ES2486815T3 - Marcadores de éster de acridinio que tienen modificadores hidrófilos - Google Patents

Marcadores de éster de acridinio que tienen modificadores hidrófilos Download PDF

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Publication number
ES2486815T3
ES2486815T3 ES02013902.8T ES02013902T ES2486815T3 ES 2486815 T3 ES2486815 T3 ES 2486815T3 ES 02013902 T ES02013902 T ES 02013902T ES 2486815 T3 ES2486815 T3 ES 2486815T3
Authority
ES
Spain
Prior art keywords
dmae
nsp
folate
conjugate
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02013902.8T
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English (en)
Spanish (es)
Inventor
Anand Natrajan
David Sharpe
Qingping Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Application granted granted Critical
Publication of ES2486815T3 publication Critical patent/ES2486815T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES02013902.8T 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos Expired - Lifetime ES2486815T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US898381 2001-07-03
US09/898,381 US6664043B2 (en) 2001-07-03 2001-07-03 Acridinium ester labels having hydrophilic modifiers

Publications (1)

Publication Number Publication Date
ES2486815T3 true ES2486815T3 (es) 2014-08-19

Family

ID=25409366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02013902.8T Expired - Lifetime ES2486815T3 (es) 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos

Country Status (6)

Country Link
US (1) US6664043B2 (enExample)
EP (1) EP1273917B1 (enExample)
JP (2) JP4467869B2 (enExample)
AU (1) AU782559B2 (enExample)
CA (1) CA2387466A1 (enExample)
ES (1) ES2486815T3 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
AU2003263917A1 (en) * 2002-08-20 2004-03-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents
US7309615B2 (en) 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US8334257B2 (en) 2005-12-20 2012-12-18 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
WO2008095004A2 (en) * 2007-01-31 2008-08-07 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
JP5209705B2 (ja) 2008-05-08 2013-06-12 株式会社日立ハイテクノロジーズ 自動分析装置
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
WO2011060228A1 (en) * 2009-11-16 2011-05-19 Siemens Healthcare Diagnostics Inc. Zwitterion-containing acridinium compounds
ES2618042T3 (es) 2012-07-10 2017-06-20 Siemens Healthcare Diagnostics Inc. Síntesis de compuestos de acridinio mediante n-alquilación de acridanos
CN104936613B (zh) 2012-11-30 2018-05-22 株式会社糖锁工学研究所 糖链加成连接子、含有糖链加成连接子与生理活性物质的化合物或其盐、以及其制造方法
FR3000551B1 (fr) * 2012-12-27 2015-06-26 Biomerieux Sa Derives de folate, particulierement utiles dans le cadre du dosage de folate(s)
CN105264377B (zh) 2013-05-14 2017-09-08 西门子医疗保健诊断公司 可降解的阳离子型表面活性剂及其在增强化学发光中的用途
JP6735665B2 (ja) 2013-07-08 2020-08-05 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． 安定性が改善され迅速に発光する親水性高量子収率アクリジニウムエステル
CN110603059B (zh) * 2017-02-23 2023-06-30 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
EP3810577B1 (en) 2018-06-25 2025-03-12 Siemens Healthcare Diagnostics, Inc. N-alkylation of acridans
CN109535062B (zh) * 2019-01-10 2021-03-23 中北大学 一种降冰片烯类两性离子单体及其制备方法
CN110850077A (zh) * 2019-11-06 2020-02-28 迪瑞医疗科技股份有限公司 妥布霉素化学发光检测试剂盒及其制备方法
CN112920399A (zh) * 2019-12-05 2021-06-08 广东菲鹏生物有限公司 吖啶化合物标记类固醇激素衍生物及其制备方法和应用
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法
JP2024527110A (ja) 2021-07-29 2024-07-19 ユーロイミューン・メディツィニシェ・ラボルディアグノシュティカ・アクチエンゲゼルシャフト 化学ルミネセンスシグナルを増大させる方法および試薬
CN116284978B (zh) * 2022-12-16 2024-09-20 厦门为正生物科技股份有限公司 一种荧光微球及其制备方法与应用
WO2024137034A1 (en) * 2022-12-21 2024-06-27 Siemens Healthcare Diagnostics Inc. Cyclosporine-acridinium esters and methods of production and use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3568063D1 (en) * 1985-01-10 1989-03-09 Molecular Diagnostics Inc Photochemical method of labelling nucleic acids for detection in hybridization assays
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
JPH0286567A (ja) * 1988-09-21 1990-03-27 Ricoh Co Ltd シート後処理制御装置
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
WO2000031543A1 (en) * 1998-11-25 2000-06-02 Bayer Corporation Measurement of hydride using chemiluminescent acridinium compounds
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
DE60018758T2 (de) * 1999-07-30 2006-01-19 Bayer Corp. Chemiliumineszierendes Substrat von Hydrolasen wie Phosphatasen
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection

Also Published As

Publication number Publication date
JP4913195B2 (ja) 2012-04-11
JP2010019854A (ja) 2010-01-28
EP1273917A2 (en) 2003-01-08
AU782559B2 (en) 2005-08-11
CA2387466A1 (en) 2003-01-03
JP2003050204A (ja) 2003-02-21
EP1273917A3 (en) 2003-09-17
EP1273917B1 (en) 2014-05-07
US6664043B2 (en) 2003-12-16
AU4573602A (en) 2003-01-09
JP4467869B2 (ja) 2010-05-26
US20030045716A1 (en) 2003-03-06

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