JP3774814B2 - システイン類の不快な臭気又は味が軽減された組成物 - Google Patents
システイン類の不快な臭気又は味が軽減された組成物 Download PDFInfo
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- JP3774814B2 JP3774814B2 JP2003336369A JP2003336369A JP3774814B2 JP 3774814 B2 JP3774814 B2 JP 3774814B2 JP 2003336369 A JP2003336369 A JP 2003336369A JP 2003336369 A JP2003336369 A JP 2003336369A JP 3774814 B2 JP3774814 B2 JP 3774814B2
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- cysteine
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- 229940031005 ethyl cysteine Drugs 0.000 description 1
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- 239000012362 glacial acetic acid Substances 0.000 description 1
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- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 239000000182 glucono-delta-lactone Substances 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 150000003840 hydrochlorides Chemical class 0.000 description 1
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- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
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- 239000001630 malic acid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 description 1
- 239000002524 monosodium citrate Substances 0.000 description 1
- 235000018342 monosodium citrate Nutrition 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 235000021062 nutrient metabolism Nutrition 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
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- 238000005096 rolling process Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000001394 sodium malate Substances 0.000 description 1
- 239000011755 sodium-L-ascorbate Substances 0.000 description 1
- 235000019187 sodium-L-ascorbate Nutrition 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
(1)システイン類含有組成物
本発明の組成物は、システイン類及び水膨潤性物質を含有することを特徴とする。なお、本明細書において、システイン類特有の不快な臭気又は味の軽減を、単にマスキングと称することがある。
なお、これらのシステイン類は予めコーティング剤でコーティングされていても良い。コーティング剤としては経口的に用いられる組成物(例えば、経口投与用組成物、口腔内用組成物、食品組成物など)において使用されるコーティング剤を広く用いることができる。
(1)サンプル瓶(直径35mm×高さ78mm)に対象とする物質(水膨潤性物質)の粉末8gを添加し、開口部をパラフィルムで覆う。この瓶を卓上振動機(VORTEX GENIE-2 MOEL G-560(SCIENTIFIC INDUSTRIES INC製))にて目盛り8で30秒間振動させる。
(2)この時点で、サンプル瓶の底面から中に封入された物質(粉末)の上面までの距離(これを「膨潤前の高さ」とする)を測定する。
(3)次に別のサンプル瓶に3mlの水を入れ、上記と同じ粉末8gを添加し、開口部をパラフィルムで覆い、(1)と同様に振動させる。サンプル瓶を24時間放置する。
(4)放置後、サンプル瓶の底面から中に封入された物質(粉末)の上面までの距離(これを「膨潤後の高さ」とする)を測定し、次の式に基づいて膨潤率を算出する。
本発明のシステイン類の不快な臭気又は味を軽減する方法は、システイン類に水膨潤性物質を組み合わせて用いることによって実施することができる。システイン類に水膨潤性物質を組み合わせることによってシステイン類特有の不快な臭気又は味、特にシステイン類特有の不快な臭気を軽減することができる。
<参考例> 水膨潤性物質の膨潤率の測定
(1)サンプル瓶(直径35mm×高さ78mm)に対象とする物質(水膨潤性物質)の粉末8gを添加し、開口部をパラフィルムで覆う。この瓶を卓上振動機(VORTEX GENIE-2 MOEL G-560(SCIENTIFIC INDUSTRIES INC製))にて目盛り8で30秒間振動させた。
(2)この時点で、サンプル瓶の底面から中に封入された物質(粉末)の上面までの距離(これを「膨潤前の高さ」とする)を測定した。
(3)次に別のサンプル瓶に3mlの水を入れ、上記と同じ粉末8gを添加し、開口部をパラフィルムで覆い、(1)と同様に振動させる。サンプル瓶を24時間放置した。
(4)放置後、サンプル瓶の底面から中に封入された物質(粉末)の上面までの距離(これを「膨潤後の高さ」とする)を測定し、次の式に基づいて膨潤率を算出した。結果を表1に示す。
実施例1:ヒドロキシプロピルセルロースのマスキング作用
膨潤性の最も低かったヒドロキシプロピルセルロース(以下、HPCと称することがある)を表2に示す量でL−システインと混合し、水適量を加えて乳鉢にて混練し、混練物を針径560μm、目開き1000μmのメッシュを通過させて造粒物を製造した。なお、表2中「HPC添加割合」とは、L−システインの配合量(1重量部)に対するHPCの配合割合を重量比で示した値である。この造粒物を被験者(10人)の舌の上におき、直後の臭味及び味について5段階評価で評価した。なお、被験者に使用した造粒物の量はL−システインが一人当たり50mgとなる量である。その結果を表3に示す。
