08-19 | Incyte Corp | Formas de dosificacion de ruxolitinib de liberacion sostenida |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| HUE050215T2 (hu) | 2013-01-15 | 2020-11-30 | Incyte Holdings Corp | Pim kináz inhibitorokként hasznos tiazolkarboxamid és piridinkarboxamid vegyületek |
| LT3489239T (lt) | 2013-03-06 | 2022-03-10 | Incyte Holdings Corporation | Jak inhibitoriaus gamybos būdai ir tarpiniai junginiai |
| JP6378918B2 (ja) * | 2013-04-03 | 2018-08-22 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とするＰｉｍ阻害剤 |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| UA120499C2 (uk) | 2013-08-07 | 2019-12-26 | Інсайт Корпорейшн | Лікування захворювань із застосуванням лікарських форм з уповільненим вивільненням для інгібітора jak1 |
| TW201605866A (zh) | 2013-08-23 | 2016-02-16 | 英塞特公司 | 可用作ｐｉｍ激酶抑制劑之呋喃并－及噻吩并－吡啶甲醯胺化合物 |
| WO2015046389A1 (ja) * | 2013-09-27 | 2015-04-02 | ロート製薬株式会社 | 新規ベンジリデンアゾリジン誘導体またはその塩を含む皮膚外用組成物 |
| TW201601763A (zh) * | 2013-09-27 | 2016-01-16 | 樂敦製藥股份有限公司 | 皮膚外用組成物 |
| WO2015122504A1 (ja) * | 2014-02-13 | 2015-08-20 | 国立大学法人 東京大学 | キナーゼ阻害剤 |
| WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
| JP5857104B2 (ja) * | 2014-06-17 | 2016-02-10 | ロート製薬株式会社 | ベンジリデンアゾリジン誘導体またはその塩を含む皮膚外用組成物 |
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| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
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| PE20190971A1 (es) | 2016-06-13 | 2019-07-09 | Glaxosmithkline Ip Dev Ltd | Compuestos quimicos |
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| IL276302B2 (en) | 2018-01-30 | 2023-11-01 | Incyte Corp | Procedures for preparing [1-(3-fluoro-2-(trifluoromethyl(isonicotinyl}piperidine-4-one) |
| SMT202400306T1 (it) | 2018-03-30 | 2024-09-16 | Incyte Corp | Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak. |
| WO2019209083A1 (ko) * | 2018-04-26 | 2019-10-31 | 재단법인 의약바이오컨버젼스연구단 | mTOR 저해제로서의 신규 화합물 및 이의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013139459A (ja) * | 2008-07-02 | 2013-07-18 | Astrazeneca Ab | 化学化合物 |
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