JP4638043B2 - ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法 - Google Patents

ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法 Download PDF

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JP4638043B2
JP4638043B2 JP2000588399A JP2000588399A JP4638043B2 JP 4638043 B2 JP4638043 B2 JP 4638043B2 JP 2000588399 A JP2000588399 A JP 2000588399A JP 2000588399 A JP2000588399 A JP 2000588399A JP 4638043 B2 JP4638043 B2 JP 4638043B2
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polymerase
nucleic acid
nucleotide
dna
target nucleic
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JP2002532104A5 (enExample
JP2002532104A (ja
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ジョーン ジー． ケイ． ウィリアムズ，
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パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000588399A 1998-12-14 1999-12-13 ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法 Expired - Lifetime JP4638043B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11207898P 1998-12-14 1998-12-14
US60/112,078 1998-12-14
US11549699P 1999-01-11 1999-01-11
US60/115,496 1999-01-11
PCT/US1999/029585 WO2000036152A1 (en) 1998-12-14 1999-12-13 A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis

Related Child Applications (1)

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JP2010035456A Division JP2010142250A (ja) 1998-12-14 2010-02-19 ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法

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JP2002532104A JP2002532104A (ja) 2002-10-02
JP2002532104A5 JP2002532104A5 (enExample) 2009-06-25
JP4638043B2 true JP4638043B2 (ja) 2011-02-23

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JP2000588399A Expired - Lifetime JP4638043B2 (ja) 1998-12-14 1999-12-13 ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法
JP2010035456A Withdrawn JP2010142250A (ja) 1998-12-14 2010-02-19 ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法

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JP2010035456A Withdrawn JP2010142250A (ja) 1998-12-14 2010-02-19 ポリメラーゼ合成による、単一分子の核酸の配列決定のためのシステムおよび方法

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US (10) US6232075B1 (enExample)
EP (1) EP1141409B2 (enExample)
JP (2) JP4638043B2 (enExample)
AT (1) ATE319857T1 (enExample)
AU (2) AU772281B2 (enExample)
CA (1) CA2355816C (enExample)
DE (1) DE69930310T3 (enExample)
WO (2) WO2000036152A1 (enExample)

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US6306607B2 (en) 2001-10-23
US9845501B2 (en) 2017-12-19
US20030194740A1 (en) 2003-10-16
AU2180200A (en) 2000-07-03
US20150218632A1 (en) 2015-08-06
DE69930310T2 (de) 2006-12-28
CA2355816C (en) 2007-10-30
US6232075B1 (en) 2001-05-15
DE69930310T3 (de) 2009-12-17
JP2010142250A (ja) 2010-07-01
US8980584B2 (en) 2015-03-17
US8530154B2 (en) 2013-09-10
AU2360200A (en) 2000-07-03
CA2355816A1 (en) 2000-06-22
JP2002532104A (ja) 2002-10-02
EP1141409B2 (en) 2009-05-27
EP1141409A4 (en) 2003-02-26
US20100093068A1 (en) 2010-04-15
US20020115076A1 (en) 2002-08-22
US6255083B1 (en) 2001-07-03
US7229799B2 (en) 2007-06-12
US20090082212A1 (en) 2009-03-26
WO2000036152A1 (en) 2000-06-22
DE69930310D1 (de) 2006-05-04
WO2000036151A1 (en) 2000-06-22
ATE319857T1 (de) 2006-03-15
US6762048B2 (en) 2004-07-13
AU772281B2 (en) 2004-04-22
US20010018184A1 (en) 2001-08-30
EP1141409A1 (en) 2001-10-10
US8192961B2 (en) 2012-06-05
US20080241833A1 (en) 2008-10-02
US20090170074A1 (en) 2009-07-02
WO2000036151A9 (en) 2001-08-02
EP1141409B1 (en) 2006-03-08

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