JP3327470B2 - バルーンカテーテルの遊離可能な被覆剤 - Google Patents
バルーンカテーテルの遊離可能な被覆剤Info
- Publication number
- JP3327470B2 JP3327470B2 JP50432892A JP50432892A JP3327470B2 JP 3327470 B2 JP3327470 B2 JP 3327470B2 JP 50432892 A JP50432892 A JP 50432892A JP 50432892 A JP50432892 A JP 50432892A JP 3327470 B2 JP3327470 B2 JP 3327470B2
- Authority
- JP
- Japan
- Prior art keywords
- balloon
- catheter
- microcapsules
- drug
- inflation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000011248 coating agent Substances 0.000 title claims description 9
- 238000000576 coating method Methods 0.000 title claims description 7
- 239000003094 microcapsule Substances 0.000 claims description 73
- 239000003814 drug Substances 0.000 claims description 57
- 229940079593 drug Drugs 0.000 claims description 56
- 238000000034 method Methods 0.000 claims description 14
- 239000002904 solvent Substances 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 5
- 230000001070 adhesive effect Effects 0.000 claims description 5
- 229940127218 antiplatelet drug Drugs 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims description 5
- 208000037803 restenosis Diseases 0.000 claims description 4
- 230000000340 anti-metabolite Effects 0.000 claims description 3
- 239000003146 anticoagulant agent Substances 0.000 claims description 3
- 229940127219 anticoagulant drug Drugs 0.000 claims description 3
- 239000002256 antimetabolite Substances 0.000 claims description 3
- 229940100197 antimetabolite Drugs 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims 3
- 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 210000000663 muscle cell Anatomy 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 description 15
- 229920000642 polymer Polymers 0.000 description 7
- 239000012790 adhesive layer Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 239000013078 crystal Substances 0.000 description 5
- 238000002399 angioplasty Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 208000031481 Pathologic Constriction Diseases 0.000 description 3
- 208000037804 stenosis Diseases 0.000 description 3
- 230000036262 stenosis Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000002775 capsule Substances 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000002594 fluoroscopy Methods 0.000 description 2
- 238000013147 laser angioplasty Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010038563 Reocclusion Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1081—Balloon catheters with special features or adapted for special applications having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
Description
にバルーン壁に付着した血小板作用化合物を有するバル
ーン血管形成カテーテルに関する。
せるためにカテーテルに膨張バルーンを取付けて用いる
技術が知られている。血小板は堅さが大きく変わり、軟
性の脂質組織から固い石灰質まで変化する。このような
場合、単純にバルーンを膨らませて強制的に血小板及び
血管壁を充分に引き伸ばして管腔を拡大することが、血
小板や他の狭窄物に対する処理としては望ましい。レー
ザー血管形成法は、狭窄箇所の血小板を蒸発させるため
にレーザーを使用する。
の研究がなされているが、そのような薬剤を必要とされ
た場所へ直接供給することは難しい。また、薬剤が全身
に供給され、治療を必要としない部分にも行き渡ってし
まうことになる傾向がある。そして治療の必要な場所に
十分に薬剤が行き渡るようにするために、1回の服用量
が大きくなりやすい。
溶液中の磁鉄鉱分子をある薬剤に結合し、直径1.5μm
のマイクロカプセルを形成した。マイクロカプセルは、
外部磁場の使用によって限定されるが、得られる局所的
効果は静脈内に与えられた薬剤の100倍に相当する〔J.
