ES2486815T3 - Marcadores de éster de acridinio que tienen modificadores hidrófilos - Google Patents

Marcadores de éster de acridinio que tienen modificadores hidrófilos Download PDF

Info

Publication number
ES2486815T3
ES2486815T3 ES02013902.8T ES02013902T ES2486815T3 ES 2486815 T3 ES2486815 T3 ES 2486815T3 ES 02013902 T ES02013902 T ES 02013902T ES 2486815 T3 ES2486815 T3 ES 2486815T3
Authority
ES
Spain
Prior art keywords
dmae
nsp
folate
conjugate
tobramycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02013902.8T
Other languages
English (en)
Spanish (es)
Inventor
Anand Natrajan
David Sharpe
Qingping Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Siemens Healthcare Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Healthcare Diagnostics Inc filed Critical Siemens Healthcare Diagnostics Inc
Application granted granted Critical
Publication of ES2486815T3 publication Critical patent/ES2486815T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ES02013902.8T 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos Expired - Lifetime ES2486815T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US898381 2001-07-03
US09/898,381 US6664043B2 (en) 2001-07-03 2001-07-03 Acridinium ester labels having hydrophilic modifiers

Publications (1)

Publication Number Publication Date
ES2486815T3 true ES2486815T3 (es) 2014-08-19

Family

ID=25409366

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02013902.8T Expired - Lifetime ES2486815T3 (es) 2001-07-03 2002-06-21 Marcadores de éster de acridinio que tienen modificadores hidrófilos

Country Status (6)

Country Link
US (1) US6664043B2 (enExample)
EP (1) EP1273917B1 (enExample)
JP (2) JP4467869B2 (enExample)
AU (1) AU782559B2 (enExample)
CA (1) CA2387466A1 (enExample)
ES (1) ES2486815T3 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
EP1539702B1 (en) * 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
EP1971355B1 (en) 2005-12-20 2020-03-11 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8106154B2 (en) * 2007-01-31 2012-01-31 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
WO2009136613A1 (ja) 2008-05-08 2009-11-12 株式会社 日立ハイテクノロジーズ 自動分析装置
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
CN105153115B (zh) * 2009-11-16 2021-08-03 西门子医疗保健诊断公司 含两性离子的吖啶鎓化合物
CN104411688B (zh) * 2012-07-10 2019-01-08 西门子医疗保健诊断公司 由9,10-二氢吖啶的n-烷基化合成吖啶鎓化合物
CN104936613B (zh) * 2012-11-30 2018-05-22 株式会社糖锁工学研究所 糖链加成连接子、含有糖链加成连接子与生理活性物质的化合物或其盐、以及其制造方法
FR3000551B1 (fr) * 2012-12-27 2015-06-26 Biomerieux Sa Derives de folate, particulierement utiles dans le cadre du dosage de folate(s)
WO2014186406A2 (en) 2013-05-14 2014-11-20 Siemens Healthcare Diagnostics Inc. Degradable cationic surfactants and use thereof in enhancing chemiluminescence
EP3019575B1 (en) 2013-07-08 2018-12-19 Siemens Healthcare Diagnostics Inc. Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission
CN110603059B (zh) * 2017-02-23 2023-06-30 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
CN112368265A (zh) 2018-06-25 2021-02-12 美国西门子医学诊断股份有限公司 9,10-二氢吖啶的n-烷基化
CN109535062B (zh) * 2019-01-10 2021-03-23 中北大学 一种降冰片烯类两性离子单体及其制备方法
CN110850077A (zh) * 2019-11-06 2020-02-28 迪瑞医疗科技股份有限公司 妥布霉素化学发光检测试剂盒及其制备方法
CN112920399A (zh) * 2019-12-05 2021-06-08 广东菲鹏生物有限公司 吖啶化合物标记类固醇激素衍生物及其制备方法和应用
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法
CN117769588B (zh) 2021-07-29 2025-02-21 欧蒙医学实验诊断股份公司 增强化学发光信号的方法和试剂
JP2025535270A (ja) 2022-10-13 2025-10-24 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 縮合複素環を有するアクリジニウム化合物
CN116284978B (zh) * 2022-12-16 2024-09-20 厦门为正生物科技股份有限公司 一种荧光微球及其制备方法与应用
EP4638467A4 (en) * 2022-12-21 2026-03-04 Siemens Healthcare Diagnostics Inc CYCLOSPORINE-ACRIDINIUM ESTERS AND THEIR PRODUCTION AND USE PROCESSES
EP4749284A1 (de) 2024-11-26 2026-05-27 pes Diagnosesysteme GmbH Bestimmung eines freien thyroid-hormons

