JP4344960B2 - アリール尿素によるｐ３８キナーゼ活性の阻害 - Google Patents

アリール尿素によるｐ３８キナーゼ活性の阻害 Download PDF

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JP4344960B2
JP4344960B2 JP55061798A JP55061798A JP4344960B2 JP 4344960 B2 JP4344960 B2 JP 4344960B2 JP 55061798 A JP55061798 A JP 55061798A JP 55061798 A JP55061798 A JP 55061798A JP 4344960 B2 JP4344960 B2 JP 4344960B2
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tert
butyl
urea
thienyl
methyl
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JP2001526687A (ja
JP2001526687A5 (enExample
Inventor
レンジス，ジロード
スコット，ウイリアム
ボンバラ，マイケル
ラウナー，デボラ
レッドマン，アニコ
スミス，ロジャー
パウルゼン，ホルガー
チェン，ジンサン
グン，デービッド
レニック，ジョエル
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バイエル、コーポレイション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
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  • Endocrinology (AREA)
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  • Dermatology (AREA)
  • AIDS & HIV (AREA)
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JP55061798A 1997-05-23 1998-05-21 アリール尿素によるｐ３８キナーゼ活性の阻害 Expired - Fee Related JP4344960B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86302297A 1997-05-23 1997-05-23
US08/863,022 1997-05-23
PCT/US1998/010375 WO1998052558A1 (en) 1997-05-23 1998-05-21 INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS

Publications (3)

Publication Number Publication Date
JP2001526687A JP2001526687A (ja) 2001-12-18
JP2001526687A5 JP2001526687A5 (enExample) 2005-12-08
JP4344960B2 true JP4344960B2 (ja) 2009-10-14

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JP55061798A Expired - Fee Related JP4344960B2 (ja) 1997-05-23 1998-05-21 アリール尿素によるｐ３８キナーゼ活性の阻害

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EP (1) EP1019040B1 (enExample)
JP (1) JP4344960B2 (enExample)
AT (1) ATE277612T1 (enExample)
AU (1) AU7585498A (enExample)
CA (1) CA2290520C (enExample)
DE (2) DE1019040T1 (enExample)
ES (1) ES2151467T3 (enExample)
PT (1) PT1019040E (enExample)
WO (1) WO1998052558A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2010065047A (ja) * 1997-05-23 2010-03-25 Bayer Corp Ｒａｆキナーゼ阻害剤

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ATE258055T1 (de) 1998-11-04 2004-02-15 Smithkline Beecham Corp Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8
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JP2002538151A (ja) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
DE60023853T2 (de) 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
EP1466906A1 (en) * 1999-03-12 2004-10-13 Boehringer Ingelheim Pharmaceuticals Inc. Heterocyclic urea and related compounds useful as anti-inflammatory agents
HUP0202248A3 (en) 1999-03-12 2006-06-28 Boehringer Ingelheim Pharma Compounds useful as anti-inflammatory agents
EP1690854A1 (en) * 1999-03-12 2006-08-16 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic urea and related compounds useful as anti-inflammatory agents
KR20010112408A (ko) * 1999-04-07 2001-12-20 모리타 다카카즈 Ｎ-치환되고-Ｎ'-치환된 우레아 유도체 및 ＴＮＦ-α 생성억제제로서의 그의 용도
US6573409B1 (en) 1999-07-02 2003-06-03 The Nutrasweet Company Process for the preparation of 3,3-dimethylbutanal
ES2292461T3 (es) 1999-07-07 2008-03-16 Astrazeneca Uk Limited Derivados de quinazolina.
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MX242553B (es) 2000-10-20 2006-12-06 Eisai Co Ltd Derivados aromaticos que contienen nitrogeno.
AU2002232439A1 (en) 2000-11-29 2002-06-11 Glaxo Group Limited Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
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