ウィダー(Widder)氏等によるアドバンスト ファーマ
ソーティカル ケモセラピー誌(Adv.Pharm.Chemothe
r.)、1979年第16巻第213ページ参照〕。
て供給する技術がウォーリンスキー(Wolinsky)氏等に
よるヨーロッパ特許公開0383429(出願人〔シー.アー
ル.バード インコーポレイテッド(C.R.Bard In
c.)〕に開示されている。薬剤は、バルーンの孔を通し
て吹きかけられる。ウォーリンスキー(Wolinsky)氏等
によるJACC第15巻第2号(1990年2月)第475−481ペー
ジをも参照されたい。
を配する技術について1990年2月28日に『内腔薬剤溶出
補綴』と題する特許出願を提出した(出願番号:07/486,
580号)。この手順は潜在的に非常に有用ながら、ステ
ントをある位置に放置することになる。対照的に、バル
ーン血管形成法は分単位の時間で行なえ、血管内には全
く器具類を残さない。
し、カテーテルの内部の管腔から2つの膨らんだバルー
ン間に形成されるスペースへ薬剤を導入するものがあ
る。この処置は、カテーテル内の管腔を通して薬剤を導
入することを要求し、薬剤量が明らかに非常に大きくな
るということを意味している。また血小板にひどく亀裂
が生じるならば2つのバルーンの間に完全な密封が存在
せず、薬剤が血管を通して体の他の部分に漏れる。
たは他の情報は、特に言及しないかぎり、この発明に関
して『先行技術』を構成しない。また以上の開示は、米
国特許法施行規則第1.56(a)に規定する調査に該当す
るものではない。
必要とされる箇所に供給する手段を提供するものであ
る。本発明はバルーンの外面に薬剤を付着させることに
よって既存のバルーンカテーテルを修正使用可能とす
る。薬剤は、マイクロカプセル型ポリマー被覆結晶の、
バルーン壁に恒久的もしくは一時的に接着した薬剤もし
くは受容器担持薬剤の形でバルーンに適用される。以上
及び以下において『薬剤』とは、管腔内の細胞に影響を
及ぼす薬剤またはいかなる薬剤の結合、そして診断試薬
をも含む。
壁面を被覆するためのポリマーから形成する容器内に入
れる。ポリマーは、溶媒、接着剤、溶接などによってバ
ルーンに付着させる。バルーンが、折り目、波形部分、
突起等を有する場合に、バルーンがしぼむときにバルー
ンを被覆しているポリマーの折り目や他の巻き込み部分
に薬剤が捉えられる。従ってマイクロカプセルは、接着
剤を使用せずにバルーンの外面に機械的に捕捉されるこ
とになる。そしてカテーテルは、従来の技術を使用して
適切な位置へ導入される。バルーンが膨らむと、ポリマ
ー被覆薬剤は血小板か血管壁と接触し、特に血小板の亀
裂を満たす。そして正確にそれが必要とされる箇所に高
濃縮形態で薬剤が供給される。実際の1回の服用量は非
常に小さくなり、影響を受けるべき領域だけに供給され
るようになる。
カテーテルまたは被覆していないカテーテルを用いる
か、そして1回の服用の所望薬剤量を医師が決定できる
ようになる。いかなるバルーンカテーテルでも、使用前
にバルーンの壁面に薬剤担持体の被覆剤を施すことによ
って使用できるようになる。管腔を拡大させるより遥か
に小さい圧力で、マイクロカプセルを破裂させることが
できるので、バルーンは、既存の血管形成バルーンより
単純な構造となる。
る。
ある。
る。
ある。
面図である。
部分拡大断面図である。
る。
有用なものであればいかなるタイプものでもよい。治療
によって本発明はそれ以後の治療を助ける診断技術をも
考えさせる。従って以上及び以下において『薬剤』には
血管をX線蛍光透視法等の方法によって可視化できるよ
うにする放射線不透過性化合物のような診断薬剤をも含
む。マイクロカプセル内の染料は、X線蛍光透視法によ
る遊離後の血小板が目に見えるようにする。またバルー
ン自身が、ある程度閉塞を示すかもしれない。頑固な閉
塞に隣接するマイクロカプセルだけが裂け、ふさがれた
管腔の逆の外見を与えるからである。
に続く分芽増殖がチェックされなければならない。血小
板の凝集と付着は血小板凝集抑制剤と血液凝固阻止剤に
よって制御できる。成長要因と受容器ブロッカーと代謝
拮抗薬が通常の細胞修復反応を制限するために使用され
る。薬剤は、液体、半流動体または結晶体から成る形態
のものとする。結晶体であれば被覆剤の有無にかかわら
ず結晶はマイクロカプセルとして作用し、そしてバルー
ン壁に振りかけられるか緩く付着する。
のいずれかに従って作るようにすればよい。米国特許第
4,897,268号、同第4,675,189号、同第4,542,025号、同
第4,530,840号、同第4,389,330号、同第4,622,244号、
同第4,464,317号及び同第4,943,449号の開示内容は本明
細書の内容として引用するが、この発明のために適当な
マイクロカプセルを形成する方法を述べている。極小カ
プセル化が、重合物の科学及び技術事典第2版(Encycl
opedia of Poly.Sci.&Eng.2ndEd.1985)第9巻第724
−745ページに、カート=ティーズ(Curt Thies)氏に
よって説明されており、またカール−オスマー(Kirl−
Othmer)第3版第15巻第470−493ページにもR.E.スパー
