JP4677538B2 - 眼内薬物送達のためのリザーバデバイス - Google Patents

眼内薬物送達のためのリザーバデバイス Download PDF

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Publication number
JP4677538B2
JP4677538B2 JP2003503145A JP2003503145A JP4677538B2 JP 4677538 B2 JP4677538 B2 JP 4677538B2 JP 2003503145 A JP2003503145 A JP 2003503145A JP 2003503145 A JP2003503145 A JP 2003503145A JP 4677538 B2 JP4677538 B2 JP 4677538B2
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JP
Japan
Prior art keywords
reservoir
delivery
delivery device
agent
hollow body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003503145A
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English (en)
Japanese (ja)
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JP2005500097A (ja
JP2005500097A5 (enExample
Inventor
サイン エリックソン ヴァーナー，
ジュアン，ユージーン ジュニア． ド
アーロン クリストファー バーンズ，
ジェイ． クーニー，マイケル
ハリソン シェリー，テリー
Original Assignee
ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of JP2005500097A publication Critical patent/JP2005500097A/ja
Publication of JP2005500097A5 publication Critical patent/JP2005500097A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/0208—Subcutaneous access sites for injecting or removing fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M2039/0205—Access sites for injecting media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/04—General characteristics of the apparatus implanted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0612—Eyes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2003503145A 2001-06-12 2002-06-12 眼内薬物送達のためのリザーバデバイス Expired - Lifetime JP4677538B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29749901P 2001-06-12 2001-06-12
PCT/US2002/018642 WO2002100318A2 (en) 2001-06-12 2002-06-12 Reservoir device for intraocular drug delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2010157037A Division JP5416048B2 (ja) 2001-06-12 2010-07-09 眼内薬物送達のためのリザーバデバイス

Publications (3)

Publication Number Publication Date
JP2005500097A JP2005500097A (ja) 2005-01-06
JP2005500097A5 JP2005500097A5 (enExample) 2006-01-05
JP4677538B2 true JP4677538B2 (ja) 2011-04-27

Family

ID=23146563

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003503145A Expired - Lifetime JP4677538B2 (ja) 2001-06-12 2002-06-12 眼内薬物送達のためのリザーバデバイス
JP2010157037A Expired - Lifetime JP5416048B2 (ja) 2001-06-12 2010-07-09 眼内薬物送達のためのリザーバデバイス
JP2012002591A Ceased JP2012096056A (ja) 2001-06-12 2012-01-10 眼内薬物送達のためのリザーバデバイス
JP2013187604A Expired - Lifetime JP5896966B2 (ja) 2001-06-12 2013-09-10 眼内薬物送達のためのリザーバデバイス

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2010157037A Expired - Lifetime JP5416048B2 (ja) 2001-06-12 2010-07-09 眼内薬物送達のためのリザーバデバイス
JP2012002591A Ceased JP2012096056A (ja) 2001-06-12 2012-01-10 眼内薬物送達のためのリザーバデバイス
JP2013187604A Expired - Lifetime JP5896966B2 (ja) 2001-06-12 2013-09-10 眼内薬物送達のためのリザーバデバイス

Country Status (7)

Country Link
US (7) US7883717B2 (enExample)
EP (2) EP1404297B1 (enExample)
JP (4) JP4677538B2 (enExample)
AT (1) ATE506929T1 (enExample)
CA (1) CA2450771C (enExample)
DE (1) DE60239868D1 (enExample)
WO (1) WO2002100318A2 (enExample)

Families Citing this family (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534139A (ja) * 1999-01-05 2002-10-15 マサチューセッツ・アイ・アンド・イア・インファーマリー 網膜と脈絡膜への経強膜徐放性薬剤標的送達
US7943162B2 (en) 1999-10-21 2011-05-17 Alcon, Inc. Drug delivery device
EP1992317B1 (en) * 2000-08-30 2012-02-29 Johns Hopkins University Devices for intraocular drug delivery
DE10105592A1 (de) * 2001-02-06 2002-08-08 Achim Goepferich Platzhalter zur Arzneistofffreigabe in der Stirnhöhle
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
JP4677538B2 (ja) * 2001-06-12 2011-04-27 ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン 眼内薬物送達のためのリザーバデバイス
BR0210287A (pt) 2001-07-23 2005-12-13 Alcon Inc Dispositivo de administração de droga oftalmológica
BR0210494A (pt) 2001-07-23 2004-06-22 Alcon Inc Dispositivo de administração de droga oftálmica
WO2003061625A2 (en) 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
AU2003217531A1 (en) * 2002-05-02 2003-11-17 Massachusetts Eye And Ear Infirmary Ocular drug delivery systems and use thereof
US20070027537A1 (en) * 2002-08-02 2007-02-01 David Castillejos Method and intra-sclera implant for treatment of glaucoma and presbyopia
EP1539066B1 (en) * 2002-09-17 2012-11-07 Iscience Surgical Corporation Apparatus surgical bypass of aqueous humor
US20050143363A1 (en) * 2002-09-29 2005-06-30 Innorx, Inc. Method for subretinal administration of therapeutics including steroids; method for localizing pharmacodynamic action at the choroid of the retina; and related methods for treatment and/or prevention of retinal diseases
US8317816B2 (en) 2002-09-30 2012-11-27 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
AR043356A1 (es) * 2003-01-24 2005-07-27 Control Delivery Sys Inc Dispositvo de liberacion sostenida para la administracion ocular de inhibidores de la anhidrasa carbonica y uso de inhibidores de la anhidrasa carbonica para su preparacion
WO2004073551A2 (en) * 2003-02-18 2004-09-02 Massachusetts Eye And Ear Infirmary Transscleral drug delivery device and related methods
US8404269B2 (en) 2003-04-11 2013-03-26 Michael Snyder Sustained release implantable eye device
ATE476960T1 (de) * 2003-05-02 2010-08-15 Surmodics Inc System zur kontrollierten freisetzung eines bioaktiven wirkstoffs im hinteren bereich des auges
US8246974B2 (en) * 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
AU2004274026A1 (en) 2003-09-18 2005-03-31 Macusight, Inc. Transscleral delivery
US20050148948A1 (en) * 2003-12-19 2005-07-07 Caputa Steven G. Sutureless ophthalmic drug delivery system and method
IL159818A0 (en) * 2004-01-12 2004-06-20 Nulens Ltd Intraocular structure
US7976520B2 (en) 2004-01-12 2011-07-12 Nulens Ltd. Eye wall anchored fixtures
US7276050B2 (en) * 2004-03-02 2007-10-02 Alan Franklin Trans-scleral drug delivery method and apparatus
US8702626B1 (en) 2004-04-21 2014-04-22 Acclarent, Inc. Guidewires for performing image guided procedures
