GB2112646A - Coated catheters - Google Patents
Coated catheters Download PDFInfo
- Publication number
- GB2112646A GB2112646A GB08227586A GB8227586A GB2112646A GB 2112646 A GB2112646 A GB 2112646A GB 08227586 A GB08227586 A GB 08227586A GB 8227586 A GB8227586 A GB 8227586A GB 2112646 A GB2112646 A GB 2112646A
- Authority
- GB
- United Kingdom
- Prior art keywords
- catheter
- tip portion
- coating
- relatively flexible
- hydrophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0054—Catheters; Hollow probes characterised by structural features with regions for increasing flexibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0063—Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body
- A61M2025/0065—Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body which become stiffer or softer when becoming wet or humid, e.g. immersed within a liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/008—Strength or flexibility characteristics of the catheter tip
- A61M2025/0081—Soft tip
Abstract
A catheter 10 has a relatively flexible body 12 formed of a hydrophobic polymer (e.g. silicone rubber), the distal tip portion 14 of which is coated with a hydrophilic polymer to impart, in the dry state, rigidity to the tip portion. When the catheter is in the body the hydrophilic coating absorbs or adsorbs physiological fluid with resultant softening of the coating so as to render the tip portion relatively flexible. The hydrophilic polymer may be formed from N-vinyl pyrrolidone, an acrylate or a methacrylate. <IMAGE>
Description
SPECIFICATION
Catheter with selectively rigidified portion
Background of the Invention
The present invention relates generally to provision of elastomeric tubing having utility for medical devices and particularly urethral and venous catheters. Such catheters normally are considered to be indwelling catheters in that they are placed and retained within the urethra or a vein for an extended period of time.
Since the catheters in use comprise a foreign body they tend to cause considerable irritation of the tissue with which they come in contact.
The problem attendant minimizing irritation of tissue arising from an indwelling catheter is aggravated by the fact that it is generally preferable to provide a relatively rigid tip for the indwelling portion to facilitate passage of the catheter through the urethra or vein. It will be appreciated that the relatively rigid tip portion of the indwelling catheter only enhances the irritation of the adjacent tissue, i.e.
bladder wall or inner wall of the vein. Thus, the invention herein resides in the provision of catheters constructed so as to have a tip portion that is relatively rigid so as to facilitate placement of the catheter, which relatively rigid tip portion in use becomes relatively less rigid whereby irritation of adjacent tissue is minimized.
A specific example of an instance where it is desirable to have different physical properties in various sections of a catheter is with respect to a urethral catheter wherein a relatively rigid curved tip is desirable to assist in the insertion of the catheter through the urethra which is curved and restrictive in the upper section.
In U.S. Patent No. 3,865,666 to Shoney it is recognized that from a structural point of view a catheter, such as a urinary catheter, must be sufficiently rigid to ensure that as it traverses the urinary tract for placement in the bladder the catheter tube will not bend to an extent which results in occluding or reducing the size of the drainage lumen and the inflation lumen utilized to expand a balloon to retain the tip of the catheter within the bladder. While Shoney describes a catheter having a relatively rigid tip portion a significant problem arises by virtue of the fact that the tip portion maintains its rigidity in use thus leading to potential irritation of the bladder wall.
Catheters of the utility discussed herein are generally formed of silicone polymers which due to the hydrophobic characteristic of the silicone may then be provided with a hydrophilic coating derived from N-vinyl pyrrolidone (NVP) or acrylate and methacrylate monomers.
U.S. Patent No. 4,055,682 to Merrill is directed to a catheter having a silicone body portion rendered hydrophilic by contacting it with NVP and exposing the catheter and NVP to ionizing radiation at high dosage rates. The hydrlphilic polymeric layer of Merrill is so thin that the stiffness of the catheter after deposition of the polymeric layer, when dry, is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking.