クス(Sparks)氏による極小カプセル化が説明されてい
る。
ための破裂、分解可能であり、管腔壁に残ったときに開
く。カプセルは、拡散を通して、または可聴範囲外の力
の印加によって破裂することにより内容物を放出する。
現在のマイクロカプセルの多くが、ある圧力の下で普通
紙複写紙のように容易に裂けることが要求される。一般
的にはマイクロカプセルの直径は2ないし100ミクロン
である。マイクロカプセル内の製剤は一般的には溶液の
形態で存在するか、さもなければマイクロカプセルのポ
リマー全体に分散させてある。結晶をマイクロカプセル
に入れることは可能であるが、薬剤結晶を採用すること
もできる。そのようなケースでマイクロカプセルは、バ
ルーンが膨らんだとき管腔壁に容易に埋め込まれ固定さ
れるように鋭い角を有する。
を拡大させるため、脆いマイクロカプセルがその内容物
を放出する。この様に、マイクロカプセルの破裂は、バ
ルーンの膨張でのみ生じ、時間や圧力に依存するもので
はない。バルーンが膨らんで管腔壁が展びるにつれて、
マイクロカプセルに含まれた結晶が壁から離れて壊れや
すくなる。代表的膨張カテーテルバルーンは、円周方向
で500%膨張し、マイクロカプセルへの取り付け点を圧
迫する。
クロスフェアを含む。マイクロカプセルからの放出メカ
ニズムは、例えばロバート=レインジャー(Robert La
nger)氏が『ドラッグデリバリーの新方法(Drug Deli
very New Methods)』と題してサイエンス(Scienc
e)誌(第249巻第1527−1533ページ、1990年9月28日
刊)に発表したような公知の放出メカニズムのいずれか
である。
いるいかなる膨張カテーテルをも含むが、カテーテルが
膨張カテーテルである必要はない。血管形成法で使用可
能かどうかにかかわらず、いかなるバルーンカテーテル
も採用することができる。より低い圧力で薬剤を放出す
ることが必要とされる場合には、バルーンをポリエチレ
ンよりむしろ単純なエラストマーで形成する。マイクロ
カプセルはそのオリジナルの製造工程において付加でき
る。また予め形成したカテーテルにスプレーコーティン
グや浸漬処理によって付加することもできる。それによ
って医師は、管腔に影響を及ぼすべき薬剤を含むいろい
ろなマイクロカプセルを加えることによってカテーテル
をあつらえて作ることができる。
テーテル10の一部分を示す。バルーン12は、1つまたは
複数の孔を設けてあるカテーテルチューブ14の遠位端に
被せて取付けてある。カテーテル10は、ガイド手段、挿
入手段またはレーザー血管形成法手段を含む。バルーン
は、その外表面にマイクロカプセル16のカバーを含む。
の詳細を示す。バルーン12が閉塞箇所に位置するまで、
カテーテル10は心臓血管系に挿入される。閉塞箇所の状
態例を、図2に示す。同図には治療を必要としている血
管20の横断面が示されている。血管内部22は、大きな脈
管内膜の垂れ縁26を含む血小板24によって塞がれてい
る。バルーン12は圧力流体の付加によって膨らみ、比較
的に滑らかな外表面、即ち作動面を示し、血小板に放射
状に外へ向かう力を及ぼす。これは血小板による閉塞の
程度を減少させる血管拡大を引き起こす。
の可能性をなくしたり、治療場所における血管の再閉塞
の可能性をなくすものではない。本発明のバルーンカテ
ーテル10は、薬剤その他を血管壁の必要な場所に直接供
与する。活性の薬剤を担持するマイクロカプセル16が、
バルーンの膨張によって血管壁の血小板や他の組織に対
して直接供給される。マイクロカプセルは、物理的接
触、超音波、侵食その他によりその内容物を放出拡散さ
せる。脈管内膜の垂れ縁が存在するところでは、本発明
は通常は到達し難くまた処理しにくい亀裂内に多くのマ
イクロカプセルを供給することを可能とする。
バルーンの上にマイクロカプセルを振りかけることによ
っても形成できる。即ち、バルーンがしぼむときにマイ
クロカプセルがバルーン壁の細孔内に付着するからであ
る。
テーテルが使用される。
イクロカプセルと薬剤が管腔内、特にすべての亀裂箇所
に拡散する。
はしぼんでおり、マイクロカプセル16の粘着層18内に捕
えられている。しかしながら粘着層18は、バルーン壁に
溶媒を振り掛け、そこにマイクロカプセル16を付着させ
るだけのものでもよい。カプセル16の1つが、液体、半
流動体または結晶体からなる薬剤30を封入した内部を示
すために、破断して示されている。図示のように、マイ
クロカプセルは、しぼんだバルーン12の胴部に付着して
いる。
面を、膨張によってバルーンとマイクロカプセル16外面
の粘着層18が引き伸ばされている状態で示す。従ってマ
イクロカプセルは、血管壁の細胞に内容物を放出するた
めに、血管に対する都合のよい接触位置をとる。脆いマ
イクロカプセルは、接着層の膨張によって破裂するので
あって、血管壁へのバルーンの圧力によって破れるので
はない。接着層が展びるに連れて、脆いマイクロカプセ
ルを破裂させる力が掛かる。図6はマイクロカプセル16
の破裂を表現する。内部の薬剤は、血管内の細胞に対し
て直接放出される。
れる薬剤の量は、全く小さい。マイクロカプセルは、治
