PE20040071A1 - Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion - Google Patents
Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacionInfo
- Publication number
- PE20040071A1 PE20040071A1 PE2003000232A PE2003000232A PE20040071A1 PE 20040071 A1 PE20040071 A1 PE 20040071A1 PE 2003000232 A PE2003000232 A PE 2003000232A PE 2003000232 A PE2003000232 A PE 2003000232A PE 20040071 A1 PE20040071 A1 PE 20040071A1
- Authority
- PE
- Peru
- Prior art keywords
- indazol
- chloro
- compositions containing
- manufacturing procedure
- substituted indazoles
- Prior art date
Links
- 150000002473 indoazoles Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0202996A FR2836914B1 (fr) | 2002-03-11 | 2002-03-11 | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040071A1 true PE20040071A1 (es) | 2004-02-13 |
Family
ID=27763684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000232A PE20040071A1 (es) | 2002-03-11 | 2003-03-07 | Indazoles substituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6858638B2 (enExample) |
| EP (1) | EP1487803A1 (enExample) |
| JP (1) | JP4643910B2 (enExample) |
| KR (1) | KR20040091128A (enExample) |
| CN (1) | CN100369899C (enExample) |
| AR (1) | AR038914A1 (enExample) |
| AU (1) | AU2003242808B2 (enExample) |
| BR (1) | BR0308339A (enExample) |
| CA (1) | CA2478540A1 (enExample) |
| EC (1) | ECSP045286A (enExample) |
| FR (1) | FR2836914B1 (enExample) |
| GT (1) | GT200300031A (enExample) |
| HN (1) | HN2003000094A (enExample) |
| HR (1) | HRP20040825A2 (enExample) |
| IL (2) | IL163805A0 (enExample) |
| MA (1) | MA27176A1 (enExample) |
| MX (1) | MXPA04008446A (enExample) |
| NO (1) | NO20044261L (enExample) |
| OA (1) | OA12784A (enExample) |
| PA (1) | PA8566701A1 (enExample) |
| PE (1) | PE20040071A1 (enExample) |
| PL (1) | PL372389A1 (enExample) |
| RU (1) | RU2004130280A (enExample) |
| SV (1) | SV2003001493A (enExample) |
| TN (1) | TNSN04175A1 (enExample) |
| TW (1) | TW200303863A (enExample) |
| UY (1) | UY27712A1 (enExample) |
| WO (1) | WO2003078402A1 (enExample) |
| ZA (1) | ZA200406730B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2836914B1 (fr) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
| GB0218625D0 (en) * | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
| AU2003286711A1 (en) | 2002-10-25 | 2004-05-13 | Vertex Pharmaceuticals Incorporated | Indazolinone compositions useful as kinase inhibitors |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2005014554A1 (en) * | 2003-08-08 | 2005-02-17 | Astex Therapeutics Limited | 1h-indazole-3-carboxamide compounds as mapkap kinase modulators |
| FR2864084B1 (fr) * | 2003-12-17 | 2006-02-10 | Aventis Pharma Sa | Nouveaux derives organophosphores des indazoles et leur utilisation comme medicaments |
| EP1694686A1 (en) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinase inhibitors |
| GB0330042D0 (en) * | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
| GB0330043D0 (en) * | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
| WO2005105788A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Indole derivatives and use thereof as kinase inhibitors |
| EP1778669A2 (en) | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
| PT1797042E (pt) * | 2004-09-29 | 2009-02-12 | Hoffmann La Roche | Derivados de indozolona como inibidores de 11b-hsd1 |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| SE0402763D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Nitro indazole derivatives |
| SE0402762D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Indazole sulphonamide derivatives |
| CA2620257A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 map kinase inhibitors and methods for using the same |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| RU2442777C2 (ru) | 2006-01-31 | 2012-02-20 | Эррэй Биофарма Инк. | Ингибиторы киназ и способы их применения |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| JP2010505961A (ja) * | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| WO2008063888A2 (en) * | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| FR2917735B1 (fr) * | 2007-06-21 | 2009-09-04 | Sanofi Aventis Sa | Nouveaux indazoles substitutes, leur preparation et leur utilisation en therapeutique |
| WO2009012312A1 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases |
| US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| BR122019016429B1 (pt) * | 2009-05-26 | 2020-03-24 | Abbvie Ireland Unlimited Company | Compostos inibidores da atividade de proteínas bcl-2 antiapoptótica e composição farmacêutica compreendendo ditos compostos |
| US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| WO2011050245A1 (en) * | 2009-10-23 | 2011-04-28 | Yangbo Feng | Bicyclic heteroaryls as kinase inhibitors |
| CN102247361B (zh) * | 2010-05-20 | 2015-04-29 | 中国医学科学院药物研究所 | 5-硝基-1氢-吲唑-3-腈在制备药物中的应用 |
| ES2699205T3 (es) | 2010-10-29 | 2019-02-07 | Abbvie Inc | Dispersiones sólidas que contienen un agente que induce la apoptosis |
| UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
| NZ708508A (en) | 2010-11-23 | 2016-06-24 | Abbvie Bahamas Ltd | Methods of treatment using selective bcl-2 inhibitors |
| AU2011332043C1 (en) | 2010-11-23 | 2016-11-10 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| RU2719446C2 (ru) * | 2014-11-03 | 2020-04-17 | Айомет Фарма Лтд | Фармацевтическое соединение |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| CA3070112A1 (en) * | 2017-07-21 | 2019-01-24 | Kadmon Corporation, Llc | Inhibitors of rho associated coiled-coil containing protein kinase |
| CN111479805B (zh) | 2017-08-29 | 2024-08-13 | 罗格斯新泽西州立大学 | 治疗性吲唑 |
| CN118715205A (zh) * | 2022-01-12 | 2024-09-27 | 艾福姆德尤股份有限公司 | 用于治疗与sting活性相关的病症的化合物和组合物 |
| JP2025509180A (ja) | 2022-03-04 | 2025-04-11 | 上海瓔黎薬業有限公司 | 五員ヘテロアリール環構造含有化合物、その医薬組成物及び使用 |
| CN114605329B (zh) * | 2022-03-28 | 2024-01-26 | 河南中医药大学 | 取代的吲唑甲酰胺或取代的氮杂吲唑甲酰胺类flt3抑制剂及其用途 |
| AU2023415105A1 (en) | 2022-12-30 | 2025-07-17 | Avicenna Biosciences, Inc. | Azaindole rock inhibitors |
| WO2025117661A1 (en) * | 2023-11-28 | 2025-06-05 | Quantx Biosciences Us, Inc. | Bicyclic heteroaryl compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS514505Y2 (enExample) | 1971-02-13 | 1976-02-07 | ||
| JPH061350B2 (ja) * | 1985-07-26 | 1994-01-05 | コニカ株式会社 | ハロゲン化銀写真感光材料 |
| JP3421349B2 (ja) | 1996-02-22 | 2003-06-30 | テュラリク インコーポレイテッド | ペンタフルオロベンゼンスルホンアミドおよび類縁体 |
| AU710173B2 (en) * | 1996-07-19 | 1999-09-16 | Tularik Inc. | Pentafluorobenzenesulfonamides and analogs |
| GB9718913D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
| WO2000027627A1 (en) | 1998-11-12 | 2000-05-18 | Eli Lilly And Company | Aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles |
| CO5170498A1 (es) * | 1999-05-28 | 2002-06-27 | Abbott Lab | Biaril sulfonamidas son utiles como inhibidores de proliferacion celular |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| KR100423899B1 (ko) * | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| CA2440842A1 (en) * | 2001-04-16 | 2002-10-24 | Eisai Co., Ltd. | Novel 1h-indazole compounds |
| JPWO2002100833A1 (ja) | 2001-06-12 | 2004-09-24 | 住友製薬株式会社 | Ｒｈｏキナーゼ阻害剤 |
| EP1401831A1 (en) * | 2001-07-03 | 2004-03-31 | Chiron Corporation | Indazole benzimidazole compounds as tyrosine and serine/threonine kinase inhibitors |
| US7101884B2 (en) | 2001-09-14 | 2006-09-05 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| FR2836915B1 (fr) * | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
| FR2836914B1 (fr) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
-
2002
- 2002-03-11 FR FR0202996A patent/FR2836914B1/fr not_active Expired - Fee Related
-
2003
- 2003-02-06 GT GT200300031A patent/GT200300031A/es unknown
- 2003-02-13 PA PA20038566701A patent/PA8566701A1/es unknown
- 2003-02-24 TW TW092103799A patent/TW200303863A/zh unknown
- 2003-03-03 SV SV2003001493A patent/SV2003001493A/es not_active Application Discontinuation
- 2003-03-07 CN CNB038058731A patent/CN100369899C/zh not_active Expired - Fee Related
- 2003-03-07 RU RU2004130280/04A patent/RU2004130280A/ru not_active Application Discontinuation
- 2003-03-07 BR BR0308339-0A patent/BR0308339A/pt not_active IP Right Cessation
- 2003-03-07 JP JP2003576408A patent/JP4643910B2/ja not_active Expired - Fee Related
- 2003-03-07 AU AU2003242808A patent/AU2003242808B2/en not_active Ceased
- 2003-03-07 HR HR20040825A patent/HRP20040825A2/hr not_active Application Discontinuation
- 2003-03-07 IL IL16380503A patent/IL163805A0/xx unknown
- 2003-03-07 MX MXPA04008446A patent/MXPA04008446A/es active IP Right Grant
- 2003-03-07 KR KR10-2004-7014298A patent/KR20040091128A/ko not_active Ceased
- 2003-03-07 CA CA002478540A patent/CA2478540A1/fr not_active Abandoned
- 2003-03-07 WO PCT/FR2003/000751 patent/WO2003078402A1/fr not_active Ceased
- 2003-03-07 PE PE2003000232A patent/PE20040071A1/es not_active Application Discontinuation
- 2003-03-07 OA OA1200400236A patent/OA12784A/fr unknown
- 2003-03-07 PL PL03372389A patent/PL372389A1/xx not_active Application Discontinuation
- 2003-03-07 EP EP03744395A patent/EP1487803A1/fr not_active Withdrawn
- 2003-03-10 AR ARP030100807A patent/AR038914A1/es unknown
- 2003-03-10 HN HN2003000094A patent/HN2003000094A/es unknown
- 2003-03-11 UY UY27712A patent/UY27712A1/es unknown
- 2003-03-11 US US10/385,870 patent/US6858638B2/en not_active Expired - Lifetime
-
2004
- 2004-08-12 MA MA27825A patent/MA27176A1/fr unknown
- 2004-08-24 ZA ZA200406730A patent/ZA200406730B/en unknown
- 2004-08-30 IL IL163805A patent/IL163805A/en not_active IP Right Cessation
- 2004-09-10 TN TNP2004000175A patent/TNSN04175A1/fr unknown
- 2004-09-10 EC EC2004005286A patent/ECSP045286A/es unknown
- 2004-10-07 NO NO20044261A patent/NO20044261L/no unknown
- 2004-10-13 US US10/963,880 patent/US7473701B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |