JP4643910B2 - 抗癌活性を有する置換インダゾール - Google Patents

抗癌活性を有する置換インダゾール Download PDF

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Publication number
JP4643910B2
JP4643910B2 JP2003576408A JP2003576408A JP4643910B2 JP 4643910 B2 JP4643910 B2 JP 4643910B2 JP 2003576408 A JP2003576408 A JP 2003576408A JP 2003576408 A JP2003576408 A JP 2003576408A JP 4643910 B2 JP4643910 B2 JP 4643910B2
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JP
Japan
Prior art keywords
indazol
benzenesulfonamide
phenyl
aryl
methanesulfonylbenzenesulfonamide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2003576408A
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English (en)
Japanese (ja)
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JP2005533004A5 (enExample
JP2005533004A (ja
Inventor
ドミニク・ダムール
ジャン−クリストフ・カリ
パトリック・ネメセク
コリン・テリエ
フレデリコ・ナルディ
ブリュノ・フィロシュ
マリ−ピエール・シェリエ
ダニエル・ベザール
Original Assignee
アベンティス・ファーマ・ソシエテ・アノニム
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Publication of JP2005533004A5 publication Critical patent/JP2005533004A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
JP2003576408A 2002-03-11 2003-03-07 抗癌活性を有する置換インダゾール Expired - Fee Related JP4643910B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0202996A FR2836914B1 (fr) 2002-03-11 2002-03-11 Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
PCT/FR2003/000751 WO2003078402A1 (fr) 2002-03-11 2003-03-07 Indazoles substitues avec une activite anticancereuse

Publications (3)

Publication Number Publication Date
JP2005533004A JP2005533004A (ja) 2005-11-04
JP2005533004A5 JP2005533004A5 (enExample) 2006-04-20
JP4643910B2 true JP4643910B2 (ja) 2011-03-02

Family

ID=27763684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003576408A Expired - Fee Related JP4643910B2 (ja) 2002-03-11 2003-03-07 抗癌活性を有する置換インダゾール

Country Status (29)

Country Link
US (2) US6858638B2 (enExample)
EP (1) EP1487803A1 (enExample)
JP (1) JP4643910B2 (enExample)
KR (1) KR20040091128A (enExample)
CN (1) CN100369899C (enExample)
AR (1) AR038914A1 (enExample)
AU (1) AU2003242808B2 (enExample)
BR (1) BR0308339A (enExample)
CA (1) CA2478540A1 (enExample)
EC (1) ECSP045286A (enExample)
FR (1) FR2836914B1 (enExample)
GT (1) GT200300031A (enExample)
HN (1) HN2003000094A (enExample)
HR (1) HRP20040825A2 (enExample)
IL (2) IL163805A0 (enExample)
MA (1) MA27176A1 (enExample)
MX (1) MXPA04008446A (enExample)
NO (1) NO20044261L (enExample)
OA (1) OA12784A (enExample)
PA (1) PA8566701A1 (enExample)
PE (1) PE20040071A1 (enExample)
PL (1) PL372389A1 (enExample)
RU (1) RU2004130280A (enExample)
SV (1) SV2003001493A (enExample)
TN (1) TNSN04175A1 (enExample)
TW (1) TW200303863A (enExample)
UY (1) UY27712A1 (enExample)
WO (1) WO2003078402A1 (enExample)
ZA (1) ZA200406730B (enExample)

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WO2005014554A1 (en) * 2003-08-08 2005-02-17 Astex Therapeutics Limited 1h-indazole-3-carboxamide compounds as mapkap kinase modulators
FR2864084B1 (fr) 2003-12-17 2006-02-10 Aventis Pharma Sa Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments
JP2007514759A (ja) 2003-12-19 2007-06-07 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
GB0330042D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
JP2008510734A (ja) 2004-08-18 2008-04-10 タケダ サン ディエゴ インコーポレイテッド キナーゼ阻害剤
BRPI0515931A (pt) * 2004-09-29 2008-08-12 Hoffmann La Roche compostos, processo para a sua preparação, composições farmacêuticas que os compreendem, método para o tratamento e/ou profilaxia de enfermidades e utilização desses compostos
DE602005023333D1 (de) 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
SE0402762D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Indazole sulphonamide derivatives
SE0402763D0 (sv) * 2004-11-11 2004-11-11 Astrazeneca Ab Nitro indazole derivatives
KR20080031460A (ko) * 2005-08-25 2008-04-08 에프. 호프만-라 로슈 아게 Ｐ38 ｍａｐ 키나아제 저해제 및 이의 사용 방법
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
JP5131990B2 (ja) 2006-01-31 2013-01-30 アレイ バイオファーマ、インコーポレイテッド キナーゼ阻害剤およびその使用方法
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
WO2008063888A2 (en) * 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
FR2917735B1 (fr) * 2007-06-21 2009-09-04 Sanofi Aventis Sa Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique
EP2170834B1 (en) 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2535347C3 (ru) * 2009-05-26 2019-05-14 ЭббВи Айэленд Анлимитед Компани Индуцирующие апоптоз средства для лечения злокачественной опухоли и иммунных и аутоиммунных заболеваний
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
WO2011050245A1 (en) * 2009-10-23 2011-04-28 Yangbo Feng Bicyclic heteroaryls as kinase inhibitors
CN102247361B (zh) * 2010-05-20 2015-04-29 中国医学科学院药物研究所 5-硝基-1氢-吲唑-3-腈在制备药物中的应用
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
EP2632436B1 (en) 2010-10-29 2018-08-29 Abbvie Inc. Solid dispersions containing an apoptosis-inducing agent
PT2642999T (pt) 2010-11-23 2017-01-05 Abbvie Ireland Unlimited Co Métodos de tratamento que utilizam inibidores seletivos de bcl-2
WO2012071336A1 (en) 2010-11-23 2012-05-31 Abbott Laboratories Salts and crystalline forms of an apoptosis-inducing agent
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CA2965741C (en) * 2014-11-03 2022-05-17 Iomet Pharma Ltd Pharmaceutical compound
GB201511382D0 (en) 2015-06-29 2015-08-12 Imp Innovations Ltd Novel compounds and their use in therapy
JP2020528415A (ja) 2017-07-21 2020-09-24 カドモン コーポレイション，リミティド ライアビリティ カンパニー Ｒｈｏ関連コイルドコイル含有プロテインキナーゼの阻害剤
CN111479805B (zh) 2017-08-29 2024-08-13 罗格斯新泽西州立大学 治疗性吲唑
JP2025504415A (ja) * 2022-01-12 2025-02-12 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する病態を治療するための化合物及び組成物
JP2025509180A (ja) 2022-03-04 2025-04-11 上海瓔黎薬業有限公司 五員ヘテロアリール環構造含有化合物、その医薬組成物及び使用
CN114605329B (zh) * 2022-03-28 2024-01-26 河南中医药大学 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途
AU2023415105A1 (en) 2022-12-30 2025-07-17 Avicenna Biosciences, Inc. Azaindole rock inhibitors
WO2025117661A1 (en) * 2023-11-28 2025-06-05 Quantx Biosciences Us, Inc. Bicyclic heteroaryl compounds

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JPS514505Y2 (enExample) 1971-02-13 1976-02-07
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ATE249213T1 (de) 1996-02-22 2003-09-15 Tularik Inc Pentafluorobenzensulfonamiden und analoge
US6482860B1 (en) * 1996-07-19 2002-11-19 Tularik Inc. Pentafluorobenzenesulfonamides and analogs
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FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation

Also Published As

Publication number Publication date
FR2836914A1 (fr) 2003-09-12
TNSN04175A1 (fr) 2007-03-12
MXPA04008446A (es) 2004-12-06
BR0308339A (pt) 2005-02-01
MA27176A1 (fr) 2005-01-03
GT200300031A (es) 2006-05-26
US20050059722A1 (en) 2005-03-17
UY27712A1 (es) 2003-09-30
AU2003242808A1 (en) 2003-09-29
ZA200406730B (en) 2005-08-24
HN2003000094A (es) 2003-12-15
SV2003001493A (es) 2003-07-10
CN100369899C (zh) 2008-02-20
AU2003242808B2 (en) 2008-09-18
PE20040071A1 (es) 2004-02-13
HRP20040825A2 (en) 2005-06-30
PA8566701A1 (es) 2003-12-10
NO20044261L (no) 2004-11-25
US6858638B2 (en) 2005-02-22
RU2004130280A (ru) 2005-06-27
PL372389A1 (en) 2005-07-25
WO2003078402A1 (fr) 2003-09-25
US7473701B2 (en) 2009-01-06
FR2836914B1 (fr) 2008-03-14
ECSP045286A (es) 2004-10-26
IL163805A0 (en) 2005-12-18
IL163805A (en) 2009-08-03
AR038914A1 (es) 2005-02-02
KR20040091128A (ko) 2004-10-27
TW200303863A (en) 2003-09-16
JP2005533004A (ja) 2005-11-04
US20040106667A1 (en) 2004-06-03
OA12784A (fr) 2006-07-10
EP1487803A1 (fr) 2004-12-22
CN1642922A (zh) 2005-07-20
CA2478540A1 (fr) 2003-09-25

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