U.S. Patents Nos. 3,566,874 and 3,695,921 to Shepherd et al are representative of indwelling Foley urethral catheters made of natural or synthetic rubber and having an external coating of a hydrophilic acrylate or methacrylate polymer grafted thereto for the stated purpose of reducing irritation and infection considered to normally accompany the use of catheters. However, it has been found that problems are encountered in use when substantially the entire outer surface of the catheter within the urethra or vein is coated with a hydrophilic polymer since as discussed in Patent No. 3,566,874 the resultant hydrophilic layers are stiff when dry.
Summary and Objects of the Invention
In normal use of the conventional urethral and veinous catheters irritation of adjacent tissue by a relatively rigid catheter is of major concern. The present invention provides a catheter tip structure that is relatively rigid for purposes of placement of the catheter and which subsequent to placement in the body is rendered less rigid so as to minimize irritation of adjacent tissue.
The invention contemplates rendering the tip portion of urethral and veinous catheters formed of relatively flexible natural rubber or synthetic rubber, e.g. silicone rubber relatively rigid by the application; e.g. by grafting, to such tip portion a hydrophilic coating such as exemplified by the referenced patents to Merrill and Shepherd et al, which coatings render the tip portion relatively rigid.
The disclosure of U.S. Patent No.
3,695,921 to Shepherd et al is hereby incorporated by reference with respect to the provision of hydrophilic acrylate and methacrylate coatings that are rigid or stiff when dry. The disclosure of U.S. Patent No. 4,055,682 to
Merrill is hereby incorporated by reference primarily for the disclosure therein with respect to catheters having stiffness imparted thereto by use of a high dose of ionizing radiation, e.g. dose to which portion 36 is subjected, albeit the disclosure of Merrill is primarily directed to the grafting of NVP to silicone catheter body so that the stiffness of the catheter after coating, when dry, is not substantially greater than that of an uncoated catheter of the same composition and degree of crosslinking.
The object of the invention comprising minimizing irritation of tissue adjacent the tip of the catheter is achieved by the hydrophilic nature of the "rigidifying" coating absorbing or adsorbing water and thereby becoming less rigid.
Various other objects and advantages of the invention will be readily apparent from the following detailed description taken in conjunction with the drawings in which an exemplary embodiment of the invention is shown.
Description of the Drawings
Figure 1 is a perspective view of an urethral catheter embodying the invention; and
Figure 2 is an enlarged cross-section of the tip portion of the catheter taken along the lines 2-2 of Fig. 1.
Description of the Preferred Embodiment
Referring more specifically to Figs. 1 and 2 of the drawings, there is provided an improved conventional constant drainage bag indwelling Foley urethral catheter 10 made of silicone rubber. The catheter 10 includes a tubular body portion 12 terminating in a tip portion indicated generally at 14. The catheter body 10 includes a drainage lumen, not shown, that connects a funnel 16 with a drainage port 18. An inflatable retaining bag or balloon 20 encompasses the tube 12, at a point inwardly of drainage port 18, and is sealed or otherwise connected thereto in conventional fashion.A longitudinally extending inflation lumen, not shown, terminates in an inflation port 22 which communicates the interior of the balloon 20 with a valve end portion or arm 24 for the introduction of air to inflate the balloon 20 to retain the catheter tip
14 in the bladder.
The body portion 12 is formed of a relatively flexible elastomer, e.g. silicone rubber, which is hydrophobic and generally inert with respect to physiological fluids it contacts. To facilitate passage of the relatively flexible catheter 10 through the urethra the tip portion 14 is rendered relatively rigid by provision of a rigidifying polymeric coating 24 which is applied, in the exemplary embodiment shown, such as from point 26 at the base of the balloon 20 to the end of the tip portion 14. It is essential to the present invention that the polymeric coating 24 be relatively rigid in a dry state, generally insoluble in physiological liquids, hydrophilic, and relatively flexible when wetted by physiological liquids such as urine or blood.The coating 24 thus may comprise a hydrophilic polymer such as formed from NVP or an acrylate or methacry
late monomer as set forth in the incorporated
Merrill and Shepherd et al patents. It will be
understood that hydrophilic polymers formed from NVP or acrylate and methacrylate mono
mers are merely exemplary and that other hydrophilic polymers are satisfactory as long as they impart sufficient rigidity, in a dry state, to the catheter tip portion 14 and are capable of softening in use, within a reasonable time, by absorption of a physiological fluid.
