JP4597664B2 - 微細流体構造 - Google Patents
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Description
本発明は、微細流体構造、そして特に、毛細管作用が、前記構造を経た液体の移送のための主要な推進力として利用される、液体の流動システムを構成する微細構造に関する。
微細スケールの経路又は構造を経た液体の移送は、多種多様の科学技術において重要な影響を及ぼす。
h=2σg1cos(θc)/gρ…(1)
hは毛細管内の流体の高さ、θcは毛細管物質に対する流体の接触角度である。
欧州特許第1120164号は、毛細管経路における微細構造の複数の使用法を示し、前記経路は、少なくとも一つの曲がった部分を有し、ベースと、中心点からの第1の半径と該第1の半径を超える第2の半径とによって構成される内側の壁と、少なくとも内側の壁から毛細管経路をカバーする外側の壁まで延びる蓋と、を備え、内側の壁と外側の壁が、ベースに固定され、毛細管経路の横の境界を構成している。微細構造自らが毛細管経路を形成しないことが明らかであるが、ただ、流体が毛細管経路の曲がった部分を移動したときに流れに影響を与え、その流れは、曲がった部分の外側の壁の近くよりも内側の壁の近くで幾分遅くなる。
前述の目的は、固体の基質(基板)に設けられる開放した微細構造を通って液体を流動するような、毛細管作用の現象を採用することにより、本発明をもって達成される。その広い有効範囲において、本発明による微細流体構造は、望ましい液体の流動システムを定義する幾何学の微細構造の様々なかたちを含む。
本発明を説明する前に、本発明の範囲は添付の特許請求の範囲とその等価物によってのみ限定されるため、ここに用いられる専門用語は、特別な実施例のみを説明するために使われ、そして限定することを意図しないことが理解される。
(実施例1;シリコンで作られた柱を有する開放経路の流れ)
流動経路は、当業者に周知の標準的な方法によって、シリコンウェーハのエッチングで製造された。生じたシリコンチップは、長さ25mm、幅5mmであった。柱によってカバーされる領域は、10mmの長さと4ミリの幅であった。柱は、高さ100μm、直径20μm、中心間距離が30μmであった。
流動経路は、当業者に周知の標準的な方法で、最初にシリコンウェーハのエッチングにより製造された。エポキシ樹脂の薄層が、一様にシリコンウェーハに適用された。生じたエポキシ樹脂でカバーされたチップは、長さ25mm、幅5mmであった。柱によってカバーされた領域は、10mmの長さと4mmの幅であった。柱は、およそ90μmの高さと、およそ20μmの直径と、約30μmの中心間距離とを有していた。
Claims (29)
- 基板(2)を備えた微細流体システムであって、該基板に、少なくとも一つの流動路と、液体サンプルを望ましい手順で処理できる機能的手段とが設けられ、前記少なくとも一つの流動路が、前記機能的手段に対して、液体サンプルの移送のための形態を構成するように配置される、微細流体システムにおいて、
前記流動路は、前記基板から上方へ突出する複数の微細ポスト(1)からなり、
前記流動路のどこに供給された液体サンプルでも供給されたところから前記液体の移動を強いるように、前記微細ポストの間の間隔が、毛細管作用を引き起こすように構成されており、
前記流動路は、開放流動路であり、毛細管の流動の生成に関与するカバーや蓋を有していないことを特徴とする、微細流体システム。 - 前記機能的手段が、化学的反応装置、分離手段、加熱手段、電磁放射線照射手段、前記機能的手段内の前記液体の磁性成分を閉じこめるための磁性手段、選択された領域で液体に電圧を供給する電極、又は、前記機能的手段内の液体サンプルを扱うその他の化学的、生物学的又は物理学的な装置又は手段、の1以上を備えている、請求項1記載の微細流体システム。
- 前記基板が、底面と側壁を有する溝を備え、前記流動路が、前記溝の底面から突出する微細ポストで構成される、請求項1又は2記載の微細流体システム。
- 前記システムが、前記流動路内の毛細管作用に寄与しないように前記流動路から離れて配置されている頂部又は蓋(15)を有する、請求項3記載の微細流体システム。
- 前記蓋(15)が、試薬、ガス、液体、サンプルの導入を可能にするためのアクセス開口(17)を有している、請求項4記載の微細流体システム。
- 前記基板(2)が、本質的に平坦であり、前記微細ポスト(1)が前記基板から突出している、請求項1又は2記載の微細流体システム。
- 前記微細ポスト(1)が、その区分間に間隔又は切れ目(11,12)を形成するように、隣接する区分に分離され、その切れ目が、有限の距離を有し、該距離が、前記区分間の毛細管流動を妨げるのに十分な大きさであり、それによって、流動の停止をもたらす、請求項1〜6のいずれか1つに記載の微細流体システム。
- 流動停止を超えて強制的に移送させるように、選択された1以上の区分にエネルギーを供給する手段が設けられる、請求項7記載の微細流体システム。
- 前記エネルギー供給手段が、脈圧発生機、超音波発生機、電磁放射線手段の中から選択される、請求項8記載の微細流体システム。
- 横断する流動を引き起こすように前記切れ目を横断するブリッジを提供するため、前記切れ目に液体を供給する手段を備えている、請求項7記載の微細流体システム。
- 前記流動路における微細ポストの表面が、化学的、生物学的又は物理的な機能性を有している、請求項1記載の微細流体システム。
- 前記微細ポストが、それらの表面に化学反応基を有している、請求項11記載の微細流体システム。
- 前記微細ポストが、それらの表面に結合する生物学的な親和力を持つ物質を有している、請求項11記載の微細流体システム。
- 前記微細ポストが、それらの表面に親水基を有している、請求項11記載の微細流体システム。
- 前記微細ポストが、それらの表面に、正及び/又は負の荷電基を有している、請求項11記載の微細流体システム。
- 前記微細ポストが、それらの表面に疎水性の構造を有している、請求項12記載の微細流体システム。
- 前記機能性が、流動路全体の微細ポストに適用され、又は、個別の領域又は流動路の一部に制限される、請求項12記載の微細流体システム。
- 前記機能性は、微細ポストの直径、高さ、形状、断面、表面コーティング、単位領域当たりの微細ポストの数、微細ポストの表面を濡らす反応、又は、これらの組み合わせから、決定される、請求項12記載の微細流体システム。
- 少なくとも一つの流動路に粒子が提供される、請求項1〜18のいずれか1つに記載の微細流体システム。
- 前記粒子が、化学的又は物理的に基板に結合され、又は、機械的に、複数の微細ポストを含む領域内に閉じこめられる、請求項19記載の微細流体システム。
- 前記流動路が、電極、又は、液体及び/又は試薬の電気操作のためのその他の手段を含む、統合されたゾーン又は境界が画された表面を有している、請求項1〜20のいずれか1つに記載の微細流体システム。
