CA2602587A1 - Multiplex fluorescence detection device having removable optical modules - Google Patents
Multiplex fluorescence detection device having removable optical modules Download PDFInfo
- Publication number
- CA2602587A1 CA2602587A1 CA002602587A CA2602587A CA2602587A1 CA 2602587 A1 CA2602587 A1 CA 2602587A1 CA 002602587 A CA002602587 A CA 002602587A CA 2602587 A CA2602587 A CA 2602587A CA 2602587 A1 CA2602587 A1 CA 2602587A1
- Authority
- CA
- Canada
- Prior art keywords
- optical
- detection device
- optical modules
- disk
- modules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
- G01N35/00069—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/173—Nucleic acid detection characterized by the use of physical, structural and functional properties staining/intercalating agent, e.g. ethidium bromide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/024—Modular construction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66746105P | 2005-04-01 | 2005-04-01 | |
| US60/667,461 | 2005-04-01 | ||
| US11/174,754 | 2005-07-05 | ||
| US11/174,754 US7507575B2 (en) | 2005-04-01 | 2005-07-05 | Multiplex fluorescence detection device having removable optical modules |
| PCT/US2006/010787 WO2006107619A1 (en) | 2005-04-01 | 2006-03-24 | Multiplex fluorescence detection device having removable optical modules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2602587A1 true CA2602587A1 (en) | 2006-10-12 |
Family
ID=36591356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002602587A Abandoned CA2602587A1 (en) | 2005-04-01 | 2006-03-24 | Multiplex fluorescence detection device having removable optical modules |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7507575B2 (https=) |
| EP (2) | EP1872112B1 (https=) |
| JP (1) | JP5021614B2 (https=) |
| KR (1) | KR101265362B1 (https=) |
| AT (1) | ATE472099T1 (https=) |
| AU (1) | AU2006232922A1 (https=) |
| BR (1) | BRPI0609544B8 (https=) |
| CA (1) | CA2602587A1 (https=) |
| DE (1) | DE602006015043D1 (https=) |
| ES (1) | ES2347077T3 (https=) |
| MX (1) | MX2007012159A (https=) |
| WO (1) | WO2006107619A1 (https=) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| EP3718635A1 (en) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Processing particle-containing samples |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US7709249B2 (en) * | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
| US20070009382A1 (en) * | 2005-07-05 | 2007-01-11 | William Bedingham | Heating element for a rotating multiplex fluorescence detection device |
| US7527763B2 (en) * | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
| US7754148B2 (en) | 2006-12-27 | 2010-07-13 | Progentech Limited | Instrument for cassette for sample preparation |
| US7727473B2 (en) | 2005-10-19 | 2010-06-01 | Progentech Limited | Cassette for sample preparation |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| AU2008276211B2 (en) | 2007-07-13 | 2015-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US9121055B2 (en) * | 2008-04-24 | 2015-09-01 | 3M Innovative Properties Company | Analysis of nucleic acid amplification curves using wavelet transformation |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| GB0817991D0 (en) * | 2008-10-02 | 2008-11-05 | Enigma Diagnostics Ltd | Fluorescence based detection methods and apparatus |
| WO2010064160A1 (en) * | 2008-12-05 | 2010-06-10 | Biocartis S.A. | Thermal cycling system comprising transport heater |
| JP5279481B2 (ja) * | 2008-12-25 | 2013-09-04 | 株式会社日立ハイテクノロジーズ | 核酸分析装置 |
| JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
| KR20120012468A (ko) * | 2009-04-15 | 2012-02-10 | 비오까르띠 에스아 | ｒｔＰＣＲ 반응을 모니터링하기 위한 광학 검출 시스템 |
