CA1191064A - Catheter with selectively rigidified portion - Google Patents
Catheter with selectively rigidified portionInfo
- Publication number
- CA1191064A CA1191064A CA000412222A CA412222A CA1191064A CA 1191064 A CA1191064 A CA 1191064A CA 000412222 A CA000412222 A CA 000412222A CA 412222 A CA412222 A CA 412222A CA 1191064 A CA1191064 A CA 1191064A
- Authority
- CA
- Canada
- Prior art keywords
- catheter
- tip portion
- coating
- polymer
- hydrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0054—Catheters; Hollow probes characterised by structural features with regions for increasing flexibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0063—Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body
- A61M2025/0065—Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body which become stiffer or softer when becoming wet or humid, e.g. immersed within a liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/008—Strength or flexibility characteristics of the catheter tip
- A61M2025/0081—Soft tip
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- External Artificial Organs (AREA)
Abstract
ABSTRACT OF THE DISCLOSURE
A catheter having a relatively soft body formed of a hydrophobic elastomer and a tip portion coated with a water insoluble hydrophilic polymer grafted thereto to impart, in the dry state, rigidity to the tip portion. In use the hydrophilic coating absorbs or adsorbs water with resultant softening of the coating so as to render the tip portion soft.
A method of facilitating placement of a catheter utilizing a transitorily rigidified tip portion is taught.
A catheter having a relatively soft body formed of a hydrophobic elastomer and a tip portion coated with a water insoluble hydrophilic polymer grafted thereto to impart, in the dry state, rigidity to the tip portion. In use the hydrophilic coating absorbs or adsorbs water with resultant softening of the coating so as to render the tip portion soft.
A method of facilitating placement of a catheter utilizing a transitorily rigidified tip portion is taught.
Description
il9~0f~
The present invention relates generally to provision of elastomeric tubing having utility for medical devices and particularly urethral and venous catheters. Such catheters normally are considered to be indwelling catheters in that they are placed and retained within the urethra or a vein for an extended period of time. Since the catheters in use comprise a foreign body they tend to cause considerable irritation of the tissue with which they come in contact.
The problem attendant minimizing irritation of tissue arising from an indwelling catheter is aggravated by the fact that it is generally preferable to provide a relatively rigid tip for the indwelling portion to facilitate passage of the catheter through the ur~thra or vein. It will be appreciated that the relatively rigid tip portion of the indwelling catheter only enhances the irritation of the adjacent~tissue, i.e., bladder wall or inner wall of the vein. Thus, the invention herein resides in the proYision of catheters constructed so as to have a tip portion that is relatively rigid so as to facilitate placement of the catheter, which relatively rigid tip portion in use becomes relatively less rigid whereby irritation of adjacent tissue is minimized.
A specific example of an instance where it is desirable to have different physical properties in various sections of a catheter is with respect to a urethral ratheter wherein a relatively rigid curved tip is desirable to assist in the insertion o the catheter through the urethra which is . `' ~ .
9~Q64 curved and restrictive in the uppex seetion.
In U.S. Patent No. 3;865,666 to Shoney it is recogni~ed that from a structural point of view a cat~eter, such as a urinary catheter, must be sufficiently rigid to ensure that as it traYerses the urinary tract for placement in the bladder the catheter tube will not bend to an extent which results in occluding or reducing the size of the drainage lumen and the in~lation lumen utilized to expand a balloon to retain the tip of the catheter within the bladder. While Shoney describes a catheter having a relatively rigid tip portion a significant problem arises by virtue of the fact that the tip portion maintains its rigidity in use thus leading to potential irritation of the bladder wall.
Catheters of the utility discussed herein are generally formed of silicone polymers which due to the hydro-phobic characteristic of the silicone may then be provided with a hydrophilic coating derived from N-vinyl pyrrolidone (NVP~ or acrylate and methacrylate monomers.
U.S. Patent No. 4,055, 682 to Merrill is directed to a catheter having a silicone body portion rendered hydrophylic by contacting it with NVP and exposing the catheter and NVP
to ionizing radiation at high dosage rates. The hydrophilic polymeric layer of Merrill is so thin that the stiffness of the catheter after deposition of the polymeric layer, when dry, is not substantially greater than that of an uncoated catheter of , J ~ the dame composition and degree of crosslinking.