It will thus be appreciated that the hydrophilic coating 24 comprises means for rendering the catheter tip portion 14 relatively rigid to facilitate placement and wherein upon indwelling placement in the bladder the tip portion 14 is rendered relatively flexible so as to minimize irritation of the bladder wall.
It will be apparent that other variations may be perceived by those skilled in the art without departing from the scope of my invention as defined in the appended claims.
Claims (8)
1. A catheter comprising an elongated relatively flexible body portion formed of a hydrophobic polymer and including a tip portion for insertion into the body, said tip portion including means rendering the tip portion relatively rigid in a dry state and relatively flexible in use in contact with physiological fluid.
2. The catheter of Claim 1 wherein said means comprises a hydrophilic polymer coating on said tip portion formed of a hydrophobic polymer.
3. The catheter of Claim 2 wherein said hydrophilic polymer is generally insoluble in physiological fluid.
4. The catheter of Claim 1 wherein the tip portion is arcuate.
5. The catheter of Claim 1 comprising a
Foley catheter.
6. The catheter of Claim 1 comprising a venous catheter.
7. The catheter of Claim 1 wherein said means comprises a hydrophilic polymeric coating formed from a monomer selected from the group comprising N-vinyl pyrrolidone, acrylate and methacrylate.
8. A method of facilitating the placement and tissue non-irritating retention of a relatively flexible hydrophobic indwelling urinary or venous catheter comprising the steps of: providing a coating, which is relatively rigid when dry, on at least a tip portion of the catheter; inserting the tip portion-coated catheter into the body; and permitting the coating to become relatively flexible by uptake of the aqueous moiety of a physiological fluid.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33629081A | 1981-12-31 | 1981-12-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2112646A true GB2112646A (en) | 1983-07-27 |
GB2112646B GB2112646B (en) | 1985-10-09 |
Family
ID=23315428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB08227586A Expired GB2112646B (en) | 1981-12-31 | 1982-09-28 | Coated catheters |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS58118766A (en) |
AU (1) | AU8984682A (en) |
BR (1) | BR8206824A (en) |
CA (1) | CA1191064A (en) |
DE (1) | DE3247576A1 (en) |
ES (1) | ES267884Y (en) |
FR (1) | FR2519255A1 (en) |
GB (1) | GB2112646B (en) |
IT (1) | IT1154592B (en) |
NL (1) | NL8203898A (en) |
SE (1) | SE8205603L (en) |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2144635A (en) * | 1983-08-08 | 1985-03-13 | Angiomedics Inc | A catheter |
WO1985001507A1 (en) * | 1983-10-04 | 1985-04-11 | Alfa-Laval Agri International Ab | Bacteria repellent surfaces |
EP0289218A2 (en) * | 1987-04-29 | 1988-11-02 | Sherwood Medical Company | A flexible composite intubation tube |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
EP0480809A2 (en) * | 1990-10-04 | 1992-04-15 | Terumo Kabushiki Kaisha | Medical device |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
US5254089A (en) * | 1992-04-02 | 1993-10-19 | Boston Scientific Corp. | Medication dispensing balloon catheter |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
FR2719223A1 (en) * | 1994-04-29 | 1995-11-03 | France Chirurgie Instr | Ophthalmological prod. for tubular probes for draining tear fluid |
US5588962A (en) * | 1994-03-29 | 1996-12-31 | Boston Scientific Corporation | Drug treatment of diseased sites deep within the body |