| US20110014094A1 (en) * | 2009-07-20 | 2011-01-20 | Samsung Electronics Co., Ltd. | Disk type microfluidic device and blood testing apparatus using the same |
| WO2011031585A1 (en) * | 2009-09-10 | 2011-03-17 | 3M Innovative Properties Company | Compensation for spectral crosstalk in multiplex nucleic acid amplification |
| CN102741430B (zh) | 2009-12-01 | 2016-07-13 | 牛津楠路珀尔科技有限公司 | 生化分析仪器、用于进行生化分析的第一模块以及相关方法 |
| KR20160088958A (ko) | 2010-02-23 | 2016-07-26 | 루미넥스 코포레이션 | 일체화된 샘플 제조, 반응 및 검출을 위한 장치 및 방법 |
| US8729502B1 (en) | 2010-10-28 | 2014-05-20 | The Research Foundation For The State University Of New York | Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection |
| CN102175612B (zh) * | 2011-01-18 | 2012-12-26 | 河北工业大学 | 一种多路光电检测装置 |
| US9096892B1 (en) | 2011-02-04 | 2015-08-04 | K2 Biomicrosystems, LLC | Nucleic acid amplification and monitoring apparatus |
| ES2653916T3 (es) | 2011-03-08 | 2018-02-09 | Universite Laval | Dispositivo centrípeto fluídico |
| JP6088487B2 (ja) | 2011-04-15 | 2017-03-01 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法 |
| CN104023834B (zh) | 2011-05-04 | 2016-09-28 | 卢米耐克斯公司 | 用于集成的样品制备、反应和检测的设备与方法 |
| USD672467S1 (en) | 2011-05-18 | 2012-12-11 | 3M Innovative Properties Company | Rotatable sample processing disk |
| MX336625B (es) | 2011-05-18 | 2016-01-26 | 3M Innovative Properties Co | Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra. |
| US9067205B2 (en) | 2011-05-18 | 2015-06-30 | 3M Innovative Properties Company | Systems and methods for valving on a sample processing device |
| CN103648649A (zh) | 2011-05-18 | 2014-03-19 | 3M创新有限公司 | 检测选定体积的材料在样本处理装置中存在的系统和方法 |
| AU2012288629B2 (en) | 2011-07-25 | 2017-02-02 | Oxford Nanopore Technologies Limited | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| RU2622432C2 (ru) | 2011-09-30 | 2017-06-15 | Бектон, Дикинсон Энд Компани | Унифицированная полоска для реактивов |
| EP2761027B1 (en) * | 2011-09-30 | 2017-10-25 | Life Technologies Corporation | Methods and systems for visualizing and evaluating data |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
| EP4361609A3 (en) | 2012-02-03 | 2024-07-17 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
| AU2013214849B2 (en) | 2012-02-03 | 2016-09-01 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
| EP2834622B1 (en) | 2012-04-03 | 2023-04-12 | Illumina, Inc. | Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing |
| EP3324175B1 (en) | 2012-04-23 | 2023-07-19 | Siemens Healthcare Diagnostics Inc. | Biological assay sample analyzer |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| CN104662172B (zh) * | 2012-08-03 | 2018-07-06 | 加州理工学院 | Pcr中具有减少的硬件和要求的多重化和定量 |
| CA2879638A1 (en) | 2012-08-10 | 2014-02-13 | Streck, Inc. | Real-time optical system for polymerase chain reaction |
| CN103364378B (zh) * | 2013-03-05 | 2016-04-20 | 江苏天瑞仪器股份有限公司 | 一种用于原子荧光光谱仪的多功能联合进样系统 |
| KR102168813B1 (ko) | 2013-03-08 | 2020-10-22 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 효소 정지 방법 |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| US8858886B1 (en) | 2013-05-08 | 2014-10-14 | Agilent Technologies, Inc. | Scanning system with interchangeable optical cartridges for fluorescence measurements |
| US10006861B2 (en) | 2013-06-28 | 2018-06-26 | Streck, Inc. | Devices for real-time polymerase chain reaction |
| DE102013012609B4 (de) * | 2013-07-26 | 2024-06-27 | Carl Zeiss Microscopy Gmbh | Optoelektronischer Detektor, insbesondere für hochauflösende Lichtrastermikroskope und Lichtrastermikroskop |
| WO2015021228A1 (en) | 2013-08-08 | 2015-02-12 | Illumina, Inc. | Fluidic system for reagent delivery to a flow cell |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| US20180268358A1 (en) * | 2015-01-09 | 2018-09-20 | Apex Industrial Technologies Llc | Order fulfillment system and method with item sensor |