U.S. Patents Nos. 3,566,874 and 3,695,921 to Shepherd et al are representative of indwelling Foley urethral catheters made of natural or synthetic rubber and having an external , . ,, . .. , . . . . , , . . , . ., . ., , _, , , . .,, .. _ ..
"
~19~
coating of a hydrophilic acrylate or methacrylate polymer grafted thereto for the stated purpose of reducing irritation and infection considered to normally accompany the use of catheters. Howe~er, it has been found that problems are en-countered in use when substantially the entire outer surface of the catheter within the urethra or vein is coated with a hydrophilic polymer fiince as discussed in Patent No. 3,566,874 the resultant hydrophilic layers are stiff when dry.
In normal use of the conventional urethral and veinous catheters irritation of adjacent tissue by a relatively rigid catheter is of major concern. The present invention provides a catheter tip structure that is relatively rigid for purposes of placement of the catheter and which subsequent to placement in the body is rendered less rigid so as to minimize irritation of adjacent tissue.
The invention contemplates rendering the tip portion of urethral and ~einous catheters formed of relatively 1exible natural rubber or synthetic rubber, e.g. silicone rubber relatively rigid by the application; e.g., by grafting, to such tip portion a hydrophilic coating such as exemplified by the referenced patents to Merrill and Shepherd et al, which coatings render the tip portion relatively rigid.
U.S. Patent No. 3,695,921 to Shepherd et al dis-closes the provision of hydrophilic acrylate and methacrylatecoatings that are rigid or stiff when dry. U.S. Patent No.
4,055,682 to Merrill discloses catheters having stiffness ~9~o~
imparted thereto by use of a high dose of ionizing radiation, e.g. dose to which portion 36 is subjected, albeit the disclosure of Merrill is primarily directed to the grafting of NVP to silicone catheter body so that the stiffness of the catheter after coating, when dry, is not substantially greater than that of an un-coated catheter of the same composition and degree of crosslinking.
The object of the invention comprising mini-mizing irritation of tissue adjacent the tip of the catheter is achieved by the hydrophilic nature of the "ri~idifying" coating absorbing or adsorbing water and thereby becoming less rigid.
The present invention provides a catheter which comprises an elongated relatively flexible body portion formed of a hydrophobic polymer and including a rigidified tip portion of minor longitudinal extent, the tip portion including a physiological fluid-insoluble hydrophilic non-hydrated polymeric coating for xendering the tip portion relatively rigid in a dry state, the coating being relatively flexible when hydrated by a physiological fluid.
Preferably, the tip portion is arcuate.
The catheter may comprise a Foley or venous catheter and the coating may comprise a hydrophilic polymeric coating formed from a monomer selected from the group comprising N~vinyl pyrrolidone, acrylate and methacrylate.
Th~ invention Eurther provides a method of i - 4 -~1~106~
permanently reversibly rigidifying a predetermined minor tip portion of the length of an elongated rela-tively flexible catheter formed of a hydrophobic polymer to facilitate insertion of the catheter into a body cavity, comp.rising externally coating only the tip portion with a rigidifying physiological fluid-insoluble hydropyhilic non-hydrated polymer which is relatively flexible when hydrated by the aqueous moiety of a physiological fluid.
The inventi.on will be more readily apparent from the following detailed description taken in con-junction with the drawings in which an exemplary em-bodiment of the invention is shown.
Figure 1 is a perspective view of an urethral catheter embodying the invention; and Figure 2 is an enlarged cross-section of the tip portion of the catheter taken along the lines
The present invention relates generally to provision of elastomeric tubing having utility for medical devices and particularly urethral and venous catheters. Such catheters normally are considered to be indwelling catheters in that they are placed and retained within the urethra or a vein for an extended period of time. Since the catheters in use comprise a foreign body they tend to cause considerable irritation of the tissue with which they come in contact.
The problem attendant minimizing irritation of tissue arising from an indwelling catheter is aggravated by the fact that it is generally preferable to provide a relatively rigid tip for the indwelling portion to facilitate passage of the catheter through the ur~thra or vein. It will be appreciated that the relatively rigid tip portion of the indwelling catheter only enhances the irritation of the adjacent~tissue, i.e., bladder wall or inner wall of the vein. Thus, the invention herein resides in the proYision of catheters constructed so as to have a tip portion that is relatively rigid so as to facilitate placement of the catheter, which relatively rigid tip portion in use becomes relatively less rigid whereby irritation of adjacent tissue is minimized.
