JP4675331B2 - Ｃ型肝炎ウイルスインヒビター - Google Patents

Ｃ型肝炎ウイルスインヒビター Download PDF

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Publication number
JP4675331B2
JP4675331B2 JP2006539980A JP2006539980A JP4675331B2 JP 4675331 B2 JP4675331 B2 JP 4675331B2 JP 2006539980 A JP2006539980 A JP 2006539980A JP 2006539980 A JP2006539980 A JP 2006539980A JP 4675331 B2 JP4675331 B2 JP 4675331B2
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JP
Japan
Prior art keywords
alkyl
compound
hcv
alkoxy
cycloalkyl
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Expired - Fee Related
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JP2006539980A
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English (en)
Japanese (ja)
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JP2007534636A (ja
JP2007534636A5 (https=
Inventor
ポール・マイケル・スコーラ
フィオナ・マクフィー
ニコラス・エイ・ミーンウェル
ピヤセナ・ヘワワサム
ジェフリー・アレン・キャンベル
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2007534636A publication Critical patent/JP2007534636A/ja
Publication of JP2007534636A5 publication Critical patent/JP2007534636A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006539980A 2003-11-12 2004-11-12 Ｃ型肝炎ウイルスインヒビター Expired - Fee Related JP4675331B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51912403P 2003-11-12 2003-11-12
PCT/US2004/038165 WO2005046712A1 (en) 2003-11-12 2004-11-12 Hepatitis c virus inhibitors

Publications (3)

Publication Number Publication Date
JP2007534636A JP2007534636A (ja) 2007-11-29
JP2007534636A5 JP2007534636A5 (https=) 2008-01-17
JP4675331B2 true JP4675331B2 (ja) 2011-04-20

Family

ID=34590359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006539980A Expired - Fee Related JP4675331B2 (ja) 2003-11-12 2004-11-12 Ｃ型肝炎ウイルスインヒビター

Country Status (8)

Country Link
US (1) US7132504B2 (https=)
EP (1) EP1687018B1 (https=)
JP (1) JP4675331B2 (https=)
AT (1) ATE542826T1 (https=)
ES (1) ES2380934T3 (https=)
IS (1) IS8448A (https=)
NO (1) NO20062267L (https=)
WO (1) WO2005046712A1 (https=)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
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