US7410480B2 (en) * 2004-04-21 2008-08-12 Acclarent, Inc. Devices and methods for delivering therapeutic substances for the treatment of sinusitis and other disorders
US8146400B2 (en) 2004-04-21 2012-04-03 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US20190314620A1 (en) 2004-04-21 2019-10-17 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US7803150B2 (en) 2004-04-21 2010-09-28 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9351750B2 (en) 2004-04-21 2016-05-31 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US7361168B2 (en) 2004-04-21 2008-04-22 Acclarent, Inc. Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US9554691B2 (en) * 2004-04-21 2017-01-31 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US9089258B2 (en) * 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8764729B2 (en) 2004-04-21 2014-07-01 Acclarent, Inc. Frontal sinus spacer
US20070167682A1 (en) 2004-04-21 2007-07-19 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US8747389B2 (en) 2004-04-21 2014-06-10 Acclarent, Inc. Systems for treating disorders of the ear, nose and throat
US7419497B2 (en) * 2004-04-21 2008-09-02 Acclarent, Inc. Methods for treating ethmoid disease
US7559925B2 (en) * 2006-09-15 2009-07-14 Acclarent Inc. Methods and devices for facilitating visualization in a surgical environment
US20070208252A1 (en) 2004-04-21 2007-09-06 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US9399121B2 (en) * 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US7462175B2 (en) 2004-04-21 2008-12-09 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US20060063973A1 (en) 2004-04-21 2006-03-23 Acclarent, Inc. Methods and apparatus for treating disorders of the ear, nose and throat
CN1976732A (zh) * 2004-04-29 2007-06-06 i科学外科公司 用于外科手术式改善房水引流的装置和方法
US20100173866A1 (en) * 2004-04-29 2010-07-08 Iscience Interventional Corporation Apparatus and method for ocular treatment
EP2193821A1 (en) * 2004-04-29 2010-06-09 iScience Interventional Corporation Apparatus for ocular treatment
WO2006002366A2 (en) * 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable ocular devices, methods and systems
US20060110428A1 (en) * 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7117870B2 (en) * 2004-07-26 2006-10-10 Clarity Corporation Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same
US20060034891A1 (en) * 2004-08-12 2006-02-16 Laurie Lawin Biodegradable controlled release bioactive agent delivery device
US8246569B1 (en) 2004-08-17 2012-08-21 California Institute Of Technology Implantable intraocular pressure drain
US20060110429A1 (en) * 2004-11-24 2006-05-25 Therakine Corporation Implant for intraocular drug delivery
EP1819373A2 (en) 2004-12-07 2007-08-22 SurModics, Inc. Coatings with crystallized active agent(s)
US9788978B2 (en) * 2004-12-20 2017-10-17 Nicholas A. Rojo Implantable systems and stents containing cells for therapeutic uses
US20060147491A1 (en) * 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
US20060198868A1 (en) * 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
JP2008530127A (ja) 2005-02-09 2008-08-07 マクサイト， インコーポレイテッド 眼の処置のための処方物
JP2008535847A (ja) * 2005-04-08 2008-09-04 サーモディクス，インコーポレイティド 網膜下に送達するための持続放出インプラント
US20060258994A1 (en) * 2005-05-12 2006-11-16 Avery Robert L Implantable delivery device for administering pharmacological agents to an internal portion of a body
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US8663673B2 (en) 2005-07-29 2014-03-04 Surmodics, Inc. Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US8114113B2 (en) 2005-09-23 2012-02-14 Acclarent, Inc. Multi-conduit balloon catheter
WO2007059144A1 (en) * 2005-11-15 2007-05-24 Surmodics, Inc. Ultrasonic nozzles for applying two-component coatings
CN103284833B (zh) 2006-01-17 2016-06-29 创森德医疗设备公司 青光眼治疗装置
EP1978892B1 (en) * 2006-01-17 2017-11-15 Novartis Ag Drug delivery treatment device
US20070179518A1 (en) * 2006-02-02 2007-08-02 Becker Bruce B Balloon Catheters and Methods for Treating Paranasal Sinuses
WO2007092620A2 (en) 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
WO2007106557A2 (en) * 2006-03-14 2007-09-20 University Of Southern California Mems device for delivery of therapeutic agents
AU2007230964B2 (en) 2006-03-23 2012-07-19 Santen Pharmaceutical Co., Ltd. Formulations and methods for vascular permeability-related diseases or conditions
US8190389B2 (en) 2006-05-17 2012-05-29 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US7909789B2 (en) 2006-06-26 2011-03-22 Sight Sciences, Inc. Intraocular implants and methods and kits therefor
EP2037882B1 (en) * 2006-06-28 2014-12-10 SurModics, Inc. Combination degradable and non-degradable matrices for active agent delivery
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
WO2008022258A2 (en) * 2006-08-16 2008-02-21 Surmodics, Inc. Methods and materials for increasing the adhesion of elution control matrices to substrates
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
US20080075779A1 (en) * 2006-09-27 2008-03-27 Chappa Ralph A Additives And Methods For Enhancing Active Agent Elution Kinetics
US8439687B1 (en) 2006-12-29 2013-05-14 Acclarent, Inc. Apparatus and method for simulated insertion and positioning of guidewares and other interventional devices
WO2008124787A2 (en) 2007-04-09 2008-10-16 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8118757B2 (en) 2007-04-30 2012-02-21 Acclarent, Inc. Methods and devices for ostium measurement
US8485199B2 (en) 2007-05-08 2013-07-16 Acclarent, Inc. Methods and devices for protecting nasal turbinate during surgery
US8968396B2 (en) 2007-07-23 2015-03-03 Powervision, Inc. Intraocular lens delivery systems and methods of use
US20090030409A1 (en) * 2007-07-27 2009-01-29 Eric Goldfarb Methods and devices for facilitating visualization in a surgical environment
US20170360609A9 (en) 2007-09-24 2017-12-21 Ivantis, Inc. Methods and devices for increasing aqueous humor outflow
WO2009073734A2 (en) 2007-12-03 2009-06-11 Medipacs, Inc. Fluid metering device
MX2010006840A (es) 2007-12-20 2010-08-12 Univ Southern California Aparato y métodos para suministrar agentes terapeuticos.