A specific example of an instance where it is desirable to have different physical properties in various sections of a catheter is with respect to a urethral ratheter wherein a relatively rigid curved tip is desirable to assist in the insertion o the catheter through the urethra which is . `' ~ .
9~Q64 curved and restrictive in the uppex seetion.
In U.S. Patent No. 3;865,666 to Shoney it is recogni~ed that from a structural point of view a cat~eter, such as a urinary catheter, must be sufficiently rigid to ensure that as it traYerses the urinary tract for placement in the bladder the catheter tube will not bend to an extent which results in occluding or reducing the size of the drainage lumen and the in~lation lumen utilized to expand a balloon to retain the tip of the catheter within the bladder. While Shoney describes a catheter having a relatively rigid tip portion a significant problem arises by virtue of the fact that the tip portion maintains its rigidity in use thus leading to potential irritation of the bladder wall.
Catheters of the utility discussed herein are generally formed of silicone polymers which due to the hydro-phobic characteristic of the silicone may then be provided with a hydrophilic coating derived from N-vinyl pyrrolidone (NVP~ or acrylate and methacrylate monomers.
U.S. Patent No. 4,055, 682 to Merrill is directed to a catheter having a silicone body portion rendered hydrophylic by contacting it with NVP and exposing the catheter and NVP
to ionizing radiation at high dosage rates. The hydrophilic polymeric layer of Merrill is so thin that the stiffness of the catheter after deposition of the polymeric layer, when dry, is not substantially greater than that of an uncoated catheter of , J ~ the dame composition and degree of crosslinking.
U.S. Patents Nos. 3,566,874 and 3,695,921 to Shepherd et al are representative of indwelling Foley urethral catheters made of natural or synthetic rubber and having an external , . ,, . .. , . . . . , , . . , . ., . ., , _, , , . .,, .. _ ..
"
~19~
coating of a hydrophilic acrylate or methacrylate polymer grafted thereto for the stated purpose of reducing irritation and infection considered to normally accompany the use of catheters. Howe~er, it has been found that problems are en-countered in use when substantially the entire outer surface of the catheter within the urethra or vein is coated with a hydrophilic polymer fiince as discussed in Patent No. 3,566,874 the resultant hydrophilic layers are stiff when dry.
In normal use of the conventional urethral and veinous catheters irritation of adjacent tissue by a relatively rigid catheter is of major concern. The present invention provides a catheter tip structure that is relatively rigid for purposes of placement of the catheter and which subsequent to placement in the body is rendered less rigid so as to minimize irritation of adjacent tissue.
The invention contemplates rendering the tip portion of urethral and ~einous catheters formed of relatively 1exible natural rubber or synthetic rubber, e.g. silicone rubber relatively rigid by the application; e.g., by grafting, to such tip portion a hydrophilic coating such as exemplified by the referenced patents to Merrill and Shepherd et al, which coatings render the tip portion relatively rigid.
U.S. Patent No. 3,695,921 to Shepherd et al dis-closes the provision of hydrophilic acrylate and methacrylatecoatings that are rigid or stiff when dry. U.S. Patent No.
4,055,682 to Merrill discloses catheters having stiffness ~9~o~
imparted thereto by use of a high dose of ionizing radiation, e.g. dose to which portion 36 is subjected, albeit the disclosure of Merrill is primarily directed to the grafting of NVP to silicone catheter body so that the stiffness of the catheter after coating, when dry, is not substantially greater than that of an un-coated catheter of the same composition and degree of crosslinking.
The object of the invention comprising mini-mizing irritation of tissue adjacent the tip of the catheter is achieved by the hydrophilic nature of the "ri~idifying" coating absorbing or adsorbing water and thereby becoming less rigid.
The present invention provides a catheter which comprises an elongated relatively flexible body portion formed of a hydrophobic polymer and including a rigidified tip portion of minor longitudinal extent, the tip portion including a physiological fluid-insoluble hydrophilic non-hydrated polymeric coating for xendering the tip portion relatively rigid in a dry state, the coating being relatively flexible when hydrated by a physiological fluid.
Preferably, the tip portion is arcuate.
The catheter may comprise a Foley or venous catheter and the coating may comprise a hydrophilic polymeric coating formed from a monomer selected from the group comprising N~vinyl pyrrolidone, acrylate and methacrylate.
