IT1270093B - Processo per la purificazione di 2,6-diisopropilfenolo - Google Patents
Processo per la purificazione di 2,6-diisopropilfenoloInfo
- Publication number
- IT1270093B IT1270093B ITMI941969A ITMI941969A IT1270093B IT 1270093 B IT1270093 B IT 1270093B IT MI941969 A ITMI941969 A IT MI941969A IT MI941969 A ITMI941969 A IT MI941969A IT 1270093 B IT1270093 B IT 1270093B
- Authority
- IT
- Italy
- Prior art keywords
- diisopropylphenol
- purification process
- propofol
- carbosollic
- crystallization
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/24—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Viene descritto un processo di purificazione del 2,6-diisopropilfenolo (Propofol) per trasformazione del Propofol grezzo in un suo estere con un acido carbosollico o solfonico, cristallizzazione e idrolisi.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941969A IT1270093B (it) | 1994-09-28 | 1994-09-28 | Processo per la purificazione di 2,6-diisopropilfenolo |
US08/457,592 US5589598A (en) | 1994-09-28 | 1995-06-01 | Process of purification of 2,6-diisopropylphenol |
AT95934071T ATE178041T1 (de) | 1994-09-28 | 1995-09-18 | Verfahren zur reinigung von 2,6-diisopropylphenol |
AU36504/95A AU687643B2 (en) | 1994-09-28 | 1995-09-18 | Process for the purification of 2,6-diisopropylphenol |
CA002200317A CA2200317C (en) | 1994-09-28 | 1995-09-18 | Process for the purification of 2,6-diisopropylphenol |
EP95934071A EP0783473B1 (en) | 1994-09-28 | 1995-09-18 | Process for the purification of 2,6-diisopropylphenol |
DE69508599T DE69508599T2 (de) | 1994-09-28 | 1995-09-18 | Verfahren zur reinigung von 2,6-diisopropylphenol |
CZ1997935A CZ290597B6 (cs) | 1994-09-28 | 1995-09-18 | Způsob čiątění 2,6-diizopropylfenolu |
PCT/EP1995/003676 WO1996010004A1 (en) | 1994-09-28 | 1995-09-18 | Process for the purification of 2,6-diisopropylphenol |
ES95934071T ES2130656T3 (es) | 1994-09-28 | 1995-09-18 | Procedimiento para la purificacion de 2,6-diisopropilfenol. |
DK95934071T DK0783473T3 (da) | 1994-09-28 | 1995-09-18 | Fremgangsmåde til oprensning af 2,6-diisopropylphenol |
JP51132896A JP3701974B2 (ja) | 1994-09-28 | 1995-09-18 | 2,6−ジイソプロピルフェノールの精製方法 |
HU9701798A HU215409B (hu) | 1994-09-28 | 1995-09-18 | Eljárás 2,6-diizopropil-fenol tisztítására |
ZA957899A ZA957899B (en) | 1994-09-28 | 1995-09-19 | Process for the purification of 2,6-diisopropylphenol |
NO971425A NO306506B1 (no) | 1994-09-28 | 1997-03-25 | Fremgangsmaate for rensing av 2,6-diisopropylfenol |
FI971264A FI118923B (fi) | 1994-09-28 | 1997-03-26 | Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi |
GR990401414T GR3030327T3 (en) | 1994-09-28 | 1999-05-27 | Process for the purification of 2,6-diisopropylphenol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI941969A IT1270093B (it) | 1994-09-28 | 1994-09-28 | Processo per la purificazione di 2,6-diisopropilfenolo |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI941969A0 ITMI941969A0 (it) | 1994-09-28 |
ITMI941969A1 ITMI941969A1 (it) | 1996-03-28 |
IT1270093B true IT1270093B (it) | 1997-04-28 |
Family
ID=11369606
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI941969A IT1270093B (it) | 1994-09-28 | 1994-09-28 | Processo per la purificazione di 2,6-diisopropilfenolo |
Country Status (17)
Country | Link |
---|---|
US (1) | US5589598A (it) |
EP (1) | EP0783473B1 (it) |
JP (1) | JP3701974B2 (it) |
AT (1) | ATE178041T1 (it) |
AU (1) | AU687643B2 (it) |
CA (1) | CA2200317C (it) |
CZ (1) | CZ290597B6 (it) |
DE (1) | DE69508599T2 (it) |
DK (1) | DK0783473T3 (it) |
ES (1) | ES2130656T3 (it) |
