JP4787912B2 - ロキソプロフェン含有医薬組成物 - Google Patents

ロキソプロフェン含有医薬組成物 Download PDF

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Publication number
JP4787912B2
JP4787912B2 JP2011512760A JP2011512760A JP4787912B2 JP 4787912 B2 JP4787912 B2 JP 4787912B2 JP 2011512760 A JP2011512760 A JP 2011512760A JP 2011512760 A JP2011512760 A JP 2011512760A JP 4787912 B2 JP4787912 B2 JP 4787912B2
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Prior art keywords
salt
loxoprofen
hydrochloride
loxoprofen sodium
pharmaceutical composition
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Japanese (ja)
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JPWO2011093498A1 (ja
Inventor
俊樹 薄井
政明 春原
雅哉 高宮
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Kowa Co Ltd
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Kowa Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011512760A 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物 Active JP4787912B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2011512760A JP4787912B2 (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP2010018015 2010-01-29
JP2010018015 2010-01-29
JP2010149089 2010-06-30
JP2010149115 2010-06-30
JP2010149089 2010-06-30
JP2010149061 2010-06-30
JP2010149061 2010-06-30
JP2010149115 2010-06-30
JP2011512760A JP4787912B2 (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物
PCT/JP2011/051945 WO2011093498A1 (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011136591A Division JP2012031147A (ja) 2010-01-29 2011-06-20 ロキソプロフェン含有医薬組成物

Publications (2)

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JP4787912B2 true JP4787912B2 (ja) 2011-10-05
JPWO2011093498A1 JPWO2011093498A1 (ja) 2013-06-06

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JP2011512760A Active JP4787912B2 (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物
JP2011017776A Pending JP2012031131A (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物
JP2011136591A Pending JP2012031147A (ja) 2010-01-29 2011-06-20 ロキソプロフェン含有医薬組成物
JP2013182739A Active JP5575961B2 (ja) 2010-01-29 2013-09-04 ロキソプロフェン含有医薬組成物
JP2014130149A Active JP5809736B2 (ja) 2010-01-29 2014-06-25 ロキソプロフェン含有新医薬組成物

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JP2011017776A Pending JP2012031131A (ja) 2010-01-29 2011-01-31 ロキソプロフェン含有医薬組成物
JP2011136591A Pending JP2012031147A (ja) 2010-01-29 2011-06-20 ロキソプロフェン含有医薬組成物
JP2013182739A Active JP5575961B2 (ja) 2010-01-29 2013-09-04 ロキソプロフェン含有医薬組成物
JP2014130149A Active JP5809736B2 (ja) 2010-01-29 2014-06-25 ロキソプロフェン含有新医薬組成物

Country Status (4)

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JP (5) JP4787912B2 (OSRAM)
KR (1) KR20120112644A (OSRAM)
CN (1) CN102740854A (OSRAM)
WO (1) WO2011093498A1 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013018766A1 (ja) * 2011-07-29 2013-02-07 興和株式会社 安定な医薬組成物
WO2013047869A1 (ja) * 2011-09-29 2013-04-04 興和株式会社 ロキソプロフェン又はその塩を含有する医薬組成物

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5525323B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5525324B2 (ja) * 2009-04-28 2014-06-18 興和株式会社 ロキソプロフェン含有医薬製剤
JP5624367B2 (ja) * 2009-05-28 2014-11-12 興和株式会社 ロキソプロフェン含有医薬製剤
TWI629059B (zh) * 2010-12-28 2018-07-11 興和股份有限公司 Antipyretic and analgesic composition
JP6008857B2 (ja) * 2011-07-29 2016-10-19 興和株式会社 ロキソプロフェンを含有する医薬組成物
JP6114573B2 (ja) * 2012-02-29 2017-04-12 第一三共ヘルスケア株式会社 ロキソプロフェンナトリウムと制酸剤を含有する固形製剤
WO2014002599A1 (ja) * 2012-06-25 2014-01-03 興和株式会社 生薬等含有医薬組成物
JP6149625B2 (ja) * 2012-11-09 2017-06-21 大正製薬株式会社 医薬組成物
JP6197513B2 (ja) * 2012-11-09 2017-09-20 大正製薬株式会社 医薬組成物
JP6252177B2 (ja) * 2013-01-28 2017-12-27 大正製薬株式会社 固形製剤
CN103333064B (zh) * 2013-07-17 2014-04-23 珠海金鸿药业股份有限公司 洛索洛芬钠化合物及其药物组合物
CN104257984A (zh) * 2014-09-28 2015-01-07 白杨 一种包衣处理的六味地黄丸的制备方法
CN104224740A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的百合固金丸的制备方法
CN104288433A (zh) * 2014-09-28 2015-01-21 白杨 一种包衣处理的枸菊地黄丸的制备方法
CN104225161A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的归芍地黄丸的制备方法
CN104225187A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的知柏地黄丸的制备方法
CN104225162A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的桂附地黄丸的制备方法
CN104225160A (zh) * 2014-09-28 2014-12-24 白杨 一种包衣处理的七味都气丸的制备方法
CN106580968A (zh) * 2016-11-22 2017-04-26 郑州仁宏医药科技有限公司 一种治疗牙齿肿痛的西药散剂及其制备方法
EP3415143A1 (en) * 2017-06-16 2018-12-19 Kai-Uwe Kern Bromhexine for the treatment of pain
CN113332252A (zh) * 2021-06-07 2021-09-03 大桐制药（中国）有限责任公司 一种洛索洛芬钠片的制备方法