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
MX2010007382A (es) 2008-01-03 2010-12-20 Univ Southern California Dispositivos implantables para suministro de farmacos, y aparato y metodos para recargar los dispositivos.
US9873001B2 (en) 2008-01-07 2018-01-23 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8608632B1 (en) 2009-07-03 2013-12-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye
US10022558B1 (en) 2008-01-07 2018-07-17 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US8602959B1 (en) 2010-05-21 2013-12-10 Robert Park Methods and devices for delivery of radiation to the posterior portion of the eye
DK2676701T3 (en) * 2008-01-07 2016-05-23 Salutaris Medical Devices Inc Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye
US9056201B1 (en) 2008-01-07 2015-06-16 Salutaris Medical Devices, Inc. Methods and devices for minimally-invasive delivery of radiation to the eye
US20110207987A1 (en) * 2009-11-02 2011-08-25 Salutaris Medical Devices, Inc. Methods And Devices For Delivering Appropriate Minimally-Invasive Extraocular Radiation
CA2711490A1 (en) * 2008-01-14 2009-07-23 Surmodics, Inc. Devices and methods for elution of nucleic acid delivery complexes
JP2011513002A (ja) 2008-03-05 2011-04-28 イバンティス インコーポレイテッド 緑内障を治療する方法及び器具
US8182432B2 (en) 2008-03-10 2012-05-22 Acclarent, Inc. Corewire design and construction for medical devices
US20090263449A1 (en) * 2008-04-09 2009-10-22 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
US8936811B2 (en) * 2008-05-07 2015-01-20 Surmodics, Inc. Device coated with glycogen particles comprising nucleic acid complexes
ES2534864T3 (es) * 2008-05-08 2015-04-29 Minipumps, Llc Bombas implantables y cánulas para las mismas
CN103349803B (zh) 2008-05-08 2016-12-28 迷你泵有限责任公司 可植入药物传送装置与用于填充该装置的设备和方法
US8486278B2 (en) 2008-05-08 2013-07-16 Minipumps, Llc Drug-delivery pumps and methods of manufacture
US9333297B2 (en) 2008-05-08 2016-05-10 Minipumps, Llc Drug-delivery pump with intelligent control
ES2700863T3 (es) 2008-07-30 2019-02-19 Acclarent Inc Dispositivos de localización del ostium paranasal
CA2737804A1 (en) * 2008-09-18 2010-03-25 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US20100189765A1 (en) * 2008-11-26 2010-07-29 Erickson Signe R Implantable ocular drug delivery device and methods
MX2011006726A (es) * 2009-01-02 2011-07-20 Alcon Res Ltd Implante oftalmico recargable in situ.
USD691267S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691270S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
USD691268S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to eye
USD691269S1 (en) 2009-01-07 2013-10-08 Salutaris Medical Devices, Inc. Fixed-shape cannula for posterior delivery of radiation to an eye
US8425473B2 (en) 2009-01-23 2013-04-23 Iscience Interventional Corporation Subretinal access device
US20100191177A1 (en) * 2009-01-23 2010-07-29 Iscience Interventional Corporation Device for aspirating fluids
SG173167A1 (en) 2009-01-29 2011-08-29 Forsight Labs Llc Posterior segment drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US20100241155A1 (en) 2009-03-20 2010-09-23 Acclarent, Inc. Guide system with suction
US8435290B2 (en) * 2009-03-31 2013-05-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US7978742B1 (en) 2010-03-24 2011-07-12 Corning Incorporated Methods for operating diode lasers
USD629503S1 (en) 2009-05-08 2010-12-21 Sean Caffey Implantable drug-delivery pump
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
EP3412260B1 (en) 2009-05-18 2020-08-26 Dose Medical Corporation Drug eluting ocular implant
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
CN102481171B (zh) 2009-07-09 2015-01-28 伊万提斯公司 用于输送眼部植入物的单人操作装置
AU2010271218B2 (en) 2009-07-09 2017-02-02 Alcon Inc. Ocular implants and methods for delivering ocular implants into the eye
WO2011022484A1 (en) * 2009-08-18 2011-02-24 Replenish Pumps. Llc Electrolytic drug-delivery pump with adaptive control
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
US8545431B2 (en) * 2009-09-21 2013-10-01 Alcon Research, Ltd. Lumen clearing valve for glaucoma drainage device
US8419673B2 (en) 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
US8721580B2 (en) * 2009-09-21 2014-05-13 Alcon Research, Ltd. Power saving glaucoma drainage device
US8382750B2 (en) * 2009-10-28 2013-02-26 Vivant Medical, Inc. System and method for monitoring ablation size
US20110160740A1 (en) * 2009-12-28 2011-06-30 Acclarent, Inc. Tissue Removal in The Paranasal Sinus and Nasal Cavity
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
US8529622B2 (en) 2010-02-05 2013-09-10 Sight Sciences, Inc. Intraocular implants and related kits and methods
US8038650B2 (en) * 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device
US8900298B2 (en) 2010-02-23 2014-12-02 Powervision, Inc. Fluid for accommodating intraocular lenses
CA2807535C (en) 2010-08-05 2019-03-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
JP5907966B2 (ja) 2010-08-05 2016-04-26 フォーサイト・ビジョン フォー・インコーポレーテッド 埋め込み型治療デバイス
EP2600876B1 (en) 2010-08-05 2015-04-29 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
WO2012043081A1 (ja) * 2010-09-27 2012-04-05 テルモ株式会社 医療用装置
WO2012058274A2 (en) 2010-10-26 2012-05-03 Surmodics, Inc. Coatings and methods for controlled elution of hydrophilic active agents
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
