DK2489662T3 - Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater - Google Patents
Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivaterInfo
- Publication number
- DK2489662T3 DK2489662T3 DK12000613.5T DK12000613T DK2489662T3 DK 2489662 T3 DK2489662 T3 DK 2489662T3 DK 12000613 T DK12000613 T DK 12000613T DK 2489662 T3 DK2489662 T3 DK 2489662T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenylthiazolidin
- alkylimino
- benzylidene
- intermediates
- derivatives
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2006054409 | 2006-11-23 | ||
| EP07849225.3A EP2094676B1 (en) | 2006-11-23 | 2007-11-22 | New process for the preparation of 2-iminothiazolidin-4-one derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2489662T3 true DK2489662T3 (da) | 2014-10-20 |
Family
ID=39316391
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07849225.3T DK2094676T3 (da) | 2006-11-23 | 2007-11-22 | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater |
| DK12000613.5T DK2489662T3 (da) | 2006-11-23 | 2007-11-22 | Mellemprodukter af en ny fremgangsmåde til fremstillingen af 5-benzyliden-2-alkylimino-3-phenylthiazolidin-4-on derivater |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07849225.3T DK2094676T3 (da) | 2006-11-23 | 2007-11-22 | Ny fremgangsmåde til fremstillingen af 2-iminothiazolidin-4-on-derivater |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8263780B2 (OSRAM) |
| EP (2) | EP2489662B1 (OSRAM) |
| JP (1) | JP4669564B2 (OSRAM) |
| KR (1) | KR101255879B1 (OSRAM) |
| CN (2) | CN103087004A (OSRAM) |
| AU (1) | AU2007323042B2 (OSRAM) |
| CA (1) | CA2669069C (OSRAM) |
| DK (2) | DK2094676T3 (OSRAM) |
| ES (2) | ES2410793T3 (OSRAM) |
| IL (1) | IL198847A (OSRAM) |
| MX (1) | MX2009005048A (OSRAM) |
| TW (1) | TWI460166B (OSRAM) |
| WO (1) | WO2008062376A2 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295418A1 (en) | 2003-11-21 | 2011-03-16 | Actelion Pharmaceuticals Ltd. | 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents |
| USRE43833E1 (en) | 2003-11-21 | 2012-11-27 | Actelion Pharmaceuticals Ltd. | Thiazolidin-4-one derivatives |
| US8912340B2 (en) | 2006-11-23 | 2014-12-16 | Actelion Pharmaceuticals Ltd. | Process for the preparation of 2-imino-thiazolidin-4-one derivatives |
| KR101718639B1 (ko) | 2008-03-17 | 2017-03-21 | 액테리온 파마슈티칼 리미티드 | 선별적 ｓ1ｐ₁ 수용체 작동약에 대한 투약 섭생 |
| GB0819182D0 (en) * | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
| SI2885266T1 (sl) | 2012-08-17 | 2020-10-30 | Actelion Pharmaceuticals Ltd | Postopek za pripravo (2Z,5Z)-5-(3-kloro-4-((R)-2,3-dihidroksipropoksi) benziliden)-2-(propilimino)-3-(O-tolil)tiazolidin-4-on in v omenjenem postopku uporabljena vmesna spojina |
| WO2016091996A1 (en) | 2014-12-11 | 2016-06-16 | Actelion Pharmaceuticals Ltd | Dosing regimen for a selective s1p1 receptor agonist |
| MA41139A (fr) | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
| JOP20190207A1 (ar) | 2017-03-14 | 2019-09-10 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على بونيسيمود |
| WO2019060147A1 (en) * | 2017-09-19 | 2019-03-28 | Teva Pharmaceuticals Usa, Inc. | NEW CRYSTALLINE POLYMORPHE FROM PONESIMOD |
| US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
| US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
| US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
| KR20220034818A (ko) * | 2019-07-10 | 2022-03-18 | 바이엘 악티엔게젤샤프트 | 2-(페닐이미노)-1,3-티아졸리딘-4-온의 제조 방법 |
| KR20220034151A (ko) * | 2019-07-10 | 2022-03-17 | 바이엘 악티엔게젤샤프트 | 2-(페닐이미노)-1,3-티아졸리딘-4-온의 제조 방법 |
| PH12022551043A1 (en) | 2019-10-31 | 2023-05-03 | Idorsia Pharmaceuticals Ltd | Combination of a cxcr7 antagonist with an s1p1 receptor modulator |
| KR20200019639A (ko) | 2020-01-30 | 2020-02-24 | 전대연 | 만남의 스마트 도착시스템 |
| KR20220143032A (ko) * | 2020-02-18 | 2022-10-24 | 바이엘 악티엔게젤샤프트 | 2-(페닐이미노)-3-알킬-1,3-티아졸리딘-4-온의 제조 방법 |
| US20240368094A1 (en) | 2021-08-17 | 2024-11-07 | Teva Czech Industries S.R.O | Polymorphs of ponesimod |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152691A1 (en) * | 2022-02-10 | 2023-08-17 | Metrochem Api Pvt Ltd | Process for the preparation of ponesimod and its intermediates thereof |
| CN117924210A (zh) * | 2024-01-22 | 2024-04-26 | 赣南师范大学 | 一种2-亚氨基噻唑烷-4-酮类化合物的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3077402A (en) * | 1954-12-06 | 1963-02-12 | Polaroid Corp | Photographic color processes, products, and compositions |