療場所の細胞に作用する薬剤の量を容易に担持すること
ができる。体の他の場所に対して望ましくない薬剤の効
果を及ぼすのを防止する手段と同様に、本発明も同程度
まで1回の服用量を小さくすることができる。
ルは、図4の例と比較すると薄い粘着層18によってバル
ーン12に付着している。この形態のマイクロカプセル
は、所望の場所において単に押されるだけで簡単につぶ
れる。図7のマイクロカプセルは、図9で示すように血
管壁の組織に埋め込むこんでから所定時間後に内容物を
放出することができる。これはマイクロカプセルを血管
壁に接触させて破裂させる例と対照的なものである。
目32、波形部位や突起内に機械的に保持される例を示し
ている。そのような構造はしぼんだバルーンによく現わ
れるものであり、接着剤や溶接などによってマイクロカ
プセルを付着させる必要がない。バルーン12が膨らむに
つれて、折り目32がなくなり、治療場所にマイクロカプ
セルを排出する。
す。そのような場合は、図10で示すように形成される折
り目内にマイクロカプセル16を入れることが可能であ
る。バルーンへのいっそう多量に流体を入れることによ
って、襞からマイクロカプセル16を放出させることにな
る。マイクロカプセルがない設計では二面的反応がでる
が、バルーンは管腔壁に対して『固定される』ために部
分的に膨らみ、そして最後に高い圧力によって管腔いっ
ぱいに膨らむ。
形態で具表現され得る。本開示は本発明の原則的な例で
あって、個々の実施例に本発明を制限するものではな
い。
例を案出することができようが、これらは本発明の請求
の範囲内に属するものである。
Claims (15)
- 【請求項1】カテーテル本体と、該カテーテル本体の長
手方向に沿って配したバルーンからなり、該バルーンを
膨ませたり、しぼませたりできるカテーテルにおいて、 (a)上記バルーンの外面上に複数のマイクロカプセル
があり、 (b)上記マイクロカプセルが各々人体管腔内の治療ま
たは診断のための薬剤または薬剤化合物を担持し、 (c)上記カテーテルが所望の位置に配され、かつ膨ら
んだ際に上記マイクロカプセルから薬剤が放出される ようにしたことを特徴とするカテーテル。 - 【請求項2】上記薬剤は、再狭窄制限剤、血小板凝集抑
制剤、抗平滑筋細胞分芽増殖薬及び診断用染料からなる
グループから選択される請求項1のカテーテル。 - 【請求項3】上記薬剤は、血小板凝集抑制剤、血液凝固
阻止剤、抗炎症剤、代謝拮抗剤及びこれらの化合物から
なるグループから選択される請求項1のカテーテル。 - 【請求項4】カテーテル本体と、該カテーテル本体の長
手方向に沿って配する膨張バルーンからなる膨張カテー
テルにおいて、 (a)上記バルーンの外面の上に複数マイクロカプセル
があり、 (b)上記マイクロカプセルが各々人体管腔内に作用す
る薬剤を担持し、 (c)上記カテーテルが所望の位置に配されかつ膨らん
だ際に上記マイクロカプセルから内容物が放出される ようにしたことを特徴とする膨張カテーテル。 - 【請求項5】上記薬剤は、再狭窄制限剤、血小板凝集抑
制剤、抗平滑筋細胞分芽増殖薬及び診断用染料からなる
グループから選択される請求項4の膨張カテーテル。 - 【請求項6】上記薬剤は、血小板凝集抑制剤、血液凝固
阻止剤、抗炎症剤、代謝拮抗剤及びこれらの化合物から
なるグループから選択される請求項4の膨張カテーテ
ル。 - 【請求項7】上記マイクロカプセルが接着剤によって上
記バルーン表面に付着する請求項4の膨張カテーテル。 - 【請求項8】上記マイクロカプセルが溶媒によって上記
バルーン表面 - 【請求項9】上記バルーンがしぼむ際に、上記マイクロ
カプセルが上記バルーンに形成される折り目内に保持さ
れる請求項4の膨張カテーテル。 - 【請求項10】以下の要件からなるバルーンカテーテル
の製造方法: (a)バルーンを有するカテーテルを得、そして (b)上記外面に薬剤を含んでいる複数のマイクロカプ
セルを供給する。 - 【請求項11】上記バルーンへ上記マイクロカプセルを
供給するステップが、上記バルーンにマイクロカプセル
を付着させるものである請求項10の方法。 - 【請求項12】上記バルーンへ上記マイクロカプセルを
溶媒によって付着させるものである請求項11の方法。 - 【請求項13】上記マイクロカプセルを上記バルーンに
供給するステップが、上記バルーンを膨らませて、そし
て上記バルーン上へ薬剤を含んでいるマイクロカプセル
を振りかけるものであり、そして、上記バルーンをしぼ
ませて該バルーンの壁に形成される折り目内に上記マイ
クロカプセルを保持させるものである請求項11の方法。 - 【請求項14】カテーテル本体とカテーテル本体の長手
方向に沿って配する膨張バルーンからなる膨張カテーテ
ルにおいて、 (a)放出可能に薬剤を担持している上記バルーン外面
被覆剤を有し、 (b)上記薬剤が管腔内で作用するものであり、 (c)上記カテーテルが所定の位置に配されて膨らんだ
際に上記被覆剤を放出するものであり、 (d)上記被覆剤がマイクロカプセルである (e)上記マイクロカプセルを溶媒によって上記バルー
ンの表面に付着させる ことを特徴とする膨張カテーテル。 - 【請求項15】15.カテーテル本体とカテーテル本体の