WO2012065006A2 (en) 2010-11-11 2012-05-18 Forsight Vision4, Inc. Methods and apparatus to determine porous structures for drug delivery
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US10286146B2 (en) 2011-03-14 2019-05-14 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9603997B2 (en) 2011-03-14 2017-03-28 Minipumps, Llc Implantable drug pumps and refill devices therefor
US9919099B2 (en) 2011-03-14 2018-03-20 Minipumps, Llc Implantable drug pumps and refill devices therefor
CN103547255B (zh) 2011-04-14 2018-07-06 加利福尼亚大学董事会 多层薄膜药物递送装置以及其制造和使用方法
EP3824910A1 (en) 2011-05-18 2021-05-26 The Regents of The University of California Compositions and methods for treating retinal diseases
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
US8657776B2 (en) 2011-06-14 2014-02-25 Ivantis, Inc. Ocular implants for delivery into the eye
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
EP3903733B1 (en) 2011-09-16 2025-08-27 ForSight Vision4, Inc. Fluid exchange apparatus
US8585631B2 (en) 2011-10-18 2013-11-19 Alcon Research, Ltd. Active bimodal valve system for real-time IOP control
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8840578B2 (en) 2011-12-09 2014-09-23 Alcon Research, Ltd. Multilayer membrane actuators
WO2013090197A1 (en) 2011-12-12 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9125721B2 (en) 2011-12-13 2015-09-08 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US8663150B2 (en) 2011-12-19 2014-03-04 Ivantis, Inc. Delivering ocular implants into the eye
US9241829B2 (en) 2011-12-20 2016-01-26 Abbott Medical Optics Inc. Implantable intraocular drug delivery apparatus, system and method
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
CN104302689A (zh) 2012-03-14 2015-01-21 麦德医像公司 含有过量活性分子的智能聚合物材料
US8894603B2 (en) 2012-03-20 2014-11-25 Sight Sciences, Inc. Ocular delivery systems and methods
US9358156B2 (en) 2012-04-18 2016-06-07 Invantis, Inc. Ocular implants for delivery into an anterior chamber of the eye
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
JP6549482B2 (ja) 2012-06-01 2019-07-24 サーモディクス，インコーポレイテッド バルーンカテーテルをコーティングするための装置および方法
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
US10617558B2 (en) 2012-11-28 2020-04-14 Ivantis, Inc. Apparatus for delivering ocular implants into an anterior chamber of the eye
US9528633B2 (en) 2012-12-17 2016-12-27 Novartis Ag MEMS check valve
US9295389B2 (en) 2012-12-17 2016-03-29 Novartis Ag Systems and methods for priming an intraocular pressure sensor in an intraocular implant
US9572712B2 (en) 2012-12-17 2017-02-21 Novartis Ag Osmotically actuated fluidic valve
EP2968113B8 (en) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9597227B2 (en) * 2013-03-15 2017-03-21 Abbott Medical Optics Inc. Trans-sclera portal for delivery of therapeutic agents
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US10195020B2 (en) 2013-03-15 2019-02-05 Powervision, Inc. Intraocular lens storage and loading devices and methods of use
ES2972168T3 (es) 2013-03-28 2024-06-11 Forsight Vision4 Inc Implante oftálmico para administración de sustancias terapéuticas
US20140336619A1 (en) * 2013-05-13 2014-11-13 Abbott Cardiovascular Systems Inc. Ophthalmic shunt and method
US20160137717A1 (en) 2013-06-20 2016-05-19 Gabriela Burian Use of a vegf antagonist in treating choroidal neovascularisation
EP3010526A1 (en) 2013-06-20 2016-04-27 Novartis AG Use of a vegf antagonist in treating macular edema
EP3010542A1 (en) 2013-06-20 2016-04-27 Novartis AG Treatment of polypoidal choroidal vasculopathy
KR20160029794A (ko) 2013-07-11 2016-03-15 노파르티스 아게 소아 환자의 맥락망막 신생혈관성 및 투과성 장애의 치료에 있어서 vegf 길항제의 용도
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
US9289324B2 (en) 2013-08-26 2016-03-22 Novartis Ag Externally adjustable passive drainage device
US9283115B2 (en) 2013-08-26 2016-03-15 Novartis Ag Passive to active staged drainage device
US10376413B2 (en) * 2013-10-27 2019-08-13 Microsert Ltd. Implantable drug delivery device and a system and method for deployment of such devices
US9445941B2 (en) 2013-11-07 2016-09-20 Drug Delivery Company, Llc Bioresorbable drug eluting intravitreal implant system and method
US9681983B2 (en) 2014-03-13 2017-06-20 Novartis Ag Debris clearance system for an ocular implant
US9603742B2 (en) 2014-03-13 2017-03-28 Novartis Ag Remote magnetic driven flow system
CA2950187A1 (en) 2014-05-29 2015-12-03 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US9655774B2 (en) * 2014-06-19 2017-05-23 California Institute Of Technology Small molecule transport device for drug delivery or waste removal
WO2016011056A1 (en) 2014-07-14 2016-01-21 Ivantis, Inc. Ocular implant delivery system and method
CA2955186C (en) 2014-07-15 2023-08-29 Forsight Vision4, Inc. Ocular implant delivery device and method
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
CN107249515B (zh) * 2014-11-10 2019-10-01 弗赛特影像4股份有限公司 可膨胀药物递送装置和使用方法
US10299958B2 (en) 2015-03-31 2019-05-28 Sight Sciences, Inc. Ocular delivery systems and methods
US9655777B2 (en) 2015-04-07 2017-05-23 Novartis Ag System and method for diagphragm pumping using heating element
US11197779B2 (en) 2015-08-14 2021-12-14 Ivantis, Inc. Ocular implant with pressure sensor and delivery system
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
KR20180084104A (ko) 2015-11-20 2018-07-24 포사이트 비젼4, 인크. 연장 방출 약물 전달 장치를 위한 다공성 구조물
JP6885609B2 (ja) * 2015-11-23 2021-06-16 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ 薬物送達のための涙器システム