FI (1) | FI118923B (it) |
GR (1) | GR3030327T3 (it) |
HU (1) | HU215409B (it) |
IT (1) | IT1270093B (it) |
NO (1) | NO306506B1 (it) |
WO (1) | WO1996010004A1 (it) |
ZA (1) | ZA957899B (it) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705039A (en) * | 1995-10-13 | 1998-01-06 | Albemarle Corporation | Process for purifying a 2,6-dialkylphenol |
US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
DE69907935T2 (de) * | 1998-09-22 | 2004-03-11 | Exxonmobil Chemical Patents Inc., Baytown | Verfahren zur herstellung von durch zeolith gebundenen zeolithen mit hohem sio2-gehalt und ihre verwendung |
KR20000047871A (ko) * | 1998-12-04 | 2000-07-25 | 강재헌 | 고순도 2,6-디이소프로필페놀의 정제방법 |
ES2325918T3 (es) * | 2001-12-28 | 2009-09-24 | Eisai Corporation Of North America | Formulaciones farmaceuticas de base acuosa de profarmacos de propofol solubles en agua. |
CA2480881C (en) * | 2002-04-08 | 2012-09-11 | Guilford Pharmaceuticals, Inc. | Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same |
US8664452B2 (en) | 2010-06-23 | 2014-03-04 | Harman Finochem Limited | Process for preparing extra pure 2, 6-diisopropyl phenol |
EP2522651B1 (en) | 2011-05-12 | 2013-11-20 | Siegfried AG | Process for the purification of 2,6-diisopropyl phenol |
CN103360219B (zh) * | 2012-04-06 | 2015-08-19 | 辽宁诺康生物制药有限责任公司 | 一种高纯度丙泊酚的合成方法 |
KR20160048123A (ko) * | 2013-08-30 | 2016-05-03 | 퓨라닉스 테크놀러지스 비.브이. | 2-포밀-퓨란-5카복실산과 2, 5-퓨란디카복실산을 포함하는 산성 조성물을 정제하는 방법 |
CN104649867B (zh) * | 2013-11-21 | 2017-02-15 | 辽宁药联制药有限公司 | 一种丙泊酚的制备方法 |
CN108530269A (zh) * | 2018-04-11 | 2018-09-14 | 南安市创培电子科技有限公司 | 一种高纯度丙泊酚的生产方法 |
JP7288665B2 (ja) * | 2019-08-02 | 2023-06-08 | 株式会社デ・ウエスタン・セラピテクス研究所 | エチルアニリノトルエンスルホン酸誘導体の製造方法 |
WO2021156776A1 (en) * | 2020-02-06 | 2021-08-12 | Nandkumar Chodankar | Simple manufacturing and purification technology for high purity propofol |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3271314A (en) * | 1958-12-04 | 1966-09-06 | Ethyl Corp | 2, 6-diisopropylphenol |
GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
FI912102A (fi) * | 1991-04-30 | 1992-10-31 | Leiras Oy | Foerfarande foer rening av 2,6-diisopropylfenol |
-
1994
- 1994-09-28 IT ITMI941969A patent/IT1270093B/it active IP Right Grant
-
1995
- 1995-06-01 US US08/457,592 patent/US5589598A/en not_active Expired - Lifetime
- 1995-09-18 AT AT95934071T patent/ATE178041T1/de active
- 1995-09-18 CA CA002200317A patent/CA2200317C/en not_active Expired - Fee Related
- 1995-09-18 DE DE69508599T patent/DE69508599T2/de not_active Expired - Lifetime
- 1995-09-18 ES ES95934071T patent/ES2130656T3/es not_active Expired - Lifetime
- 1995-09-18 CZ CZ1997935A patent/CZ290597B6/cs not_active IP Right Cessation
- 1995-09-18 EP EP95934071A patent/EP0783473B1/en not_active Expired - Lifetime
- 1995-09-18 HU HU9701798A patent/HU215409B/hu not_active IP Right Cessation
- 1995-09-18 DK DK95934071T patent/DK0783473T3/da active
- 1995-09-18 WO PCT/EP1995/003676 patent/WO1996010004A1/en active IP Right Grant
- 1995-09-18 JP JP51132896A patent/JP3701974B2/ja not_active Expired - Fee Related
- 1995-09-18 AU AU36504/95A patent/AU687643B2/en not_active Ceased
- 1995-09-19 ZA ZA957899A patent/ZA957899B/xx unknown
-
1997
- 1997-03-25 NO NO971425A patent/NO306506B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971264A patent/FI118923B/fi not_active IP Right Cessation
-
1999
- 1999-05-27 GR GR990401414T patent/GR3030327T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA957899B (en) | 1996-05-09 |
FI118923B (fi) | 2008-05-15 |
HUT77183A (hu) | 1998-03-02 |
JPH10506626A (ja) | 1998-06-30 |
