JP5021614B2 - 取り外し可能な光学モジュールを有する多重蛍光検出装置 - Google Patents

取り外し可能な光学モジュールを有する多重蛍光検出装置 Download PDF

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JP5021614B2
JP5021614B2 JP2008504192A JP2008504192A JP5021614B2 JP 5021614 B2 JP5021614 B2 JP 5021614B2 JP 2008504192 A JP2008504192 A JP 2008504192A JP 2008504192 A JP2008504192 A JP 2008504192A JP 5021614 B2 JP5021614 B2 JP 5021614B2
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optical
disk
optical module
module
light
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JP2008537594A5 (https=
JP2008537594A (ja
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ベディンガム，ウィリアム
ディー． ルドワイズ，ピーター
ダブリュ． ロボール，バリー
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3M Innovative Properties Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/173—Nucleic acid detection characterized by the use of physical, structural and functional properties staining/intercalating agent, e.g. ethidium bromide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/024—Modular construction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2008504192A 2005-04-01 2006-03-24 取り外し可能な光学モジュールを有する多重蛍光検出装置 Expired - Lifetime JP5021614B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66746105P 2005-04-01 2005-04-01
US60/667,461 2005-04-01
US11/174,754 US7507575B2 (en) 2005-04-01 2005-07-05 Multiplex fluorescence detection device having removable optical modules
US11/174,754 2005-07-05
PCT/US2006/010787 WO2006107619A1 (en) 2005-04-01 2006-03-24 Multiplex fluorescence detection device having removable optical modules

Publications (3)

Publication Number Publication Date
JP2008537594A JP2008537594A (ja) 2008-09-18
JP2008537594A5 JP2008537594A5 (https=) 2009-05-07
JP5021614B2 true JP5021614B2 (ja) 2012-09-12

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Country Link
US (2) US7507575B2 (https=)
EP (2) EP2207026A1 (https=)
JP (1) JP5021614B2 (https=)
KR (1) KR101265362B1 (https=)
AT (1) ATE472099T1 (https=)
AU (1) AU2006232922A1 (https=)
BR (1) BRPI0609544B8 (https=)
CA (1) CA2602587A1 (https=)
DE (1) DE602006015043D1 (https=)
ES (1) ES2347077T3 (https=)
MX (1) MX2007012159A (https=)
WO (1) WO2006107619A1 (https=)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) * 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7527763B2 (en) * 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US20070009382A1 (en) * 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
CN102046807B (zh) * 2008-04-24 2014-11-26 3M创新有限公司 利用小波变换分析核酸扩增曲线
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
GB0817991D0 (en) * 2008-10-02 2008-11-05 Enigma Diagnostics Ltd Fluorescence based detection methods and apparatus
JP5655232B2 (ja) * 2008-12-05 2015-01-21 ビオカルティ ナームローゼ フェノーツハップＢｉｏｃａｒｔｉｓ ＮＶ 搬送ヒータを有する熱サイクルシステム
JP5279481B2 (ja) * 2008-12-25 2013-09-04 株式会社日立ハイテクノロジーズ 核酸分析装置
EP2391732B1 (en) 2009-01-30 2015-05-27 Oxford Nanopore Technologies Limited Methods using adaptors for nucleic acid constructs in transmembrane sequencing
EP2419743B1 (en) * 2009-04-15 2020-08-05 Biocartis NV OPTICAL DETECTION SYSTEM FOR MONITORING rtPCR REACTION
EP2277624A3 (en) * 2009-07-20 2013-12-18 Samsung Electronics Co., Ltd. Disk type microfluidic device and blood testing apparatus using the same
CN102482720B (zh) * 2009-09-10 2014-10-08 3M创新有限公司 对多重核酸扩增中的光谱串扰的补偿
US9127313B2 (en) 2009-12-01 2015-09-08 Oxford Nanopore Technologies Limited Biochemical analysis instrument
AU2011220873B2 (en) 2010-02-23 2014-07-10 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
CN102175612B (zh) * 2011-01-18 2012-12-26 河北工业大学 一种多路光电检测装置
US9096892B1 (en) 2011-02-04 2015-08-04 K2 Biomicrosystems, LLC Nucleic acid amplification and monitoring apparatus
CA3043100C (en) 2011-03-08 2022-03-01 Universite Laval Fluidic centripetal device
ES2769028T3 (es) * 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
CN104023834B (zh) 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
JP6298404B2 (ja) 2011-07-25 2018-03-20 オックスフォード ナノポール テクノロジーズ リミテッド 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
WO2013049443A1 (en) * 2011-09-30 2013-04-04 Life Technologies Corporation Methods and systems for visualizing and evaluating data
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CN114717296B (zh) 2012-02-03 2025-04-04 加州理工学院 多路生化测定中信号的编码和解码
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
CN204832037U (zh) 2012-04-03 2015-12-02 伊鲁米那股份有限公司 检测设备
BR112014026197B1 (pt) * 2012-04-23 2020-10-13 Siemens Healthcare Diagnostics Inc. analisador de amostra e método para analisar uma amostra de ensaio
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
EP3901243A1 (en) * 2012-08-03 2021-10-27 California Institute of Technology Multiplexing and quantification in pcr with reduced hardware and requirements
EP2883039A1 (en) 2012-08-10 2015-06-17 Streck Inc. Real-time optical system for polymerase chain reaction
CN103364378B (zh) * 2013-03-05 2016-04-20 江苏天瑞仪器股份有限公司 一种用于原子荧光光谱仪的多功能联合进样系统
CA2901545C (en) 2013-03-08 2019-10-08 Oxford Nanopore Technologies Limited Use of spacer elements in a nucleic acid to control movement of a helicase
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
US8858886B1 (en) 2013-05-08 2014-10-14 Agilent Technologies, Inc. Scanning system with interchangeable optical cartridges for fluorescence measurements
EP3014251A1 (en) 2013-06-28 2016-05-04 Streck Inc. Devices for real-time polymerase chain reaction
DE102013012609B4 (de) * 2013-07-26 2024-06-27 Carl Zeiss Microscopy Gmbh Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop
ES2939140T3 (es) 2013-08-08 2023-04-19 Illumina Inc Sistema de fluido para el suministro de reactivos a una celda de flujo
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
GB201418159D0 (en) 2014-10-14 2014-11-26 Oxford Nanopore Tech Ltd Method
US20180268358A1 (en) * 2015-01-09 2018-09-20 Apex Industrial Technologies Llc Order fulfillment system and method with item sensor
WO2016160996A1 (en) * 2015-03-30 2016-10-06 DeNovix, Inc. Apparatus and method for measuring fluorescence of a sample
US10209242B2 (en) 2015-05-21 2019-02-19 Emit Imaging, Inc. Fluorescence histo-tomography (FHT) systems and methods
KR20180048586A (ko) * 2015-08-31 2018-05-10 인비크로, 엘엘씨 형광 조직-단층촬영(fht) 시스템 및 방법
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US10272510B2 (en) * 2016-01-14 2019-04-30 United Technologies Corporation Electrical discharge machining apparatus
JP6687834B2 (ja) * 2016-02-03 2020-04-28 株式会社Ｊｖｃケンウッド 分析装置及び分析方法
WO2017204513A1 (ko) * 2016-05-25 2017-11-30 옵토레인 주식회사 피씨알모듈 및 이를 이용한 검사방법
GB201609220D0 (en) 2016-05-25 2016-07-06 Oxford Nanopore Tech Ltd Method
WO2017204512A1 (ko) * 2016-05-25 2017-11-30 옵토레인 주식회사 피씨알모듈
CN106198480B (zh) * 2016-08-30 2018-09-14 广州蓝勃生物科技有限公司 一种自动干式荧光检测仪
CN106290286A (zh) * 2016-09-20 2017-01-04 广东顺德工业设计研究院(广东顺德创新设计研究院) 时间分辨荧光分析系统及检测装置
GB201704771D0 (en) 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
US10431441B2 (en) * 2018-01-31 2019-10-01 Palodex Group Oy Reducing calibration of components in an imaging plate scanner
US12454720B2 (en) 2018-04-17 2025-10-28 ChromaCode, Inc. Methods and systems for multiplex analysis
GB201807793D0 (en) 2018-05-14 2018-06-27 Oxford Nanopore Tech Ltd Method
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
CN110656046A (zh) * 2019-11-01 2020-01-07 中国人民解放军军事科学院军事医学研究院 一种探测装置及pcr仪
CN112823890B (zh) * 2020-07-30 2024-07-19 北京金诺美科技股份有限公司 一种实时荧光定量pcr仪
CN112798773A (zh) * 2020-12-27 2021-05-14 北京工业大学 一种基于stm32单片机的高分辨率酶标仪电控系统
US12461030B2 (en) * 2021-03-10 2025-11-04 Northeastern University Point of care viral detection system using turbo fluorescence in situ hybridization
EP4419893A4 (en) * 2021-10-20 2025-08-06 Bio Rad Laboratories Inc FLUORESCENCE DETECTION SYSTEM