| US20160290866A1 (en) * | 2015-03-30 | 2016-10-06 | DeNovix, Inc. | Apparatus and method for measuring fluorescence of a sample |
| US10209242B2 (en) | 2015-05-21 | 2019-02-19 | Emit Imaging, Inc. | Fluorescence histo-tomography (FHT) systems and methods |
| CA2987919A1 (en) * | 2015-08-31 | 2017-03-09 | Invicro Llc | Fluorescence histo-tomography (fht) systems and methods |
| USD799715S1 (en) | 2015-10-23 | 2017-10-10 | Gene POC, Inc. | Fluidic centripetal device |
| US10272510B2 (en) * | 2016-01-14 | 2019-04-30 | United Technologies Corporation | Electrical discharge machining apparatus |
| JP6687834B2 (ja) * | 2016-02-03 | 2020-04-28 | 株式会社Ｊｖｃケンウッド | 分析装置及び分析方法 |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| KR101972579B1 (ko) * | 2016-05-25 | 2019-08-23 | (주)옵토레인 | 피씨알모듈 및 이를 이용한 검사방법 |
| WO2017204512A1 (ko) * | 2016-05-25 | 2017-11-30 | 옵토레인 주식회사 | 피씨알모듈 |
| CN106198480B (zh) * | 2016-08-30 | 2018-09-14 | 广州蓝勃生物科技有限公司 | 一种自动干式荧光检测仪 |
| CN106290286A (zh) * | 2016-09-20 | 2017-01-04 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | 时间分辨荧光分析系统及检测装置 |
| GB201704771D0 (en) * | 2017-01-05 | 2017-05-10 | Illumina Inc | Modular optical analytic systems and methods |
| US10431441B2 (en) * | 2018-01-31 | 2019-10-01 | Palodex Group Oy | Reducing calibration of components in an imaging plate scanner |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| US12203129B2 (en) | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| CN110656046A (zh) * | 2019-11-01 | 2020-01-07 | 中国人民解放军军事科学院军事医学研究院 | 一种探测装置及pcr仪 |
| CN112823890B (zh) * | 2020-07-30 | 2024-07-19 | 北京金诺美科技股份有限公司 | 一种实时荧光定量pcr仪 |
| CN112798773A (zh) * | 2020-12-27 | 2021-05-14 | 北京工业大学 | 一种基于stm32单片机的高分辨率酶标仪电控系统 |
| US12461029B2 (en) * | 2021-03-10 | 2025-11-04 | Northeastern University | Continuous flow air sampling and rapid pathogen detection system |
| EP4419893A4 (en) * | 2021-10-20 | 2025-08-06 | Bio Rad Laboratories Inc | FLUORESCENCE DETECTION SYSTEM |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2055944A1 (de) | 1970-11-13 | 1972-05-18 | Leitz Ernst Gmbh | Fluoreszenzauflichtilluminator |
| US3918793A (en) * | 1970-05-02 | 1975-11-11 | Leitz Ernst Gmbh | Fluorescence illuminator for incident light microscope |
| DE2420545C3 (de) | 1974-04-27 | 1979-01-25 | H. Maihak Ag, 2000 Hamburg | Infrarotstrahleranordnung |
| JPS55156840A (en) | 1979-05-25 | 1980-12-06 | Olympus Optical Co Ltd | Specimen detector |
| JPS6120839A (ja) | 1984-07-10 | 1986-01-29 | Fuji Photo Film Co Ltd | バクテリアカウンタ |
| US4726676A (en) * | 1986-02-06 | 1988-02-23 | General Signal Corporation | Optical signal power measurement method and apparatus |
| US4927766A (en) | 1986-05-27 | 1990-05-22 | The Boc Group, Inc. | Gas constituent measurement and recording |
| US4909990A (en) | 1987-09-02 | 1990-03-20 | Myron J. Block | Immunoassay apparatus |
| GB8919700D0 (en) | 1989-08-31 | 1989-10-11 | Electricity Council | Infra-red radiation emission arrangement |
| US7273749B1 (en) | 1990-06-04 | 2007-09-25 | University Of Utah Research Foundation | Container for carrying out and monitoring biological processes |
| US5296958A (en) * | 1992-05-29 | 1994-03-22 | Eastman Kodak Company | Multiple wavelength laser beam scanning system |
| JPH0634546A (ja) | 1992-07-17 | 1994-02-08 | Tosoh Corp | 蛍光検出器 |
| CA2100020C (en) | 1992-07-17 | 2001-09-11 | Walter Blumenfeld | Methods and apparatus for detecting bacterial growth by spectrophotometric sampling of a fiber-optic array |
| US5414600A (en) | 1993-07-30 | 1995-05-09 | Cogent Light Technologies, Inc. | Condensing and collecting optical system using an ellipsoidal reflector |