WO1996010004A1 (en) | 1996-04-04 |
FI971264A0 (fi) | 1997-03-26 |
ATE178041T1 (de) | 1999-04-15 |
CZ290597B6 (cs) | 2002-08-14 |
FI971264A (fi) | 1997-03-26 |
DE69508599T2 (de) | 1999-11-18 |
NO971425L (no) | 1997-03-25 |
DK0783473T3 (da) | 1999-10-18 |
GR3030327T3 (en) | 1999-09-30 |
NO971425D0 (no) | 1997-03-25 |
EP0783473A1 (en) | 1997-07-16 |
ITMI941969A0 (it) | 1994-09-28 |
ES2130656T3 (es) | 1999-07-01 |
CA2200317C (en) | 2007-04-17 |
HU215409B (hu) | 1998-12-28 |
AU3650495A (en) | 1996-04-19 |
CA2200317A1 (en) | 1996-04-04 |
EP0783473B1 (en) | 1999-03-24 |
US5589598A (en) | 1996-12-31 |
AU687643B2 (en) | 1998-02-26 |
NO306506B1 (no) | 1999-11-15 |
CZ93597A3 (en) | 1997-09-17 |
ITMI941969A1 (it) | 1996-03-28 |
DE69508599D1 (de) | 1999-04-29 |
JP3701974B2 (ja) | 2005-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IT1270093B (it) | Processo per la purificazione di 2,6-diisopropilfenolo | |
BR9203816A (pt) | Processo para purificacao de acido carboxilico,e processo para producao de anidrido acetico | |
MX9201704A (es) | Proceso para preparar acido tereftalico crudo adecuado para reduccion para preparar acido tereftalico purificado. | |
BR0301150B1 (pt) | processo para a preparaÇço de Ácido metacrÍlico e seus Ésteres. | |
FR2644178B1 (fr) | Micro-organisme de l'espece bacillus coagulans et procede utilisant ce micro-organisme pour produire de l'acide l(+)lactique optiquement pur | |
MY116928A (en) | Purification of crude acrylic acid by crystallization | |
IT8721254A0 (it) | Processo di risoluzione ottica di acido 2 (6 metossi 2naftil)propionico. | |
ITMI911555A1 (it) | Processo per la produzione di soluzioni acquose di acido lattico purificate a partire da brodi di fermentazione. | |
ES2158500T3 (es) | Tratamiento de corrientes de residuos acuosos. | |
ES2149543T3 (es) | Composiciones para eliminar incrustaciones de cal. | |
BR9204603A (pt) | Processo para oxidar etano em acido acetico | |
IT1210895B (it) | Processo per la rimozione di anidride carbonica e,se presente,acido solfidrico da una miscela gassosa | |
DE3684434D1 (de) | Verfahren zur herstellung von 2-keto-d-glukarsaeure. | |
ES2117223T3 (es) | Procedimiento para la preparacion de acidos taurocolanicos. | |
BR8103872A (pt) | Processo de preparacao de cultura biologicamente pura de uma variante do microorganismo clostridum thermoaceticum cultura resultante ,e processo para a conversao de carboidraatos de acido acetico | |
BR0009518A (pt) | Processo para a preparação de um éster do ácido 2-hidroxi-4-metiltiobutìrico | |
IT1269977B (it) | Purificazione del propofol | |
PT100439A (pt) | Esteres de arilalquilo do acido 4,5-dihidroxi-9,10-dihidro-9,10-dioxo-2-antracenocarboxilico com actividade terapeutica | |
ES2130729T3 (es) | Procedimiento para la esterificacion de acido (met)acrilico con un alcanol. | |
PT98700A (pt) | Processo para a preparacao de acidos aminometanofosfonico e de acidos aminometil-fosfinicos | |
IT1189273B (it) | Procedimento di fermentazione a stadio unico per la preparazione di acido 9-idrossi-3-osso-4,17(20)-pregnadien-20-carbossilico,utile come intermedio per la produzione di sterroidi | |
IT8022033A0 (it) | Processo per la preparazione di acido ursodesossicolico ad alta purezza. | |
ITMI912704A0 (it) | Processo per l'allontanamento del cadmio da soluzioni di acido fosferico | |
FR2731218B1 (fr) | Procede de preparation de l'acide 3-chloropropionique | |
ES2156628T3 (es) | Procedimiento para la preparacion de halogenodifluor-acetatos de alquilo. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970825 |