JP4272375B2 - ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 - Google Patents

ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 Download PDF

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JP4272375B2
JP4272375B2 JP2001519702A JP2001519702A JP4272375B2 JP 4272375 B2 JP4272375 B2 JP 4272375B2 JP 2001519702 A JP2001519702 A JP 2001519702A JP 2001519702 A JP2001519702 A JP 2001519702A JP 4272375 B2 JP4272375 B2 JP 4272375B2
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heterocycloalkyl
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JP2003513015A5 (enExample
JP2003513015A (ja
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ステファン・エヴァン・ウェッバー
ドナルド・ジェームズ・スカリツキー
ジャヤシュリー・ギリッシュ・ティッケ
ロバート・アーノルド・カンプフ
ジョセフ・ティモシー・マラコヴィッツ
ウォルター・ブライアン・イーストマン
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Cancer Research Technology Ltd
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Cancer Research Technology Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001519702A 1999-08-31 2000-08-31 ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 Expired - Lifetime JP4272375B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15214299P 1999-08-31 1999-08-31
US60/152,142 1999-08-31
PCT/US2000/023882 WO2001016136A2 (en) 1999-08-31 2000-08-31 Tricyclic inhibitors of poly(adp-ribose) polymerases

Publications (3)

Publication Number Publication Date
JP2003513015A JP2003513015A (ja) 2003-04-08
JP2003513015A5 JP2003513015A5 (enExample) 2006-09-21
JP4272375B2 true JP4272375B2 (ja) 2009-06-03

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US (1) US6548494B1 (enExample)
EP (1) EP1208104B1 (enExample)
JP (1) JP4272375B2 (enExample)
KR (1) KR20020038742A (enExample)
CN (1) CN1384835A (enExample)
AP (1) AP1553A (enExample)
AR (1) AR035162A1 (enExample)
AT (1) ATE287406T1 (enExample)
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BG (1) BG106562A (enExample)
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EA (1) EA200200306A1 (enExample)
EC (1) ECSP003637A (enExample)
EE (1) EE200200100A (enExample)
ES (1) ES2234657T3 (enExample)
GE (1) GEP20043268B (enExample)
GT (1) GT200000145A (enExample)
HK (1) HK1045509B (enExample)
HR (1) HRP20020271A2 (enExample)
HU (1) HUP0202703A3 (enExample)
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MA (1) MA25876A1 (enExample)
MX (1) MXPA02002138A (enExample)
MY (1) MY135910A (enExample)
NO (1) NO322475B1 (enExample)
NZ (1) NZ516793A (enExample)
OA (1) OA12016A (enExample)
PA (1) PA8501801A1 (enExample)
PE (1) PE20010538A1 (enExample)
PL (1) PL354242A1 (enExample)
PT (1) PT1208104E (enExample)
SI (1) SI1208104T1 (enExample)
SK (1) SK2592002A3 (enExample)
SV (1) SV2003000162A (enExample)
UA (1) UA73144C2 (enExample)
UY (1) UY26323A1 (enExample)
WO (1) WO2001016136A2 (enExample)
YU (1) YU15102A (enExample)
ZA (1) ZA200200830B (enExample)

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