JP5198256B2 - 縮合複素環式化合物、並びにそれらの組成物及び使用 - Google Patents
縮合複素環式化合物、並びにそれらの組成物及び使用 Download PDFInfo
- Publication number
- JP5198256B2 JP5198256B2 JP2008510301A JP2008510301A JP5198256B2 JP 5198256 B2 JP5198256 B2 JP 5198256B2 JP 2008510301 A JP2008510301 A JP 2008510301A JP 2008510301 A JP2008510301 A JP 2008510301A JP 5198256 B2 JP5198256 B2 JP 5198256B2
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- Japan
- Prior art keywords
- substituted
- unsubstituted
- aryl
- alkyl
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC1C(*=CC)=C(C)CC1 Chemical compound CC1C(*=CC)=C(C)CC1 0.000 description 5
- VNKZQBKUCFALNT-UHFFFAOYSA-N CN1C=COC1 Chemical compound CN1C=COC1 VNKZQBKUCFALNT-UHFFFAOYSA-N 0.000 description 1
- SKMUADUXCABNRO-UHFFFAOYSA-N CN1C=CSC1 Chemical compound CN1C=CSC1 SKMUADUXCABNRO-UHFFFAOYSA-N 0.000 description 1
- SJRJJKPEHAURKC-UHFFFAOYSA-N CN1CCOCC1 Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 1
- FNKSTXGVEUSZJJ-UHFFFAOYSA-N CN1COCC1 Chemical compound CN1COCC1 FNKSTXGVEUSZJJ-UHFFFAOYSA-N 0.000 description 1
- DGYVIUKQSWPZCL-UHFFFAOYSA-N CN1CSCC1 Chemical compound CN1CSCC1 DGYVIUKQSWPZCL-UHFFFAOYSA-N 0.000 description 1
- SDFLTYHTFPTIGX-UHFFFAOYSA-N C[n]1c(cccc2)c2c2c1cccc2 Chemical compound C[n]1c(cccc2)c2c2c1cccc2 SDFLTYHTFPTIGX-UHFFFAOYSA-N 0.000 description 1
- MCTWTZJPVLRJOU-UHFFFAOYSA-N C[n]1cncc1 Chemical compound C[n]1cncc1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 description 1
- XILPCSMEKCBYFO-UHFFFAOYSA-N C[n]1cnnc1 Chemical compound C[n]1cnnc1 XILPCSMEKCBYFO-UHFFFAOYSA-N 0.000 description 1
- VWSPMHNPEFIUMD-UHFFFAOYSA-N Cc(cc1)cnc1N(CC1)CC2=C1N=CNC2=O Chemical compound Cc(cc1)cnc1N(CC1)CC2=C1N=CNC2=O VWSPMHNPEFIUMD-UHFFFAOYSA-N 0.000 description 1
- LHDNANWILVFGFL-UHFFFAOYSA-N Cc1ccc(N(CC2)Cc3c2ncnc3C)nc1 Chemical compound Cc1ccc(N(CC2)Cc3c2ncnc3C)nc1 LHDNANWILVFGFL-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67776005P | 2005-05-04 | 2005-05-04 | |
| US60/677,760 | 2005-05-04 | ||
| PCT/US2006/017614 WO2006119504A2 (en) | 2005-05-04 | 2006-05-04 | Fused heterocyclic compounds, and compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012132675A Division JP5722280B2 (ja) | 2005-05-04 | 2012-06-12 | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546639A JP2008546639A (ja) | 2008-12-25 |
| JP2008546639A5 JP2008546639A5 (https=) | 2009-06-25 |
| JP5198256B2 true JP5198256B2 (ja) | 2013-05-15 |
Family
ID=37308747
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510301A Expired - Lifetime JP5198256B2 (ja) | 2005-05-04 | 2006-05-04 | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
| JP2012132675A Expired - Lifetime JP5722280B2 (ja) | 2005-05-04 | 2012-06-12 | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012132675A Expired - Lifetime JP5722280B2 (ja) | 2005-05-04 | 2012-06-12 | 縮合複素環式化合物、並びにそれらの組成物及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7745451B2 (https=) |
| EP (1) | EP1885369B1 (https=) |
| JP (2) | JP5198256B2 (https=) |
| CA (1) | CA2606760C (https=) |
| ES (1) | ES2552804T3 (https=) |
| MX (1) | MX2007013595A (https=) |
| WO (1) | WO2006119504A2 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007013595A (es) * | 2005-05-04 | 2008-01-24 | Renovis Inc | Compuestos heterociclicos fusionados y composiciones y usos de estos. |
| EP2136639B1 (en) * | 2007-04-02 | 2016-03-09 | Evotec AG | Pyrid-2-yl fused heterocyclic compounds, and compositions and uses thereof |