膨潤率の比較的高かった低置換度ヒドロキシプロピルセルロース(以下、LHPCと称することがある)7.5gをL−システイン5gと混合し(システイン1重量部に対するHPC添加割合(重量比);1.5)、実施例1と同様にして造粒物を製造し、評価した。その結果を表4に示す。
Claims (10)
- システイン類、水膨潤性物質として少なくともクロスポリビニルピロリドン及び甘味剤として少なくともアスパルテームを含有し、該水膨潤性物質の配合量が組成物全量に対して0.005〜20重量%であり、湿式造粒されたことを特徴とする、システイン類の不快な臭気又は味が軽減された組成物。
- さらに、ヒドロキシプロピルセルロース、低置換度ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、結晶セルロース、カルメロース及びその塩、クロスカルメロースナトリウム、コポリビドン、ポリビニルピロリドン並びにメチルセルロースからなる群から選択される少なくとも1種の水膨潤性物質を含有する請求項1に記載の組成物。
- 水膨潤性物質の配合量が、重量比でシステイン類の配合量の0.5倍以上である請求項1又は2に記載の組成物。
- 水膨潤性物質の配合量が、重量比でシステイン類の配合量の1倍以上である請求項1〜3のいずれかに記載の組成物。
- 水膨潤性物質の配合量が、重量比でシステイン類の配合量の1.5倍以上である請求項1〜4のいずれかに記載の組成物。
- さらに、酸味剤を含有する請求項1〜5のいずれかに記載の組成物。
- 酸味剤がアスコルビン酸、その誘導体及びそれらの塩からなる群から選択される少なくとも1種である請求項6に記載の組成物。
- さらに、サッカリン、サッカリンナトリウム、エリスリトール、キシリトール、マンニトール、ソルビトール、マルチトール、トレハロース及びステビアからなる群から選択される少なくとも1種の甘味剤を含有する請求項1〜7のいずれかに記載の組成物。
- 固体であることを特徴とする請求項1〜8のいずれかに記載の組成物。
- 顆粒剤、細粒剤又は散剤の形態を有することを特徴とする請求項9に記載の組成物。
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JP2003336369A JP3774814B2 (ja) | 2003-09-26 | 2003-09-26 | システイン類の不快な臭気又は味が軽減された組成物 |
PCT/JP2004/012364 WO2005029980A1 (ja) | 2003-09-26 | 2004-08-27 | システイン類の不快な臭気又は味が軽減された組成物 |
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JP2003336369A JP3774814B2 (ja) | 2003-09-26 | 2003-09-26 | システイン類の不快な臭気又は味が軽減された組成物 |
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JP2007031285A (ja) * | 2005-07-22 | 2007-02-08 | Aska Pharmaceutical Co Ltd | 苦味が軽減したエピナスチン含有安定化製剤 |
JP2008127350A (ja) * | 2006-11-22 | 2008-06-05 | Ss Pharmaceut Co Ltd | 臭いを防止した固形組成物 |
JP5676834B2 (ja) * | 2006-11-29 | 2015-02-25 | エスエス製薬株式会社 | 消化管への刺激性を減少した経口固形組成物 |
JP5605805B2 (ja) * | 2008-12-25 | 2014-10-15 | 共和薬品工業株式会社 | ドネペジル経口製剤 |
JP4565219B2 (ja) * | 2008-12-26 | 2010-10-20 | アサヒビール株式会社 | ポリフェノール含有顆粒またはポリフェノール含有チュアブル錠剤およびその製造方法 |
JP2012207038A (ja) * | 2012-07-20 | 2012-10-25 | Ssp Co Ltd | 消化管への刺激性を減少した経口固形組成物 |
JP2014055187A (ja) * | 2013-12-25 | 2014-03-27 | Ss Pharmaceut Co Ltd | 消化管への刺激性を減少した経口固形組成物 |
JP2015199720A (ja) * | 2014-03-31 | 2015-11-12 | 富山化学工業株式会社 | セフテラムピボキシルを含む粒状固形製剤 |
JP6799795B2 (ja) * | 2015-08-21 | 2020-12-16 | 大正製薬株式会社 | 経口組成物 |
US20220183338A1 (en) * | 2019-02-20 | 2022-06-16 | Suntory Holdings Limited | Protein-containing oral composition and method for improving flavor of protein-containing oral composition |
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JP3776941B2 (ja) * | 1993-12-24 | 2006-05-24 | 塩野義製薬株式会社 | 味覚の改善された顆粒剤及びその製造方法 |
JP4681713B2 (ja) * | 2000-06-29 | 2011-05-11 | 大洋薬品工業株式会社 | フィルムコーティング組成物およびそれを用いた防臭性固形製剤 |
JP2002179559A (ja) * | 2000-10-06 | 2002-06-26 | Takeda Chem Ind Ltd | 薄層糖衣錠およびその製造方法 |
JP2003155232A (ja) * | 2001-09-07 | 2003-05-27 | Takeda Chem Ind Ltd | 不快な臭いが低減されたl−システイン配合固形製剤およびその製造方法 |
JP2003235512A (ja) * | 2002-02-22 | 2003-08-26 | Ajinomoto Co Inc | 呈味性が改善されたアミノ酸含有組成物 |
JP4501023B2 (ja) * | 2002-11-14 | 2010-07-14 | 小林製薬株式会社 | システイン類の苦味及び臭気が軽減された組成物 |
JP4501024B2 (ja) * | 2002-11-14 | 2010-07-14 | 小林製薬株式会社 | システイン類の苦味及び臭気が軽減された組成物 |
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