JP3502694B2 - グルカゴン様インスリン分泌刺激複合体、組成物および方法 - Google Patents

グルカゴン様インスリン分泌刺激複合体、組成物および方法

Info

Publication number
JP3502694B2
JP3502694B2 JP12791095A JP12791095A JP3502694B2 JP 3502694 B2 JP3502694 B2 JP 3502694B2 JP 12791095 A JP12791095 A JP 12791095A JP 12791095 A JP12791095 A JP 12791095A JP 3502694 B2 JP3502694 B2 JP 3502694B2
Authority
JP
Japan
Prior art keywords
glp
molecule
glucagon
insulin
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP12791095A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08269097A (ja
Inventor
ジョン・アリソン・ギャロウェイ
ジェイムズ・アーサー・ホフマン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH08269097A publication Critical patent/JPH08269097A/ja
Application granted granted Critical
Publication of JP3502694B2 publication Critical patent/JP3502694B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP12791095A 1995-03-21 1995-05-26 グルカゴン様インスリン分泌刺激複合体、組成物および方法 Expired - Fee Related JP3502694B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US407831 1995-03-21
US08/407,831 US5705483A (en) 1993-12-09 1995-03-21 Glucagon-like insulinotropic peptides, compositions and methods

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2002204749A Division JP2003048899A (ja) 1995-03-21 2002-07-12 グルカゴン様インスリン分泌刺激複合体、組成物および方法
JP2003312979A Division JP2004002480A (ja) 1995-03-21 2003-09-04 グルカゴン様インスリン分泌刺激複合体、組成物および方法

Publications (2)

Publication Number Publication Date
JPH08269097A JPH08269097A (ja) 1996-10-15
JP3502694B2 true JP3502694B2 (ja) 2004-03-02

Family

ID=23613700

Family Applications (3)

Application Number Title Priority Date Filing Date
JP12791095A Expired - Fee Related JP3502694B2 (ja) 1995-03-21 1995-05-26 グルカゴン様インスリン分泌刺激複合体、組成物および方法
JP2002204749A Pending JP2003048899A (ja) 1995-03-21 2002-07-12 グルカゴン様インスリン分泌刺激複合体、組成物および方法
JP2003312979A Pending JP2004002480A (ja) 1995-03-21 2003-09-04 グルカゴン様インスリン分泌刺激複合体、組成物および方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2002204749A Pending JP2003048899A (ja) 1995-03-21 2002-07-12 グルカゴン様インスリン分泌刺激複合体、組成物および方法
JP2003312979A Pending JP2004002480A (ja) 1995-03-21 2003-09-04 グルカゴン様インスリン分泌刺激複合体、組成物および方法

Country Status (28)

Country Link
US (7) US5705483A (https=)
EP (2) EP1364967B1 (https=)
JP (3) JP3502694B2 (https=)
KR (1) KR100388583B1 (https=)
CN (1) CN1185257C (https=)
AT (2) ATE312119T1 (https=)
AU (1) AU708159B2 (https=)
BR (1) BR9503036A (https=)
CA (1) CA2150080A1 (https=)
CO (1) CO4650140A1 (https=)
CZ (1) CZ292972B6 (https=)
DE (2) DE69534678T2 (https=)
DK (2) DK0733644T3 (https=)
ES (2) ES2218536T3 (https=)
FI (1) FI952536L (https=)
HU (1) HUT74729A (https=)
IL (2) IL113809A (https=)
MY (1) MY134820A (https=)
NO (1) NO322837B1 (https=)
NZ (1) NZ272186A (https=)
PE (1) PE23296A1 (https=)
PL (1) PL182113B1 (https=)
PT (1) PT733644E (https=)
RU (1) RU2147588C1 (https=)
SI (1) SI1364967T1 (https=)
TW (1) TW389769B (https=)
UA (1) UA44696C2 (https=)
ZA (1) ZA954141B (https=)

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WO1995005848A1 (en) * 1993-08-24 1995-03-02 Novo Nordisk A/S Protracted glp-1
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FI952536A7 (fi) 1996-09-22
FI952536A0 (fi) 1995-05-24
CA2150080A1 (en) 1996-09-22
US6388053B1 (en) 2002-05-14
PL182113B1 (pl) 2001-11-30
ES2250789T3 (es) 2006-04-16
US5705483A (en) 1998-01-06
US6410513B1 (en) 2002-06-25
US6703365B2 (en) 2004-03-09
CN1185257C (zh) 2005-01-19
FI952536L (fi) 1996-09-22
US7232879B2 (en) 2007-06-19
PT733644E (pt) 2004-07-30
PE23296A1 (es) 1996-06-15
US5977071A (en) 1999-11-02
CZ292972B6 (cs) 2004-01-14
IL113809A (en) 2000-07-26
IL134853A0 (en) 2001-05-20
CZ132195A3 (en) 1996-10-16
RU2147588C1 (ru) 2000-04-20
DE69534678D1 (de) 2006-01-12
RU95108231A (ru) 1997-03-20
DE69532914T2 (de) 2005-03-31
EP0733644A1 (en) 1996-09-25
TW389769B (en) 2000-05-11
ES2218536T3 (es) 2004-11-16
US6133235A (en) 2000-10-17
JPH08269097A (ja) 1996-10-15
EP0733644B1 (en) 2004-04-21
EP1364967B1 (en) 2005-12-07
ATE264869T1 (de) 2004-05-15
CN1131674A (zh) 1996-09-25
NO952034D0 (no) 1995-05-23
HU9501508D0 (en) 1995-07-28
AU708159B2 (en) 1999-07-29
IL113809A0 (en) 1995-08-31
HUT74729A (en) 1997-02-28
DK1364967T3 (da) 2006-03-27
UA44696C2 (uk) 2002-03-15
BR9503036A (pt) 1997-09-23
NO952034L (no) 1996-09-23
JP2003048899A (ja) 2003-02-21
KR100388583B1 (ko) 2003-09-13
MY134820A (en) 2007-12-31
ATE312119T1 (de) 2005-12-15
EP1364967A3 (en) 2004-01-28
PL308783A1 (en) 1996-09-30
AU2026895A (en) 1996-10-03
US20020165342A1 (en) 2002-11-07
KR960034219A (ko) 1996-10-22
DE69532914D1 (de) 2004-05-27
DK0733644T3 (da) 2004-08-16
DE69534678T2 (de) 2006-09-07
NO322837B1 (no) 2006-12-11
US20040127399A1 (en) 2004-07-01
NZ272186A (en) 1997-01-29
JP2004002480A (ja) 2004-01-08
EP1364967A2 (en) 2003-11-26
SI1364967T1 (sl) 2006-04-30
CO4650140A1 (es) 1998-09-03
ZA954141B (en) 1996-11-22

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