| WO1995030139A1 (en) | 1994-04-29 | 1995-11-09 | Perkin-Elmer Corporation | System for real time detection of nucleic acid amplification products |
| US5766889A (en) | 1994-06-08 | 1998-06-16 | The Perkin-Elmer Corporation | Method for determining the characteristics of the concentration growth of target nucleic acid molecules in polymerase chain reaction sample |
| US6327031B1 (en) | 1998-09-18 | 2001-12-04 | Burstein Technologies, Inc. | Apparatus and semi-reflective optical system for carrying out analysis of samples |
| GB9418981D0 (en) | 1994-09-21 | 1994-11-09 | Univ Glasgow | Apparatus and method for carrying out analysis of samples |
| US5585069A (en) | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5639668A (en) | 1995-09-14 | 1997-06-17 | Boehringer Mannheim Corporation | Optical apparatus for performing an immunoassay |
| US6342349B1 (en) | 1996-07-08 | 2002-01-29 | Burstein Technologies, Inc. | Optical disk-based assay devices and methods |
| US5751874A (en) * | 1996-09-13 | 1998-05-12 | Nuvisions International, Inc. | Coupling device for linking optical fiber connectors |
| DE19707226A1 (de) * | 1997-02-24 | 1998-08-27 | Bodenseewerk Perkin Elmer Co | Lichtabtastvorrichtung |
| ID22965A (id) | 1997-02-28 | 1999-12-23 | Burstein Lab Inc | Laboratorium dalam suatu disk |
| EP0969452A4 (en) * | 1997-03-25 | 2000-12-27 | Sanyo Electric Co | INFORMATION REPRODUCING AND RECORDING DEVICE AND REFERENCE MARK DETECTION CIRCUIT |
| WO1999013370A1 (de) * | 1997-09-05 | 1999-03-18 | Leica Microsystems Ag | Mikroskop, insbesondere fluoreszenzmikroskop, insbesondere stereo-fluoreszenzmikroskop |
| US6597450B1 (en) | 1997-09-15 | 2003-07-22 | Becton, Dickinson And Company | Automated Optical Reader for Nucleic Acid Assays |
| US6561428B2 (en) * | 1997-10-17 | 2003-05-13 | Hand Held Products, Inc. | Imaging device having indicia-controlled image parsing mode |
| US5994150A (en) | 1997-11-19 | 1999-11-30 | Imation Corp. | Optical assaying method and system having rotatable sensor disk with multiple sensing regions |
| ATE391451T1 (de) * | 1998-01-26 | 2008-04-15 | Massachusetts Inst Technology | Endoskop zur erfassung von fluoreszenzbilder |
| US6210882B1 (en) | 1998-01-29 | 2001-04-03 | Mayo Foundation For Medical Education And Reseach | Rapid thermocycling for sample analysis |
| US6014618A (en) * | 1998-08-06 | 2000-01-11 | Dsp Software Engineering, Inc. | LPAS speech coder using vector quantized, multi-codebook, multi-tap pitch predictor and optimized ternary source excitation codebook derivation |
| US6161946A (en) | 1998-11-09 | 2000-12-19 | Bishop; Christopher B. | Light reflector |
| WO2000036151A1 (en) * | 1998-12-14 | 2000-06-22 | Li-Cor, Inc. | A heterogeneous assay for pyrophosphate detection |
| JP3597729B2 (ja) * | 1999-05-11 | 2004-12-08 | 日立ソフトウエアエンジニアリング株式会社 | 蛍光測光方法及び蛍光測光装置 |
| US7410793B2 (en) | 1999-05-17 | 2008-08-12 | Applera Corporation | Optical instrument including excitation source |
| AU4307700A (en) | 1999-06-26 | 2001-01-31 | Packard Instrument Company, Inc. | Microplate reader |
| US7088650B1 (en) * | 1999-08-23 | 2006-08-08 | Worthington Mark O | Methods and apparatus for optical disc data acquisition using physical synchronization markers |
| CN1311436A (zh) * | 2000-03-01 | 2001-09-05 | 上海和泰光电科技有限公司 | 旋转平台上的生物芯片荧光图象的读取 |
| JP2001281587A (ja) * | 2000-03-31 | 2001-10-10 | Fuji Photo Optical Co Ltd | 光走査装置用光源部の保持構造 |
| US6795189B2 (en) | 2000-06-15 | 2004-09-21 | Packard Instrument Company | Universal microplate analyzer |
| US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US6734401B2 (en) * | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