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055944A1 (de) 1970-11-13 1972-05-18 Leitz Ernst Gmbh Fluoreszenzauflichtilluminator
US3918793A (en) * 1970-05-02 1975-11-11 Leitz Ernst Gmbh Fluorescence illuminator for incident light microscope
DE2420545C3 (de) 1974-04-27 1979-01-25 H. Maihak Ag, 2000 Hamburg Infrarotstrahleranordnung
JPS55156840A (en) 1979-05-25 1980-12-06 Olympus Optical Co Ltd Specimen detector
JPS6120839A (ja) 1984-07-10 1986-01-29 Fuji Photo Film Co Ltd バクテリアカウンタ
US4726676A (en) * 1986-02-06 1988-02-23 General Signal Corporation Optical signal power measurement method and apparatus
US4927766A (en) 1986-05-27 1990-05-22 The Boc Group, Inc. Gas constituent measurement and recording
US4909990A (en) 1987-09-02 1990-03-20 Myron J. Block Immunoassay apparatus
GB8919700D0 (en) 1989-08-31 1989-10-11 Electricity Council Infra-red radiation emission arrangement
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5296958A (en) * 1992-05-29 1994-03-22 Eastman Kodak Company Multiple wavelength laser beam scanning system
CA2100020C (en) 1992-07-17 2001-09-11 Walter Blumenfeld Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array
JPH0634546A (ja) 1992-07-17 1994-02-08 Tosoh Corp 蛍光検出器
US5414600A (en) 1993-07-30 1995-05-09 Cogent Light Technologies, Inc. Condensing and collecting optical system using an ellipsoidal reflector
DE69519783T2 (de) 1994-04-29 2001-06-07 Perkin-Elmer Corp., Foster City Verfahren und vorrichtung zur echtzeiterfassung der produkte von nukleinsäureamplifikation
US5766889A (en) 1994-06-08 1998-06-16 The Perkin-Elmer Corporation Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US6327031B1 (en) 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5639668A (en) 1995-09-14 1997-06-17 Boehringer Mannheim Corporation Optical apparatus for performing an immunoassay
US6342349B1 (en) 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US5751874A (en) * 1996-09-13 1998-05-12 Nuvisions International, Inc. Coupling device for linking optical fiber connectors
DE19707226A1 (de) * 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
CN1249816A (zh) 1997-02-28 2000-04-05 伯斯坦恩实验室股份有限公司 盘片中的实验室
EP0969452A4 (en) * 1997-03-25 2000-12-27 Sanyo Electric Co INFORMATION REPRODUCING AND RECORDING DEVICE AND REFERENCE MARK DETECTION CIRCUIT
DE59802165D1 (de) * 1997-09-05 2001-12-20 Leica Microsystems Mikroskop, insbesondere fluoreszenzmikroskop, insbesondere stereo-fluoreszenzmikroskop
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
US6561428B2 (en) * 1997-10-17 2003-05-13 Hand Held Products, Inc. Imaging device having indicia-controlled image parsing mode
US5994150A (en) 1997-11-19 1999-11-30 Imation Corp. Optical assaying method and system having rotatable sensor disk with multiple sensing regions
DE69938493T2 (de) * 1998-01-26 2009-05-20 Massachusetts Institute Of Technology, Cambridge Endoskop zur erfassung von fluoreszenzbilder
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US6014618A (en) * 1998-08-06 2000-01-11 Dsp Software Engineering, Inc. LPAS speech coder using vector quantized, multi-codebook, multi-tap pitch predictor and optimized ternary source excitation codebook derivation
US6161946A (en) 1998-11-09 2000-12-19 Bishop; Christopher B. Light reflector
WO2000036152A1 (en) * 1998-12-14 2000-06-22 Li-Cor, Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
JP3597729B2 (ja) * 1999-05-11 2004-12-08 日立ソフトウエアエンジニアリング株式会社 蛍光測光方法及び蛍光測光装置
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
WO2001001112A1 (en) 1999-06-26 2001-01-04 Packard Instrument Company, Inc. Microplate reader
US7088650B1 (en) * 1999-08-23 2006-08-08 Worthington Mark O Methods and apparatus for optical disc data acquisition using physical synchronization markers
CN1311436A (zh) * 2000-03-01 2001-09-05 上海和泰光电科技有限公司 旋转平台上的生物芯片荧光图象的读取
JP2001281587A (ja) * 2000-03-31 2001-10-10 Fuji Photo Optical Co Ltd 光走査装置用光源部の保持構造
US6795189B2 (en) 2000-06-15 2004-09-21 Packard Instrument Company Universal microplate analyzer
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
FR2812306B1 (fr) 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