US11938058B2 (en) 2015-12-15 2024-03-26 Alcon Inc. Ocular implant and delivery system
KR101750651B1 (ko) * 2016-01-28 2017-06-23 동국대학교 산학협력단 약물 잔류 방지능 및 재충전 기능을 갖는 안구 내 약물 주입 장치
CN109195556B (zh) 2016-04-05 2021-03-26 弗赛特影像4股份有限公司 可植入眼睛药物递送装置
CA3022830A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
USD814637S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
USD815285S1 (en) 2016-05-11 2018-04-10 Salutaris Medical Devices, Inc. Brachytherapy device
USD814638S1 (en) 2016-05-11 2018-04-03 Salutaris Medical Devices, Inc. Brachytherapy device
JP7054211B2 (ja) 2016-05-20 2022-04-13 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト 涙腺ドラッグ送給デバイス
US11213430B2 (en) 2016-05-26 2022-01-04 Cochlear Limited Inner ear plug
USD808528S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
USD808529S1 (en) 2016-08-31 2018-01-23 Salutaris Medical Devices, Inc. Holder for a brachytherapy device
US11351058B2 (en) 2017-03-17 2022-06-07 W. L. Gore & Associates, Inc. Glaucoma treatment systems and methods
WO2018226640A1 (en) 2017-06-05 2018-12-13 The Regents Of The University Of The University Of California Compositions for treating retinal diseases and methods for making and using them
US10744313B2 (en) 2017-07-27 2020-08-18 University Of Utah Research Foundation Therapeutic delivery device
WO2019051034A1 (en) * 2017-09-06 2019-03-14 Children's National Medical Center POROUS IMPLANTABLE DEVICES
EP3713528A1 (en) 2017-11-21 2020-09-30 ForSight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
WO2019164834A1 (en) 2018-02-22 2019-08-29 Ivantis, Inc. Ocular implant and delivery system
AU2019256527B2 (en) 2018-04-19 2025-01-23 Spiral Therapeutics, Inc. Inner ear drug delivery devices and methods of use
AU2019333136B2 (en) * 2018-08-29 2022-11-17 W. L. Gore & Associates, Inc. Drug therapy delivery systems and methods
US11583627B1 (en) 2018-10-18 2023-02-21 University Of South Florida Implantable drug storage devices for drug delivery
US11628466B2 (en) 2018-11-29 2023-04-18 Surmodics, Inc. Apparatus and methods for coating medical devices
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
CN109431678B (zh) * 2018-12-17 2021-05-28 中国医学科学院北京协和医院 经巩膜药物传输系统
US11779739B2 (en) * 2018-12-21 2023-10-10 Perfect Ip, Llc Drug delivery system and method
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
US11504270B1 (en) 2019-09-27 2022-11-22 Sight Sciences, Inc. Ocular delivery systems and methods
TW202140071A (zh) * 2020-02-14 2021-11-01 美商英福卡斯公司 用於治療眼部疾病之具有一自我密封儲存槽之可植入式藥物遞送裝置
CN112569457B (zh) * 2020-12-10 2024-02-13 北京大学第三医院（北京大学第三临床医学院） 一种持续给药囊管系统
US11540940B2 (en) 2021-01-11 2023-01-03 Alcon Inc. Systems and methods for viscoelastic delivery
KR20240013804A (ko) * 2021-05-27 2024-01-30 더블유. 엘. 고어 앤드 어소시에이트스, 인코포레이티드 약물 치료 전달 시스템 및 방법
US20220378612A1 (en) * 2021-05-28 2022-12-01 Sight Sciences, Inc. Intraocular devices, systems, and methods
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
USD1101145S1 (en) 2022-08-11 2025-11-04 Genentech, Inc. Ocular incision guide tool
WO2025100463A1 (ja) * 2023-11-10 2025-05-15 公立大学法人名古屋市立大学 細胞移植器具

Family Cites Families (209)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2585815A (en) 1947-01-16 1952-02-12 Mclintock Duncan Menzies Injection syringe
US2564977A (en) 1949-01-19 1951-08-21 Hu Quang Hsi Medical injecting apparatus
US3232117A (en) 1962-09-14 1966-02-01 Roger Gilmont Instr Inc Micrometer buret
US3416530A (en) 1966-03-02 1968-12-17 Richard A. Ness Eyeball medication dispensing tablet
US3618604A (en) 1969-06-09 1971-11-09 Alza Corp Ocular insert
US3641237A (en) 1970-09-30 1972-02-08 Nat Patent Dev Corp Zero order release constant elution rate drug dosage
US4034756A (en) 1971-01-13 1977-07-12 Alza Corporation Osmotically driven fluid dispenser
US3831583A (en) * 1971-03-05 1974-08-27 Univ California Implantable bulb for inflation of surgical implements
US3995635A (en) 1971-09-09 1976-12-07 Alza Corporation Ocular insert
US3986510A (en) 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3828777A (en) 1971-11-08 1974-08-13 Alza Corp Microporous ocular device
US3826258A (en) 1972-02-07 1974-07-30 S Abraham Gradual release medicine carrier
US3845201A (en) 1972-04-24 1974-10-29 S Loucas Solid state ophthalmic medication delivery method
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3914402A (en) 1973-06-14 1975-10-21 Alza Corp Ophthalmic dosage form, for releasing medication over time
US4179497A (en) 1973-12-17 1979-12-18 Merck & Co., Inc. Solid state ophthalmic medication
US3902495A (en) 1974-01-28 1975-09-02 Cavitron Corp Flow control system
US3961628A (en) 1974-04-10 1976-06-08 Alza Corporation Ocular drug dispensing system
US3949748A (en) 1974-09-26 1976-04-13 Oscar Malmin Injection syringe having aspirating and metering capabilities
US3949750A (en) 1974-10-07 1976-04-13 Freeman Jerre M Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same
US3926188A (en) 1974-11-14 1975-12-16 Alza Corp Laminated drug dispenser
US4142526A (en) 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4014335A (en) * 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4057619A (en) 1975-06-30 1977-11-08 Alza Corporation Ocular therapeutic system with selected membranes for administering ophthalmic drug
NL188266C (nl) 1975-07-29 1992-05-18 Merck & Co Inc Werkwijze ter bereiding van een oogheelkundig inplantaat.
US3977404A (en) 1975-09-08 1976-08-31 Alza Corporation Osmotic device having microporous reservoir
US4034758A (en) 1975-09-08 1977-07-12 Alza Corporation Osmotic therapeutic system for administering medicament
US4014333A (en) 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4077407A (en) 1975-11-24 1978-03-07 Alza Corporation Osmotic devices having composite walls
US4014334A (en) 1976-02-02 1977-03-29 Alza Corporation Laminated osmotic system for dispensing beneficial agent
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4111201A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for delivering selected beneficial agents having varying degrees of solubility
US4111203A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4160452A (en) 1977-04-07 1979-07-10 Alza Corporation Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4186184A (en) 1977-12-27 1980-01-29 Alza Corporation Selective administration of drug with ocular therapeutic system
US4220152A (en) 1978-05-08 1980-09-02 Pfizer Inc. Delivery system
US4220153A (en) 1978-05-08 1980-09-02 Pfizer Inc. Controlled release delivery system
US4200098A (en) 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4300557A (en) 1980-01-07 1981-11-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method for treating intraocular malignancies
DE3068986D1 (en) 1980-01-28 1984-09-27 Merck & Co Inc Ophthalmic inserts for lowering intraocular pressure comprising carbonic anhydrase inhibitors
US4309776A (en) 1980-05-13 1982-01-12 Ramon Berguer Intravascular implantation device and method of using the same
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4484922A (en) 1981-06-25 1984-11-27 Rosenwald Peter L Occular device
US4439198A (en) 1981-07-09 1984-03-27 University Of Illinois Foundation Biodegradable ocular insert for controlled delivery of ophthalmic medication
US4730013A (en) 1981-10-08 1988-03-08 Merck & Co., Inc. Biosoluble ocular insert
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4673405A (en) 1983-03-04 1987-06-16 Alza Corporation Osmotic system with instant drug availability
US4883459A (en) 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4774091A (en) 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
US4627850A (en) 1983-11-02 1986-12-09 Alza Corporation Osmotic capsule
US4777049A (en) 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
US4634418A (en) 1984-04-06 1987-01-06 Binder Perry S Hydrogel seton
US4851228A (en) 1984-06-20 1989-07-25 Merck & Co., Inc. Multiparticulate controlled porosity osmotic
US4634427A (en) 1984-09-04 1987-01-06 American Hospital Supply Company Implantable demand medication delivery assembly
US5049142A (en) 1984-11-07 1991-09-17 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US5053030A (en) * 1984-11-07 1991-10-01 Herrick Robert S Intracanalicular implant for horizontal canalicular blockade treatment of the eye
US4712550A (en) 1985-04-08 1987-12-15 Sinnett Kevin B Retinal tack
US4693886A (en) 1985-04-22 1987-09-15 Alza Corporation Osmotic device with inert core
US4609374A (en) 1985-04-22 1986-09-02 Alza Corporation Osmotic device comprising means for governing initial time of agent release therefrom
EP0201611A1 (de) 1985-05-10 1986-11-20 B. Braun-SSC AG Zwei-Kanülen-Spritze
FR2582221B1 (fr) 1985-05-21 1987-09-25 Applied Precision Ltd Dispositif implantable d'injection chronique d'une substance, notamment therapeutique
US4861335A (en) * 1985-07-26 1989-08-29 Duoject Medical Systems Inc. Syringe
US4840615A (en) 1985-09-30 1989-06-20 Mcghan Medical Corporation Self-sealing injection reservoir
US4781675A (en) 1985-11-27 1988-11-01 White Thomas C Infusion cannula
EP0228185B1 (en) * 1985-11-27 1990-07-25 Thomas C. White Tissue-implantable fluid-dissipating device
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5147647A (en) 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
ATE141166T1 (de) 1986-12-23 1996-08-15 Liposome Co Inc Guanidinaminoglycosid enthaltende liposome
US4781680A (en) 1987-03-02 1988-11-01 Vir Engineering Resealable injection site
US4853229A (en) * 1987-10-26 1989-08-01 Alza Corporation Method for adminstering tiny pills
JP2702953B2 (ja) * 1988-01-30 1998-01-26 オリンパス光学工業株式会社 薬液含浸セラミックス
US4865846A (en) 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US5174999A (en) 1988-12-13 1992-12-29 Alza Corporation Delivery system comprising fluid ingress and drug egress
AU4951690A (en) 1988-12-30 1990-08-01 David M. Anderson Stabilized microporous materials and hydrogel materials
US5141748A (en) 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US5098443A (en) 1989-03-23 1992-03-24 University Of Miami Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
US4979938A (en) 1989-05-11 1990-12-25 Iomed, Inc. Method of iontophoretically treating acne, furuncles and like skin disorders
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
US5092837A (en) 1989-12-20 1992-03-03 Robert Ritch Method for the treatment of glaucoma
US5171270A (en) 1990-03-29 1992-12-15 Herrick Robert S Canalicular implant having a collapsible flared section and method
US5324280A (en) 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5128145A (en) 1990-06-13 1992-07-07 Alza Corporation Dosage form for Parkinson's disease, spasticity and muscle spasms
US5238687A (en) 1990-07-11 1993-08-24 Alza Corporation Delivery device with a protective sleeve
US5084021A (en) 1990-11-02 1992-01-28 Baldwin Brian E Patient controlled infusion apparatus and method
US5378475A (en) * 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5334189A (en) 1991-06-03 1994-08-02 Wade Stephen E Device for controlled diffusion of a chemical substance
US5213576A (en) * 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
US5282829A (en) 1991-08-15 1994-02-01 United States Surgical Corporation Hollow body implants
FR2682090B1 (fr) 1991-10-03 1993-12-31 Holzstoff Holding Sa Systeme-reservoir pour diffusion prolongee d'un principe actif.
