JP3261129B2 - リン脂質で被覆した微細結晶である水不溶性薬剤の注射可能な製剤 - Google Patents

リン脂質で被覆した微細結晶である水不溶性薬剤の注射可能な製剤

Info

Publication number
JP3261129B2
JP3261129B2 JP50885491A JP50885491A JP3261129B2 JP 3261129 B2 JP3261129 B2 JP 3261129B2 JP 50885491 A JP50885491 A JP 50885491A JP 50885491 A JP50885491 A JP 50885491A JP 3261129 B2 JP3261129 B2 JP 3261129B2
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JP
Japan
Prior art keywords
drug
water
coated
particles
drug substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50885491A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05507685A (ja
Inventor
ハイネス、ダンカン・エイチ
Original Assignee
ファルマ・ロジック・インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by ファルマ・ロジック・インコーポレイテッド filed Critical ファルマ・ロジック・インコーポレイテッド
Publication of JPH05507685A publication Critical patent/JPH05507685A/ja
Application granted granted Critical
Publication of JP3261129B2 publication Critical patent/JP3261129B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP50885491A 1990-04-26 1991-04-23 リン脂質で被覆した微細結晶である水不溶性薬剤の注射可能な製剤 Expired - Lifetime JP3261129B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US514,012 1990-04-26
US07/514,012 US5091188A (en) 1990-04-26 1990-04-26 Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs

Publications (2)

Publication Number Publication Date
JPH05507685A JPH05507685A (ja) 1993-11-04
JP3261129B2 true JP3261129B2 (ja) 2002-02-25

Family

ID=24045456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50885491A Expired - Lifetime JP3261129B2 (ja) 1990-04-26 1991-04-23 リン脂質で被覆した微細結晶である水不溶性薬剤の注射可能な製剤

Country Status (16)

Country Link
US (2) US5091188A (enExample)
EP (1) EP0533690B1 (enExample)
JP (1) JP3261129B2 (enExample)
KR (1) KR0159114B1 (enExample)
AT (1) ATE181234T1 (enExample)
AU (1) AU7852891A (enExample)
CA (1) CA2078990C (enExample)
DE (1) DE69131349T2 (enExample)
DK (1) DK0533690T3 (enExample)
ES (1) ES2134776T3 (enExample)
GR (1) GR3030825T3 (enExample)
MX (1) MX25532A (enExample)
RU (1) RU2100030C1 (enExample)
TW (1) TW203559B (enExample)
WO (1) WO1991016068A1 (enExample)
ZA (1) ZA913122B (enExample)

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US5091188A (en) 1992-02-25
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