US6545758B1 (en) 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6452879B1 (en) * 2000-09-29 2002-09-17 Fujitsu Limited Optical storage apparatus
AU2001296499A1 (en) 2000-10-04 2002-04-15 Cogent Light Technologies, Inc. Temperature control for arc lamps
SE0004296D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US20020172980A1 (en) * 2000-11-27 2002-11-21 Phan Brigitte Chau Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems
WO2002043866A2 (en) 2000-12-01 2002-06-06 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
US20030077598A1 (en) * 2001-01-04 2003-04-24 Phan Brigitte Chau Dual bead assays including covalent linkages for improved specificity and related optical analysis discs
WO2002073605A2 (en) 2001-03-14 2002-09-19 Burstein Technologies, Inc. Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US20030054563A1 (en) 2001-09-17 2003-03-20 Gyros Ab Detector arrangement for microfluidic devices
US6597832B2 (en) * 2001-12-07 2003-07-22 Yu-Feng Cheng Optical fiber selector
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US20040246252A1 (en) * 2002-01-14 2004-12-09 Morrow Jesse James Method and apparatus for visualizing data
US20050023765A1 (en) 2002-01-31 2005-02-03 Coombs James Howard Bio-safety features for optical analysis disc and disc system including same
US6767155B2 (en) * 2002-04-05 2004-07-27 Eastman Kodak Company High stability latch mechanism
JP4338529B2 (ja) 2002-04-08 2009-10-07 ユロス・パテント・アクチボラゲット ホーミングプロセス
US6833536B2 (en) 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
EP2775291B1 (en) 2002-05-17 2016-01-13 Life Technologies Corporation Apparatus for differentiating multiple fluorescence signals by excitation wavelength
AU2003243281A1 (en) 2002-05-17 2003-12-02 Applera Corporation Optical instrument includung excitation source
US20030219754A1 (en) 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
AUPS267802A0 (en) 2002-05-30 2002-06-20 Bio-Molecular Holdings Pty Limited Improved dna amplification apparatus and method
JP4193421B2 (ja) 2002-06-06 2008-12-10 ソニー株式会社 バイオアッセイ装置及びその製造方法、並びにバイオアッセイ方法
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
CN101158695A (zh) 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用方法
US20050014249A1 (en) 2003-02-21 2005-01-20 Norbert Staimer Chromatographic analysis on optical bio-discs and methods relating thereto
US20050032089A1 (en) 2003-03-05 2005-02-10 Phan Brigitte Chau Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs
CA2525482C (en) 2003-04-04 2015-02-17 F. Hoffmann-La Roche Ag Improved system for multicolor real-time pcr comprising 3 to 6 pairs of forester resonance energy transfer (fret) probes
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
US6879032B2 (en) * 2003-07-18 2005-04-12 Agilent Technologies, Inc. Folded flex circuit interconnect having a grid array interface
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
US20050074784A1 (en) 2003-10-07 2005-04-07 Tuan Vo-Dinh Integrated biochip with continuous sampling and processing (CSP) system
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
US7295316B2 (en) 2004-01-14 2007-11-13 Applera Corporation Fluorescent detector with automatic changing filters
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
US7709249B2 (en) 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US20070009382A1 (en) 2005-07-05 2007-01-11 William Bedingham Heating element for a rotating multiplex fluorescence detection device
US7527763B2 (en) 2005-07-05 2009-05-05 3M Innovative Properties Company Valve control system for a rotating multiplex fluorescence detection device
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods

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CA2602587A1 (en) 2006-10-12
US20060223169A1 (en) 2006-10-05
DE602006015043D1 (de) 2010-08-05
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US20090218517A1 (en) 2009-09-03
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EP2207026A1 (en) 2010-07-14
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WO2006107619A1 (en) 2006-10-12
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BRPI0609544B8 (pt) 2021-07-27
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