JP4669564B2 - ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 - Google Patents

２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 Download PDF

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Publication number
JP4669564B2
JP4669564B2 JP2009537744A JP2009537744A JP4669564B2 JP 4669564 B2 JP4669564 B2 JP 4669564B2 JP 2009537744 A JP2009537744 A JP 2009537744A JP 2009537744 A JP2009537744 A JP 2009537744A JP 4669564 B2 JP4669564 B2 JP 4669564B2
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Prior art keywords
thiazolidin
hydroxy
benz
ylidene
phenyl
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Japanese (ja)
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JP2010510976A5 (OSRAM
JP2010510976A (ja
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アベレ ステファン
ボリィ マーチン
シュミット ガンサー
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Actelion Pharmaceuticals Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2009537744A 2006-11-23 2007-11-22 ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法 Active JP4669564B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006054409 2006-11-23
PCT/IB2007/054752 WO2008062376A2 (en) 2006-11-23 2007-11-22 New process for the preparation of 2-imino-thiazolidin-4-one derivatives

Publications (3)

Publication Number Publication Date
JP2010510976A JP2010510976A (ja) 2010-04-08
JP2010510976A5 JP2010510976A5 (OSRAM) 2010-05-20
JP4669564B2 true JP4669564B2 (ja) 2011-04-13

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JP2009537744A Active JP4669564B2 (ja) 2006-11-23 2007-11-22 ２−イミノ−チアゾリジン−４−オン誘導体の製造のための新規な方法

Country Status (13)

Country Link
US (1) US8263780B2 (OSRAM)
EP (2) EP2489662B1 (OSRAM)
JP (1) JP4669564B2 (OSRAM)
KR (1) KR101255879B1 (OSRAM)
CN (2) CN101541772B (OSRAM)
AU (1) AU2007323042B2 (OSRAM)
CA (1) CA2669069C (OSRAM)
DK (2) DK2489662T3 (OSRAM)
ES (2) ES2410793T3 (OSRAM)
IL (1) IL198847A (OSRAM)
MX (1) MX2009005048A (OSRAM)
TW (1) TWI460166B (OSRAM)
WO (1) WO2008062376A2 (OSRAM)

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PL1689726T3 (pl) 2003-11-21 2011-05-31 Actelion Pharmaceuticals Ltd Pochodne 5-(benz-(z)-ylideno)tiazolidyn-4-onu jako środki immunosupresyjne
USRE43833E1 (en) 2003-11-21 2012-11-27 Actelion Pharmaceuticals Ltd. Thiazolidin-4-one derivatives
US8912340B2 (en) 2006-11-23 2014-12-16 Actelion Pharmaceuticals Ltd. Process for the preparation of 2-imino-thiazolidin-4-one derivatives
BRPI0909625B1 (pt) 2008-03-17 2021-09-08 Actelion Pharmaceuticals Ltd Agonista seletivo do receptor s1p1 para o uso como um medicamento, uso de um agonista seletivo do receptor s1p1 e kit contendo diferentes unidades de medicação de um agonista seletivo do receptor s1p1
GB0819182D0 (en) 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms
HUE050733T2 (hu) 2012-08-17 2021-01-28 Actelion Pharmaceuticals Ltd Eljárás (2Z,5Z)-5-(3-klór-4-((R)-2,3-dihidroxipropoxi)benzilidén)-2-(pro-pilimino)-3-(O-tolil)tiazolidin-4-on elõállítására és ezen eljárásban alkalmazott köztitermék
AU2015359346B2 (en) 2014-12-11 2020-05-07 Laboratoires Juvise Pharmaceuticals Dosing regimen for a selective S1P1 receptor agonist
MA41139A (fr) 2014-12-11 2017-10-17 Actelion Pharmaceuticals Ltd Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
WO2019060147A1 (en) * 2017-09-19 2019-03-28 Teva Pharmaceuticals Usa, Inc. NEW CRYSTALLINE POLYMORPHE FROM PONESIMOD
US11013723B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms of a thiazolidinone compound, compositions and methods of use thereof
US11186556B1 (en) 2018-10-16 2021-11-30 Celgene Corporation Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof
US11014940B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Thiazolidinone and oxazolidinone compounds and formulations
US11014897B1 (en) 2018-10-16 2021-05-25 Celgene Corporation Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof
WO2021005081A1 (de) * 2019-07-10 2021-01-14 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen
WO2021005082A1 (de) * 2019-07-10 2021-01-14 Bayer Aktiengesellschaft Verfahren zur herstellung von 2-(phenylimino)-1,3-thiazolidin-4-onen
CA3156298A1 (en) 2019-10-31 2021-05-06 Laetitia POUZOL Combination of a cxcr7 antagonist with an s1p1 receptor modulator
KR20200019639A (ko) 2020-01-30 2020-02-24 전대연 만남의 스마트 도착시스템
US20230105595A1 (en) * 2020-02-18 2023-04-06 Bayer Aktiengesellschaft Process of preparing 2-(phenylimino)-3-alkyl-1,3-thiazolidin-4-ones
EP4387960A1 (en) 2021-08-17 2024-06-26 Teva Czech Industries s.r.o Polymorphs of ponesimod
EP4212156A1 (en) 2022-01-13 2023-07-19 Abivax Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator
WO2023152691A1 (en) * 2022-02-10 2023-08-17 Metrochem Api Pvt Ltd Process for the preparation of ponesimod and its intermediates thereof
CN117924210A (zh) * 2024-01-22 2024-04-26 赣南师范大学 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法