| PT2139334E (pt) * | 2007-04-17 | 2013-10-02 | Evotec Ag | Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos |
| JP2011502148A (ja) | 2007-10-31 | 2011-01-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛の治療用としてのp2x3受容体アンタゴニスト |
| CA2703915C (en) | 2007-10-31 | 2015-02-24 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| SG187502A1 (en) | 2008-02-01 | 2013-02-28 | Takeda Pharmaceutical | Oxim derivatives as hsp90 inhibitors |
| CA2715835C (en) | 2008-02-29 | 2017-03-21 | Renovis, Inc. | Amide compounds, compositions and uses thereof |
| MX2011004570A (es) | 2008-10-31 | 2011-06-17 | Merck Sharp & Dohme | Antagonistas del receptor p2x3 para el tratamiento del dolor. |
| AU2012202178B2 (en) * | 2008-12-19 | 2012-11-01 | Amgen Inc. | Method for the preparation of 1-acetyl-6-amino-3, 3-dimethyl-2, 3 -dihydroindole |
| AU2009327349B2 (en) * | 2008-12-19 | 2012-03-15 | Amgen Inc. | Method for the preparation of 1-acetyl-6-amino-3, 3-dimethyl-2, 3 -dihydroindole |
| PL2399910T3 (pl) | 2009-02-13 | 2014-09-30 | Shionogi & Co | Pochodne triazyny jako antagoniści receptora p2x3 i/albo p2x2/3 i kompozycja farmaceutyczna zawierająca je |
| WO2010111059A1 (en) | 2009-03-23 | 2010-09-30 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| AU2010229142A1 (en) | 2009-03-23 | 2011-10-13 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| US8569512B2 (en) | 2009-03-23 | 2013-10-29 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| UA112517C2 (uk) * | 2010-07-06 | 2016-09-26 | Новартіс Аг | Тетрагідропіридопіримідинові похідні |
| JP6075621B2 (ja) * | 2010-08-10 | 2017-02-08 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
| CN103153968B (zh) | 2010-08-10 | 2016-02-03 | 盐野义制药株式会社 | 三唑衍生物及含有其的具有镇痛作用的药物组合物 |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2790705B1 (en) | 2011-12-15 | 2017-12-06 | Novartis AG | Use of inhibitors of the activity or function of pi3k |
| FR2984323B1 (fr) * | 2011-12-16 | 2019-08-30 | L'oreal | Coupleur de structure 7 amino-1,2,3,4-tetrahydroquinoleines, composition tinctoriale en comprenant, procedes et utilisations |
| FR2984318B1 (fr) | 2011-12-16 | 2014-06-27 | Oreal | Coupleur de structure 7 amino-1,2,3,4-tetrahydroquinoleines cationiques, composition tinctoriale en comprenant, procedes et utilisations |
| WO2013118855A1 (ja) | 2012-02-09 | 2013-08-15 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
| WO2013134518A1 (en) * | 2012-03-09 | 2013-09-12 | Amgen Inc. | Sulfamide sodium channel inhibitors |
| UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| TWI499591B (zh) * | 2013-01-11 | 2015-09-11 | Lilly Co Eli | 雙環嘧啶化合物 |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
| PL3089971T3 (pl) | 2014-01-01 | 2021-01-25 | Medivation Technologies Llc | Związki i sposoby ich zastosowania |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| EP3230281B1 (en) | 2014-12-09 | 2021-05-26 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
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| US20100317676A1 (en) | 2010-12-16 |
| CA2606760C (en) | 2014-12-23 |
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| EP1885369B1 (en) | 2015-09-23 |
| JP2008546639A (ja) | 2008-12-25 |
| US7745451B2 (en) | 2010-06-29 |
| US8859545B2 (en) | 2014-10-14 |
| EP1885369A4 (en) | 2010-04-14 |
| WO2006119504A3 (en) | 2009-06-11 |
| WO2006119504A2 (en) | 2006-11-09 |
| CA2606760A1 (en) | 2006-11-09 |
| MX2007013595A (es) | 2008-01-24 |
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