US5681572A (en) 1991-10-18 1997-10-28 Seare, Jr.; William J. Porous material product and process
US5830492A (en) 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5178635A (en) 1992-05-04 1993-01-12 Allergan, Inc. Method for determining amount of medication in an implantable device
US6096756A (en) 1992-09-21 2000-08-01 Albert Einstein College Of Medicine Of Yeshiva University Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists
US5336175A (en) 1992-10-29 1994-08-09 Mames Robert N Method for the treatment of retinal detachments
US5576480A (en) 1992-11-06 1996-11-19 Pall Corporation System and method for testing the integrity of porous elements
US5443505A (en) * 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5985328A (en) 1994-03-07 1999-11-16 Regents Of The University Of California Micromachined porous membranes with bulk support
US5770076A (en) 1994-03-07 1998-06-23 The Regents Of The University Of California Micromachined capsules having porous membranes and bulk supports
US5578042A (en) * 1994-03-14 1996-11-26 Cumming; J. Stuart Ophthalmic kit and method for lens insertion
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
DE69529572T2 (de) 1994-11-10 2003-06-18 The University Of Kentucky Research Foundation, Lexington Implantierbare wiederauffüllbare vorrichtung mit gesteuerter freisetzung zur verabreichung von arzneistoffen unmittelbar an einen inneren teil des körpers
US5725493A (en) * 1994-12-12 1998-03-10 Avery; Robert Logan Intravitreal medicine delivery
US5704915A (en) 1995-02-14 1998-01-06 Therex Limited Partnership Hemodialysis access device
US5554132A (en) 1995-03-30 1996-09-10 Abbott Laboratories Hand grip for use with syringe
US5651979A (en) 1995-03-30 1997-07-29 Gel Sciences, Inc. Apparatus and method for delivering a biologically active compound into a biological environment
JP3670291B2 (ja) * 1995-05-14 2005-07-13 オプトノール リミティド 眼内移植片、導入装置
IL113723A (en) 1995-05-14 2002-11-10 Optonol Ltd Intraocular implant
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5989216A (en) 1995-06-29 1999-11-23 Sims Deltec, Inc. Access portal and method
US6685940B2 (en) 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US5773019A (en) 1995-09-27 1998-06-30 The University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6641708B1 (en) 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB2310149A (en) 1996-02-15 1997-08-20 Nomix Chipman Ltd Spray gun
US5904144A (en) 1996-03-22 1999-05-18 Cytotherapeutics, Inc. Method for treating ophthalmic diseases
US5951512A (en) 1996-05-28 1999-09-14 Horizon Medical Products, Inc. Infusion port with modified drug reservoir
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5928662A (en) * 1996-07-31 1999-07-27 Phillips; Andrew F. Ocular drug delivery device
AU7533696A (en) 1996-12-13 1998-06-18 Ciba-Geigy Ag New materials
KR100523199B1 (ko) 1997-03-31 2005-10-21 알자 코포레이션 확산 주입형 투여 시스템 및 투여 방법, 및 그 시스템의 제조 방법
US7160687B1 (en) 1997-05-29 2007-01-09 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5968008A (en) 1997-08-04 1999-10-19 Grams; Guenter A. Cannula with parallel channels and sliding sheath
US6306426B1 (en) 1997-08-11 2001-10-23 Allergan Sales, Inc. Implant device with a retinoid for improved biocompatibility
US5902598A (en) 1997-08-28 1999-05-11 Control Delivery Systems, Inc. Sustained release drug delivery devices
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6331523B1 (en) 1998-03-12 2001-12-18 Genentech, Inc. Method of enhancing the survival of retinal neurons and treating ocular diseases using FGF-5
US6196993B1 (en) 1998-04-20 2001-03-06 Eyelab Group, Llc Ophthalmic insert and method for sustained release of medication to the eye
US5993414A (en) 1998-04-23 1999-11-30 Medtronic, Inc. Implantable device
FR2784296B1 (fr) 1998-09-18 2001-01-05 Imedex Biomateriaux Dispositif pour la formulation et la delivrance d'un melange, notamment pour l'application chirurgicale de ce melange
US7973068B2 (en) 1998-10-20 2011-07-05 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
DE69917484T2 (de) 1998-12-14 2005-05-12 Tre Esse Progettazione Biomedica S.R.L. Kathetersystem zur durchführung einer intramyokardialen therapeutischen behandlung
DE19948783C2 (de) 1999-02-18 2001-06-13 Alcove Surfaces Gmbh Implantat
US7914442B1 (en) 1999-03-01 2011-03-29 Gazdzinski Robert F Endoscopic smart probe and method
US20050119601A9 (en) 1999-04-26 2005-06-02 Lynch Mary G. Shunt device and method for treating glaucoma
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU770975B2 (en) 1999-06-18 2004-03-11 Alcon Laboratories, Inc. Topical ophthalmic mast cell stabilizers for treating allergic eye diseases
US6551291B1 (en) 1999-08-04 2003-04-22 Johns Hopkins University Non-traumatic infusion cannula and treatment methods using same
US6638263B1 (en) 1999-10-12 2003-10-28 Durect Corporation Regulation of drug delivery through flow diversion
TR200201047T2 (tr) 1999-10-21 2002-07-22 Alcon, Inc. İlaç verme vasıtası.
US6416777B1 (en) 1999-10-21 2002-07-09 Alcon Universal Ltd. Ophthalmic drug delivery device
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
RU2262331C2 (ru) 2000-01-12 2005-10-20 Бектон, Дикинсон Энд Компани Шунт, имплантат, система и способ снижения внутриглазного давления, способ изготовления имплантата для роговицы (варианты)
US20050119737A1 (en) 2000-01-12 2005-06-02 Bene Eric A. Ocular implant and methods for making and using same
US20030212383A1 (en) 2001-01-05 2003-11-13 Dana Cote System and methods for reducing intraocular pressure
DE10008826C2 (de) 2000-02-25 2002-03-14 Disetronic Licensing Ag Mikroperfusionsvorrichtung mit Sammelbehältnis
US7077848B1 (en) 2000-03-11 2006-07-18 John Hopkins University Sutureless occular surgical methods and instruments for use in such methods
WO2001068377A1 (en) 2000-03-13 2001-09-20 Seiko Epson Corporation Method for surface treatment, surface-treated article and device for surface treatment
US7141152B2 (en) 2000-03-16 2006-11-28 Le Febre David A Analyte species separation system
US6945969B1 (en) 2000-03-31 2005-09-20 Medtronic, Inc. Catheter for target specific drug delivery
US7708711B2 (en) 2000-04-14 2010-05-04 Glaukos Corporation Ocular implant with therapeutic agents and methods thereof
US6375972B1 (en) * 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
EP1992317B1 (en) 2000-08-30 2012-02-29 Johns Hopkins University Devices for intraocular drug delivery
ES2294025T3 (es) 2000-09-06 2008-04-01 Alcon, Inc. Composiciones de revestimiento de pegajosidad cambiable para implantes oftalmicos.