- 前記流動路が、光学的要素又はその他の送信、集光、反射又は吸光のための手段を含む、統合されたゾーン又は境界が画された表面を有している、請求項1〜21のいずれか1つに記載の微細流体システム。
- 前記流動路が、磁性の機能性、又は磁性物質の操作及び又は検知のための手段を含む、統合されたゾーン又は境界が画された表面を有している、請求項1〜22のいずれか1つに記載の微細流体システム。
- 前記流動路が、統合されたゾーン又は境界が画された表面であって該ゾーンを加熱又は冷却する温度調節手段を含むゾーン又は表面を有している、請求項1〜23のいずれか1つに記載の微細流体システム。
- 請求項1記載の微細流動システムが用いられることを特徴とする、化学的又は生物学的処理を微細スケールで行うための方法。
- 請求項1,2,11,15又は19のいずれか一つに記載の微細流体システムが、クロマトグラフィの分離ステップに用いられていることを特徴とする、イオン交換クロマトグラフィを行う方法。
- 請求項1記載の微細流体システムが、クロマトグラフィの準備ステップに用いられていることを特徴とする、疎水的相互作用のクロマトグラフィを行う方法。
- 請求項1記載の微細流体システムが用いられていることを特徴とする、物理的、化学的、生物学的処理を微細スケールで行う、サンプルを集中させるための方法。
- 請求項1記載の微細流体システムが用いられていることを特徴とする、物理的、化学的、又は生物学的処理を微細スケールで行う、セル又は他の微細な生物学的な要素の分離のための方法。
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Application Number | Priority Date | Filing Date | Title |
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SE0201738A SE0201738D0 (sv) | 2002-06-07 | 2002-06-07 | Micro-fluid structures |
PCT/SE2003/000919 WO2003103835A1 (en) | 2002-06-07 | 2003-06-04 | Micro fluidic structures |
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JP4597664B2 true JP4597664B2 (ja) | 2010-12-15 |
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EP (1) | EP1511570B1 (ja) |
JP (1) | JP4597664B2 (ja) |
CN (1) | CN100342972C (ja) |
AT (1) | ATE404285T1 (ja) |
AU (1) | AU2003243080B2 (ja) |
BR (1) | BR0311495B1 (ja) |
DE (2) | DE60322891D1 (ja) |
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Cited By (7)
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JP2018176412A (ja) * | 2017-04-19 | 2018-11-15 | 天亮醫療器材股▲ふん▼有限公司SKYLA Corporation | 検出装置およびその注入口構造 |
KR20190017952A (ko) | 2016-06-14 | 2019-02-20 | 덴카 주식회사 | 액체 시료 검사 키트용 막 담체, 액체 시료 검사 키트 및 액체 시료 검사 키트의 제조 방법 |
WO2019117103A1 (ja) * | 2017-12-11 | 2019-06-20 | デンカ株式会社 | 液体試料検査キット用膜担体、液体試料検査キット及び膜担体 |
WO2019117102A1 (ja) * | 2017-12-11 | 2019-06-20 | デンカ株式会社 | 液体試料検査キット用膜担体、液体試料検査キット、液体試料検査キットの製造方法、液体試料の検査方法及び膜担体 |
US11162938B2 (en) | 2017-03-28 | 2021-11-02 | Denka Company Limited | Membrane carrier, kit for testing liquid sample using same, and manufacturing method thereof |
WO2021220956A1 (ja) | 2020-04-28 | 2021-11-04 | デンカ株式会社 | 検出装置及び検出方法 |
US11385227B2 (en) | 2017-03-28 | 2022-07-12 | Denka Company Limited | Membrane carrier and kit for testing liquid sample using same |
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US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
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CN100342972C (zh) | 2007-10-17 |
US8025854B2 (en) | 2011-09-27 |
BR0311495A (pt) | 2005-03-15 |
CN1658972A (zh) | 2005-08-24 |
ATE404285T1 (de) | 2008-08-15 |
BR0311495B1 (pt) | 2012-08-21 |
WO2003103835A1 (en) | 2003-12-18 |
SE0201738D0 (sv) | 2002-06-07 |
DE03757231T1 (de) | 2005-07-14 |
US20120028818A1 (en) | 2012-02-02 |
US20050042766A1 (en) | 2005-02-24 |
AU2003243080A1 (en) | 2003-12-22 |
JP2005532151A (ja) | 2005-10-27 |
EP1511570A1 (en) | 2005-03-09 |
EP1511570B1 (en) | 2008-08-13 |
US20160354779A1 (en) | 2016-12-08 |
DE60322891D1 (de) | 2008-09-25 |
AU2003243080B2 (en) | 2008-10-16 |
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