| NL270002A (OSRAM) * | 1960-10-08 | |||
| OA03835A (fr) * | 1970-07-17 | 1971-12-24 | Rhone Poulenc Sa | Nouveaux dérivés de la thiazolidine, leur préparation et les compositions qui les contiennent. |
| PT97507B (pt) * | 1990-04-27 | 1998-08-31 | Orion Yhtymae Oy | Processo para apreparacao de novos derivados de catecol farmacologicamente activos |
| TW221689B (OSRAM) * | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd | |
| US5677322A (en) * | 1993-02-26 | 1997-10-14 | Otsuka Pharmaceutical Co., Ltd. | Maillard reaction inhibitor |
| KR960022486A (ko) | 1994-12-29 | 1996-07-18 | 김준웅 | 신규 티아졸리딘-4-온 유도체 |
| US6353006B1 (en) * | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| ATE393150T1 (de) | 1999-09-14 | 2008-05-15 | Shionogi & Co | 2-imino-1,3-thiazin-derivate |
| US6380229B1 (en) * | 1999-11-12 | 2002-04-30 | Fujimoto Co., Ltd. | 2-(N-cyanoimino)thiazolidin-4-one derivatives |
| US20050019825A9 (en) * | 2002-03-15 | 2005-01-27 | Qing Dong | Common ligand mimics: pseudothiohydantoins |
| BR0312650A (pt) | 2002-07-10 | 2005-05-03 | Applied Research Systems | Derivados de benzeno fundido azolidinona-vinila |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| ES2315566T3 (es) * | 2002-11-22 | 2009-04-01 | Smithkline Beecham Corporation | Tiazolidin-4-onas para inhibir proteinas hyak3. |
| US20040167192A1 (en) * | 2003-01-16 | 2004-08-26 | David Solow-Cordero | Methods of treating conditions associated with an Edg-7 receptor |
| EP2295418A1 (en) * | 2003-11-21 | 2011-03-16 | Actelion Pharmaceuticals Ltd. | 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents |
| JP2007523957A (ja) * | 2004-02-25 | 2007-08-23 | スミスクライン・ビーチャム・コーポレイション | 新規化学化合物 |
| WO2006094233A1 (en) * | 2005-03-03 | 2006-09-08 | Sirtris Pharmaceuticals, Inc. | N,n'-dicyclic isothiourea sirtuin modulators |
| KR101718639B1 (ko) * | 2008-03-17 | 2017-03-21 | 액테리온 파마슈티칼 리미티드 | 선별적 ｓ1ｐ₁ 수용체 작동약에 대한 투약 섭생 |
| GB0819182D0 (en) * | 2008-10-20 | 2008-11-26 | Actelion Pharmaceuticals Ltd | Crystalline forms |
-
2007
- 2007-11-22 DK DK07849225.3T patent/DK2094676T3/da active
- 2007-11-22 CN CN2012105461683A patent/CN103087004A/zh active Pending
- 2007-11-22 ES ES07849225T patent/ES2410793T3/es active Active
- 2007-11-22 MX MX2009005048A patent/MX2009005048A/es active IP Right Grant
- 2007-11-22 EP EP12000613.5A patent/EP2489662B1/en active Active
- 2007-11-22 KR KR1020097011745A patent/KR101255879B1/ko active Active
- 2007-11-22 ES ES12000613.5T patent/ES2523401T3/es active Active
- 2007-11-22 DK DK12000613.5T patent/DK2489662T3/da active
- 2007-11-22 WO PCT/IB2007/054752 patent/WO2008062376A2/en not_active Ceased
- 2007-11-22 AU AU2007323042A patent/AU2007323042B2/en active Active
- 2007-11-22 CA CA2669069A patent/CA2669069C/en active Active
- 2007-11-22 CN CN2007800431941A patent/CN101541772B/zh active Active
- 2007-11-22 JP JP2009537744A patent/JP4669564B2/ja active Active
- 2007-11-22 TW TW096144311A patent/TWI460166B/zh active
- 2007-11-22 US US12/516,055 patent/US8263780B2/en active Active
- 2007-11-22 EP EP07849225.3A patent/EP2094676B1/en active Active
-
2009
- 2009-05-20 IL IL198847A patent/IL198847A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20100317867A1 (en) | 2010-12-16 |
| CA2669069A1 (en) | 2008-05-29 |
| US8263780B2 (en) | 2012-09-11 |
| IL198847A0 (en) | 2010-02-17 |
| KR101255879B1 (ko) | 2013-04-17 |
| AU2007323042A1 (en) | 2008-05-29 |
| CN103087004A (zh) | 2013-05-08 |
| JP4669564B2 (ja) | 2011-04-13 |
| EP2489662A1 (en) | 2012-08-22 |
| JP2010510976A (ja) | 2010-04-08 |
| TW200831474A (en) | 2008-08-01 |
| MX2009005048A (es) | 2009-05-25 |
| AU2007323042B2 (en) | 2012-12-20 |
| BRPI0718986A2 (pt) | 2014-02-11 |
| WO2008062376A3 (en) | 2008-07-10 |
| EP2094676A2 (en) | 2009-09-02 |
| DK2094676T3 (da) | 2013-06-10 |
| CA2669069C (en) | 2015-02-17 |
| KR20090081009A (ko) | 2009-07-27 |
| US20110201821A2 (en) | 2011-08-18 |
| EP2489662B1 (en) | 2014-08-06 |
| WO2008062376A2 (en) | 2008-05-29 |
| ES2523401T3 (es) | 2014-11-25 |
| ES2410793T3 (es) | 2013-07-03 |
| IL198847A (en) | 2015-07-30 |
| CN101541772A (zh) | 2009-09-23 |
| EP2094676B1 (en) | 2013-04-10 |
| TWI460166B (zh) | 2014-11-11 |
| CN101541772B (zh) | 2013-04-17 |
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