| US6563581B1 (en) | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
| FR2812306B1 (fr) | 2000-07-28 | 2005-01-14 | Gabriel Festoc | Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles |
| US6545758B1 (en) | 2000-08-17 | 2003-04-08 | Perry Sandstrom | Microarray detector and synthesizer |
| US6452879B1 (en) * | 2000-09-29 | 2002-09-17 | Fujitsu Limited | Optical storage apparatus |
| US6616304B2 (en) | 2000-10-04 | 2003-09-09 | Cogent Light Technologies, Inc. | Temperature control for arc lamps |
| SE0004296D0 (sv) | 2000-11-23 | 2000-11-23 | Gyros Ab | Device and method for the controlled heating in micro channel systems |
| US20020172980A1 (en) * | 2000-11-27 | 2002-11-21 | Phan Brigitte Chau | Methods for decreasing non-specific binding of beads in dual bead assays including related optical biodiscs and disc drive systems |
| US20020076354A1 (en) | 2000-12-01 | 2002-06-20 | Cohen David Samuel | Apparatus and methods for separating components of particulate suspension |
| US20030077598A1 (en) * | 2001-01-04 | 2003-04-24 | Phan Brigitte Chau | Dual bead assays including covalent linkages for improved specificity and related optical analysis discs |
| WO2002073605A2 (en) | 2001-03-14 | 2002-09-19 | Burstein Technologies, Inc. | Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus |
| US20030054563A1 (en) | 2001-09-17 | 2003-03-20 | Gyros Ab | Detector arrangement for microfluidic devices |
| US6597832B2 (en) * | 2001-12-07 | 2003-07-22 | Yu-Feng Cheng | Optical fiber selector |
| US6889468B2 (en) | 2001-12-28 | 2005-05-10 | 3M Innovative Properties Company | Modular systems and methods for using sample processing devices |
| WO2003060668A2 (en) * | 2002-01-14 | 2003-07-24 | Burstein Technologies, Inc. | Method and apparatus for visualizing data |
| US20050023765A1 (en) | 2002-01-31 | 2005-02-03 | Coombs James Howard | Bio-safety features for optical analysis disc and disc system including same |
| US6767155B2 (en) * | 2002-04-05 | 2004-07-27 | Eastman Kodak Company | High stability latch mechanism |
| WO2003087779A1 (en) | 2002-04-08 | 2003-10-23 | Gyros Ab | Homing process |
| US6833536B2 (en) | 2002-05-22 | 2004-12-21 | Applera Corporation | Non-contact radiant heating and temperature sensing device for a chemical reaction chamber |
| EP2674745B1 (en) | 2002-05-17 | 2016-04-13 | Life Technologies Corporation | Instrument for detecting and measuring fluorescence |
| EP2775291B1 (en) | 2002-05-17 | 2016-01-13 | Life Technologies Corporation | Apparatus for differentiating multiple fluorescence signals by excitation wavelength |
| US20030219754A1 (en) | 2002-05-23 | 2003-11-27 | Oleksy Jerome E. | Fluorescence polarization detection of nucleic acids |
| AUPS267802A0 (en) | 2002-05-30 | 2002-06-20 | Bio-Molecular Holdings Pty Limited | Improved dna amplification apparatus and method |
| JP4193421B2 (ja) | 2002-06-06 | 2008-12-10 | ソニー株式会社 | バイオアッセイ装置及びその製造方法、並びにバイオアッセイ方法 |
| US7452507B2 (en) * | 2002-08-02 | 2008-11-18 | Sandia Corporation | Portable apparatus for separating sample and detecting target analytes |
| CN101158695A (zh) | 2002-12-04 | 2008-04-09 | 斯宾克斯公司 | 流体的可程控微量控制用方法 |
| US20050014249A1 (en) | 2003-02-21 | 2005-01-20 | Norbert Staimer | Chromatographic analysis on optical bio-discs and methods relating thereto |
| US20050032089A1 (en) | 2003-03-05 | 2005-02-10 | Phan Brigitte Chau | Sample preparation for colorimetric and fluorescent assays as implemented on optical analysis discs |
| ATE550099T1 (de) | 2003-04-04 | 2012-04-15 | Hoffmann La Roche | Verbessertes system für mehrfarbige echtzeit-pcr |