US6303290B1 (en) 2000-09-13 2001-10-16 The Trustees Of The University Of Pennsylvania Encapsulation of biomaterials in porous glass-like matrices prepared via an aqueous colloidal sol-gel process
CA2434156A1 (en) 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
ES2320533T3 (es) 2001-01-03 2009-05-25 BAUSCH & LOMB INCORPORATED Dispositivos de administracion de farmacos de liberacion sostenida con multiples agentes.
JP2004521882A (ja) 2001-01-03 2004-07-22 ボシュ・アンド・ロム・インコーポレイテッド 組立式透過性プラグを備えた徐放薬剤送達装置
WO2002053130A2 (en) 2001-01-03 2002-07-11 Bausch & Lomb Incorporated Sustained release drug delivery devices with coated drug cores
DE60219607T2 (de) 2001-01-09 2007-12-27 Microchips, Inc., Bedford Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
US6872198B1 (en) 2001-01-24 2005-03-29 Arrow International, Inc. Double-y-shaped multi-lumen catheter with selectively attachable hubs
EP1365738A2 (en) 2001-01-26 2003-12-03 Bausch & Lomb Incorporated Improved process for the production of sustained release drug delivery devices
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US6713081B2 (en) 2001-03-15 2004-03-30 The United States Of America As Represented By The Department Of Health And Human Services Ocular therapeutic agent delivery devices and methods for making and using such devices
JP4677538B2 (ja) 2001-06-12 2011-04-27 ジョンズ ホプキンズ ユニヴァーシティ スクール オヴ メディシン 眼内薬物送達のためのリザーバデバイス
JP4426286B2 (ja) 2001-07-10 2010-03-03 テバ ファーマシューティカル インダストリーズ リミティド ０次、０次−二相性、上昇型又は下降型薬物放出のための薬物送達システム
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
BR0210287A (pt) 2001-07-23 2005-12-13 Alcon Inc Dispositivo de administração de droga oftalmológica
BR0210494A (pt) 2001-07-23 2004-06-22 Alcon Inc Dispositivo de administração de droga oftálmica
MXPA04001076A (es) 2001-08-03 2005-02-17 Glaucoma Res Technologies Inc Metodo e implante intraescleral para tratamiento de glaucoma y presbicia.
EP1420716B1 (en) 2001-08-29 2012-08-15 Ricardo A. P. De Carvalho An implantable and sealable system for unidirectional delivery of therapeutic agents to targeted tissues
US7749528B2 (en) 2001-08-29 2010-07-06 Ricardo Azevedo Pontes De Carvalho Implantable and sealable medical device for unidirectional delivery of therapeutic agents to tissues
CA2461896C (en) 2001-09-28 2012-09-18 Santen Pharmaceutical Co., Ltd. Injections for eye tissues containing drug bonded to polyethylene glycol
AU2002341959A1 (en) 2001-10-04 2003-04-14 Case Western Reserve University Drug delivery devices and methods
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
WO2003044483A2 (en) 2001-11-15 2003-05-30 Arryx, Inc. Sample chip
WO2003061625A2 (en) 2002-01-18 2003-07-31 Snyder Michael E Sustained release ophthalmological device and method of making and using the same
KR101191254B1 (ko) 2002-03-11 2012-10-16 알콘, 인코퍼레이티드 이식 가능한 약물 전달 시스템
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7968569B2 (en) 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
US7939094B2 (en) 2002-06-19 2011-05-10 Boston Scientific Scimed, Inc. Multiphase polymeric drug release region
US20040019325A1 (en) 2002-07-29 2004-01-29 Medrip Ltd. Syringe Pump
US7468065B2 (en) 2002-09-18 2008-12-23 Allergan, Inc. Apparatus for delivery of ocular implants
US7094222B1 (en) 2003-04-28 2006-08-22 The United States Of America As Represented By The Secretary Of Navy Syringe device for simultaneous infusion and withdrawal
US20110076278A1 (en) 2005-08-02 2011-03-31 Mehran Khodadoust Modulators of Hypoxia Inducible Factor-1 and Related Uses for the Treatment of Ocular Disorders
US20070212397A1 (en) 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
JP2009534129A (ja) 2006-04-18 2009-09-24 カスケード オフタルミクス 眼圧減衰装置
WO2008083118A1 (en) 2006-12-26 2008-07-10 Qlt Plug Delivery, Inc. Drug delivery implants for inhibition of optical defects
BRPI0811007A2 (pt) 2007-04-30 2015-01-27 Alcon Res Ltd Tratamento de degeneração macular relacionada à idade usando inibidores de fator de complemento d
US7901726B2 (en) 2007-08-31 2011-03-08 Boston Scientific Scimed, Inc. Porous medical articles for therapeutic agent delivery
GB0718737D0 (en) 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
US20100100043A1 (en) 2007-10-05 2010-04-22 Racenet Danyel J Flexible Access Device For Use In Surgical Procedure
MX2011006726A (es) 2009-01-02 2011-07-20 Alcon Res Ltd Implante oftalmico recargable in situ.
EP3412260B1 (en) 2009-05-18 2020-08-26 Dose Medical Corporation Drug eluting ocular implant
US8821474B2 (en) 2010-02-22 2014-09-02 Microsert Ltd. Slow release liquid drug delivery device
US8038650B2 (en) 2010-02-22 2011-10-18 Microsert Ltd. Slow release liquid drug delivery device

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US20170172794A1 (en) 2017-06-22
WO2002100318A2 (en) 2002-12-19
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US9180046B2 (en) 2015-11-10
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US8486052B2 (en) 2013-07-16
US20180243131A1 (en) 2018-08-30
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