Th~ invention Eurther provides a method of i - 4 -~1~106~
permanently reversibly rigidifying a predetermined minor tip portion of the length of an elongated rela-tively flexible catheter formed of a hydrophobic polymer to facilitate insertion of the catheter into a body cavity, comp.rising externally coating only the tip portion with a rigidifying physiological fluid-insoluble hydropyhilic non-hydrated polymer which is relatively flexible when hydrated by the aqueous moiety of a physiological fluid.
The inventi.on will be more readily apparent from the following detailed description taken in con-junction with the drawings in which an exemplary em-bodiment of the invention is shown.
Figure 1 is a perspective view of an urethral catheter embodying the invention; and Figure 2 is an enlarged cross-section of the tip portion of the catheter taken along the lines
2-2 of Figure 1.
Referring more specifically to Figures 1 and 2 of the drawings, there is provided an improved conventional constant drainage bag indwelling Foley urethral catheter 10 made of silicone rubber. The catheter 10 includes a tubular body portion 12 ter-minating in a tip portion indicated generally at 14.
The catheter body 10 includes a drainage lumen, not shown, that connects a funnel 16 with a drainage port 18. An inflatable retaining . . ~, ~ 1191~)64 ~ ! ' bag or balloon 20 encompasses the tube 12, at a point inwardly of drainage port 18, and is sealed or otherwise connected thereto in conventional fashion. A ~ongitudinally extending inflation lumen, not shown, terminates in an inflation port 22 which communicates the interior of the balloon 20 with a valve end porti~n or arm 23 for the introduction of air to inflate the balloon 20 to retain the catheter tip 14 in the bladder.
The body portion 12 is formed of a relatively flexible elastom~r, e.g., silicone rubber, which is hydrophobic and generally inert with respect to plysiological fluids it contacts. To facilitate passage of the relatively flexible catheter 10 through the urethra the tip portion 14 is rendered relatively rigid by provision of a rigidifying polymeric coating 24 which is applied, in the exemplary embodiment shown, such as from point 26 at the base of the balloon 20 to the end of the tip portion 14. It is essential to the present invention that the polymeric coating 24 be relatively rigid in a dry state, generally insoluble in physiological liquids, hydrophilic, and relatively flexible when wetted by physiological liquids such as ~rine and blood. The coatiny 2~ thus may comprise a hydrophilic polymer such as formed from NVP or an acrylate or methacrylate mQnomer as set forth in the Merrill and Shepherd et al patents. It will be understood that hydrophilic polymers formed from NVP or acrylate and methacrylate monomers are merely exemplary and that other hydrophilic polymers are ~ satisfactory as lon~ as they impart sufficient rigidity, in a dry state, to the catheter tip portion 14 and are capable of softening in use, within a reasonable time, by absorption of a physiological fluid.
~ 5~
~ 64 ~l It will thus be appreciated that the hydrophilic coating 24 comprises means for rendering the catheter tip portion 14 relatively rigid to facilitate placement and wherein upon indwelling placement in the bladder the tip portion 14 is rendered relatively flexible so as to minimize irritation of the bladder wall.
It will be apparent that other variations may be perceived by those skilled in the art without dPparting from the scope of my invention as defined in the appended claims.
~ (6~ ~
,,, .,.~
Referring more specifically to Figures 1 and 2 of the drawings, there is provided an improved conventional constant drainage bag indwelling Foley urethral catheter 10 made of silicone rubber. The catheter 10 includes a tubular body portion 12 ter-minating in a tip portion indicated generally at 14.
The catheter body 10 includes a drainage lumen, not shown, that connects a funnel 16 with a drainage port 18. An inflatable retaining . . ~, ~ 1191~)64 ~ ! ' bag or balloon 20 encompasses the tube 12, at a point inwardly of drainage port 18, and is sealed or otherwise connected thereto in conventional fashion. A ~ongitudinally extending inflation lumen, not shown, terminates in an inflation port 22 which communicates the interior of the balloon 20 with a valve end porti~n or arm 23 for the introduction of air to inflate the balloon 20 to retain the catheter tip 14 in the bladder.