| US7148043B2 (en) | 2003-05-08 | 2006-12-12 | Bio-Rad Laboratories, Inc. | Systems and methods for fluorescence detection with a movable detection module |
| US7238269B2 (en) | 2003-07-01 | 2007-07-03 | 3M Innovative Properties Company | Sample processing device with unvented channel |
| US6879032B2 (en) * | 2003-07-18 | 2005-04-12 | Agilent Technologies, Inc. | Folded flex circuit interconnect having a grid array interface |
| US7317415B2 (en) | 2003-08-08 | 2008-01-08 | Affymetrix, Inc. | System, method, and product for scanning of biological materials employing dual analog integrators |
| US20050074784A1 (en) | 2003-10-07 | 2005-04-07 | Tuan Vo-Dinh | Integrated biochip with continuous sampling and processing (CSP) system |
| US20050130177A1 (en) | 2003-12-12 | 2005-06-16 | 3M Innovative Properties Company | Variable valve apparatus and methods |
| US7322254B2 (en) | 2003-12-12 | 2008-01-29 | 3M Innovative Properties Company | Variable valve apparatus and methods |
| US7295316B2 (en) | 2004-01-14 | 2007-11-13 | Applera Corporation | Fluorescent detector with automatic changing filters |
| US7709249B2 (en) * | 2005-04-01 | 2010-05-04 | 3M Innovative Properties Company | Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector |
| US7507575B2 (en) | 2005-04-01 | 2009-03-24 | 3M Innovative Properties Company | Multiplex fluorescence detection device having removable optical modules |
| US7527763B2 (en) | 2005-07-05 | 2009-05-05 | 3M Innovative Properties Company | Valve control system for a rotating multiplex fluorescence detection device |
| US7754474B2 (en) | 2005-07-05 | 2010-07-13 | 3M Innovative Properties Company | Sample processing device compression systems and methods |
| US20070009382A1 (en) | 2005-07-05 | 2007-01-11 | William Bedingham | Heating element for a rotating multiplex fluorescence detection device |
-
2005
- 2005-07-05 US US11/174,754 patent/US7507575B2/en not_active Expired - Lifetime
-
2006
- 2006-03-24 WO PCT/US2006/010787 patent/WO2006107619A1/en not_active Ceased
- 2006-03-24 ES ES06748651T patent/ES2347077T3/es not_active Expired - Lifetime
- 2006-03-24 JP JP2008504192A patent/JP5021614B2/ja not_active Expired - Lifetime
- 2006-03-24 CA CA002602587A patent/CA2602587A1/en not_active Abandoned
- 2006-03-24 EP EP06748651A patent/EP1872112B1/en not_active Expired - Lifetime
- 2006-03-24 AU AU2006232922A patent/AU2006232922A1/en not_active Abandoned
- 2006-03-24 BR BRPI0609544A patent/BRPI0609544B8/pt active IP Right Grant
- 2006-03-24 DE DE602006015043T patent/DE602006015043D1/de not_active Expired - Lifetime
- 2006-03-24 AT AT06748651T patent/ATE472099T1/de not_active IP Right Cessation
- 2006-03-24 EP EP10161462A patent/EP2207026A1/en not_active Withdrawn
- 2006-03-24 KR KR1020077025261A patent/KR101265362B1/ko not_active Expired - Lifetime
- 2006-03-24 MX MX2007012159A patent/MX2007012159A/es active IP Right Grant
-
2009
- 2009-02-24 US US12/391,293 patent/US20090218517A1/en not_active Abandoned
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| BRPI0609544A2 (pt) | 2011-10-18 |
| JP2008537594A (ja) | 2008-09-18 |
| KR20080014758A (ko) | 2008-02-14 |
| AU2006232922A1 (en) | 2006-10-12 |
| WO2006107619A1 (en) | 2006-10-12 |
| US20060223169A1 (en) | 2006-10-05 |
| US7507575B2 (en) | 2009-03-24 |
| ES2347077T3 (es) | 2010-10-25 |
| BRPI0609544B1 (pt) | 2018-02-06 |
| DE602006015043D1 (de) | 2010-08-05 |
| EP1872112B1 (en) | 2010-06-23 |
| US20090218517A1 (en) | 2009-09-03 |
| EP1872112A1 (en) | 2008-01-02 |
| MX2007012159A (es) | 2007-12-10 |
| JP5021614B2 (ja) | 2012-09-12 |
| BRPI0609544B8 (pt) | 2021-07-27 |
| ATE472099T1 (de) | 2010-07-15 |
| KR101265362B1 (ko) | 2013-05-20 |
| EP2207026A1 (en) | 2010-07-14 |
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