US5599298A (en) * | 1993-12-30 | 1997-02-04 | Boston Scientific Corporation | Bodily sample collection balloon catheter method |
US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5868719A (en) * | 1997-01-15 | 1999-02-09 | Boston Scientific Corporation | Drug delivery balloon catheter device |
US6193746B1 (en) | 1992-07-08 | 2001-02-27 | Ernst Peter Strecker | Endoprosthesis that can be percutaneously implanted in the patient's body |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US6494861B1 (en) | 1997-01-15 | 2002-12-17 | Boston Scientific Corporation | Drug delivery system |
US7066904B2 (en) | 1990-12-28 | 2006-06-27 | Boston Scientific Scimed, Inc. | Triggered release hydrogel drug delivery system |
US7407671B2 (en) | 1998-03-31 | 2008-08-05 | Boston Scientific Scimed, Inc. | Temperature controlled solute delivery system |
WO2009010975A1 (en) * | 2007-07-16 | 2009-01-22 | Med-I-Dynamix Fluid Monitoring Ltd. | Systems and methods for removal of urine |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02299663A (en) * | 1989-05-15 | 1990-12-11 | Unitika Ltd | Anti-infectious catheter |
ATE91638T1 (en) * | 1989-09-25 | 1993-08-15 | Schneider Usa Inc | MULTI-LAYER EXTRUSION AS A PROCESS FOR MANUFACTURING BALLOONS FOR VESSEL PLASTIC. |
US6702789B1 (en) | 1997-03-11 | 2004-03-09 | Alcove Medical, Inc. | Catheter having insertion control mechanism and anti-bunching mechanism |
US7976518B2 (en) | 2005-01-13 | 2011-07-12 | Corpak Medsystems, Inc. | Tubing assembly and signal generator placement control device and method for use with catheter guidance systems |
DE112008000881A5 (en) | 2007-01-21 | 2010-01-21 | Hemoteq Ag | Medical device for the treatment of occlusions of body passages and for the prevention of imminent reocclusions |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
EP2611476B1 (en) | 2010-09-02 | 2016-08-10 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
WO2013036772A1 (en) | 2011-09-08 | 2013-03-14 | Corpak Medsystems, Inc. | Apparatus and method used with guidance system for feeding and suctioning |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3435826A (en) * | 1964-05-27 | 1969-04-01 | Edwards Lab Inc | Embolectomy catheter |
US3419010A (en) * | 1966-01-17 | 1968-12-31 | Cordis Corp | Catheter |
JPS5821651B2 (en) * | 1973-11-19 | 1983-05-02 | ハイ ボルテ−ジ エンジニアリング コ−ポレ−シヨン | catheter |
CS173836B1 (en) * | 1974-03-19 | 1977-03-31 | ||
US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
-
1982
- 1982-09-27 CA CA000412222A patent/CA1191064A/en not_active Expired
- 1982-09-28 GB GB08227586A patent/GB2112646B/en not_active Expired
- 1982-10-01 SE SE8205603A patent/SE8205603L/en not_active Application Discontinuation
- 1982-10-07 NL NL8203898A patent/NL8203898A/en not_active Application Discontinuation
- 1982-10-15 ES ES1982267884U patent/ES267884Y/en not_active Expired
- 1982-10-28 AU AU89846/82A patent/AU8984682A/en not_active Abandoned
- 1982-11-04 FR FR8218528A patent/FR2519255A1/en not_active Withdrawn
- 1982-11-25 BR BR8206824A patent/BR8206824A/en unknown
- 1982-11-26 IT IT24460/82A patent/IT1154592B/en active
- 1982-12-22 JP JP57235115A patent/JPS58118766A/en active Pending
- 1982-12-22 DE DE19823247576 patent/DE3247576A1/en not_active Withdrawn
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2144635A (en) * | 1983-08-08 | 1985-03-13 | Angiomedics Inc | A catheter |
WO1985001507A1 (en) * | 1983-10-04 | 1985-04-11 | Alfa-Laval Agri International Ab | Bacteria repellent surfaces |
EP0289218A2 (en) * | 1987-04-29 | 1988-11-02 | Sherwood Medical Company | A flexible composite intubation tube |
EP0289218A3 (en) * | 1987-04-29 | 1990-06-27 | Sherwood Medical Company | A flexible composite intubation tube |
AU610578B2 (en) * | 1987-04-29 | 1991-05-23 | Sherwood Medical Company | A flexible composite intubation tube |
US6409716B1 (en) | 1989-12-15 | 2002-06-25 | Scimed Life Systems, Inc. | Drug delivery |
US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
EP0480809A2 (en) * | 1990-10-04 | 1992-04-15 | Terumo Kabushiki Kaisha | Medical device |
EP0480809A3 (en) * | 1990-10-04 | 1992-11-04 | Terumo Kabushiki Kaisha | Medical device |
US5229211A (en) * | 1990-10-04 | 1993-07-20 | Terumo Kabushiki Kaisha | Medical device for insertion into a body |
US5843089A (en) * | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5954706A (en) * | 1990-12-28 | 1999-09-21 | Boston Scientific Corporation | Drug delivery |
US7066904B2 (en) | 1990-12-28 | 2006-06-27 | Boston Scientific Scimed, Inc. | Triggered release hydrogel drug delivery system |
US6364893B1 (en) | 1990-12-28 | 2002-04-02 | Scimed Life Systems, Inc. | Stent lining |
US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5102402A (en) * | 1991-01-04 | 1992-04-07 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5254089A (en) * | 1992-04-02 | 1993-10-19 | Boston Scientific Corp. | Medication dispensing balloon catheter |
US6193746B1 (en) | 1992-07-08 | 2001-02-27 | Ernst Peter Strecker | Endoprosthesis that can be percutaneously implanted in the patient's body |
US6645241B1 (en) | 1992-07-08 | 2003-11-11 | Ernst Peter Strecker | Endoprosthesis that can be percutaneously implanted in the patient's body |
US5919145A (en) * | 1993-12-30 | 1999-07-06 | Boston Scientific Corporation | Bodily sample collection balloon catheter |
US5599298A (en) * | 1993-12-30 | 1997-02-04 | Boston Scientific Corporation | Bodily sample collection balloon catheter method |
US5588962A (en) * | 1994-03-29 | 1996-12-31 | Boston Scientific Corporation | Drug treatment of diseased sites deep within the body |
FR2719223A1 (en) * | 1994-04-29 | 1995-11-03 | France Chirurgie Instr | Ophthalmological prod. for tubular probes for draining tear fluid |
US5868719A (en) * | 1997-01-15 | 1999-02-09 | Boston Scientific Corporation | Drug delivery balloon catheter device |
US6494861B1 (en) | 1997-01-15 | 2002-12-17 | Boston Scientific Corporation | Drug delivery system |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US7407671B2 (en) | 1998-03-31 | 2008-08-05 | Boston Scientific Scimed, Inc. | Temperature controlled solute delivery system |
WO2009010975A1 (en) * | 2007-07-16 | 2009-01-22 | Med-I-Dynamix Fluid Monitoring Ltd. | Systems and methods for removal of urine |
US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US11278648B2 (en) | 2009-07-10 | 2022-03-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
Also Published As
Publication number | Publication date |
---|---|
DE3247576A1 (en) | 1983-07-07 |
SE8205603L (en) | 1983-07-01 |
IT1154592B (en) | 1987-01-21 |
CA1191064A (en) | 1985-07-30 |
JPS58118766A (en) | 1983-07-14 |
IT8224460A0 (en) | 1982-11-26 |
SE8205603D0 (en) | 1982-10-01 |
AU8984682A (en) | 1983-07-07 |
NL8203898A (en) | 1983-07-18 |
GB2112646B (en) | 1985-10-09 |
IT8224460A1 (en) | 1984-05-26 |
ES267884U (en) | 1983-04-16 |
BR8206824A (en) | 1983-10-04 |
ES267884Y (en) | 1983-11-16 |
FR2519255A1 (en) | 1983-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |