JP4712384B2 - Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体 - Google Patents

Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体 Download PDF

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JP4712384B2
JP4712384B2 JP2004534697A JP2004534697A JP4712384B2 JP 4712384 B2 JP4712384 B2 JP 4712384B2 JP 2004534697 A JP2004534697 A JP 2004534697A JP 2004534697 A JP2004534697 A JP 2004534697A JP 4712384 B2 JP4712384 B2 JP 4712384B2
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methyl
phenyl
ethyl
propyl
pyrrolidinyl
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JP2006500393A (ja
JP2006500393A5 (https=
Inventor
バテイスタ，キヤスリーン
ビニヤン，ジル
コノリー，ピーター・ジエイ
ライツ，アレン・ビー
モーガン・ロス，テイナ
スコツト，マルコム
ミドルトン，ステイーブ・エイ
オーシニ，マイケル
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2004534697A 2002-09-09 2003-09-05 Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体 Expired - Fee Related JP4712384B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40913402P 2002-09-09 2002-09-09
US60/409,134 2002-09-09
PCT/US2003/027956 WO2004022558A2 (en) 2002-09-09 2003-09-05 Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders

Publications (3)

Publication Number Publication Date
JP2006500393A JP2006500393A (ja) 2006-01-05
JP2006500393A5 JP2006500393A5 (https=) 2006-10-26
JP4712384B2 true JP4712384B2 (ja) 2011-06-29

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JP2004534697A Expired - Fee Related JP4712384B2 (ja) 2002-09-09 2003-09-05 Ｏｒｌ−１受容体介在障害の治療に有用なヒドロキシアルキル置換１，３，８−トリアザスピロ［４．５］デカン−４−オン誘導体

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US (3) US7081463B2 (https=)
EP (1) EP1601674B1 (https=)
JP (1) JP4712384B2 (https=)
KR (1) KR20050043935A (https=)
CN (1) CN100402529C (https=)
AR (1) AR041205A1 (https=)
AU (1) AU2003268512A1 (https=)
BR (1) BR0306309A (https=)
CA (1) CA2498275C (https=)
CL (1) CL2003001814A1 (https=)
EA (1) EA009369B1 (https=)
MX (1) MXPA05002622A (https=)
NO (1) NO20051743L (https=)
NZ (1) NZ538307A (https=)
PL (1) PL377047A1 (https=)
RS (1) RS20050208A (https=)
TW (1) TWI296627B (https=)
WO (1) WO2004022558A2 (https=)
ZA (1) ZA200502836B (https=)

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EA200500331A1 (ru) 2005-08-25
US20060030577A1 (en) 2006-02-09
RS20050208A (sr) 2007-08-03
US20090124614A1 (en) 2009-05-14
AU2003268512A1 (en) 2004-03-29
US8778956B2 (en) 2014-07-15
JP2006500393A (ja) 2006-01-05
TWI296627B (en) 2008-05-11
US7081463B2 (en) 2006-07-25
CN100402529C (zh) 2008-07-16
NZ538307A (en) 2008-04-30
TW200418857A (en) 2004-10-01
US7582649B2 (en) 2009-09-01
CA2498275C (en) 2011-07-12
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US20040142955A1 (en) 2004-07-22
EA009369B1 (ru) 2007-12-28
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NO20051743L (no) 2005-05-18
CA2498275A1 (en) 2004-03-18
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