長手方向に沿って配する膨張バルーンからなる膨張カテ
ーテルにおいて、 (a)放出可能に薬剤を担持している上記バルーン外面
被覆剤を有し、 (b)上記薬剤が管腔内で作用するものであり、 (c)上記カテーテルが所定の位置に配されて膨らんだ
際に上記被覆剤を放出するものであり、 (d)上記被覆剤がマイクロカプセルである (e)上記マイクロカプセルを、接着剤によって上記バ
ルーン表面に付着させる ことを特徴とする膨張カテーテル。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US637,436 | 1991-01-04 | ||
US07/637,436 US5102402A (en) | 1991-01-04 | 1991-01-04 | Releasable coatings on balloon catheters |
PCT/US1991/009411 WO1992011890A1 (en) | 1991-01-04 | 1991-12-11 | Releasable coatings on balloon catheters |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05505132A JPH05505132A (ja) | 1993-08-05 |
JP3327470B2 true JP3327470B2 (ja) | 2002-09-24 |
Family
ID=24555922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50432892A Expired - Fee Related JP3327470B2 (ja) | 1991-01-04 | 1991-12-11 | バルーンカテーテルの遊離可能な被覆剤 |
Country Status (7)
Country | Link |
---|---|
US (1) | US5102402A (ja) |
EP (1) | EP0519063B1 (ja) |
JP (1) | JP3327470B2 (ja) |
CA (1) | CA2077539C (ja) |
DE (1) | DE69119753T2 (ja) |
IE (1) | IE78821B1 (ja) |
WO (1) | WO1992011890A1 (ja) |
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- 1991-12-11 CA CA002077539A patent/CA2077539C/en not_active Expired - Fee Related
- 1991-12-11 DE DE69119753T patent/DE69119753T2/de not_active Expired - Fee Related
- 1991-12-11 JP JP50432892A patent/JP3327470B2/ja not_active Expired - Fee Related
- 1991-12-11 EP EP92904500A patent/EP0519063B1/en not_active Expired - Lifetime
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1992
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JP4896871B2 (ja) * | 2004-04-07 | 2012-03-14 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | カテーテルアセンブリのバルーンを改変する方法 |
JP2012166038A (ja) * | 2006-02-09 | 2012-09-06 | B Braun Melsungen Ag | 折り畳まれたバルーンに被膜する方法 |
Also Published As
Publication number | Publication date |
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DE69119753D1 (de) | 1996-06-27 |
US5102402A (en) | 1992-04-07 |
CA2077539A1 (en) | 1992-07-05 |
DE69119753T2 (de) | 1997-01-23 |
EP0519063B1 (en) | 1996-05-22 |
IE78821B1 (en) | 1998-02-25 |
IE920018A1 (en) | 1992-07-15 |
WO1992011890A1 (en) | 1992-07-23 |
JPH05505132A (ja) | 1993-08-05 |
CA2077539C (en) | 2002-11-12 |
EP0519063A1 (en) | 1992-12-23 |
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