EA201100119A1 - Химические соединения 251 - Google Patents

Химические соединения 251

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Publication number
EA201100119A1
EA201100119A1 EA201100119A EA201100119A EA201100119A1 EA 201100119 A1 EA201100119 A1 EA 201100119A1 EA 201100119 A EA201100119 A EA 201100119A EA 201100119 A EA201100119 A EA 201100119A EA 201100119 A1 EA201100119 A1 EA 201100119A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pim
relates
chemical compounds
modulators
inhibitors
Prior art date
Application number
EA201100119A
Other languages
English (en)
Other versions
EA018989B1 (ru
Inventor
Лесли Дейкин
Джеймс Эдуард Даулинг
Мишелл Лемб
Джон Рид
Цибинь Су
Сяолань Чжэн
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41050276&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201100119(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201100119A1 publication Critical patent/EA201100119A1/ru
Publication of EA018989B1 publication Critical patent/EA018989B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Изобретение относится к химическим соединениям формулы I,и их солям. В некоторых вариантах осуществления изобретение относится к ингибиторам или модуляторам активности PIM-1, и/или PIM-2, и/или PIM-3 протеинкиназы или функции фермента. В других вариантах осуществления изобретение относится к фармацевтическим композициям, которые содержат соединения, описанные в настоящей заявке, и к их применению для предотвращения и лечения состояний и заболеваний, связанных с PIM киназой, предпочтительно злокачественного новообразования.
EA201100119A 2008-07-02 2009-07-02 Производные 2,4-диоксотиазолидинилиденметана EA018989B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7763908P 2008-07-02 2008-07-02
US18327809P 2009-06-02 2009-06-02
PCT/GB2009/050773 WO2010001169A2 (en) 2008-07-02 2009-07-02 Chemical compounds 251

Publications (2)

Publication Number Publication Date
EA201100119A1 true EA201100119A1 (ru) 2011-08-30
EA018989B1 EA018989B1 (ru) 2013-12-30

Family

ID=41050276

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100119A EA018989B1 (ru) 2008-07-02 2009-07-02 Производные 2,4-диоксотиазолидинилиденметана

Country Status (27)

Country Link
US (2) US8901307B2 (ru)
EP (1) EP2310010A2 (ru)
JP (2) JP5261575B2 (ru)
KR (1) KR20110031367A (ru)
CN (2) CN103804371A (ru)
AR (1) AR072791A1 (ru)
AU (1) AU2009265362B2 (ru)
BR (1) BRPI0914599A2 (ru)
CA (1) CA2729557A1 (ru)
CL (1) CL2010001636A1 (ru)
CO (1) CO6341555A2 (ru)
CR (1) CR20110016A (ru)
DO (1) DOP2010000408A (ru)
EA (1) EA018989B1 (ru)
EC (1) ECSP10010735A (ru)
HN (1) HN2010002786A (ru)
IL (1) IL210127A0 (ru)
MX (1) MX2010014233A (ru)
MY (1) MY155961A (ru)
NI (1) NI201100007A (ru)
NZ (1) NZ590859A (ru)
PE (1) PE20120304A1 (ru)
SV (1) SV2011003786A (ru)
TW (1) TWI461423B (ru)
UY (1) UY31952A (ru)
WO (1) WO2010001169A2 (ru)
ZA (1) ZA201100844B (ru)

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CL2010001636A1 (es) 2011-07-15
BRPI0914599A2 (pt) 2017-06-06
EA018989B1 (ru) 2013-12-30
JP2013139459A (ja) 2013-07-18
CO6341555A2 (es) 2011-11-21
US20150051185A1 (en) 2015-02-19
US8901307B2 (en) 2014-12-02
UY31952A (es) 2010-01-29
CN103804371A (zh) 2014-05-21
NZ590859A (en) 2012-08-31
CR20110016A (es) 2011-03-11
AU2009265362B2 (en) 2012-07-19
JP2011526616A (ja) 2011-10-13
CA2729557A1 (en) 2010-01-07
KR20110031367A (ko) 2011-03-25
ECSP10010735A (es) 2011-01-31
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CN102137666A (zh) 2011-07-27
MX2010014233A (es) 2011-03-25
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AR072791A1 (es) 2010-09-22
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US20110218182A1 (en) 2011-09-08
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ZA201100844B (en) 2011-10-26
MY155961A (en) 2015-12-31
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