The body portion 12 is formed of a relatively flexible elastom~r, e.g., silicone rubber, which is hydrophobic and generally inert with respect to plysiological fluids it contacts. To facilitate passage of the relatively flexible catheter 10 through the urethra the tip portion 14 is rendered relatively rigid by provision of a rigidifying polymeric coating 24 which is applied, in the exemplary embodiment shown, such as from point 26 at the base of the balloon 20 to the end of the tip portion 14. It is essential to the present invention that the polymeric coating 24 be relatively rigid in a dry state, generally insoluble in physiological liquids, hydrophilic, and relatively flexible when wetted by physiological liquids such as ~rine and blood. The coatiny 2~ thus may comprise a hydrophilic polymer such as formed from NVP or an acrylate or methacrylate mQnomer as set forth in the Merrill and Shepherd et al patents. It will be understood that hydrophilic polymers formed from NVP or acrylate and methacrylate monomers are merely exemplary and that other hydrophilic polymers are ~ satisfactory as lon~ as they impart sufficient rigidity, in a dry state, to the catheter tip portion 14 and are capable of softening in use, within a reasonable time, by absorption of a physiological fluid.
~ 5~
~ 64 ~l It will thus be appreciated that the hydrophilic coating 24 comprises means for rendering the catheter tip portion 14 relatively rigid to facilitate placement and wherein upon indwelling placement in the bladder the tip portion 14 is rendered relatively flexible so as to minimize irritation of the bladder wall.
It will be apparent that other variations may be perceived by those skilled in the art without dPparting from the scope of my invention as defined in the appended claims.
~ (6~ ~
,,, .,.~
Claims (7)
1. A catheter comprising an elongated relatively flexible body portion formed of a hydrophobic polymer and including a rigidified tip portion of minor longitudinal extent, said tip portion including a physiological fluid-insoluble hydrophilic non-hydrated polymeric coating for rendering the tip portion relatively rigid in a dry state, said coating being relatively flexible when hydrated by a physiological fluid.
2. The catheter of claim 1 wherein the tip por-tion is arcuate.
3. The catheter of claim 1 comprising a Foley catheter.
4. The catheter of claim 1 comprising a venous catheter.
5. The catheter of claim 1 wherein said coating comprises a hydrophilic polymeric coating formed from a monomer selected from the group comprising N-vinyl pyrro-lidone, acrylate and methacrylate.
6. A method of permanently reversibly rigidify-ing a predetermined minor tip portion of the length of an elongated relatively flexible catheter formed of a hydro-phobic polymer to facilitate insertion of the catheter into a body cavity, comprising externally coating only the tip portionwith a rigidifying physiological fluid-insoluble hydrophilic non-hydrated polymer which is relatively flexible when hydrated by the aqueous moiety of a physiological fluid.
7. The method of claim 6 wherein said polymer com-prises a hydrophilic polymer formed from a monomer selected from the group comprising N-vinyl pyrrolidone, acrylate and methacrylate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33629081A | 1981-12-31 | 1981-12-31 | |
| US336,290 | 1981-12-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1191064A true CA1191064A (en) | 1985-07-30 |
Family
ID=23315428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000412222A Expired CA1191064A (en) | 1981-12-31 | 1982-09-27 | Catheter with selectively rigidified portion |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS58118766A (en) |
| AU (1) | AU8984682A (en) |
| BR (1) | BR8206824A (en) |
| CA (1) | CA1191064A (en) |
| DE (1) | DE3247576A1 (en) |
| ES (1) | ES267884Y (en) |
| FR (1) | FR2519255A1 (en) |
| GB (1) | GB2112646B (en) |
| IT (1) | IT1154592B (en) |
| NL (1) | NL8203898A (en) |
| SE (1) | SE8205603L (en) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4531943A (en) * | 1983-08-08 | 1985-07-30 | Angiomedics Corporation | Catheter with soft deformable tip |
| SE8305444L (en) * | 1983-10-04 | 1985-04-05 | Vilhelm Einar Stellan Hjerten | BACTERY REFUSING SURFACE |
| US4798597A (en) * | 1987-04-29 | 1989-01-17 | Sherwood Medical Co | Flexible composite intubation tube |
| JPH02299663A (en) * | 1989-05-15 | 1990-12-11 | Unitika Ltd | Anti-infectious catheter |
