JP4669564B2 - ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 - Google Patents

２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 Download PDF

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Publication number
JP4669564B2
JP4669564B2 JP2009537744A JP2009537744A JP4669564B2 JP 4669564 B2 JP4669564 B2 JP 4669564B2 JP 2009537744 A JP2009537744 A JP 2009537744A JP 2009537744 A JP2009537744 A JP 2009537744A JP 4669564 B2 JP4669564 B2 JP 4669564B2
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Prior art keywords
thiazolidin
hydroxy
benz
ylidene
phenyl
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Japanese (ja)
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JP2010510976A (ja
JP2010510976A5 (OSRAM
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アベレ ステファン
ボリィ マーチン
シュミット ガンサー
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009537744A 2006-11-23 2007-11-22 ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 Active JP4669564B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006054409 2006-11-23
PCT/IB2007/054752 WO2008062376A2 (en) 2006-11-23 2007-11-22 New process for the preparation of 2-imino-thiazolidin-4-one derivatives

Publications (3)

Publication Number Publication Date
JP2010510976A JP2010510976A (ja) 2010-04-08
JP2010510976A5 JP2010510976A5 (OSRAM) 2010-05-20
JP4669564B2 true JP4669564B2 (ja) 2011-04-13

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ID=39316391

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JP2009537744A Active JP4669564B2 (ja) 2006-11-23 2007-11-22 ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法

Country Status (13)

Country Link
US (1) US8263780B2 (OSRAM)
EP (2) EP2094676B1 (OSRAM)
JP (1) JP4669564B2 (OSRAM)
KR (1) KR101255879B1 (OSRAM)
CN (2) CN103087004A (OSRAM)
AU (1) AU2007323042B2 (OSRAM)
CA (1) CA2669069C (OSRAM)
DK (2) DK2489662T3 (OSRAM)
ES (2) ES2410793T3 (OSRAM)
IL (1) IL198847A (OSRAM)
MX (1) MX2009005048A (OSRAM)
TW (1) TWI460166B (OSRAM)
WO (1) WO2008062376A2 (OSRAM)

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USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
SI1689726T1 (sl) 2003-11-21 2011-01-31 Actelion Pharmaceuticals Ltd Derivati 5-(benz-(z)-iliden)-tiazolidin-4-ona kot imunosupresivna sredstva
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
PT2278960T (pt) 2008-03-17 2017-03-09 Actelion Pharmaceuticals Ltd Regime de dosagem para um agonista seletivo do recetor s1p1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
RS60408B1 (sr) * 2012-08-17 2020-07-31 Actelion Pharmaceuticals Ltd Postupak za pripremanje (2z,5z)-5-(3-hloro-4-((r)-2,3-dihidroksipropoksi)benziliden)-2-(propilimino)-3-(o-tolil)tiazolidin-4-ona i međujedinjenja upotrebljena u pomenutom postupku
EP3256125B1 (en) 2014-12-11 2022-01-26 Actelion Pharmaceuticals Ltd Dosing regimen for ponesimod, a selective s1p1 receptor agonist
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US11220488B2 (en) 2017-09-19 2022-01-11 Teva Pharmaceuticals International Gmbh Crystalline polymorph of Ponesimod
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
BR112022000185A2 (pt) * 2019-07-10 2022-02-22 Bayer Ag Método de preparação de 2-(fenilimino)-1,3-tiazolidin-4-onas
JP2022540115A (ja) * 2019-07-10 2022-09-14 バイエル・アクチエンゲゼルシヤフト ２－（フェニルイミノ）－１，３－チアゾリジン－４－オン類の調製方法
KR20220093330A (ko) 2019-10-31 2022-07-05 이도르시아 파마슈티컬스 리미티드 Cxcr7 안타고니스트와 s1p1 수용체 조절인자의 조합
KR20200019639A (ko) 2020-01-30 2020-02-24 전대연 만남의 스마트 도착시스템
KR20220143032A (ko) * 2020-02-18 2022-10-24 바이엘 악티엔게젤샤프트 2-(페닐이미노)-3-알킬-1,3-티아졸리딘-4-온의 제조 방법
WO2023022896A1 (en) 2021-08-17 2023-02-23 Teva Czech Industries S.R.O Polymorphs of ponesimod
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
CN117924210A (zh) * 2024-01-22 2024-04-26 赣南师范大学 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法

