AU782559B2 - Acridinium ester labels having hydrophilic modifiers - Google Patents

Acridinium ester labels having hydrophilic modifiers Download PDF

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Publication number
AU782559B2
AU782559B2 AU45736/02A AU4573602A AU782559B2 AU 782559 B2 AU782559 B2 AU 782559B2 AU 45736/02 A AU45736/02 A AU 45736/02A AU 4573602 A AU4573602 A AU 4573602A AU 782559 B2 AU782559 B2 AU 782559B2
Authority
AU
Australia
Prior art keywords
conjugate
group
acridinium ester
acridinium
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU45736/02A
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English (en)
Other versions
AU4573602A (en
Inventor
Qingping Jiang
Anand Natrajan
David Sharpe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of AU4573602A publication Critical patent/AU4573602A/en
Application granted granted Critical
Publication of AU782559B2 publication Critical patent/AU782559B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU45736/02A 2001-07-03 2002-05-31 Acridinium ester labels having hydrophilic modifiers Ceased AU782559B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/898381 2001-07-03
US09/898,381 US6664043B2 (en) 2001-07-03 2001-07-03 Acridinium ester labels having hydrophilic modifiers

Publications (2)

Publication Number Publication Date
AU4573602A AU4573602A (en) 2003-01-09
AU782559B2 true AU782559B2 (en) 2005-08-11

Family

ID=25409366

Family Applications (1)

Application Number Title Priority Date Filing Date
AU45736/02A Ceased AU782559B2 (en) 2001-07-03 2002-05-31 Acridinium ester labels having hydrophilic modifiers

Country Status (6)

Country Link
US (1) US6664043B2 (enExample)
EP (1) EP1273917B1 (enExample)
JP (2) JP4467869B2 (enExample)
AU (1) AU782559B2 (enExample)
CA (1) CA2387466A1 (enExample)
ES (1) ES2486815T3 (enExample)

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* Cited by examiner, † Cited by third party
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US6653456B2 (en) * 2001-07-31 2003-11-25 Roche Diagnostics Corporation Site-specific aminoglycoside derivatives and their use in immunodiagnostic assays
EP1539702B1 (en) * 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
EP1971355B1 (en) 2005-12-20 2020-03-11 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8106154B2 (en) * 2007-01-31 2012-01-31 Affymax, Inc. Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
JP4887319B2 (ja) 2008-03-17 2012-02-29 株式会社日立ハイテクノロジーズ 自動分析装置、及び光電子増倍管を用いた分析システム
WO2009136613A1 (ja) 2008-05-08 2009-11-12 株式会社 日立ハイテクノロジーズ 自動分析装置
JP5124498B2 (ja) 2009-01-30 2013-01-23 株式会社日立ハイテクノロジーズ 自動分析装置
CN105153115B (zh) * 2009-11-16 2021-08-03 西门子医疗保健诊断公司 含两性离子的吖啶鎓化合物
CN104411688B (zh) * 2012-07-10 2019-01-08 西门子医疗保健诊断公司 由9,10-二氢吖啶的n-烷基化合成吖啶鎓化合物
CN104936613B (zh) * 2012-11-30 2018-05-22 株式会社糖锁工学研究所 糖链加成连接子、含有糖链加成连接子与生理活性物质的化合物或其盐、以及其制造方法
FR3000551B1 (fr) * 2012-12-27 2015-06-26 Biomerieux Sa Derives de folate, particulierement utiles dans le cadre du dosage de folate(s)
WO2014186406A2 (en) 2013-05-14 2014-11-20 Siemens Healthcare Diagnostics Inc. Degradable cationic surfactants and use thereof in enhancing chemiluminescence
EP3019575B1 (en) 2013-07-08 2018-12-19 Siemens Healthcare Diagnostics Inc. Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission
CN110603059B (zh) * 2017-02-23 2023-06-30 美国西门子医学诊断股份有限公司 化学发光雄烯二酮缀合物
CN112368265A (zh) 2018-06-25 2021-02-12 美国西门子医学诊断股份有限公司 9,10-二氢吖啶的n-烷基化
CN109535062B (zh) * 2019-01-10 2021-03-23 中北大学 一种降冰片烯类两性离子单体及其制备方法
CN110850077A (zh) * 2019-11-06 2020-02-28 迪瑞医疗科技股份有限公司 妥布霉素化学发光检测试剂盒及其制备方法
CN112920399A (zh) * 2019-12-05 2021-06-08 广东菲鹏生物有限公司 吖啶化合物标记类固醇激素衍生物及其制备方法和应用
CN112684163B (zh) * 2021-01-29 2022-08-09 安邦（厦门）生物科技有限公司 一种吖啶类化合物标记原料工作液及制备方法
CN117769588B (zh) 2021-07-29 2025-02-21 欧蒙医学实验诊断股份公司 增强化学发光信号的方法和试剂
JP2025535270A (ja) 2022-10-13 2025-10-24 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 縮合複素環を有するアクリジニウム化合物
CN116284978B (zh) * 2022-12-16 2024-09-20 厦门为正生物科技股份有限公司 一种荧光微球及其制备方法与应用
EP4638467A4 (en) * 2022-12-21 2026-03-04 Siemens Healthcare Diagnostics Inc CYCLOSPORINE-ACRIDINIUM ESTERS AND THEIR PRODUCTION AND USE PROCESSES
EP4749284A1 (de) 2024-11-26 2026-05-27 pes Diagnosesysteme GmbH Bestimmung eines freien thyroid-hormons

