JP4467869B2 - 親水性修飾剤を有するアクリジニウムエステル標識 - Google Patents

親水性修飾剤を有するアクリジニウムエステル標識 Download PDF

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JP4467869B2
JP4467869B2 JP2002185836A JP2002185836A JP4467869B2 JP 4467869 B2 JP4467869 B2 JP 4467869B2 JP 2002185836 A JP2002185836 A JP 2002185836A JP 2002185836 A JP2002185836 A JP 2002185836A JP 4467869 B2 JP4467869 B2 JP 4467869B2
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dmae
nsp
conjugate
assay
folate
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JP2003050204A (ja
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アナンド、ナトラジアン
デイヴィド、シャープ
クインピン、ジァン
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002185836A 2001-07-03 2002-06-26 親水性修飾剤を有するアクリジニウムエステル標識 Expired - Lifetime JP4467869B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/898381 2001-07-03
US09/898,381 US6664043B2 (en) 2001-07-03 2001-07-03 Acridinium ester labels having hydrophilic modifiers

Related Child Applications (1)

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JP2009239298A Division JP4913195B2 (ja) 2001-07-03 2009-10-16 親水性修飾剤を有するアクリジニウムエステル標識

Publications (2)

Publication Number Publication Date
JP2003050204A JP2003050204A (ja) 2003-02-21
JP4467869B2 true JP4467869B2 (ja) 2010-05-26

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ID=25409366

Family Applications (2)

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JP2002185836A Expired - Lifetime JP4467869B2 (ja) 2001-07-03 2002-06-26 親水性修飾剤を有するアクリジニウムエステル標識
JP2009239298A Expired - Lifetime JP4913195B2 (ja) 2001-07-03 2009-10-16 親水性修飾剤を有するアクリジニウムエステル標識

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JP2009239298A Expired - Lifetime JP4913195B2 (ja) 2001-07-03 2009-10-16 親水性修飾剤を有するアクリジニウムエステル標識

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Country Link
US (1) US6664043B2 (enExample)
EP (1) EP1273917B1 (enExample)
JP (2) JP4467869B2 (enExample)
AU (1) AU782559B2 (enExample)
CA (1) CA2387466A1 (enExample)
ES (1) ES2486815T3 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
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US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
EP1539702B1 (en) * 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US8334257B2 (en) 2005-12-20 2012-12-18 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
JP2010520855A (ja) * 2007-01-31 2010-06-17 アフィーマックス・インコーポレイテッド 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
US20110058984A1 (en) 2008-05-08 2011-03-10 Hitachi High-Technologies Corporation Automatic analyzer
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
US8778624B2 (en) * 2009-11-16 2014-07-15 Siemens Healthcare Diagnostics Inc. Zwitterion-containing acridinium compounds
EP2872489B1 (en) * 2012-07-10 2016-12-21 Siemens Healthcare Diagnostics Inc. Synthesis of acridinium compounds by n-alkylation of acridans
WO2014084110A1 (ja) * 2012-11-30 2014-06-05 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
FR3000551B1 (fr) * 2012-12-27 2015-06-26 Biomerieux Sa Derives de folate, particulierement utiles dans le cadre du dosage de folate(s)
ES2769887T3 (es) 2013-05-14 2020-06-29 Siemens Healthcare Diagnostics Inc Tensioactivos catiónicos degradables y su uso para la mejora de la quimioluminiscencia
US20170320830A1 (en) 2013-07-08 2017-11-09 Siemens Healthcare Diagnostics Inc. Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission
CN116693587A (zh) * 2017-02-23 2023-09-05 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
CN112368265A (zh) 2018-06-25 2021-02-12 美国西门子医学诊断股份有限公司 9,10-二氢吖啶的n-烷基化
CN109535062B (zh) * 2019-01-10 2021-03-23 中北大学 一种降冰片烯类两性离子单体及其制备方法
CN110850077A (zh) * 2019-11-06 2020-02-28 迪瑞医疗科技股份有限公司 妥布霉素化学发光检测试剂盒及其制备方法
CN112920399A (zh) * 2019-12-05 2021-06-08 广东菲鹏生物有限公司 吖啶化合物标记类固醇激素衍生物及其制备方法和应用
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法
WO2023006581A1 (en) 2021-07-29 2023-02-02 Euroimmun Medizinische Labordiagnostika Ag A method and reagents for enhancing the chemiluminescent signal
CN116284978B (zh) * 2022-12-16 2024-09-20 厦门为正生物科技股份有限公司 一种荧光微球及其制备方法与应用
AU2023409213B2 (en) * 2022-12-21 2025-12-18 Siemens Healthcare Diagnostics Inc. Cyclosporine-acridinium esters and methods of production and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
JPH0286567A (ja) * 1988-09-21 1990-03-27 Ricoh Co Ltd シート後処理制御装置
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
BR9907248A (pt) * 1998-11-25 2000-10-17 Bayer Ag Determinação de hidreto usando compostos de acridìnio quimiluminescentes
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
AU6381900A (en) * 1999-07-30 2001-02-19 Bayer Corporation Chemiluminescent substrates of hydrolytic enzymes such as phosphatases
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection

Also Published As

Publication number Publication date
US20030045716A1 (en) 2003-03-06
AU782559B2 (en) 2005-08-11
AU4573602A (en) 2003-01-09
EP1273917A2 (en) 2003-01-08
JP2010019854A (ja) 2010-01-28
ES2486815T3 (es) 2014-08-19
US6664043B2 (en) 2003-12-16
CA2387466A1 (en) 2003-01-03
JP4913195B2 (ja) 2012-04-11
EP1273917A3 (en) 2003-09-17
EP1273917B1 (en) 2014-05-07
JP2003050204A (ja) 2003-02-21

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