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US3077402A (en) * 1954-12-06 1963-02-12 Polaroid Corp Photographic color processes, products, and compositions
NL270002A (OSRAM) 1960-10-08
OA03835A (fr) * 1970-07-17 1971-12-24 Rhone Poulenc Sa Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent.
EP0526598B1 (en) 1990-04-27 1996-12-18 Orion-Yhtymà„ Oy New pharmacologically active catechol derivatives
TW221689B (OSRAM) * 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
DK0638075T3 (da) * 1993-02-26 2002-02-18 Otsuka Pharma Co Ltd Thiazol- eller imidazolderivater som Maillard-reaktionsinhibitorer
KR960022486A (ko) 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
US6353006B1 (en) * 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
WO2001019807A1 (en) 1999-09-14 2001-03-22 Shionogi & Co., Ltd. 2-imino-1,3-thiazine derivatives
IL144229A (en) * 1999-11-12 2006-10-05 Fujimoto Brothers Co Ltd New history of N) –2– cyanoimino) thiazolidine – 4 – on
US20050019825A9 (en) * 2002-03-15 2005-01-27 Qing Dong Common ligand mimics: pseudothiohydantoins
AU2003255528B2 (en) 2002-07-10 2009-07-16 Merck Serono Sa Azolidinone-vinyl fused-benzene derivatives
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
ES2315566T3 (es) * 2002-11-22 2009-04-01 Smithkline Beecham Corporation Tiazolidin-4-onas para inhibir proteinas hyak3.
US20040167192A1 (en) * 2003-01-16 2004-08-26 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
SI1689726T1 (sl) * 2003-11-21 2011-01-31 Actelion Pharmaceuticals Ltd Derivati 5-(benz-(z)-iliden)-tiazolidin-4-ona kot imunosupresivna sredstva
WO2005082901A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Novel chemical compounds
WO2006094233A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N,n'-dicyclic isothiourea sirtuin modulators
PT2278960T (pt) * 2008-03-17 2017-03-09 Actelion Pharmaceuticals Ltd Regime de dosagem para um agonista seletivo do recetor s1p1
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

Also Published As

Publication number Publication date
DK2489662T3 (da) 2014-10-20
JP2010510976A (ja) 2010-04-08
EP2489662B1 (en) 2014-08-06
AU2007323042B2 (en) 2012-12-20
CN101541772A (zh) 2009-09-23
CN103087004A (zh) 2013-05-08
CA2669069C (en) 2015-02-17
US8263780B2 (en) 2012-09-11
WO2008062376A3 (en) 2008-07-10
TWI460166B (zh) 2014-11-11
BRPI0718986A2 (pt) 2014-02-11
US20110201821A2 (en) 2011-08-18
EP2094676A2 (en) 2009-09-02
US20100317867A1 (en) 2010-12-16
IL198847A (en) 2015-07-30
ES2523401T3 (es) 2014-11-25
KR101255879B1 (ko) 2013-04-17
MX2009005048A (es) 2009-05-25
WO2008062376A2 (en) 2008-05-29
AU2007323042A1 (en) 2008-05-29
ES2410793T3 (es) 2013-07-03
IL198847A0 (en) 2010-02-17
CA2669069A1 (en) 2008-05-29
EP2094676B1 (en) 2013-04-10
EP2489662A1 (en) 2012-08-22
DK2094676T3 (da) 2013-06-10
CN101541772B (zh) 2013-04-17
KR20090081009A (ko) 2009-07-27
TW200831474A (en) 2008-08-01

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