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE40572T1 (de) * 1985-01-10 1989-02-15 Molecular Diagnostics Inc Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben.
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
JPH0286567A (ja) * 1988-09-21 1990-03-27 Ricoh Co Ltd シート後処理制御装置
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
US5663074A (en) * 1988-09-26 1997-09-02 Chiron Diagnostics Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
JP2002530678A (ja) * 1998-11-25 2002-09-17 バイエル コーポレイション 化学発光性アクリジニウム化合物を使用するヒドリドの測定
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection
JP3819294B2 (ja) * 1999-07-30 2006-09-06 バイエル コーポレイション 燐酸酵素のような加水分解性酵素の化学発光基質

Also Published As

Publication number Publication date
JP4467869B2 (ja) 2010-05-26
EP1273917A3 (en) 2003-09-17
EP1273917A2 (en) 2003-01-08
AU4573602A (en) 2003-01-09
JP2003050204A (ja) 2003-02-21
EP1273917B1 (en) 2014-05-07
US20030045716A1 (en) 2003-03-06
JP4913195B2 (ja) 2012-04-11
JP2010019854A (ja) 2010-01-28
CA2387466A1 (en) 2003-01-03
AU782559B2 (en) 2005-08-11
US6664043B2 (en) 2003-12-16

Similar Documents

Publication Publication Date Title
JP4913195B2 (ja) 親水性修飾剤を有するアクリジニウムエステル標識
ES2739383T3 (es) Haptenos de paliperidona
ES2700649T3 (es) Compuestos de acridinio que contienen zwiteriones
ES2926662T3 (es) Anticuerpos contra haptenos de risperidona y uso de los mismos
ES2665953T3 (es) Inmunoensayos que emplean reactivos quimioluminiscentes no particulados
ES2828097T3 (es) Métodos para detectar dimetilarginina simétrica
ES2669565T3 (es) Haptenos de risperidona y paliperidona
ES2664952T3 (es) Anticuerpos para haptenos de quetiapina y uso de los mismos
ES2941663T3 (es) Reactivos zwitteriónicos
ES2881305T3 (es) Diseño de ensayo sandwich para pequeñas moléculas
ES2526190T3 (es) Novedosas aplicaciones de compuestos de acridinio y derivados en ensayos homogéneos
ES2559311T3 (es) Reactivo de extracción de fármacos inmunosupresores para inmunoanálisis
ES2863624T3 (es) Ensayo en sándwich para moléculas pequeñas
JP4068137B2 (ja) ビオチニル化した化学発光性標識、結合体、測定法及び測定法キット
ES2392900T3 (es) Ésteres de acridinio estables con emisión de luz rápida
ES2524603T3 (es) Inmunoensayos para topiramato
JPH09504505A (ja) プテリン誘導体およびその製法と利用法
ES2527059T3 (es) Compuestos de acridinio con alto rendimiento cuántico y sus usos en mejoramiento de la sensibilidad de ensayo
US20220107327A1 (en) Multi-target crosslinkers and uses thereof
ES2906117T3 (es) Conjugados de androstenodiona quimioluminiscente
ES2733357A1 (es) Compuesto para la deteccion de celulas senescentes y uso del mismo
ES2701233T3 (es) Derivados de folato, particularmente útiles en el marco de la dosificación de folatos(s)
ES2360699T3 (es) Inmunoensayo basado en la inhibición enzimática.
ES2398042T3 (es) Kit y procedimiento para el marcaje de biomoléculas
ES2234299T3 (es) Ensayo para la determinacion de cobalamina.