| EP0420488B1 (en) * | 1989-09-25 | 1993-07-21 | Schneider (Usa) Inc. | Multilayer extrusion as process for making angioplasty balloons |
| US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
| US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
| US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| JPH0783761B2 (en) * | 1990-10-04 | 1995-09-13 | テルモ株式会社 | Medical equipment |
| US6524274B1 (en) | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
| US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
| US5254089A (en) * | 1992-04-02 | 1993-10-19 | Boston Scientific Corp. | Medication dispensing balloon catheter |
| DE4222380A1 (en) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | Endoprosthesis implantable percutaneously in a patient's body |
| US5599298A (en) * | 1993-12-30 | 1997-02-04 | Boston Scientific Corporation | Bodily sample collection balloon catheter method |
| US5588962A (en) * | 1994-03-29 | 1996-12-31 | Boston Scientific Corporation | Drug treatment of diseased sites deep within the body |
| FR2719223B1 (en) * | 1994-04-29 | 1996-10-04 | France Chirurgie Instr | Ophthalmological product. |
| US5868719A (en) * | 1997-01-15 | 1999-02-09 | Boston Scientific Corporation | Drug delivery balloon catheter device |
| US6494861B1 (en) | 1997-01-15 | 2002-12-17 | Boston Scientific Corporation | Drug delivery system |
| US6702789B1 (en) | 1997-03-11 | 2004-03-09 | Alcove Medical, Inc. | Catheter having insertion control mechanism and anti-bunching mechanism |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| AU3212199A (en) | 1998-03-31 | 1999-10-18 | Scimed Life Systems, Inc. | Temperature controlled solute delivery system |
| US7976518B2 (en) | 2005-01-13 | 2011-07-12 | Corpak Medsystems, Inc. | Tubing assembly and signal generator placement control device and method for use with catheter guidance systems |
| CA2673991C (en) | 2007-01-21 | 2012-02-07 | Hemoteq Ag | Methods for coating catheter balloons with a defined quantity of active agent |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| WO2009010975A1 (en) * | 2007-07-16 | 2009-01-22 | Med-I-Dynamix Fluid Monitoring Ltd. | Systems and methods for removal of urine |
| US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
| US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| WO2012031236A1 (en) | 2010-09-02 | 2012-03-08 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| WO2013028208A1 (en) | 2011-08-25 | 2013-02-28 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
| WO2013036772A1 (en) | 2011-09-08 | 2013-03-14 | Corpak Medsystems, Inc. | Apparatus and method used with guidance system for feeding and suctioning |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3435826A (en) * | 1964-05-27 | 1969-04-01 | Edwards Lab Inc | Embolectomy catheter |
| US3419010A (en) * | 1966-01-17 | 1968-12-31 | Cordis Corp | Catheter |
| JPS5821651B2 (en) * | 1973-11-19 | 1983-05-02 | ハイ ボルテ−ジ エンジニアリング コ−ポレ−シヨン | catheter |
| CS173836B1 (en) * | 1974-03-19 | 1977-03-31 | ||
| US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
-
1982
- 1982-09-27 CA CA000412222A patent/CA1191064A/en not_active Expired
- 1982-09-28 GB GB08227586A patent/GB2112646B/en not_active Expired
- 1982-10-01 SE SE8205603A patent/SE8205603L/en not_active Application Discontinuation
- 1982-10-07 NL NL8203898A patent/NL8203898A/en not_active Application Discontinuation
- 1982-10-15 ES ES1982267884U patent/ES267884Y/en not_active Expired
- 1982-10-28 AU AU89846/82A patent/AU8984682A/en not_active Abandoned
- 1982-11-04 FR FR8218528A patent/FR2519255A1/en not_active Withdrawn
- 1982-11-25 BR BR8206824A patent/BR8206824A/en unknown
- 1982-11-26 IT IT24460/82A patent/IT1154592B/en active
- 1982-12-22 JP JP57235115A patent/JPS58118766A/en active Pending
- 1982-12-22 DE DE19823247576 patent/DE3247576A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES267884Y (en) | 1983-11-16 |
| ES267884U (en) | 1983-04-16 |
| FR2519255A1 (en) | 1983-07-08 |
| GB2112646B (en) | 1985-10-09 |
| GB2112646A (en) | 1983-07-27 |
| DE3247576A1 (en) | 1983-07-07 |
| SE8205603D0 (en) | 1982-10-01 |
| IT8224460A0 (en) | 1982-11-26 |
| IT8224460A1 (en) | 1984-05-26 |
| IT1154592B (en) | 1987-01-21 |
| JPS58118766A (en) | 1983-07-14 |
| AU8984682A (en) | 1983-07-07 |
| BR8206824A (en) | 1983-10-04 |
| SE8205603L (en) | 1983-07-01 |
| NL8203898A (en) | 1983-07-18 |
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