JP4554081B2 - ヒンダードアルコールまたはフェノールの水溶性プロドラッグ - Google Patents
ヒンダードアルコールまたはフェノールの水溶性プロドラッグ Download PDFInfo
- Publication number
- JP4554081B2 JP4554081B2 JP2000563666A JP2000563666A JP4554081B2 JP 4554081 B2 JP4554081 B2 JP 4554081B2 JP 2000563666 A JP2000563666 A JP 2000563666A JP 2000563666 A JP2000563666 A JP 2000563666A JP 4554081 B2 JP4554081 B2 JP 4554081B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- propofol
- compound according
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AZYMLIHPQZLCEM-UHFFFAOYSA-N CCNC(C(C(C)C)N(CC)CCCCN)O Chemical compound CCNC(C(C(C)C)N(CC)CCCCN)O AZYMLIHPQZLCEM-UHFFFAOYSA-N 0.000 description 1
- IRIQXYKPTIIYPV-UHFFFAOYSA-N CCNC(C(C(C)C)N(CC)CCCCNC(C)C)=O Chemical compound CCNC(C(C(C)C)N(CC)CCCCNC(C)C)=O IRIQXYKPTIIYPV-UHFFFAOYSA-N 0.000 description 1
- FYNFRMRJGQZHCO-NRFANRHFSA-N CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O Chemical compound CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O FYNFRMRJGQZHCO-NRFANRHFSA-N 0.000 description 1
- WNYKGTOBONPIFC-DHUJRADRSA-N CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(OCc1ccccc1)(OCc1ccccc1)=O Chemical compound CC[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(OCc1ccccc1)(OCc1ccccc1)=O WNYKGTOBONPIFC-DHUJRADRSA-N 0.000 description 1
- 0 C[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(*)(*)=O Chemical compound C[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(*)(*)=O 0.000 description 1
- YQUZMRVVIPYEFY-FQEVSTJZSA-N C[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O Chemical compound C[C@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)OCOP(O)(O)=O YQUZMRVVIPYEFY-FQEVSTJZSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/131,385 US6204257B1 (en) | 1998-08-07 | 1998-08-07 | Water soluble prodrugs of hindered alcohols |
US09/131,385 | 1998-08-07 | ||
PCT/US1999/017779 WO2000008033A1 (en) | 1998-08-07 | 1999-08-06 | Water soluble prodrugs of hindered alcohols or phenols |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002522443A JP2002522443A (ja) | 2002-07-23 |
JP2002522443A5 JP2002522443A5 (US20010025035A1-20010927-C00001.png) | 2006-09-28 |
JP4554081B2 true JP4554081B2 (ja) | 2010-09-29 |
Family
ID=22449234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000563666A Expired - Fee Related JP4554081B2 (ja) | 1998-08-07 | 1999-08-06 | ヒンダードアルコールまたはフェノールの水溶性プロドラッグ |
Country Status (27)
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
ES2211151T3 (es) * | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
US6362172B2 (en) | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
US6362234B1 (en) * | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
US6448401B1 (en) * | 2000-11-20 | 2002-09-10 | Bristol-Myers Squibb Company | Process for water soluble azole compounds |
WO2002085928A2 (fr) * | 2001-04-20 | 2002-10-31 | Debiopharm S.A. | Cyclosporine modifiee utilisable en tant que pro-drogue et son utilisation |
CA2459125A1 (en) | 2001-09-26 | 2003-04-03 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
NZ533535A (en) * | 2001-12-21 | 2005-12-23 | Guilford Pharm Inc | Process for preparing water-soluble phosphonooxymethyl derivatives of alcohol and phenol |
US20050042280A1 (en) * | 2001-12-28 | 2005-02-24 | Rogers Tracey L. | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
IL164217A0 (en) * | 2002-04-08 | 2005-12-18 | Guilford Pharm Inc | Pharmaceutical compositions containing water-soluble propofol and methods of administering same |
ITRM20020306A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
ZA200504940B (en) * | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
US7230003B2 (en) * | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
US7250412B2 (en) * | 2003-10-24 | 2007-07-31 | Auspex Pharmaceuticals, Inc. | PH sensitive prodrugs of 2,6-Diisopropylphenol |
US7834043B2 (en) * | 2003-12-11 | 2010-11-16 | Abbott Laboratories | HIV protease inhibiting compounds |
EP1694277A2 (en) * | 2003-12-17 | 2006-08-30 | MGI GP, Inc. | Methods of administering water-soluble prodrugs of propofol for extended sedation |
US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
SG152239A1 (en) | 2004-04-15 | 2009-05-29 | Proteolix Inc | Compounds for proteasome enzyme inhibition |
US20050256324A1 (en) * | 2004-05-10 | 2005-11-17 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
PT2030981E (pt) | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
EP2336138A3 (en) * | 2004-07-06 | 2011-11-16 | Abbott Laboratories | Prodrugs of HIV protease inhibitors |
PL1781596T3 (pl) * | 2004-07-12 | 2009-04-30 | Xenoport Inc | Aminokwasowe pochodne prekursory leków związku propofolu i ich zastosowanie |
WO2006017351A1 (en) * | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
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AU2005281359A1 (en) * | 2004-08-26 | 2006-03-16 | Apparao Satyam | Prodrugs and codrugs containing novel bio-cleavable disulfide linkers |
US20080214508A1 (en) * | 2004-09-17 | 2008-09-04 | Mgi Gp, Inc. | Methods of Administering Water-Soluble Prodrugs of Propofol |
CA2586410A1 (en) * | 2004-12-23 | 2006-07-06 | Xenoport, Inc. | Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof |
KR20080019228A (ko) | 2005-06-17 | 2008-03-03 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 하나 이상의 디 및/또는 모노-(전자전달제) 인산염 유도체또는 그의 착염을 함유하는 담체 |
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