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0982298A1 (en) * 1994-04-08 2000-03-01 Ciba Corning Diagnostics Corp. Novel functionalized hydrophilic acridinium esters
US6080591A (en) * 1988-09-26 2000-06-27 Bayer Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection

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ATE40572T1 (de) * 1985-01-10 1989-02-15 Molecular Diagnostics Inc Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben.
JPH0286567A (ja) * 1988-09-21 1990-03-27 Ricoh Co Ltd シート後処理制御装置
CA1339491C (en) * 1988-09-26 1997-10-07 Say-Jong Law Nucleophilic polysubstituted aryl acridinium ester and uses thereof
DE4004296A1 (de) * 1990-02-13 1991-08-14 Hoechst Ag Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6165800A (en) * 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
JP2002530678A (ja) * 1998-11-25 2002-09-17 バイエル コーポレイション 化学発光性アクリジニウム化合物を使用するヒドリドの測定
US6187566B1 (en) * 1999-03-09 2001-02-13 Applied Gene Technologies, Inc. Method of labeling a nucleic acid amplicon with simultaneous contamination prevention
JP3819294B2 (ja) * 1999-07-30 2006-09-06 バイエル コーポレイション 燐酸酵素のような加水分解性酵素の化学発光基質

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6080591A (en) * 1988-09-26 2000-06-27 Bayer Corporation Nucleophilic polysubstituted aryl acridinium ester conjugates and syntheses thereof
EP0982298A1 (en) * 1994-04-08 2000-03-01 Ciba Corning Diagnostics Corp. Novel functionalized hydrophilic acridinium esters
US6242188B1 (en) * 1999-07-30 2001-06-05 Applied Gene Technologies, Inc. Sample processing to release nucleic acids for direct detection

Also Published As

Publication number Publication date
JP4467869B2 (ja) 2010-05-26
EP1273917A3 (en) 2003-09-17
EP1273917A2 (en) 2003-01-08
ES2486815T3 (es) 2014-08-19
AU4573602A (en) 2003-01-09
JP2003050204A (ja) 2003-02-21
EP1273917B1 (en) 2014-05-07
US20030045716A1 (en) 2003-03-06
JP4913195B2 (ja) 2012-04-11
JP2010019854A (ja) 2010-01-28
CA2387466A1 (en) 2003-01-03
US6664043B2 (en) 2003-12-16

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