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US3077402A (en) * 1954-12-06 1963-02-12 Polaroid Corp Photographic color processes, products, and compositions
NL270002A (OSRAM) * 1960-10-08
OA03835A (fr) 1970-07-17 1971-12-24 Rhone Poulenc Sa Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent.
ATE146462T1 (de) 1990-04-27 1997-01-15 Orion Yhtymae Oy Pharmakologisch aktive catecholderivate
TW221689B (OSRAM) * 1991-08-27 1994-03-11 Otsuka Pharma Co Ltd
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KR960022486A (ko) 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
US6353006B1 (en) * 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
AU6877300A (en) 1999-09-14 2001-04-17 Shionogi & Co., Ltd. 2-imino-1,3-thiazine derivatives
JP4285723B2 (ja) * 1999-11-12 2009-06-24 株式会社フジモト・コーポレーション 新規な２−（ｎ−シアノイミノ）チアゾリジン−４−オン誘導体
US20050019825A9 (en) * 2002-03-15 2005-01-27 Qing Dong Common ligand mimics: pseudothiohydantoins
US7846925B2 (en) 2002-07-10 2010-12-07 Merck Serono Sa Azolidinone-vinyl fused-benzene derivatives
GB0217152D0 (en) 2002-07-24 2002-09-04 Novartis Ag Organic compounds
WO2004047760A2 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Novel chemical compounds
US20040167192A1 (en) * 2003-01-16 2004-08-26 David Solow-Cordero Methods of treating conditions associated with an Edg-7 receptor
PL1689726T3 (pl) * 2003-11-21 2011-05-31 Actelion Pharmaceuticals Ltd Pochodne 5-(benz-(z)-ylideno)tiazolidyn-4-onu jako środki immunosupresyjne
WO2005082901A1 (en) * 2004-02-25 2005-09-09 Smithkline Beecham Corporation Novel chemical compounds
WO2006094233A1 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. N,n'-dicyclic isothiourea sirtuin modulators
BRPI0909625B1 (pt) * 2008-03-17 2021-09-08 Actelion Pharmaceuticals Ltd Agonista seletivo do receptor s1p1 para o uso como um medicamento, uso de um agonista seletivo do receptor s1p1 e kit contendo diferentes unidades de medicação de um agonista seletivo do receptor s1p1
GB0819182D0 (en) * 2008-10-20 2008-11-26 Actelion Pharmaceuticals Ltd Crystalline forms

Also Published As

Publication number Publication date
US20100317867A1 (en) 2010-12-16
EP2094676B1 (en) 2013-04-10
CN101541772A (zh) 2009-09-23
MX2009005048A (es) 2009-05-25
EP2489662B1 (en) 2014-08-06
WO2008062376A2 (en) 2008-05-29
WO2008062376A3 (en) 2008-07-10
AU2007323042A1 (en) 2008-05-29
CA2669069C (en) 2015-02-17
KR20090081009A (ko) 2009-07-27
US20110201821A2 (en) 2011-08-18
CN101541772B (zh) 2013-04-17
TWI460166B (zh) 2014-11-11
EP2094676A2 (en) 2009-09-02
CA2669069A1 (en) 2008-05-29
JP2010510976A (ja) 2010-04-08
TW200831474A (en) 2008-08-01
ES2523401T3 (es) 2014-11-25
DK2489662T3 (da) 2014-10-20
KR101255879B1 (ko) 2013-04-17
CN103087004A (zh) 2013-05-08
BRPI0718986A2 (pt) 2014-02-11
AU2007323042B2 (en) 2012-12-20
IL198847A (en) 2015-07-30
EP2489662A1 (en) 2012-08-22
ES2410793T3 (es) 2013-07-03
IL198847A0 (en) 2010-02-17
US8263780B2 (en) 2012-09-11
DK2094676T3 (da) 2013-06-10

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