Citations (7)

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Publication number Priority date Publication date Assignee Title
WO1996033704A1 (en) * 1995-04-26 1996-10-31 Taisho Pharmaceutical Co., Ltd. Preparation for oral administration
JP2000143505A (ja) * 1998-11-06 2000-05-23 Sankyo Co Ltd ロキソプロフェンを含有する医薬組成物
JP2001316250A (ja) * 2000-02-28 2001-11-13 Takeda Chem Ind Ltd 固形圧縮製剤
WO2006048939A1 (ja) * 2004-11-05 2006-05-11 Lead Chemical Co., Ltd. 非ステロイド消炎鎮痛薬を含有する非水系経皮吸収製剤
JP2007055924A (ja) * 2005-08-24 2007-03-08 Taisho Pharmaceut Co Ltd イブプロフェン及び塩酸アンブロキソール含有固形製剤
JP2007284423A (ja) * 2006-03-24 2007-11-01 Daiichi Sankyo Healthcare Co Ltd 医薬用製剤およびその製造方法
JP2008163017A (ja) * 2006-12-06 2008-07-17 Saitama Daiichi Seiyaku Kk 外用医薬組成物及び貼付剤

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AU2003262264A1 (en) * 2002-08-22 2004-03-11 Ono Pharmaceutical Co., Ltd. Agent for reducing side effects of diclofenac
JP5232520B2 (ja) * 2007-04-17 2013-07-10 第一三共ヘルスケア株式会社 ロキソプロフェンを含有する抗アデノウイルス剤
JP2010215611A (ja) * 2009-01-28 2010-09-30 Kowa Co ロキソプロフェン含有医薬製剤
JP2010235599A (ja) * 2009-03-11 2010-10-21 Kowa Co ロキソプロフェン含有医薬製剤
JP2011006407A (ja) * 2009-05-28 2011-01-13 Kowa Co ロキソプロフェン含有医薬製剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033704A1 (en) * 1995-04-26 1996-10-31 Taisho Pharmaceutical Co., Ltd. Preparation for oral administration
JP2000143505A (ja) * 1998-11-06 2000-05-23 Sankyo Co Ltd ロキソプロフェンを含有する医薬組成物
JP2001316250A (ja) * 2000-02-28 2001-11-13 Takeda Chem Ind Ltd 固形圧縮製剤
WO2006048939A1 (ja) * 2004-11-05 2006-05-11 Lead Chemical Co., Ltd. 非ステロイド消炎鎮痛薬を含有する非水系経皮吸収製剤
JP2007055924A (ja) * 2005-08-24 2007-03-08 Taisho Pharmaceut Co Ltd イブプロフェン及び塩酸アンブロキソール含有固形製剤
JP2007284423A (ja) * 2006-03-24 2007-11-01 Daiichi Sankyo Healthcare Co Ltd 医薬用製剤およびその製造方法
JP2008163017A (ja) * 2006-12-06 2008-07-17 Saitama Daiichi Seiyaku Kk 外用医薬組成物及び貼付剤

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013018766A1 (ja) * 2011-07-29 2013-02-07 興和株式会社 安定な医薬組成物
WO2013047869A1 (ja) * 2011-09-29 2013-04-04 興和株式会社 ロキソプロフェン又はその塩を含有する医薬組成物

Also Published As

Publication number Publication date
KR20120112644A (ko) 2012-10-11
CN102740854A (zh) 2012-10-17
JP2014169345A (ja) 2014-09-18
JP2012031131A (ja) 2012-02-16
WO2011093498A1 (ja) 2011-08-04
JP5809736B2 (ja) 2015-11-11
JP2013237710A (ja) 2013-11-28
JP5575961B2 (ja) 2014-08-20
JP2012031147A (ja) 2012-02-16
JPWO2011093498A1 (ja) 2013-06-06

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