JP4812393B2 - 蛍光分子計測システム - Google Patents

蛍光分子計測システム Download PDF

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Publication number
JP4812393B2
JP4812393B2 JP2005303835A JP2005303835A JP4812393B2 JP 4812393 B2 JP4812393 B2 JP 4812393B2 JP 2005303835 A JP2005303835 A JP 2005303835A JP 2005303835 A JP2005303835 A JP 2005303835A JP 4812393 B2 JP4812393 B2 JP 4812393B2
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JP
Japan
Prior art keywords
sample
laser
substrate
fluorescence
cell
Prior art date
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Expired - Fee Related
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JP2005303835A
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English (en)
Japanese (ja)
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JP2006276000A (ja
JP2006276000A5 (enExample
Inventor
正敬 白井
剛志 曽根原
隆 穴沢
千文 合田
千宗 植松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi High Tech Corp
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Hitachi High Technologies Corp
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Publication date
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Priority to JP2005303835A priority Critical patent/JP4812393B2/ja
Priority to US11/349,898 priority patent/US7439522B2/en
Publication of JP2006276000A publication Critical patent/JP2006276000A/ja
Publication of JP2006276000A5 publication Critical patent/JP2006276000A5/ja
Application granted granted Critical
Publication of JP4812393B2 publication Critical patent/JP4812393B2/ja
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Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Optical Measuring Cells (AREA)
JP2005303835A 2005-03-04 2005-10-19 蛍光分子計測システム Expired - Fee Related JP4812393B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2005303835A JP4812393B2 (ja) 2005-03-04 2005-10-19 蛍光分子計測システム
US11/349,898 US7439522B2 (en) 2005-03-04 2006-02-09 Counting system for fluorescent molecules

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005059858 2005-03-04
JP2005059858 2005-03-04
JP2005303835A JP4812393B2 (ja) 2005-03-04 2005-10-19 蛍光分子計測システム

Publications (3)

Publication Number Publication Date
JP2006276000A JP2006276000A (ja) 2006-10-12
JP2006276000A5 JP2006276000A5 (enExample) 2008-05-01
JP4812393B2 true JP4812393B2 (ja) 2011-11-09

Family

ID=36943257

Family Applications (1)

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JP2005303835A Expired - Fee Related JP4812393B2 (ja) 2005-03-04 2005-10-19 蛍光分子計測システム

Country Status (2)

Country Link
US (1) US7439522B2 (enExample)
JP (1) JP4812393B2 (enExample)

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JP5202971B2 (ja) * 2008-01-28 2013-06-05 オリンパス株式会社 測定装置及び測定方法
EP2322101A4 (en) * 2008-07-08 2013-04-10 Hitachi Ltd LIGHT METER
WO2010085548A2 (en) * 2009-01-22 2010-07-29 Li-Cor, Inc. Single molecule proteomics with dynamic probes
US8993972B2 (en) * 2009-01-23 2015-03-31 University Of Maryland Baltimore County Fluorescence based sensors utilizing a mirrored cavity
JP5660464B2 (ja) * 2011-07-25 2015-01-28 横河電機株式会社 濃度測定方法、および濃度測定システム
KR20140090509A (ko) * 2013-01-09 2014-07-17 성균관대학교산학협력단 내부 전반사기를 이용한 형광 검출 장치
CN103776806B (zh) * 2014-01-06 2016-01-06 浙江农林大学 包合物包合率测定仪的测定方法
JP2015184114A (ja) * 2014-03-24 2015-10-22 富士フイルム株式会社 増強ラマン分光装置
WO2016063912A1 (ja) 2014-10-24 2016-04-28 国立大学法人東京大学 粒子検出方法、粒子検出装置および粒子検出システム
US10181190B2 (en) * 2014-11-04 2019-01-15 Olympus Corporation Microscope and microscope image acquisition method
JP6635052B2 (ja) * 2015-02-05 2020-01-22 株式会社ニコン 構造化照明顕微鏡、及び観察方法
JP6781989B2 (ja) * 2015-04-21 2020-11-11 国立大学法人 東京大学 微粒子検出システム及び微粒子検出プログラム
US10989661B2 (en) * 2015-05-01 2021-04-27 The Board Of Regents Of The University Of Texas System Uniform and scalable light-sheets generated by extended focusing
US10509215B2 (en) * 2016-03-14 2019-12-17 Olympus Corporation Light-field microscope
US10876970B2 (en) 2016-04-12 2020-12-29 The Board Of Regents Of The University Of Texas System Light-sheet microscope with parallelized 3D image acquisition
JP7217677B2 (ja) * 2019-07-16 2023-02-03 株式会社日立製作所 サンプル測定装置、及びサンプル測定方法
CN111220588B (zh) * 2020-03-24 2023-05-16 哈尔滨工业大学（威海） 一种基于油膜荧光亮度的流场辐聚辐散测量方法

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JPS6321556A (ja) 1986-07-15 1988-01-29 Hitachi Ltd Ｄｎａ塩基配列決定装置
JPS6483136A (en) * 1987-09-25 1989-03-28 Hitachi Ltd Fluorescence detection type electrophoretic apparatus
JPH0695073B2 (ja) * 1988-09-01 1994-11-24 工業技術院長 蛍光測定用試料保持体
US5184192A (en) * 1991-07-17 1993-02-02 Millipore Corporation Photometric apparatus with a flow cell coated with an amorphous fluoropolymer
JP2785530B2 (ja) * 1991-09-13 1998-08-13 株式会社日立製作所 電気泳動装置
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JPH07134101A (ja) 1993-11-11 1995-05-23 Hitachi Electron Eng Co Ltd Ｄｎａ塩基配列決定装置
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JP3387783B2 (ja) * 1997-07-04 2003-03-17 日立ソフトウエアエンジニアリング株式会社 スキャナ装置
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JP2000338086A (ja) * 1999-05-27 2000-12-08 Hitachi Ltd 電気泳動装置
US7186988B2 (en) * 2001-03-06 2007-03-06 Evotec Oai Ag Method for analyzing chemical and or biological samples
JP3678192B2 (ja) * 2001-11-21 2005-08-03 横河電機株式会社 計測装置
JP2003177097A (ja) 2001-12-12 2003-06-27 Mitsubishi Chemicals Corp 光学分析用チップ
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JP2003315308A (ja) * 2002-04-22 2003-11-06 Hitachi High-Technologies Corp 電気泳動装置及びその製造方法並びにその使用方法
JP2004069397A (ja) * 2002-08-02 2004-03-04 Nec Corp 分析チップおよび分析装置
JP2004069395A (ja) * 2002-08-02 2004-03-04 Nec Corp マイクロチップ、マイクロチップの製造方法および成分検出方法
US6999173B2 (en) * 2003-09-25 2006-02-14 Ffa Sciences Llc Method and apparatus for ratio fluorometry
JPWO2005088280A1 (ja) * 2004-03-17 2008-01-31 オリンパス株式会社 光測定装置及び光測定方法
US7315376B2 (en) * 2005-01-07 2008-01-01 Advanced Molecular Systems, Llc Fluorescence detection system

Also Published As

Publication number Publication date
US20060197034A1 (en) 2006-09-07
JP2006276000A (ja) 2006-10-12
US7439522B2 (en) 2008-10-21

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